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Aliases for HYKK Gene

Aliases for HYKK Gene

  • Hydroxylysine Kinase 2 3 5
  • Aminoglycoside Phosphotransferase Domain-Containing Protein 1 3 4
  • 5-Hydroxy-L-Lysine Kinase 3 4
  • 5-Hydroxylysine Kinase 2 3
  • AGPHD1 3 4
  • Aminoglycoside Phosphotransferase Domain Containing 1 2
  • EC 2.7.1.81 4

External Ids for HYKK Gene

Previous HGNC Symbols for HYKK Gene

  • AGPHD1

Previous GeneCards Identifiers for HYKK Gene

  • GC15P078800

Summaries for HYKK Gene

GeneCards Summary for HYKK Gene

HYKK (Hydroxylysine Kinase) is a Protein Coding gene. Diseases associated with HYKK include Tobacco Addiction. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and hydroxylysine kinase activity.

UniProtKB/Swiss-Prot for HYKK Gene

  • Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Additional gene information for HYKK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYKK Gene

Genomics for HYKK Gene

GeneHancer (GH) Regulatory Elements for HYKK Gene

Promoters and enhancers for HYKK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I078506 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 216 2.1 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 YY1 POLR2B GLIS2 FOS HYKK IREB2 PSMA4 ENSG00000279373 GC15M078021
GH15I078539 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.3 +33.4 33441 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 PSMA4 CHRNA5 HYKK IREB2 GC15M078021
GH15I078564 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.8 +58.3 58263 2.2 HDGF ARNT ARID4B SIN3A TCF12 ELK1 ZNF143 SP3 NCOA1 REST CHRNA5 PSMA4 IREB2 TBC1D2B HYKK MORF4L1 ADAMTS7 CRABP1 RASGRF1 ENSG00000261762
GH15I078307 Enhancer 0.9 Ensembl ENCODE 19.2 -199.1 -199134 0.9 SOX13 CTCF MAX RAD21 CC2D1A MTA3 POLR2A ZNF143 SMC3 ZNF444 IREB2 ENSG00000259562 HYKK WDR61 CRABP1 ENSG00000260988 ENSG00000259322 GC15P078331 GC15M078021
GH15I077621 Enhancer 1.1 ENCODE dbSUPER 10.6 -884.7 -884659 2.7 HDGF ZNF133 GLI4 ZNF2 ZBTB7B TCF12 ZNF207 MCM3 NCOA1 ZNF488 ENSG00000259562 IREB2 TBC1D2B WDR61 HMG20A ENSG00000259322 ENSG00000260988 PSMA4 HYKK LOC645752
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYKK on UCSC Golden Path with GeneCards custom track

Genomic Locations for HYKK Gene

Genomic Locations for HYKK Gene
chr15:78,507,564-78,537,373
(GRCh38/hg38)
Size:
29,810 bases
Orientation:
Plus strand
chr15:78,799,906-78,829,715
(GRCh37/hg19)

Genomic View for HYKK Gene

Genes around HYKK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYKK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYKK Gene

Proteins for HYKK Gene

  • Protein details for HYKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU49-HYKK_HUMAN
    Recommended name:
    Hydroxylysine kinase
    Protein Accession:
    A2RU49
    Secondary Accessions:
    • B7ZMA5
    • F8W6X5
    • Q6ZTN0

    Protein attributes for HYKK Gene

    Size:
    373 amino acids
    Molecular mass:
    41933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HYKK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYKK Gene

Post-translational modifications for HYKK Gene

  • Ubiquitination at isoforms=3186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HYKK Gene

Domains & Families for HYKK Gene

Gene Families for HYKK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HYKK Gene

Suggested Antigen Peptide Sequences for HYKK Gene

Graphical View of Domain Structure for InterPro Entry

A2RU49

UniProtKB/Swiss-Prot:

HYKK_HUMAN :
  • Belongs to the aminoglycoside phosphotransferase family.
Family:
  • Belongs to the aminoglycoside phosphotransferase family.
genes like me logo Genes that share domains with HYKK: view

Function for HYKK Gene

Molecular function for HYKK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=280 uM for (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; KM=7.6 uM for (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; KM=810 uM for ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; KM=3.5 uM for GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; Vmax=4.95 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; Vmax=0.49 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; Vmax=5.28 umol/min/mg enzyme toward ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472}; Vmax=0.57 umol/min/mg enzyme toward GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472};
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Enzyme Numbers (IUBMB) for HYKK Gene

Phenotypes From GWAS Catalog for HYKK Gene

Gene Ontology (GO) - Molecular Function for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047992 hydroxylysine kinase activity TAS --
genes like me logo Genes that share ontologies with HYKK: view

Phenotypes for HYKK Gene

genes like me logo Genes that share phenotypes with HYKK: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYKK Gene

Localization for HYKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYKK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYKK gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with HYKK: view

Pathways & Interactions for HYKK Gene

genes like me logo Genes that share pathways with HYKK: view

Gene Ontology (GO) - Biological Process for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with HYKK: view

No data available for SIGNOR curated interactions for HYKK Gene

Drugs & Compounds for HYKK Gene

(2) Drugs for HYKK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for HYKK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxylysine
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoate
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid
  • (2S,5R)-5-hydroxylysine
  • (5R)-5-hydroxy-L-lysine
  • 5-Hydroxy-L-lysine
1190-94-9
5-phosphonooxy-L-lysine
genes like me logo Genes that share compounds with HYKK: view

Transcripts for HYKK Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYKK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for HYKK Gene

GeneLoc Exon Structure for
HYKK
ECgene alternative splicing isoforms for
HYKK

Expression for HYKK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYKK Gene

NURSA nuclear receptor signaling pathways regulating expression of HYKK Gene:

HYKK

Evidence on tissue expression from TISSUES for HYKK Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HYKK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYKK Gene

Orthologs for HYKK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYKK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPHD1 33
  • 99.37 (n)
HYKK 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HYKK 33 34
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Hykk 33
  • 84.54 (n)
mouse
(Mus musculus)
Mammalia Hykk 33 16 34
  • 84 (n)
dog
(Canis familiaris)
Mammalia HYKK 33 34
  • 78.11 (n)
oppossum
(Monodelphis domestica)
Mammalia HYKK 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HYKK 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPHD1 33 34
  • 62.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hykk 33
  • 64.05 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171550 33
  • 56.13 (n)
HYKK (1 of 2) 34
  • 47 (a)
OneToMany
HYKK (2 of 2) 34
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004612 33
  • 45.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31751 33 34
  • 45.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
Species where no ortholog for HYKK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYKK Gene

ENSEMBL:
Gene Tree for HYKK (if available)
TreeFam:
Gene Tree for HYKK (if available)

Paralogs for HYKK Gene

No data available for Paralogs for HYKK Gene

Variants for HYKK Gene

Sequence variations from dbSNP and Humsavar for HYKK Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000075156 -- 78,512,078(+) A/G intron_variant
rs1000193566 -- 78,522,813(+) A/T intron_variant
rs1000204834 -- 78,507,668(+) G/C 5_prime_UTR_variant, non_coding_transcript_variant
rs1000222910 -- 78,522,428(+) G/A intron_variant
rs1000347785 -- 78,528,883(+) A/C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HYKK Gene

Variant ID Type Subtype PubMed ID
esv2749911 CNV deletion 23290073
esv3636985 CNV loss 21293372
nsv1038816 CNV gain 25217958
nsv1116464 OTHER inversion 24896259
nsv94512 CNV deletion 16902084

Variation tolerance for HYKK Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYKK Gene

Human Gene Mutation Database (HGMD)
HYKK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYKK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYKK Gene

Disorders for HYKK Gene

MalaCards: The human disease database

(1) MalaCards diseases for HYKK Gene - From: DISEASES

Disorder Aliases PubMed IDs
tobacco addiction
  • tobacco addiction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search HYKK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HYKK

genes like me logo Genes that share disorders with HYKK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYKK Gene

Publications for HYKK Gene

  1. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. (PMID: 22241472) Veiga-da-Cunha M … Van Schaftingen E (The Journal of biological chemistry 2012) 2 3 4 58
  2. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (PMID: 18780872) Liu P … You M (Journal of the National Cancer Institute 2008) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures. (PMID: 27072204) Sun H … Wang S (Journal of cancer research and therapeutics 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for HYKK Gene

Sources for HYKK Gene

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