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Aliases for HYAL4 Gene

Aliases for HYAL4 Gene

  • Hyaluronoglucosaminidase 4 2 3 5
  • Chondroitin Sulfate Endo-Beta-N-Acetylgalactosaminidase 3 4
  • Chondroitin Sulfate Hydrolase 3 4
  • EC 4 56
  • Hyal-4 3 4
  • CSHY 3 4
  • Hyaluronoglucosaminidase-4 4
  • Hyaluronidase 4 2
  • Hyaluronidase-4 3
  • EC 3.2.1 56

External Ids for HYAL4 Gene

Previous GeneCards Identifiers for HYAL4 Gene

  • GC07P121963
  • GC07P123025
  • GC07P123039
  • GC07P123014
  • GC07P123079
  • GC07P123272
  • GC07P123469
  • GC07P117848

Summaries for HYAL4 Gene

Entrez Gene Summary for HYAL4 Gene

  • This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for HYAL4 Gene

HYAL4 (Hyaluronoglucosaminidase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Articular Cartilage Extracellular Matrix Pathway. Gene Ontology (GO) annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is SPAM1.

UniProtKB/Swiss-Prot for HYAL4 Gene

  • Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

Additional gene information for HYAL4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL4 Gene

Genomics for HYAL4 Gene

GeneHancer (GH) Regulatory Elements for HYAL4 Gene

Promoters and enhancers for HYAL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I123745 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.2 -80.7 -80686 6.1 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D WASL ENSG00000272686 HYAL4 PIR33062 GC07P123667
GH07I123556 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.8 -271.4 -271426 2.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 NDUFA5 ENSG00000272686 HYAL4 ASB15 IQUB
GH07I123533 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.8 -294.2 -294164 1.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B GLIS2 IQUB NDUFA5 HYAL4 RNU6-296P GC07M123458
GH07I123797 Enhancer 1.2 Ensembl ENCODE 9 -30.8 -30836 2.2 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B ZNF213 FOS ENSG00000272686 HYAL4 RNU6-11P HYALP1
GH07I123655 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 9.7 -172.8 -172834 2.3 MCM7 ZBTB40 LMOD2 WASL HYAL4 GC07P123667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYAL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYAL4 gene promoter:

Genomic Locations for HYAL4 Gene

Genomic Locations for HYAL4 Gene
48,499 bases
Plus strand

Genomic View for HYAL4 Gene

Genes around HYAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL4 Gene

Proteins for HYAL4 Gene

  • Protein details for HYAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D0VXG1
    • Q9UL99
    • Q9Y6T9

    Protein attributes for HYAL4 Gene

    481 amino acids
    Molecular mass:
    54249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HYAL4 Gene

Selected DME Specific Peptides for HYAL4 Gene


Post-translational modifications for HYAL4 Gene

  • Glycosylation at isoforms=86, posLast=115115, posLast=177177, and isoforms=343

Domains & Families for HYAL4 Gene

Gene Families for HYAL4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for HYAL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 56 family.
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL4: view

Function for HYAL4 Gene

Molecular function for HYAL4 Gene

GENATLAS Biochemistry:
hyaluroglucosaminidase 4,differentially expressed in placenta and skeletal muscle,involved inglycosaminoglycan catabolism,clustered with HYAL1P1 and SPAM1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity). {ECO:0000269 PubMed:19889881}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269 PubMed:19889881};
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
UniProtKB/Swiss-Prot Function:
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

Enzyme Numbers (IUBMB) for HYAL4 Gene

Phenotypes From GWAS Catalog for HYAL4 Gene

Gene Ontology (GO) - Molecular Function for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with HYAL4: view
genes like me logo Genes that share phenotypes with HYAL4: view

Animal Models for HYAL4 Gene

MGI Knock Outs for HYAL4:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HYAL4 Gene

Localization for HYAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYAL4 gene
Compartment Confidence
peroxisome 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HYAL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HYAL4 Gene

Pathways & Interactions for HYAL4 Gene

genes like me logo Genes that share pathways with HYAL4: view

Pathways by source for HYAL4 Gene

2 KEGG pathways for HYAL4 Gene
1 R&D Systems pathway for HYAL4 Gene

Interacting Proteins for HYAL4 Gene

Gene Ontology (GO) - Biological Process for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006027 glycosaminoglycan catabolic process TAS 10493834
GO:0008152 metabolic process IEA --
GO:0030207 chondroitin sulfate catabolic process IEA --
genes like me logo Genes that share ontologies with HYAL4: view

No data available for SIGNOR curated interactions for HYAL4 Gene

Drugs & Compounds for HYAL4 Gene

(1) Drugs for HYAL4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(1) Additional Compounds for HYAL4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulphate)
  • GalNAc4S
  • N-Acetyl-D-galactosamine 4-sulfate
  • N-Acetyl-D-galactosamine 4-sulphate
genes like me logo Genes that share compounds with HYAL4: view

Transcripts for HYAL4 Gene

mRNA/cDNA for HYAL4 Gene

Unigene Clusters for HYAL4 Gene

Hyaluronoglucosaminidase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL4 Gene

No ASD Table

Relevant External Links for HYAL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYAL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYAL4 Gene

mRNA differential expression in normal tissues according to GTEx for HYAL4 Gene

This gene is overexpressed in Muscle - Skeletal (x20.7), Testis (x9.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for HYAL4 Gene

This gene is overexpressed in Cerebrospinal fluid (45.8), Breast (13.1), and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HYAL4 Gene

Protein tissue co-expression partners for HYAL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HYAL4 Gene:


SOURCE GeneReport for Unigene cluster for HYAL4 Gene:


mRNA Expression by UniProt/SwissProt for HYAL4 Gene:

Tissue specificity: Detected in placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for HYAL4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HYAL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYAL4 Gene

Orthologs for HYAL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYAL4 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia HYAL4 33 34
  • 89.37 (n)
(Bos Taurus)
Mammalia HYAL4 33 34
  • 87.36 (n)
(Mus musculus)
Mammalia Hyal4 33 16 34
  • 84.34 (n)
(Rattus norvegicus)
Mammalia Hyal4 33
  • 82.81 (n)
(Monodelphis domestica)
Mammalia HYAL4 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia HYAL4 34
  • 69 (a)
(Gallus gallus)
Aves -- 34
  • 45 (a)
(Anolis carolinensis)
Reptilia HYAL4 34
  • 72 (a)
(Danio rerio)
Actinopterygii LOC100149853 33
  • 59.22 (n)
hyal4 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea T22C8.2 35
  • 30 (a)
chhy-1 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for HYAL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HYAL4 Gene

Gene Tree for HYAL4 (if available)
Gene Tree for HYAL4 (if available)

Paralogs for HYAL4 Gene

Paralogs for HYAL4 Gene

(5) SIMAP similar genes for HYAL4 Gene using alignment to 4 proteins: Pseudogenes for HYAL4 Gene

genes like me logo Genes that share paralogs with HYAL4: view

Variants for HYAL4 Gene

Sequence variations from dbSNP and Humsavar for HYAL4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000008666 -- 123,869,468(+) C/T intron_variant
rs1000029655 -- 123,772,975(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000069034 -- 123,825,448(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000069644 -- 123,778,827(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000132227 -- 123,838,761(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HYAL4 Gene

Variant ID Type Subtype PubMed ID
nsv478913 CNV novel sequence insertion 20440878
esv3891198 CNV gain 25118596

Variation tolerance for HYAL4 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYAL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYAL4 Gene

Disorders for HYAL4 Gene

Additional Disease Information for HYAL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HYAL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYAL4 Gene

Publications for HYAL4 Gene

  1. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. (PMID: 19889881) Kaneiwa T … Yamada S (Glycobiology 2010) 3 4 22 58
  2. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PMID: 10493834) Csóka AB … Stern R (Genomics 1999) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. (PMID: 10989127) Fiszer-Szafarz B … Zou L (Journal of biochemical and biophysical methods 2000) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HYAL4 Gene

Sources for HYAL4 Gene

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