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Aliases for HYAL3 Gene

Aliases for HYAL3 Gene

  • Hyaluronoglucosaminidase 3 2 3 5
  • Lung Carcinoma Protein 3 3 4
  • EC 3.2.1.35 4 56
  • HYAL-3 3 4
  • LUCA-3 3 4
  • LUCA3 3 4
  • Hyaluronoglucosaminidase-3 4
  • Hyaluronidase-3 3

External Ids for HYAL3 Gene

Previous GeneCards Identifiers for HYAL3 Gene

  • GC03P049651
  • GC03P049819
  • GC03M050179
  • GC03M050284
  • GC03M050301
  • GC03M050305
  • GC03M050331

Summaries for HYAL3 Gene

Entrez Gene Summary for HYAL3 Gene

  • This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for HYAL3 Gene

HYAL3 (Hyaluronoglucosaminidase 3) is a Protein Coding gene. Diseases associated with HYAL3 include Mucopolysaccharidosis, Type Ix and Lung Squamous Cell Carcinoma. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include virus receptor activity and hyaluronoglucuronidase activity. An important paralog of this gene is HYAL2.

UniProtKB/Swiss-Prot for HYAL3 Gene

  • Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.

Gene Wiki entry for HYAL3 Gene

Additional gene information for HYAL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL3 Gene

Genomics for HYAL3 Gene

GeneHancer (GH) Regulatory Elements for HYAL3 Gene

Promoters and enhancers for HYAL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I050297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 570.1 -1.4 -1447 6.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HYAL3 HYAL1 NAT6 SEMA3F-AS1 RBM5 TMEM115 CYB561D2 AMT DAG1 RNF123
GH03I050257 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.5 +32.0 31967 19.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SEMA3B SEMA3B-AS1 HYAL3 CYB561D2 IFRD2 GNAI2 AMT HYAL1 AMIGO3 DOCK3
GH03I050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.4 +54.2 54212 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 HYAL3 RBM5 SEMA3F-AS1 RBM6 HYAL1 CYB561D2 RHOA-IT1 AMT HEMK1
GH03I050332 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.2 -38.2 -38204 9.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 RASSF1 RASSF1-AS1 HYAL3 CYB561D2 RBM6 SEMA3F-AS1 NICN1 RBM5 RHOA-IT1 TMEM115
GH03I050319 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 -23.1 -23085 5.2 HDGF CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 HYAL2 RBM6 RBM5 AMT SEMA3F-AS1 TMEM115 HYAL3 RHOA-IT1 RASSF1 HEMK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYAL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYAL3 gene promoter:

Genomic Locations for HYAL3 Gene

Genomic Locations for HYAL3 Gene
chr3:50,292,828-50,299,468
(GRCh38/hg38)
Size:
6,641 bases
Orientation:
Minus strand
chr3:50,330,259-50,336,899
(GRCh37/hg19)

Genomic View for HYAL3 Gene

Genes around HYAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL3 Gene

Proteins for HYAL3 Gene

  • Protein details for HYAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43820-HYAL3_HUMAN
    Recommended name:
    Hyaluronidase-3
    Protein Accession:
    O43820
    Secondary Accessions:
    • O60540
    • Q8NFK2
    • Q8NFK3
    • Q8NFK4
    • Q96E56
    • Q9BRW9

    Protein attributes for HYAL3 Gene

    Size:
    417 amino acids
    Molecular mass:
    46501 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70915.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305};

    Alternative splice isoforms for HYAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYAL3 Gene

Selected DME Specific Peptides for HYAL3 Gene

O43820:
  • GVVLWGDLS
  • LRPHGLWGFY
  • FVRHRLEEAFRVAL
  • PLWAGNWG
  • ACSHQRCHGHGRC
  • GTAHNGGIPQA
  • WLWAASSALFPSIYLPP
  • LDPQEQL
  • GWAGPTC

Post-translational modifications for HYAL3 Gene

Domains & Families for HYAL3 Gene

Gene Families for HYAL3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HYAL3 Gene

Graphical View of Domain Structure for InterPro Entry

O43820

UniProtKB/Swiss-Prot:

HYAL3_HUMAN :
  • Belongs to the glycosyl hydrolase 56 family.
Family:
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL3: view

Function for HYAL3 Gene

Molecular function for HYAL3 Gene

GENATLAS Biochemistry:
hyaluroglucosaminidase 3,secreted in the sperm and involved in fertilization,involved in glycosaminoglycan catabolism
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
UniProtKB/Swiss-Prot Function:
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
UniProtKB/Swiss-Prot Induction:
Expression is not significantly up- or down-regulated by ultraviolet irradiation B (UV-B) in epidermis (PubMed:21699545).

Enzyme Numbers (IUBMB) for HYAL3 Gene

Phenotypes From GWAS Catalog for HYAL3 Gene

Gene Ontology (GO) - Molecular Function for HYAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 NOT virus receptor activity IDA 11296287
GO:0003824 catalytic activity IEA --
GO:0004415 hyalurononglucosaminidase activity IDA,IEA 11944887
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HYAL3: view
genes like me logo Genes that share phenotypes with HYAL3: view

Animal Models for HYAL3 Gene

MGI Knock Outs for HYAL3:

Animal Model Products

miRNA for HYAL3 Gene

miRTarBase miRNAs that target HYAL3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HYAL3 Gene

Localization for HYAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL3 Gene

Secreted. Cell membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Endoplasmic reticulum. Early endosome. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail. {ECO:0000250 UniProtKB:Q8VEI3}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYAL3 gene
Compartment Confidence
lysosome 5
extracellular 4
endoplasmic reticulum 4
endosome 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for HYAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0002080 acrosomal membrane ISS --
GO:0005576 extracellular region IEA --
GO:0005764 lysosome IDA 16600643
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with HYAL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HYAL3 Gene

Pathways & Interactions for HYAL3 Gene

genes like me logo Genes that share pathways with HYAL3: view

Interacting Proteins for HYAL3 Gene

Gene Ontology (GO) - Biological Process for HYAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001552 ovarian follicle atresia ISS --
GO:0005975 carbohydrate metabolic process IEA --
GO:0006954 inflammatory response IDA 18390475
GO:0007338 single fertilization IEA --
GO:0007341 penetration of zona pellucida ISS --
genes like me logo Genes that share ontologies with HYAL3: view

No data available for SIGNOR curated interactions for HYAL3 Gene

Drugs & Compounds for HYAL3 Gene

(1) Drugs for HYAL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(1) Additional Compounds for HYAL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulphate)
  • GalNAc4S
  • N-Acetyl-D-galactosamine 4-sulfate
  • N-Acetyl-D-galactosamine 4-sulphate
45233-43-0
genes like me logo Genes that share compounds with HYAL3: view

Transcripts for HYAL3 Gene

Unigene Clusters for HYAL3 Gene

Hyaluronoglucosaminidase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - -
SP19: - - - - -
SP20: - -
SP21: -
SP22:
SP23: - - - - - - - - -
SP24: - -
SP25: - - -
SP26:
SP27: -

ExUns: 11d · 11e ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - -
SP8:
SP9:
SP10: - - - -
SP11: - - -
SP12:
SP13: - - -
SP14: - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

ExUns: 22b ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HYAL3 Gene

GeneLoc Exon Structure for
HYAL3
ECgene alternative splicing isoforms for
HYAL3

Expression for HYAL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYAL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HYAL3 Gene

This gene is overexpressed in Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of HYAL3 Gene:

HYAL3

SOURCE GeneReport for Unigene cluster for HYAL3 Gene:

Hs.129910

mRNA Expression by UniProt/SwissProt for HYAL3 Gene:

O43820-HYAL3_HUMAN
Tissue specificity: Expressed in sperm (PubMed:20586096). Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level) (PubMed:21699545). Bone marrow, testis and kidney (PubMed:10493834).

Evidence on tissue expression from TISSUES for HYAL3 Gene

  • Bone marrow(4)
  • Nervous system(2.9)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with HYAL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYAL3 Gene

Orthologs for HYAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYAL3 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia HYAL3 33 34
  • 86.87 (n)
cow
(Bos Taurus)
Mammalia HYAL3 33
  • 86.7 (n)
-- 34
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hyal3 33
  • 83.62 (n)
mouse
(Mus musculus)
Mammalia Hyal3 33 16 34
  • 81.43 (n)
oppossum
(Monodelphis domestica)
Mammalia HYAL3 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HYAL3 33 34
  • 62.66 (n)
lizard
(Anolis carolinensis)
Reptilia HYAL3 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hyal3 33 34
  • 50.66 (n)
worm
(Caenorhabditis elegans)
Secernentea T22C8.2 35
  • 29 (a)
chhy-1 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
Species where no ortholog for HYAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HYAL3 Gene

ENSEMBL:
Gene Tree for HYAL3 (if available)
TreeFam:
Gene Tree for HYAL3 (if available)

Paralogs for HYAL3 Gene

Paralogs for HYAL3 Gene

(6) SIMAP similar genes for HYAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HYAL3: view

Variants for HYAL3 Gene

Sequence variations from dbSNP and Humsavar for HYAL3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs117179004 likely-benign, Deficiency of hyaluronoglucosaminidase 50,300,616(-) G/A upstream_transcript_variant
rs1283 likely-benign, Deficiency of hyaluronoglucosaminidase 50,299,991(-) G/A/C/T upstream_transcript_variant
rs142342237 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,514(-) G/C upstream_transcript_variant
rs150976767 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,024(-) C/T upstream_transcript_variant
rs182987423 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,049(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HYAL3 Gene

Variant ID Type Subtype PubMed ID
nsv954855 CNV deletion 24416366
nsv834693 CNV loss 17160897
nsv834692 CNV loss 17160897
nsv590255 CNV loss 21841781
nsv523662 CNV loss 19592680
nsv523560 CNV loss 19592680
nsv470561 CNV loss 18288195
nsv460531 CNV loss 19166990
nsv3813 CNV deletion 18451855
esv2759148 CNV loss 17122850
dgv8317n54 CNV loss 21841781
dgv8316n54 CNV loss 21841781

Variation tolerance for HYAL3 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYAL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYAL3 Gene

Disorders for HYAL3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HYAL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucopolysaccharidosis, type ix
  • mps9
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search HYAL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HYAL3

genes like me logo Genes that share disorders with HYAL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYAL3 Gene

Publications for HYAL3 Gene

  1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PMID: 10493834) Csóka AB … Stern R (Genomics 1999) 2 3 4 58
  2. Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes. (PMID: 21699545) Kurdykowski S … Maquart FX (Photochemistry and photobiology 2011) 3 4 58
  3. Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm. (PMID: 20586096) Reese KL … Martin-Deleon PA (Molecular reproduction and development 2010) 3 4 58
  4. Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. (PMID: 16203124) Adams JR … Byers S (Matrix biology : journal of the International Society for Matrix Biology 2006) 3 22 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58

Products for HYAL3 Gene

Sources for HYAL3 Gene