Aliases for HYAL2 Gene
External Ids for HYAL2 Gene
Previous GeneCards Identifiers for HYAL2 Gene
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
GeneCards Summary for HYAL2 Gene
HYAL2 (Hyaluronidase 2) is a Protein Coding gene. Diseases associated with HYAL2 include Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome and Cor Triatriatum Sinister. Among its related pathways are Microglia Activation During Neuroinflammation: Overview and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and virus receptor activity. An important paralog of this gene is HYAL1.
UniProtKB/Swiss-Prot Summary for HYAL2 Gene
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.