Aliases for HUNK Gene

Aliases for HUNK Gene

  • Hormonally Up-Regulated Neu-Associated Kinase 2 3 5
  • Hormonally Up-Regulated Neu Tumor-Associated Kinase 3 4
  • Hormonally Upregulated Neu-Associated Kinase 2 3
  • EC 2.7.11.1 4 52
  • B19 3 4
  • Hormonally Upregulated Neu Tumor-Associated Kinase 3
  • Serine/Threonine Protein Kinase MAK-V 3
  • Serine/Threonine-Protein Kinase MAK-V 4
  • EC 2.7.11 52
  • MAKV 4

External Ids for HUNK Gene

Previous GeneCards Identifiers for HUNK Gene

  • GC21P029823
  • GC21P032166
  • GC21P032167
  • GC21P033245
  • GC21P018704

Summaries for HUNK Gene

GeneCards Summary for HUNK Gene

HUNK (Hormonally Up-Regulated Neu-Associated Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK3.

Additional gene information for HUNK Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HUNK Gene

Genomics for HUNK Gene

GeneHancer (GH) Regulatory Elements for HUNK Gene

Promoters and enhancers for HUNK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J031871 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.2 +1.0 985 4.2 CTCF POLR2G TEAD4 ZFX ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 ZBTB7A HUNK HSALNG0132647 CFAP298 MIS18A lnc-SOD1-10
GH21J031872 Enhancer 0.2 CraniofacialAtlas 500.7 -1.2 -1232 0.2 HUNK HSALNG0132647 L13704-002
GH21J031907 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.7 +38.3 38281 7.4 RBAK TEAD4 ZNF639 ZIC2 ZBTB7A OSR2 WT1 POLR2A FOS ZFHX2 HUNK ENSG00000238390 MIS18A-AS1 FBXW11P1 CFAP298 PAXBP1-AS1 AB372770-001 lnc-SOD1-10
GH21J031892 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 +21.5 21519 4.5 TEAD4 ZNF10 ZBTB7A KMT2B YY1 ZNF621 SMAD4 FOSL2 EHMT2 RARA HUNK MIS18A-AS1 PAXBP1 ENSG00000238390 EXOSC3P1 SCAF4 lnc-SOD1-10 AB372770-001
GH21J031897 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.3 +27.0 26977 5.9 EP300 FOXK2 POLR2G NCOR1 ZIC2 KDM6A TCF7 ZNF423 SKI TEAD1 HUNK PAXBP1 SCAF4 lnc-SOD1-10 AB372770-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HUNK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HUNK

Top Transcription factor binding sites by QIAGEN in the HUNK gene promoter:
  • AP-1
  • AREB6
  • FOXO1
  • FOXO1a
  • GATA-1
  • MyoD
  • Pax-6
  • Sox9
  • Spz1

Genomic Locations for HUNK Gene

Genomic Locations for HUNK Gene
chr21:31,873,020-32,044,633
(GRCh38/hg38)
Size:
171,614 bases
Orientation:
Plus strand
chr21:33,245,628-33,416,946
(GRCh37/hg19)
Size:
171,319 bases
Orientation:
Plus strand

Genomic View for HUNK Gene

Genes around HUNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUNK Gene

Proteins for HUNK Gene

  • Protein details for HUNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57058-HUNK_HUMAN
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase
    Protein Accession:
    P57058

    Protein attributes for HUNK Gene

    Size:
    714 amino acids
    Molecular mass:
    79686 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HUNK Gene

Selected DME Specific Peptides for HUNK Gene

P57058:
  • KIYEKKR
  • GEPAAPG
  • GGNLMHKIYE
  • RKLGEGSFAKVREGLHV
  • VAIKVIDK
  • KRPNIQQ
  • VVHRDLK
  • GEKVAIK
  • HRDLKIEN

Post-translational modifications for HUNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HUNK Gene

Domains & Families for HUNK Gene

Gene Families for HUNK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HUNK Gene

Suggested Antigen Peptide Sequences for HUNK Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase MAK-V (HUNK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57058

UniProtKB/Swiss-Prot:

HUNK_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with HUNK: view

Function for HUNK Gene

Molecular function for HUNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for HUNK Gene

Phenotypes From GWAS Catalog for HUNK Gene

Gene Ontology (GO) - Molecular Function for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,TAS 21873635
GO:0005515 protein binding IPI 20133759
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with HUNK: view
genes like me logo Genes that share phenotypes with HUNK: view

Animal Models for HUNK Gene

MGI Knock Outs for HUNK:
  • Hunk Hunk<tm1b(EUCOMM)Wtsi>
  • Hunk Hunk<tm1Lach>

Animal Model Products

  • Taconic Biosciences Mouse Models for HUNK

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HUNK Gene

Localization for HUNK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HUNK gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with HUNK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HUNK Gene

Pathways & Interactions for HUNK Gene

PathCards logo

SuperPathways for HUNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0007165 signal transduction TAS 10662544
GO:0007275 multicellular organism development TAS 10662544
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with HUNK: view

No data available for Pathways by source and SIGNOR curated interactions for HUNK Gene

Drugs & Compounds for HUNK Gene

(1) Drugs for HUNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for HUNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with HUNK: view

Transcripts for HUNK Gene

mRNA/cDNA for HUNK Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HUNK Gene

No ASD Table

Relevant External Links for HUNK Gene

GeneLoc Exon Structure for
HUNK

Expression for HUNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HUNK Gene

mRNA differential expression in normal tissues according to GTEx for HUNK Gene

This gene is overexpressed in Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for HUNK Gene

This gene is overexpressed in Liver (57.3) and Ovary (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HUNK Gene



Protein tissue co-expression partners for HUNK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HUNK

SOURCE GeneReport for Unigene cluster for HUNK Gene:

Hs.109437
genes like me logo Genes that share expression patterns with HUNK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HUNK Gene

Orthologs for HUNK Gene

This gene was present in the common ancestor of animals.

Orthologs for HUNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HUNK 31 30
  • 99.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HUNK 31 30
  • 88.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HUNK 31 30
  • 88.47 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hunk 30
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Hunk 17 31 30
  • 87.35 (n)
oppossum
(Monodelphis domestica)
Mammalia HUNK 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HUNK 31
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HUNK 31 30
  • 69.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HUNK 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hunk 30
  • 67.9 (n)
Str.7077 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24322 30
zebrafish
(Danio rerio)
Actinopterygii hunk 31
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 31
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea DC2.7a 32
  • 39 (a)
nipi-3 31
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.399 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.399 30
Species where no ortholog for HUNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUNK Gene

ENSEMBL:
Gene Tree for HUNK (if available)
TreeFam:
Gene Tree for HUNK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HUNK: view image

Paralogs for HUNK Gene

Pseudogenes.org Pseudogenes for HUNK Gene

genes like me logo Genes that share paralogs with HUNK: view

Variants for HUNK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HUNK Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs10775648 - p.Arg591Cys
rs35133981 - p.Arg157Trp
rs56021554 - p.Glu625Lys
rs56240027 - p.Met648Thr

Additional dbSNP identifiers (rs#s) for HUNK Gene

Structural Variations from Database of Genomic Variants (DGV) for HUNK Gene

Variant ID Type Subtype PubMed ID
esv1172635 CNV deletion 17803354
esv2060229 CNV deletion 18987734
esv2723338 CNV deletion 23290073
esv2723340 CNV deletion 23290073
esv2723341 CNV deletion 23290073
esv2758819 CNV loss 17122850
esv3450400 CNV insertion 20981092
esv3568155 CNV loss 25503493
esv3646872 CNV loss 21293372
esv998414 CNV deletion 20482838
nsv1066285 CNV gain 25217958
nsv1067151 CNV gain 25217958
nsv1071751 CNV deletion 25765185
nsv1123553 CNV deletion 24896259
nsv3492 CNV insertion 18451855
nsv472350 CNV novel sequence insertion 20440878
nsv510793 CNV deletion 20534489
nsv518119 CNV loss 19592680
nsv587365 CNV gain 21841781
nsv834081 CNV loss 17160897
nsv834082 CNV gain 17160897

Variation tolerance for HUNK Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HUNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HUNK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUNK Gene

Disorders for HUNK Gene

Additional Disease Information for HUNK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HUNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HUNK Gene

Publications for HUNK Gene

  1. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 41 54
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea SA … Spritz RA (The Journal of investigative dermatology 2010) 3 41 54
  5. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M … Mak TW (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 23 54

Products for HUNK Gene

Sources for HUNK Gene