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Aliases for HUNK Gene

Aliases for HUNK Gene

  • Hormonally Up-Regulated Neu-Associated Kinase 2 3 5
  • Hormonally Upregulated Neu-Associated Kinase 2 3
  • EC 4 56
  • B19 3 4
  • Hormonally Up-Regulated Neu Tumor-Associated Kinase 3
  • Hormonally Upregulated Neu Tumor-Associated Kinase 3
  • Serine/Threonine Protein Kinase MAK-V 3
  • Serine/Threonine-Protein Kinase MAK-V 4
  • EC 2.7.11 56
  • MAKV 4

External Ids for HUNK Gene

Previous GeneCards Identifiers for HUNK Gene

  • GC21P029823
  • GC21P032166
  • GC21P032167
  • GC21P033245
  • GC21P018704

Summaries for HUNK Gene

GeneCards Summary for HUNK Gene

HUNK (Hormonally Up-Regulated Neu-Associated Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKAA2.

Additional gene information for HUNK Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUNK Gene

Genomics for HUNK Gene

GeneHancer (GH) Regulatory Elements for HUNK Gene

Promoters and enhancers for HUNK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I031871 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 555.3 +0.7 690 4.2 FOXA2 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 ZNF121 GLIS2 HUNK SCAF4 PAXBP1 EVA1C C21orf59 MIS18A HUNK-AS1
GH21I031892 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.2 +21.2 21224 4.5 SOX13 TFAP4 FOXA2 ARID4B RARA ZNF350 NR2F6 GATAD2A SOX5 TFE3 HUNK MIS18A-AS1 PAXBP1 ENSG00000238390 EXOSC3P1 SCAF4 HUNK-AS1
GH21I031907 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.6 +35.8 35780 2.6 SOX13 FOXA2 CEBPG ZIC2 ZNF644 KMT2B ZFHX2 POLR2A SCRT2 ZNF600 HUNK HUNK-AS1
GH21I032258 Enhancer 1.1 Ensembl ENCODE 10.6 +385.2 385186 0.6 FOXA2 ZNF493 ZFP64 ZNF213 ARID2 ZNF143 RUNX3 DEK ZNF202 ZC3H11A PAXBP1 SCAF4 EVA1C C21orf59 URB1 MIS18A PAXBP1-AS1 MIS18A-AS1 C21orf62-AS1 LINC00846
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HUNK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HUNK gene promoter:

Genomic Locations for HUNK Gene

Genomic Locations for HUNK Gene
171,319 bases
Plus strand

Genomic View for HUNK Gene

Genes around HUNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUNK Gene

Proteins for HUNK Gene

  • Protein details for HUNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase
    Protein Accession:

    Protein attributes for HUNK Gene

    714 amino acids
    Molecular mass:
    79686 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HUNK Gene

Selected DME Specific Peptides for HUNK Gene


Post-translational modifications for HUNK Gene

Other Protein References for HUNK Gene

Domains & Families for HUNK Gene

Gene Families for HUNK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HUNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with HUNK: view

Function for HUNK Gene

Molecular function for HUNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for HUNK Gene

Phenotypes From GWAS Catalog for HUNK Gene

Gene Ontology (GO) - Molecular Function for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IBA --
GO:0005515 protein binding IPI 20133759
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with HUNK: view
genes like me logo Genes that share phenotypes with HUNK: view

Animal Models for HUNK Gene

MGI Knock Outs for HUNK:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HUNK Gene

Localization for HUNK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HUNK gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HUNK Gene

Pathways & Interactions for HUNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA --
GO:0007165 signal transduction TAS 10662544
GO:0007275 multicellular organism development TAS 10662544
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Pathways by source and SIGNOR curated interactions for HUNK Gene

Drugs & Compounds for HUNK Gene

(1) Drugs for HUNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for HUNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with HUNK: view

Transcripts for HUNK Gene

Unigene Clusters for HUNK Gene

Hormonally up-regulated Neu-associated kinase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HUNK Gene

No ASD Table

Relevant External Links for HUNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HUNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HUNK Gene

mRNA differential expression in normal tissues according to GTEx for HUNK Gene

This gene is overexpressed in Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for HUNK Gene

This gene is overexpressed in Liver (57.3) and Ovary (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HUNK Gene

Protein tissue co-expression partners for HUNK Gene

NURSA nuclear receptor signaling pathways regulating expression of HUNK Gene:


SOURCE GeneReport for Unigene cluster for HUNK Gene:

genes like me logo Genes that share expression patterns with HUNK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HUNK Gene

Orthologs for HUNK Gene

This gene was present in the common ancestor of animals.

Orthologs for HUNK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HUNK 33 34
  • 99.16 (n)
(Bos Taurus)
Mammalia HUNK 33 34
  • 88.92 (n)
(Canis familiaris)
Mammalia HUNK 33 34
  • 88.47 (n)
(Rattus norvegicus)
Mammalia Hunk 33
  • 87.72 (n)
(Mus musculus)
Mammalia Hunk 33 16 34
  • 87.35 (n)
(Monodelphis domestica)
Mammalia HUNK 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HUNK 34
  • 57 (a)
(Gallus gallus)
Aves HUNK 33 34
  • 69.96 (n)
(Anolis carolinensis)
Reptilia HUNK 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hunk 33
  • 67.9 (n)
Str.7077 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24322 33
(Danio rerio)
Actinopterygii hunk 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea DC2.7a 35
  • 39 (a)
nipi-3 34
  • 13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.399 33
Species where no ortholog for HUNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUNK Gene

Gene Tree for HUNK (if available)
Gene Tree for HUNK (if available)

Paralogs for HUNK Gene

Paralogs for HUNK Gene Pseudogenes for HUNK Gene

genes like me logo Genes that share paralogs with HUNK: view

Variants for HUNK Gene

Sequence variations from dbSNP and Humsavar for HUNK Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000002829 -- 31,935,314(+) C/T intron_variant
rs1000036994 -- 31,882,859(+) T/C intron_variant
rs1000049682 -- 31,940,341(+) TTTT/ intron_variant
rs1000094066 -- 31,964,329(+) A/G intron_variant
rs1000110478 -- 31,980,047(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HUNK Gene

Variant ID Type Subtype PubMed ID
nsv834082 CNV gain 17160897
nsv834081 CNV loss 17160897
nsv587365 CNV gain 21841781
nsv518119 CNV loss 19592680
nsv510793 CNV deletion 20534489
nsv472350 CNV novel sequence insertion 20440878
nsv3492 CNV insertion 18451855
nsv1123553 CNV deletion 24896259
nsv1071751 CNV deletion 25765185
nsv1067151 CNV gain 25217958
nsv1066285 CNV gain 25217958
esv998414 CNV deletion 20482838
esv3646872 CNV loss 21293372
esv3568155 CNV loss 25503493
esv3450400 CNV insertion 20981092
esv2758819 CNV loss 17122850
esv2723341 CNV deletion 23290073
esv2723340 CNV deletion 23290073
esv2723338 CNV deletion 23290073
esv2060229 CNV deletion 18987734
esv1172635 CNV deletion 17803354

Variation tolerance for HUNK Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HUNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUNK Gene

Disorders for HUNK Gene

Additional Disease Information for HUNK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HUNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HUNK Gene

Publications for HUNK Gene

  1. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 44 58
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 44 58
  3. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M … Mak TW (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea SA … Spritz RA (The Journal of investigative dermatology 2010) 3 44 58

Products for HUNK Gene

Sources for HUNK Gene

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