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Aliases for HULC Gene

Subcategory (RNA class) for HULC Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for HULC Gene

  • Hepatocellular Carcinoma Up-Regulated Long Non-Coding RNA 2 3 5
  • Hepatocellular Carcinoma Associated Transcript 1 (Non-Protein Coding) 2 3
  • Highly Up-Regulated In Liver Cancer Long Non-Coding RNA 2 3
  • Long Intergenic Non-Protein Coding RNA 78 2 3
  • Highly Up-Regulated In Liver Cancer (Non-Protein Coding) 3
  • Non-Protein Coding RNA 78 2
  • NCRNA00078 3
  • LINC00078 3
  • HCCAT1 3

External Ids for HULC Gene

Previous GeneCards Identifiers for HULC Gene

  • GC06P008598

Summaries for HULC Gene

Entrez Gene Summary for HULC Gene

  • This gene produces a long RNA that was discovered as upregulated in hepatocellular carcinoma and is associated with cancer progression. Expression of this transcript is regulated by microRNAs and at the transcriptional level by Sp1 family factors. The transcript may regulate gene expression by functioning as a competing RNA for microRNAs. [provided by RefSeq, Dec 2017]

GeneCards Summary for HULC Gene

HULC (Hepatocellular Carcinoma Up-Regulated Long Non-Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HULC include Hepatocellular Carcinoma.

Gene Wiki entry for HULC Gene

Additional gene information for HULC Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HULC Gene

Genomics for HULC Gene

GeneHancer (GH) Regulatory Elements for HULC Gene

Promoters and enhancers for HULC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I008626 Enhancer 0.5 ENCODE 0.3 -24.3 -24276 2.2 JUND IKZF1 CREB1 ATF7 BATF IKZF2 ATF2 LOC100506207 GC06P008626 HULC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HULC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HULC gene promoter:

Genomic Locations for HULC Gene

Genomic Locations for HULC Gene
chr6:8,652,137-8,653,846
(GRCh38/hg38)
Size:
1,710 bases
Orientation:
Plus strand
chr6:8,652,370-8,654,079
(GRCh37/hg19)

Genomic View for HULC Gene

Genes around HULC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HULC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HULC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HULC Gene

Proteins for HULC Gene

Post-translational modifications for HULC Gene

No Post-translational modifications

No data available for DME Specific Peptides for HULC Gene

Domains & Families for HULC Gene

Gene Families for HULC Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HULC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HULC Gene

Function for HULC Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HULC Gene

Localization for HULC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HULC Gene

Pathways & Interactions for HULC Gene

No Data Available

Interacting Proteins for HULC Gene

Gene Ontology (GO) - Biological Process for HULC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HULC Gene

Drugs & Compounds for HULC Gene

No Compound Related Data Available

Transcripts for HULC Gene

mRNA/cDNA for HULC Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HULC Gene

Highly up-regulated in liver cancer long non-coding RNA:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HULC Gene

No ASD Table

Relevant External Links for HULC Gene

GeneLoc Exon Structure for
HULC
ECgene alternative splicing isoforms for
HULC

Expression for HULC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HULC Gene

mRNA differential expression in normal tissues according to GTEx for HULC Gene

This gene is overexpressed in Liver (x49.9).

NURSA nuclear receptor signaling pathways regulating expression of HULC Gene:

HULC

SOURCE GeneReport for Unigene cluster for HULC Gene:

Hs.214343
genes like me logo Genes that share expression patterns with HULC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HULC Gene

Orthologs for HULC Gene

Evolution for HULC Gene

ENSEMBL:
Gene Tree for HULC (if available)
TreeFam:
Gene Tree for HULC (if available)

No data available for Orthologs for HULC Gene

Paralogs for HULC Gene

No data available for Paralogs for HULC Gene

Variants for HULC Gene

Sequence variations from dbSNP and Humsavar for HULC Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000073093 -- 8,652,583(+) A/T intron_variant
rs1001312611 -- 8,651,981(+) A/G upstream_transcript_variant
rs1003655709 -- 8,650,505(+) C/A upstream_transcript_variant
rs1004571404 -- 8,650,387(+) A/G upstream_transcript_variant
rs1004953032 -- 8,651,486(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HULC Gene

Variant ID Type Subtype PubMed ID
dgv10293n54 CNV loss 21841781
dgv5915n100 CNV loss 25217958
esv2763945 CNV loss 21179565
esv3570761 CNV loss 25503493
esv3608034 CNV loss 21293372
esv3608036 CNV loss 21293372
nsv1133014 OTHER inversion 24896259
nsv1151332 OTHER inversion 26484159
nsv600927 CNV gain 21841781

Additional Variant Information for HULC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HULC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HULC Gene

Disorders for HULC Gene

MalaCards: The human disease database

(1) MalaCards diseases for HULC Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search HULC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HULC

genes like me logo Genes that share disorders with HULC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HULC Gene

Publications for HULC Gene

  1. Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). (PMID: 23728852) Hämmerle M … Diederichs S (Hepatology (Baltimore, Md.) 2013) 2 3 58
  2. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. (PMID: 17241883) Panzitt K … Zatloukal K (Gastroenterology 2007) 2 3 58
  3. Metformin inhibits tumorigenesis in HBV-induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX. (PMID: 29231260) Jiang Z … Liu H (Journal of cellular biochemistry 2018) 3 58
  4. Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma. (PMID: 28688193) Kong D … Wang Y (Journal of cellular biochemistry 2018) 3 58
  5. Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as a scaffold of extracellular signal-regulated kinase and YB-1 to enhance hepatocarcinogenesis. (PMID: 28027578) Li D … Zhan Q (Hepatology (Baltimore, Md.) 2017) 3 58

Products for HULC Gene

Sources for HULC Gene

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