Aliases for HTRA3 Gene
Aliases for HTRA3 Gene
External Ids for HTRA3 Gene
- HGNC: 30406
- Entrez Gene: 94031
- Ensembl: ENSG00000170801
- OMIM: 608785
- UniProtKB: P83110
Previous GeneCards Identifiers for HTRA3 Gene
- GC04P008238
- GC04P008421
- GC04P008464
- GC04P008389
- GC04P008271
- GC04P008191
Summaries for HTRA3 Gene
GeneCards Summary for HTRA3 Gene
HTRA3 (HtrA Serine Peptidase 3) is a Protein Coding gene. Diseases associated with HTRA3 include Ovary Serous Adenocarcinoma and Ovarian Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is HTRA1.
UniProtKB/Swiss-Prot for HTRA3 Gene
-
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTRA3 Gene
Genomics for HTRA3 Gene
GeneHancer (GH) Regulatory Elements for HTRA3 Gene
Promoters and enhancers for HTRA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HTRA3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HTRA3 Gene
Genomic Locations for HTRA3 Gene
- chr4:8,269,754-8,307,111
- (GRCh38/hg38)
- Size:
- 37,358 bases
- Orientation:
- Plus strand
- chr4:8,271,489-8,308,838
- (GRCh37/hg19)
Genomic View for HTRA3 Gene
Genes around HTRA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Ensembl
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
HTRA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HTRA3 Gene
Proteins for HTRA3 Gene
-
Protein details for HTRA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P83110-HTRA3_HUMAN
- Recommended name:
- Serine protease HTRA3
- Protein Accession:
- P83110
- Q7Z7A2
Protein attributes for HTRA3 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 48608 Da
- Quaternary structure:
-
- Homotrimer (PubMed:26110759). Interacts with TGFB1; the interaction inhibits TGFB-mediated signaling. Interacts with BMP4; the interaction inhibits BMP4-mediated signaling. Interacts with TGFB2 and GDF5 (By similarity). Interacts with MYH9.
Protein Expression for HTRA3 Gene
Selected DME Specific Peptides for HTRA3 Gene
- P83110:
-
- GEVIGINT
- GNSGGPL
- NFIADVVEK
- GSPFALQNT
Post-translational modifications for HTRA3 Gene
No Post-translational modifications
Other Protein References for HTRA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Domains & Families for HTRA3 Gene
Gene Families for HTRA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted secreted proteins
Protein Domains for HTRA3 Gene
Suggested Antigen Peptide Sequences for HTRA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P83110- Family:
-
- Belongs to the peptidase S1C family.
Function for HTRA3 Gene
Molecular function for HTRA3 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in ovarian and endometrial cancers (EC). Decrease of 3.2-fold in endometrial cancer.
Enzyme Numbers (IUBMB) for HTRA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IDA | 18387192 |
| GO:0004252 | serine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22229724 |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for HTRA3 Gene
- GenomeRNAi human phenotypes for HTRA3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased Sindbis virus (SINV) infection
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-
-
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-
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-
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-
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miRNA for HTRA3 Gene
- miRTarBase miRNAs that target HTRA3
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HTRA3 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTRA3 Gene
Localization for HTRA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTRA3 Gene
- Secreted. Note=Secretion increased during decidualization of endometrial stromal cells.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Pathways & Interactions for HTRA3 Gene
No Data Available
Interacting Proteins for HTRA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0006508 | proteolysis | IDA | 18387192 |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | ISS | -- |
| GO:0030514 | negative regulation of BMP signaling pathway | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for HTRA3 Gene
Transcripts for HTRA3 Gene
mRNA/cDNA for HTRA3 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (116) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HTRA3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HTRA3
- genomics-online: gRNA clones - Search results for available HTRA3 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTRA3
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HTRA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTRA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HTRA3 gene related products
- orf clones - Search results for available HTRA3 gene related products
- Applied Biological Materials Clones for HTRA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HTRA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Lens
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for HTRA3 Gene
This gene is overexpressed in Heart - Atrial Appendage (x7.8).
This gene is overexpressed in Bone marrow mesenchymal stem cell (32.5), Heart (25.8), and Peripheral blood mononuclear cells (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTRA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HTRA3 Gene:
HTRA3SOURCE GeneReport for Unigene cluster for HTRA3 Gene:
Hs.479119mRNA Expression by UniProt/SwissProt for HTRA3 Gene:
P83110-HTRA3_HUMAN
Tissue specificity:
Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.
Evidence on tissue expression from TISSUES for HTRA3 Gene
- Heart(4.3)
- Nervous system(4.1)
Primer Products
-
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-
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTRA3 Gene
Orthologs for HTRA3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HTRA3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HTRA3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Htra3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Htra3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | HTRA3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HTRA3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HTRA3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HTRA3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HTRA3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | htra3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC573378 33 |
|
||
| HTRA3 (1 of 3) 34 |
|
OneToMany | |||
| HTRA3 (3 of 3) 34 |
|
OneToMany | |||
| htra3a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8464 35 |
|
|
|
| HtrA2 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HTRA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HTRA3 Gene
Variants for HTRA3 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10000359 | -- | 8,288,949(+) | T/C | intron_variant | |
| rs1000072166 | -- | 8,274,533(+) | G/A | intron_variant | |
| rs1000085674 | -- | 8,283,409(+) | A/G | intron_variant | |
| rs1000112930 | -- | 8,274,590(+) | C/T | intron_variant | |
| rs1000172930 | -- | 8,293,683(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv8956n54 | CNV | gain | 21841781 |
| dgv8957n54 | CNV | gain | 21841781 |
| esv1430054 | CNV | insertion | 17803354 |
| esv1923424 | CNV | deletion | 18987734 |
| esv2493897 | CNV | insertion | 19546169 |
| esv2727109 | CNV | deletion | 23290073 |
| esv29195 | CNV | loss | 19812545 |
| esv34196 | OTHER | inversion | 12058347 |
| esv3569280 | CNV | loss | 25503493 |
| esv3575676 | CNV | gain | 25503493 |
| esv3599544 | CNV | loss | 21293372 |
| nsv1002794 | CNV | gain | 25217958 |
| nsv1009011 | CNV | loss | 25217958 |
| nsv1073303 | CNV | deletion | 25765185 |
| nsv1125239 | CNV | insertion | 24896259 |
| nsv1132929 | CNV | insertion | 24896259 |
| nsv1136815 | CNV | deletion | 24896259 |
| nsv1142385 | CNV | tandem duplication | 24896259 |
| nsv1145025 | CNV | deletion | 24896259 |
| nsv4222 | CNV | insertion | 18451855 |
| nsv461216 | CNV | loss | 19166990 |
| nsv461218 | CNV | loss | 19166990 |
| nsv593626 | CNV | loss | 21841781 |
| nsv593627 | CNV | gain | 21841781 |
| nsv593628 | CNV | loss | 21841781 |
| nsv593634 | CNV | loss | 21841781 |
| nsv593635 | CNV | gain+loss | 21841781 |
| nsv593636 | CNV | loss | 21841781 |
| nsv829853 | CNV | gain+loss | 17160897 |
| nsv949784 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.85;
48.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HTRA3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTRA3 Gene
Disorders for HTRA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovary serous adenocarcinoma |
|
|
| ovarian cystadenocarcinoma |
|
|
Search HTRA3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HTRA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HTRA3 Gene
Publications for HTRA3 Gene
- Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. (PMID: 12513693) Nie GY … Salamonsen LA (The Biochemical journal 2003) 2 3 4 22 58
- Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. (PMID: 19424634) Narkiewicz J … Lipinska B (Oncology reports 2009) 3 4 22 58
- Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. (PMID: 16650464) Bowden MA … Nie G (Gynecologic oncology 2006) 3 4 22 58
- Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains. (PMID: 26110759) Glaza P … Lipinska B (PloS one 2015) 3 4 58
- Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. (PMID: 22229724) Singh H … Nie G (BioTechniques 2012) 3 4 58
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- Invitrogen Antibodies for HTRA3
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTRA3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 26 available HTRA3 Antibodies ranked by validation data
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Sources for HTRA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
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