Aliases for HTR7 Gene
External Ids for HTR7 Gene
Previous GeneCards Identifiers for HTR7 Gene
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
GeneCards Summary for HTR7 Gene
HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Oculogyric Crisis and Irritable Bowel Syndrome. Among its related pathways are Signaling by GPCR and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR1B.
UniProtKB/Swiss-Prot Summary for HTR7 Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation.