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Aliases for HTR7 Gene

Aliases for HTR7 Gene

  • 5-Hydroxytryptamine Receptor 7 2 3 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled) 2 3
  • 5-HT-7 3 4
  • 5-HT-X 3 4
  • 5-HT7 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled 2
  • Serotonin Receptor 7 4

External Ids for HTR7 Gene

Previous GeneCards Identifiers for HTR7 Gene

  • GC10M091383
  • GC10M091723
  • GC10M092631
  • GC10M092165
  • GC10M092490
  • GC10M086129

Summaries for HTR7 Gene

Entrez Gene Summary for HTR7 Gene

  • The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR7 Gene

HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Byssinosis and Barbiturate Dependence. Among its related pathways are GPCRs, Other and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot for HTR7 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Tocris Summary for HTR7 Gene

  • Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation.

Gene Wiki entry for HTR7 Gene

Additional gene information for HTR7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR7 Gene

Genomics for HTR7 Gene

GeneHancer (GH) Regulatory Elements for HTR7 Gene

Promoters and enhancers for HTR7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J090855 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 659.9 0.0 -16 4.7 SIN3A BMI1 ZNF48 ZNF335 GLIS2 ZNF143 FOS ATF7 SMARCA5 CEBPB HTR7 HECTD2 RPP30
GH10J090911 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.8 -54.3 -54315 2.1 RB1 ZNF133 SIN3A ZNF2 RAD21 RFX5 ZNF143 BCLAF1 RUNX3 MIXL1 HTR7 RPP30 GC10M090914 ANKRD1 PIR41318
GH10J090914 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 6.4 -60.9 -60901 7.9 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ETS1 ATF7 FOS RUNX3 ANKRD1 GC10M090914 HTR7 HECTD2 RNU6-740P
GH10J090816 Enhancer 0.6 Ensembl ENCODE 19.5 +40.2 40227 2.5 MEIS2 IKZF1 HMBOX1 HTR7 PIR38191 PIR51660
GH10J090751 Enhancer 0.6 ENCODE 17.6 +106.3 106335 0.2 SCRT1 SMARCA5 CTCF ZNF654 ZFP37 TRIM22 REST RAD21 SCRT2 VEZF1 HTR7 RPP30 GC10M090736 GC10M090739 GC10M090738 GC10M090737 PIR51660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HTR7 gene promoter:
  • deltaCREB
  • CREB

Genomic Locations for HTR7 Gene

Genomic Locations for HTR7 Gene
117,097 bases
Minus strand
117,097 bases
Minus strand

Genomic View for HTR7 Gene

Genes around HTR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR7 Gene

Proteins for HTR7 Gene

  • Protein details for HTR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 7
    Protein Accession:
    Secondary Accessions:
    • B5BUP6
    • P78336
    • P78372
    • P78516
    • Q5VX01
    • Q5VX02
    • Q5VX03

    Protein attributes for HTR7 Gene

    479 amino acids
    Molecular mass:
    53555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HTR7 Gene


neXtProt entry for HTR7 Gene

Post-translational modifications for HTR7 Gene

  • Glycosylation at Asn66 and Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR7 Gene

No data available for DME Specific Peptides for HTR7 Gene

Domains & Families for HTR7 Gene

Gene Families for HTR7 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR7: view

Function for HTR7 Gene

Molecular function for HTR7 Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate cyclase,unlikely to be associated with autistic disorder

Phenotypes From GWAS Catalog for HTR7 Gene

Gene Ontology (GO) - Molecular Function for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,IEA --
GO:0004993 G-protein coupled serotonin receptor activity TAS,IBA --
GO:0030594 neurotransmitter receptor activity IBA --
GO:0051378 serotonin binding IBA --
genes like me logo Genes that share ontologies with HTR7: view
genes like me logo Genes that share phenotypes with HTR7: view

Animal Models for HTR7 Gene

MGI Knock Outs for HTR7:

Animal Model Products

Clone Products

  • Addgene plasmids for HTR7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR7 Gene

Localization for HTR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8226867
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with HTR7: view

Pathways & Interactions for HTR7 Gene

genes like me logo Genes that share pathways with HTR7: view

Gene Ontology (GO) - Biological Process for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8226867
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with HTR7: view

No data available for SIGNOR curated interactions for HTR7 Gene

Drugs & Compounds for HTR7 Gene

(95) Drugs for HTR7 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methysergide Approved Pharma Antagonist, Partial agonist, Agonist, antagonist, Target 0
Ziprasidone Approved Pharma Antagonist, Full agonist, Agonist, Inverse agonist, Partial agonist, agonist, Target, antagonist 5-HT (serotonin)/dopamine receptor antagonist 146
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, antagonist, Target Antipsychotic medication 121
Chlorpromazine Approved, Investigational, Vet_approved Pharma Antagonist, Inverse agonist, Channel blocker, antagonist, Target, binder 19
Cyproheptadine Approved Pharma Antagonist, antagonist, Target 20

(12) Additional Compounds for HTR7 Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist, Inhibition, Inhibitor
  • N-Desmethyl eletriptan
SB 269970 hydrochloride

(5) Tocris Compounds for HTR7 Gene

Compound Action Cas Number
AS 19 Potent 5-HT7 agonist 1000578-26-6
LP 12 hydrochloride 5-HT7 agonist 1185136-22-4
LP 44 High affinity 5-HT7 agonist 824958-12-5
SB 258719 hydrochloride Selective 5-HT7 antagonist 1217674-10-6
SB 269970 hydrochloride Potent and selective 5-HT7 antagonist; brain penetrant 261901-57-9
genes like me logo Genes that share compounds with HTR7: view

Transcripts for HTR7 Gene

mRNA/cDNA for HTR7 Gene

Unigene Clusters for HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled:
Representative Sequences:

Clone Products

  • Addgene plasmids for HTR7

Alternative Splicing Database (ASD) splice patterns (SP) for HTR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -
SP3: -

Relevant External Links for HTR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR7 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for HTR7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR7 Gene

Protein tissue co-expression partners for HTR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of HTR7 Gene:


SOURCE GeneReport for Unigene cluster for HTR7 Gene:


mRNA Expression by UniProt/SwissProt for HTR7 Gene:

Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.

Evidence on tissue expression from TISSUES for HTR7 Gene

  • Nervous system(4.9)
  • Muscle(3.1)
  • Blood(2.9)
  • Intestine(2.9)
  • Heart(2.7)
  • Stomach(2.5)
  • Lung(2.4)
  • Adrenal gland(2.3)
  • Kidney(2.2)
  • Liver(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with HTR7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR7 Gene

Orthologs for HTR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR7 34 33
  • 99.37 (n)
(Bos Taurus)
Mammalia HTR7 34 33
  • 91.49 (n)
(Canis familiaris)
Mammalia HTR7 34 33
  • 91.28 (n)
(Mus musculus)
Mammalia Htr7 16 34 33
  • 90.88 (n)
(Rattus norvegicus)
Mammalia Htr7 33
  • 90.82 (n)
(Monodelphis domestica)
Mammalia HTR7 34
  • 84 (a)
(Gallus gallus)
Aves HTR7 34 33
  • 79.17 (n)
(Anolis carolinensis)
Reptilia HTR7 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr7 33
  • 70.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia htr7-A 33
(Danio rerio)
Actinopterygii HTR7 (3 of 4) 34
  • 79 (a)
LOC562111 33
  • 73.04 (n)
HTR7 (4 of 4) 34
  • 73 (a)
HTR7 (2 of 4) 34
  • 66 (a)
HTR7 (1 of 4) 34
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 34 33
  • 55.82 (n)
CG7431 35
  • 41 (a)
CG6919 35
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT7 33
  • 53.69 (n)
(Caenorhabditis elegans)
Secernentea ser-7 34 33
  • 49.3 (n)
M03F4.3 35
  • 39 (a)
C09B7.1b 35
  • 32 (a)
C09B7.1a 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for HTR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR7 Gene

Gene Tree for HTR7 (if available)
Gene Tree for HTR7 (if available)
Evolutionary constrained regions (ECRs) for HTR7: view image

Paralogs for HTR7 Gene

(25) SIMAP similar genes for HTR7 Gene using alignment to 2 proteins:

  • Q5VX04_HUMAN Pseudogenes for HTR7 Gene

genes like me logo Genes that share paralogs with HTR7: view

Variants for HTR7 Gene

Sequence variations from dbSNP and Humsavar for HTR7 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000008358 -- 90,803,651(-) C/A intron_variant
rs1000057222 -- 90,838,352(-) C/T intron_variant
rs1000058477 -- 90,745,320(-) A/G intron_variant
rs1000110615 -- 90,756,316(-) G/A intron_variant
rs1000118211 -- 90,832,052(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HTR7 Gene

Variant ID Type Subtype PubMed ID
dgv1338n54 CNV gain 21841781
dgv1346n54 CNV gain 21841781
dgv952n100 CNV gain 25217958
esv1923742 CNV deletion 18987734
esv2422237 CNV duplication 17116639
esv26200 CNV loss 19812545
esv2739474 CNV deletion 23290073
esv3390334 CNV insertion 20981092
esv3394038 CNV insertion 20981092
esv3624194 CNV loss 21293372
nsv1036058 CNV gain 25217958
nsv467432 CNV gain 19166990
nsv516743 CNV gain 19592680
nsv831945 CNV gain 17160897

Variation tolerance for HTR7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR7 Gene

Disorders for HTR7 Gene

MalaCards: The human disease database

(38) MalaCards diseases for HTR7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • cotton mill fever
barbiturate dependence
irritable bowel syndrome
  • ibd
psychosexual disorder
  • psychosexual disorders
  • pathological stealing
- elite association - COSMIC cancer census association via MalaCards
Search HTR7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR7 Gene

Publications for HTR7 Gene

  1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PMID: 8226867) Bard JA … Weinshank RL (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. (PMID: 17406648) Cross S … Veenstra-Vanderweele J (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008) 3 22 44 58
  3. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. (PMID: 16192982) Ikeda M … Ozaki N (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006) 3 22 44 58
  4. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M … Kennedy JL (Schizophrenia research 2001) 3 22 44 58
  5. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. (PMID: 9084407) Heidmann DE … Hamblin MW (Journal of neurochemistry 1997) 3 4 22 58

Products for HTR7 Gene

Sources for HTR7 Gene

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