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Aliases for HTR6 Gene

Aliases for HTR6 Gene

  • 5-Hydroxytryptamine Receptor 6 2 3 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled 2 3
  • Serotonin Receptor 6 3 4
  • 5-HT6 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 6 2
  • 5-HT6R 3
  • 5-HT-6 4

External Ids for HTR6 Gene

Previous GeneCards Identifiers for HTR6 Gene

  • GC01P019551
  • GC01P019016
  • GC01P019137
  • GC01P019461
  • GC01P019737
  • GC01P019864
  • GC01P019991
  • GC01P018237

Summaries for HTR6 Gene

Entrez Gene Summary for HTR6 Gene

  • This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

GeneCards Summary for HTR6 Gene

HTR6 (5-Hydroxytryptamine Receptor 6) is a Protein Coding gene. Diseases associated with HTR6 include Schizophrenia 5 and Acute Stress Disorder. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is ADRB1.

UniProtKB/Swiss-Prot for HTR6 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

Tocris Summary for HTR6 Gene

  • Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and a role in spatial learning and memory.

Gene Wiki entry for HTR6 Gene

Additional gene information for HTR6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR6 Gene

Genomics for HTR6 Gene

GeneHancer (GH) Regulatory Elements for HTR6 Gene

Promoters and enhancers for HTR6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019642 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.2 -16.6 -16645 11.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF143 ZNF548 FOS MCM3 NBL1 UBR4 MUL1 HTR6 GC01M019654 RPS14P3 MINOS1-NBL1
GH01J019481 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 -180.3 -180251 6.9 HDGF ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 SP3 MXD4 CAPZB MINOS1 OTUD3 RNU4-28P EMC1 HTR6 NBL1 AKR7A3 PIR41915
GH01J019687 Enhancer 0.6 ENCODE 36.1 +23.3 23335 2.6 SMARCA5 BCOR ZNF768 PTBP1 ZNF280D ZMYM3 RELA ZNF580 ZFP36 RCOR1 HTR6 GC01P019680 PIR33395 GC01P019759 TMCO4
GH01J019659 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.5 -5.5 -5519 1.3 HDGF HDAC1 PKNOX1 ATF1 ARID4B SIN3A ZNF48 RAD21 RFX5 GLIS2 HTR6 GC01M019654
GH01J019432 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -213.4 -213446 39.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 MEF2D SSRP1 GLIS1 CAPZB EMC1 NBL1 RNU4-28P HTR6 AKR7A2 OTUD3 AKR7A3 PQLC2 UBR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HTR6 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • CREB
  • deltaCREB
  • NF-AT
  • NF-AT1

Genomic Locations for HTR6 Gene

Genomic Locations for HTR6 Gene
chr1:19,665,287-19,680,966
(GRCh38/hg38)
Size:
15,680 bases
Orientation:
Plus strand
chr1:19,991,780-20,006,055
(GRCh37/hg19)
Size:
14,276 bases
Orientation:
Plus strand

Genomic View for HTR6 Gene

Genes around HTR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR6 Gene

Proteins for HTR6 Gene

  • Protein details for HTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50406-5HT6R_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 6
    Protein Accession:
    P50406
    Secondary Accessions:
    • Q13640
    • Q5TGZ1

    Protein attributes for HTR6 Gene

    Size:
    440 amino acids
    Molecular mass:
    46954 Da
    Quaternary structure:
    • Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5 (By similarity).

neXtProt entry for HTR6 Gene

Post-translational modifications for HTR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR6 Gene

Domains & Families for HTR6 Gene

Gene Families for HTR6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for HTR6 Gene

Suggested Antigen Peptide Sequences for HTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50406

UniProtKB/Swiss-Prot:

5HT6R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR6: view

Function for HTR6 Gene

Molecular function for HTR6 Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
GENATLAS Biochemistry:
5-hydroxytrhyptamine (serotonin) receptor,subtype 6,prominently expressed in the caudal nucleus,G protein coupled receptor superfamily,activating adenylate cyclase

Phenotypes From GWAS Catalog for HTR6 Gene

Gene Ontology (GO) - Molecular Function for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,IBA --
GO:0004969 histamine receptor activity TAS 8522988
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0005515 protein binding IPI 17189269
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with HTR6: view
genes like me logo Genes that share phenotypes with HTR6: view

Animal Models for HTR6 Gene

MGI Knock Outs for HTR6:

Animal Model Products

Clone Products

  • Addgene plasmids for HTR6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR6 Gene

Localization for HTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8522988
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR6 Gene

Pathways & Interactions for HTR6 Gene

genes like me logo Genes that share pathways with HTR6: view

Gene Ontology (GO) - Biological Process for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8522988
GO:0007268 chemical synaptic transmission TAS 8522988
GO:0021795 cerebral cortex cell migration ISS,IEA --
genes like me logo Genes that share ontologies with HTR6: view

No data available for SIGNOR curated interactions for HTR6 Gene

Drugs & Compounds for HTR6 Gene

(154) Drugs for HTR6 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Inverse agonist, agonist, Target, antagonist 408
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, antagonist, Target Antipsychotic medication 121
Iloperidone Approved Pharma Antagonist, antagonist, Target Dopamine (D2) and serotonin (5HT2) receptor antagonist 0
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist, antagonist SR-2A inhibitor 498
Asenapine Approved Pharma Antagonist, Full agonist, Agonist, antagonist, Target Inhibits adrenergic receptor/5-HT receptor 55

(4) Additional Compounds for HTR6 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist, Inhibition, Inhibitor
WAY 181187 oxalate

(5) Tocris Compounds for HTR6 Gene

Compound Action Cas Number
EMD 386088 hydrochloride Potent 5-HT6 agonist 1171123-46-8
EMDT oxalate Selective 5-HT6 agonist 263744-72-5
ST 1936 oxalate Selective, high affinity 5-HT6 agonist 1210-81-7
WAY 181187 oxalate High affinity and selective 5-HT6 agonist
WAY 208466 dihydrochloride Selective 5-HT6 agonist 1207064-61-6

(83) ApexBio Compounds for HTR6 Gene

Compound Action Cas Number
(±)-MDMA hydrochloride 92279-84-0
2-Methyl-5-hydroxytryptamine hydrochloride 845861-49-6
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
BGC 20-761 5-HT6 antagonist,selective and high affinity 17375-63-2
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
Cisapride 81098-60-4
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dexfenfluramine hydrochloride 3239-45-0
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Duloxetine HCl 136434-34-9
Eltoprazine hydrochloride 98206-09-8
EMD 386088 hydrochloride 1171123-46-8
EMDT oxalate 263744-72-5
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 46611 185259-85-2
Iloperidone hydrochloride 1299470-39-5
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
Lu AE58054 5-HT(6)R antagonist 467459-31-0
Lu AE58054 Hydrochloride 5-HT(6)R antagonist 467458-02-2
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
Metergoline 17692-51-2
Methysergide maleate 129-49-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
NPS ALX Compound 4a dihydrochloride 299433-10-6
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Pizotifen Malate 5189-11-7
Psilocin 520-53-6
R 1485 dihydrochloride
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
Ro 04-6790 202466-68-0
RS 39604 hydrochloride 167710-87-4
RS 67333 hydrochloride 168986-60-5
RU 24969 66611-26-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258585 hydrochloride 1216468-02-8
SB 258719 hydrochloride 1217674-10-6
SB 271046 hydrochloride Selective 5-HT6 antagonist 209481-24-3
SB 399885 hydrochloride 402713-81-9
SB271046 209481-20-9
SB742457 5-HT6 receptor antagonist,highly selective and high affinity 607742-69-8
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
SGS 518 oxalate 445441-27-0
ST 1936 oxalate 1210-81-7
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WAY 208466 dihydrochloride 1207064-61-6
WY 45233 succinate 448904-47-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR6: view

Drug Products

Transcripts for HTR6 Gene

mRNA/cDNA for HTR6 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR6 Gene

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled:
Representative Sequences:

Clone Products

  • Addgene plasmids for HTR6

Alternative Splicing Database (ASD) splice patterns (SP) for HTR6 Gene

No ASD Table

Relevant External Links for HTR6 Gene

GeneLoc Exon Structure for
HTR6
ECgene alternative splicing isoforms for
HTR6

Expression for HTR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR6 Gene

mRNA differential expression in normal tissues according to GTEx for HTR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x11.9), Brain - Putamen (basal ganglia) (x10.9), Brain - Caudate (basal ganglia) (x8.7), and Brain - Cortex (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of HTR6 Gene:

HTR6

SOURCE GeneReport for Unigene cluster for HTR6 Gene:

Hs.22180

mRNA Expression by UniProt/SwissProt for HTR6 Gene:

P50406-5HT6R_HUMAN
Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus.

Evidence on tissue expression from TISSUES for HTR6 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with HTR6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR6 Gene

Orthologs for HTR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR6 34 33
  • 98.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HTR6 34 33
  • 89.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HTR6 34 33
  • 89.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr6 33
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Htr6 16 34 33
  • 86.45 (n)
oppossum
(Monodelphis domestica)
Mammalia HTR6 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR6 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR6 34 33
  • 69.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR6 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr6 33
  • 68.41 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC568269 33
  • 65.32 (n)
htr6 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DopR 35
  • 37 (a)
CG6989 35
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea ser-5 34
  • 22 (a)
ManyToMany
ser-6 34
  • 20 (a)
ManyToMany
Species where no ortholog for HTR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR6 Gene

ENSEMBL:
Gene Tree for HTR6 (if available)
TreeFam:
Gene Tree for HTR6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR6: view image

Paralogs for HTR6 Gene

Paralogs for HTR6 Gene

(8) SIMAP similar genes for HTR6 Gene using alignment to 1 proteins:

  • 5HT6R_HUMAN
genes like me logo Genes that share paralogs with HTR6: view

Variants for HTR6 Gene

Sequence variations from dbSNP and Humsavar for HTR6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000265157 -- 19,670,852(+) T/C intron_variant
rs1000316231 -- 19,671,094(+) G/A intron_variant
rs1000380701 -- 19,664,953(+) C/G upstream_transcript_variant
rs1000602665 -- 19,672,311(+) T/C intron_variant
rs1000654851 -- 19,672,549(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HTR6 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV insertion 20534489
nsv545729 CNV loss 21841781
nsv954899 CNV deletion 24416366

Variation tolerance for HTR6 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR6 Gene

Human Gene Mutation Database (HGMD)
HTR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR6 Gene

Disorders for HTR6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for HTR6 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia 5
  • sczd5
acute stress disorder
  • traumatic stress disorder
amnestic disorder
  • amnesia
schizophrenia
  • sczd
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search HTR6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR6 Gene

Publications for HTR6 Gene

  1. Risperidone-related weight gain: genetic and nongenetic predictors. (PMID: 16633140) Lane HY … Chang WH (Journal of clinical psychopharmacology 2006) 3 22 44 58
  2. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population. (PMID: 16682118) Tochigi M … Sasaki T (Neuroscience letters 2006) 3 22 44 58
  3. Serotonergic genes and personality traits in the Korean population. (PMID: 14698468) Ham BJ … Lee MS (Neuroscience letters 2004) 3 22 44 58
  4. Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders. (PMID: 14741325) Lane HY … Chang WH (Schizophrenia research 2004) 3 22 44 58
  5. Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese. (PMID: 15531082) Kan R … Wang L (Neuroscience letters 2004) 3 22 44 58

Products for HTR6 Gene

  • Addgene plasmids for HTR6

Sources for HTR6 Gene

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