Aliases for HTR6 Gene
External Ids for HTR6 Gene
Previous GeneCards Identifiers for HTR6 Gene
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
GeneCards Summary for HTR6 Gene
HTR6 (5-Hydroxytryptamine Receptor 6) is a Protein Coding gene. Diseases associated with HTR6 include Schizophrenia and Meckel Syndrome, Type 1. Among its related pathways are Signaling by GPCR and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and histamine receptor activity. An important paralog of this gene is HTR2C.
UniProtKB/Swiss-Prot Summary for HTR6 Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and a role in spatial learning and memory.