The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples... See more...

Aliases for HTR5A Gene

Aliases for HTR5A Gene

  • 5-Hydroxytryptamine Receptor 5A 2 3 4 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled 2 3
  • 5-HT-5A 3 4
  • 5-HT-5 3 4
  • 5-HT5A 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 5A 2
  • Serotonin Receptor 5A 4

External Ids for HTR5A Gene

Previous GeneCards Identifiers for HTR5A Gene

  • GC07P153085
  • GC07P154176
  • GC07P154253
  • GC07P154299
  • GC07P154492
  • GC07P154862
  • GC07P148594

Summaries for HTR5A Gene

Entrez Gene Summary for HTR5A Gene

  • The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR5A Gene

HTR5A (5-Hydroxytryptamine Receptor 5A) is a Protein Coding gene. Diseases associated with HTR5A include Attention Deficit-Hyperactivity Disorder and Schizophrenia. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR7.

UniProtKB/Swiss-Prot Summary for HTR5A Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Tocris Summary for HTR5A Gene

  • Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents, but a functional transcript has not been identified in humans.

Gene Wiki entry for HTR5A Gene

Additional gene information for HTR5A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR5A Gene

Genomics for HTR5A Gene

GeneHancer (GH) Regulatory Elements for HTR5A Gene

Promoters and enhancers for HTR5A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J155071 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 508.8 -0.1 -74 0.5 RXRA ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 USF1 TEAD4 ZNF639 ZNF10 HTR5A PAXIP1-AS2 PAXIP1 ENSG00000273183 HTR5A-AS1 piR-38051-270
GH07J155108 Enhancer 0.5 Ensembl 7.5 +38.2 38177 1.8 EP300 EZH2 NFATC1 PBX3 BCL3 ZSCAN4 HTR5A ENSG00000228806 ENSG00000274637 lnc-HTR5A-2 lnc-PAXIP1-2
GH07J154658 Enhancer 0.2 FANTOM5 1.5 -411.8 -411751 0.2 HTR5A HSALNG0062519 LOC105375581 DPP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR5A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR5A

Top Transcription factor binding sites by QIAGEN in the HTR5A gene promoter:
  • IRF-7A
  • NRSF form 1
  • NRSF form 2
  • Pax-4a

Genomic Locations for HTR5A Gene

Genomic Locations for HTR5A Gene
17,069 bases
Plus strand
15,426 bases
Plus strand

Genomic View for HTR5A Gene

Genes around HTR5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR5A Gene

Proteins for HTR5A Gene

  • Protein details for HTR5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 5A
    Protein Accession:
    Secondary Accessions:
    • Q2M2D2

    Protein attributes for HTR5A Gene

    357 amino acids
    Molecular mass:
    40255 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR5A Gene

Post-translational modifications for HTR5A Gene

  • Glycosylation at Asn6 and Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR5A Gene

Domains & Families for HTR5A Gene

Gene Families for HTR5A Gene

Protein Domains for HTR5A Gene

  • 5-hydroxytryptamine receptor signature
  • 5-hydroxytryptamine 5A receptor signature

Suggested Antigen Peptide Sequences for HTR5A Gene

GenScript: Design optimal peptide antigens:
  • Serotonin receptor 5A (5HT5A_HUMAN)
  • cDNA FLJ36936 fis, clone BRACE2005395, highly similar to 5-HYDROXYTRYPTAMINE 5A RECEPTOR (A4D2N2_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 5A (Q14D80_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR5A: view

Function for HTR5A Gene

Molecular function for HTR5A Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 5A,G protein coupled receptor superfamily,unlikely to be associated with autistic disorder

Phenotypes From GWAS Catalog for HTR5A Gene

Gene Ontology (GO) - Molecular Function for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004993 G protein-coupled serotonin receptor activity IDA,IEA 7988681
GO:0030594 neurotransmitter receptor activity IBA 21873635
GO:0051378 serotonin binding IBA 21873635
genes like me logo Genes that share ontologies with HTR5A: view
genes like me logo Genes that share phenotypes with HTR5A: view

Animal Models for HTR5A Gene

MGI Knock Outs for HTR5A:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR5A

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR5A Gene

Localization for HTR5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR5A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR5A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HTR5A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR5A Gene

Pathways & Interactions for HTR5A Gene

genes like me logo Genes that share pathways with HTR5A: view

Pathways by source for HTR5A Gene

1 Qiagen pathway for HTR5A Gene
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
genes like me logo Genes that share ontologies with HTR5A: view

No data available for SIGNOR curated interactions for HTR5A Gene

Drugs & Compounds for HTR5A Gene

(87) Drugs for HTR5A Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Asenapine Approved Pharma Antagonist, Full agonist, Agonist, antagonist, Target Inhibits adrenergic receptor/5-HT receptor 57
Vortioxetine Approved, Investigational Pharma 5-HT receptors antagonist 80
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, antagonist Antipsychotic medication 134
Ergotamine Approved Pharma Full agonist, Agonist, Antagonist, Partial agonist, agonist 6
Metergoline Approved Pharma Antagonist, Inverse agonist 0

(1) Additional Compounds for HTR5A Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist, Inhibition, Inhibitor

(1) Tocris Compounds for HTR5A Gene

Compound Action Cas Number
SB 699551 Selective 5-ht5a antagonist 864741-95-7

(67) ApexBio Compounds for HTR5A Gene

Compound Action Cas Number
(±)-MDMA hydrochloride 92279-84-0
2-Methyl-5-hydroxytryptamine hydrochloride 845861-49-6
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
Cisapride 81098-60-4
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dexfenfluramine hydrochloride 3239-45-0
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Duloxetine HCl 136434-34-9
Eltoprazine hydrochloride 98206-09-8
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 46611 185259-85-2
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
Methysergide maleate 129-49-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Pizotifen Malate 5189-11-7
Psilocin 520-53-6
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
RS 39604 hydrochloride 167710-87-4
RS 67333 hydrochloride 168986-60-5
RU 24969 66611-26-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258719 hydrochloride 1217674-10-6
SB 699551 864741-95-7
SB271046 209481-20-9
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WY 45233 succinate 448904-47-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR5A: view

Drug Products

Transcripts for HTR5A Gene

mRNA/cDNA for HTR5A Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR5A Gene

No ASD Table

Relevant External Links for HTR5A Gene

GeneLoc Exon Structure for

Expression for HTR5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR5A Gene

mRNA differential expression in normal tissues according to GTEx for HTR5A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.1), Brain - Cerebellum (x7.5), Brain - Frontal Cortex (BA9) (x7.4), Brain - Cortex (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.3), and Brain - Hypothalamus (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR5A

SOURCE GeneReport for Unigene cluster for HTR5A Gene:


Evidence on tissue expression from TISSUES for HTR5A Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with HTR5A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR5A Gene

Orthologs for HTR5A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR5A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR5A 31 30
  • 99.35 (n)
(Ornithorhynchus anatinus)
Mammalia HTR5A 31
  • 90 (a)
(Canis familiaris)
Mammalia HTR5A 31 30
  • 88.52 (n)
(Bos Taurus)
Mammalia HTR5A 31 30
  • 87.3 (n)
(Rattus norvegicus)
Mammalia Htr5a 30
  • 84.41 (n)
(Mus musculus)
Mammalia Htr5a 17 31 30
  • 84.22 (n)
(Monodelphis domestica)
Mammalia HTR5A 31
  • 77 (a)
(Gallus gallus)
Aves HTR5A 31 30
  • 77.56 (n)
(Anolis carolinensis)
Reptilia HTR5A 31
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr5a 30
  • 73.19 (n)
(Danio rerio)
Actinopterygii htr5a 31
  • 77 (a)
htr5al 31 30
  • 73.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 32
  • 46 (a)
5-HT1B 32
  • 44 (a)
CG6989 32
  • 32 (a)
Species where no ortholog for HTR5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR5A Gene

Gene Tree for HTR5A (if available)
Gene Tree for HTR5A (if available)
Evolutionary constrained regions (ECRs) for HTR5A: view image

Paralogs for HTR5A Gene

Paralogs for HTR5A Gene

(35) SIMAP similar genes for HTR5A Gene using alignment to 5 proteins:

  • A4D2N2_HUMAN
  • Q14D80_HUMAN
  • Q75LH0_HUMAN
  • Q86UN1_HUMAN Pseudogenes for HTR5A Gene

genes like me logo Genes that share paralogs with HTR5A: view

Variants for HTR5A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR5A Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs193920930 Uncertain Significance: Malignant tumor of prostate 155,070,978(+) G/C MISSENSE_VARIANT
rs746290830 A colorectal cancer sample p.Arg262Cys

Additional dbSNP identifiers (rs#s) for HTR5A Gene

Structural Variations from Database of Genomic Variants (DGV) for HTR5A Gene

Variant ID Type Subtype PubMed ID
esv2735525 CNV deletion 23290073
esv3542734 CNV deletion 23714750
esv3615621 CNV loss 21293372
esv9298 CNV loss 19470904
nsv1022356 CNV gain 25217958
nsv1137312 CNV deletion 24896259
nsv1143195 CNV tandem duplication 24896259
nsv366608 CNV deletion 16902084
nsv512006 CNV loss 21212237
nsv513740 CNV insertion 21212237
nsv821049 CNV duplication 20802225
nsv8239 CNV loss 18304495
nsv824406 CNV loss 20364138
nsv824407 CNV loss 20364138
nsv957560 CNV deletion 24416366

Variation tolerance for HTR5A Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR5A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR5A Gene

Disorders for HTR5A Gene

MalaCards: The human disease database

(2) MalaCards diseases for HTR5A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • adhd
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search HTR5A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR5A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTR5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR5A Gene

Publications for HTR5A Gene

  1. [Alcohol dependence and polymorphisms of serotonin-related genes]. (PMID: 15581469) Gorwood P … Hamon M (Medecine sciences : M/S 2004) 3 23 41 54
  2. Cloning and characterisation of the human 5-HT5A serotonin receptor. (PMID: 7988681) Rees S … Lee M (FEBS letters 1994) 2 3 4 54
  3. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. (PMID: 19381154) Brezo J … Turecki G (Molecular psychiatry 2010) 3 41 54
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41 54
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54

Products for HTR5A Gene

Sources for HTR5A Gene