Aliases for HTR5A Gene
External Ids for HTR5A Gene
Previous GeneCards Identifiers for HTR5A Gene
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
GeneCards Summary for HTR5A Gene
HTR5A (5-Hydroxytryptamine Receptor 5A) is a Protein Coding gene. Diseases associated with HTR5A include Attention Deficit-Hyperactivity Disorder and Schizophrenia. Among its related pathways are Signaling by GPCR and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot Summary for HTR5A Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents, but a functional transcript has not been identified in humans.