Aliases for HTR4 Gene
External Ids for HTR4 Gene
Previous GeneCards Identifiers for HTR4 Gene
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
GeneCards Summary for HTR4 Gene
HTR4 (5-Hydroxytryptamine Receptor 4) is a Protein Coding gene. Diseases associated with HTR4 include Irritable Bowel Syndrome and Constipation. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is DRD5.
UniProtKB/Swiss-Prot Summary for HTR4 Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.