This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012] See more...

Aliases for HTR3E Gene

Aliases for HTR3E Gene

  • 5-Hydroxytryptamine Receptor 3E 2 3 4 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic 2 3
  • 5-HT3-E 3 4
  • 5-HT3E 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit E 3
  • Serotonin Receptor 3E 4
  • 5-HT3c1 3
  • HTR3E 5

External Ids for HTR3E Gene

Previous GeneCards Identifiers for HTR3E Gene

  • GC03P185217
  • GC03P185139
  • GC03P185136
  • GC03P185300
  • GC03P183814
  • GC03P181225

Summaries for HTR3E Gene

Entrez Gene Summary for HTR3E Gene

  • This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

GeneCards Summary for HTR3E Gene

HTR3E (5-Hydroxytryptamine Receptor 3E) is a Protein Coding gene. Diseases associated with HTR3E include Irritable Bowel Syndrome and Obsessive-Compulsive Disorder. Among its related pathways are Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics and Taste transduction. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3C.

UniProtKB/Swiss-Prot Summary for HTR3E Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3E Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3E Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR3E Gene

Genomics for HTR3E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HTR3E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184531 Enhancer 0.5 FANTOM5 Ensembl 4.9 +434.3 434337 2 ZBTB33 THPO CHRD LINC01840 EPHB3 LINC02054 SNORD66 EIF4G1 FAM131A LINC01839 HTR3E
GH03J184110 Enhancer 1 Ensembl ENCODE 0.4 +13.5 13451 0.7 NCOR1 IKZF1 HES1 MNT TAF9B THAP11 MAFF NBN SAP130 ZNF316 EIF2B5 HTR3C CAMK2N2 ABCC5 PSMD2 VWA5B2 HSP90AA5P HTR3E-AS1 HTR3E EIF2B5-DT
GH03J184084 Enhancer 0.8 Ensembl 0.4 -11.4 -11363 1 NCOR1 JUND CEBPA CEBPB BHLHE40 EP300 NBN FOSL2 NFE2 SKIL ENSG00000207351 HTR3C ALG3 VWA5B2 MIR1224 HSALNG0031202 HSALNG0031203 HTR3E EIF2B5-DT
GH03J184067 Enhancer 0.7 Ensembl 0.3 -29.0 -28963 1 NCOR1 MYC IKZF1 ZNF592 TAL1 SMARCA4 FOXM1 EP400 TCF12 MTA2 HTR3E-AS1 CAMK2N2 ABCC5 ALG3 EIF2B5 ECE2 ABCC5-AS1 VWA5B2 MIR1224 HTR3C
GH03J184129 Enhancer 0.5 Ensembl 0.3 +32.0 32037 0.2 REST CTCF FOXA2 RAD21 SMC3 TEAD3 CEBPB FOXA3 piR-60051-076 piR-57133-436 EIF2B5 EIF2B5-DT HTR3E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR3E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR3E

Top Transcription factor binding sites by QIAGEN in the HTR3E gene promoter:
  • aMEF-2
  • CP2
  • CUTL1
  • FOXO1
  • FOXO1a
  • FOXO4
  • LCR-F1
  • MEF-2A
  • RREB-1
  • Sp1

Genomic Locations for HTR3E Gene

Latest Assembly
chr3:184,097,064-184,106,995
(GRCh38/hg38)
Size:
9,932 bases
Orientation:
Plus strand

Previous Assembly
chr3:183,814,852-183,824,783
(GRCh37/hg19 by Entrez Gene)
Size:
9,932 bases
Orientation:
Plus strand

chr3:183,814,852-183,824,783
(GRCh37/hg19 by Ensembl)
Size:
9,932 bases
Orientation:
Plus strand

Genomic View for HTR3E Gene

Genes around HTR3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3E Gene

Proteins for HTR3E Gene

  • Protein details for HTR3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5X5Y0-5HT3E_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3E
    Protein Accession:
    A5X5Y0
    Secondary Accessions:
    • A8IKD7
    • E9PGF1
    • Q495G1
    • Q495G3
    • Q6V706
    • Q6V707
    • Q7Z6B2

    Protein attributes for HTR3E Gene

    Size:
    456 amino acids
    Molecular mass:
    51438 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3E Gene

Post-translational modifications for HTR3E Gene

  • Glycosylation at Asn175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HTR3E Gene

Domains & Families for HTR3E Gene

Gene Families for HTR3E Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for HTR3E Gene

GenScript: Design optimal peptide antigens:
  • Serotonin receptor 3E (5HT3E_HUMAN)
  • Serotonin receptor 3 subunit E splice variant 3 (A8IKD7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A5X5Y0

UniProtKB/Swiss-Prot:

5HT3E_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
genes like me logo Genes that share domains with HTR3E: view

Function for HTR3E Gene

Molecular function for HTR3E Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Phenotypes From GWAS Catalog for HTR3E Gene

Gene Ontology (GO) - Molecular Function for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005515 protein binding IPI --
GO:0022850 serotonin-gated cation-selective channel activity IBA,IDA 17392525
genes like me logo Genes that share ontologies with HTR3E: view
genes like me logo Genes that share phenotypes with HTR3E: view

miRNA for HTR3E Gene

miRTarBase miRNAs that target HTR3E

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTR3E Gene

Localization for HTR3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3E Gene

Cell membrane. Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3E gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
cytosol 0

Gene Ontology (GO) - Cellular Components for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IBA 21873635
genes like me logo Genes that share ontologies with HTR3E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3E Gene

Pathways & Interactions for HTR3E Gene

genes like me logo Genes that share pathways with HTR3E: view

Pathways by source for HTR3E Gene

2 KEGG pathways for HTR3E Gene
1 Qiagen pathway for HTR3E Gene
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007268 chemical synaptic transmission TAS --
GO:0034220 ion transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with HTR3E: view

No data available for SIGNOR curated interactions for HTR3E Gene

Drugs & Compounds for HTR3E Gene

(25) Drugs for HTR3E Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 3544
Chlorprothixene Approved, Experimental, Investigational, Withdrawn Pharma Target, inhibitor 4
Dihydroergocornine Approved Pharma Target, antagonist, agonist 0
Dihydroergocristine Approved, Experimental Pharma Target, antagonist 0
Ergoloid mesylate Approved Pharma Target, antagonist, agonist 0

(1) Additional Compounds for HTR3E Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methyl-5-hydroxytryptamine hydrochloride
845861-49-6

(4) Tocris Compounds for HTR3E Gene

Compound Action Cas Number
2-Methyl-5-hydroxytryptamine hydrochloride 5-HT3 agonist/potent 5-HT6 ligand 845861-49-6
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
N-Methylquipazine dimaleate 5-HT3 agonist 171205-17-7
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(9) ApexBio Compounds for HTR3E Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
3-AQC 201216-42-4
EMD 386088 hydrochloride 1171123-46-8
N-Methylquipazine dimaleate 171205-17-7
Quipazine dimaleate 150323-78-7
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3E: view

Drug products for research

Transcripts for HTR3E Gene

mRNA/cDNA for HTR3E Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3E

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3E Gene

No ASD Table

Relevant External Links for HTR3E Gene

GeneLoc Exon Structure for
HTR3E

Expression for HTR3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR3E Gene

mRNA differential expression in normal tissues according to GTEx for HTR3E Gene

This gene is overexpressed in Colon - Transverse (x24.2) and Small Intestine - Terminal Ileum (x14.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR3E

SOURCE GeneReport for Unigene cluster for HTR3E Gene:

Hs.449179

mRNA Expression by UniProt/SwissProt for HTR3E Gene:

A5X5Y0-5HT3E_HUMAN
Tissue specificity: Expressed in adult colon and intestine.
genes like me logo Genes that share expression patterns with HTR3E: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3E Gene

Orthologs for HTR3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HTR3E 29 30
  • 98.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HTR3E 29 30
  • 84.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HTR3E 29 30
  • 82.67 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 66 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101733760 29
  • 52.62 (n)
Zebrafish
(Danio rerio)
Actinopterygii CU207281.1 30
  • 45 (a)
ManyToMany
CU207281.2 30
  • 32 (a)
ManyToMany
Species where no ortholog for HTR3E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HTR3E Gene

ENSEMBL:
Gene Tree for HTR3E (if available)
TreeFam:
Gene Tree for HTR3E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR3E: view image
Alliance of Genome Resources:
Additional Orthologs for HTR3E

Paralogs for HTR3E Gene

(9) SIMAP similar genes for HTR3E Gene using alignment to 2 proteins:

  • 5HT3E_HUMAN
  • C9J420_HUMAN

Pseudogenes.org Pseudogenes for HTR3E Gene

genes like me logo Genes that share paralogs with HTR3E: view

Variants for HTR3E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR3E Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs145547998 Likely Benign: not provided 184,105,324(+) G/A
NM_182589.2(HTR3E):c.662G>A (p.Arg221Gln)
MISSENSE
rs149134892 Benign: not provided 184,106,595(+) T/G
NM_182589.2(HTR3E):c.1318T>G (p.Leu440Val)
MISSENSE
rs13324468 -- p.Ala430Thr
rs7627615 -- p.Ala71Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HTR3E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HTR3E Gene

Variant ID Type Subtype PubMed ID
esv2664042 CNV deletion 23128226
esv3598937 CNV loss 21293372

Variation tolerance for HTR3E Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR3E Gene

Human Gene Mutation Database (HGMD)
HTR3E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3E
Leiden Open Variation Database (LOVD)
HTR3E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3E Gene

Disorders for HTR3E Gene

MalaCards: The human disease database

(2) MalaCards diseases for HTR3E Gene - From: COP and GCD

Disorder Aliases PubMed IDs
irritable bowel syndrome
  • ibd
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards
Search HTR3E in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR3E

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HTR3E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3E Gene

Publications for HTR3E Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B … Rappold GA (Gene 2003) 2 3 4
  2. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin EK … Redline S (American journal of respiratory and critical care medicine 2010) 3 40
  3. Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PMID: 20602613) Hammer C … Niesler B (Pharmacogenomics 2010) 3 40
  4. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke TW … Fasching PA (Acta obstetricia et gynecologica Scandinavica 2010) 3 40
  5. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A … Maier W (Pharmacogenetics and genomics 2009) 3 40

Products for HTR3E Gene

Sources for HTR3E Gene