Aliases for HTR3E Gene
External Ids for HTR3E Gene
Previous GeneCards Identifiers for HTR3E Gene
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
GeneCards Summary for HTR3E Gene
HTR3E (5-Hydroxytryptamine Receptor 3E) is a Protein Coding gene. Diseases associated with HTR3E include Irritable Bowel Syndrome and Obsessive-Compulsive Disorder. Among its related pathways are Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics and Taste transduction. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3C.
UniProtKB/Swiss-Prot Summary for HTR3E Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).