Aliases for HTR3D Gene
External Ids for HTR3D Gene
Previous GeneCards Identifiers for HTR3D Gene
The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
GeneCards Summary for HTR3D Gene
HTR3D (5-Hydroxytryptamine Receptor 3D) is a Protein Coding gene. Diseases associated with HTR3D include Primary Angle-Closure Glaucoma and Epilepsy, Familial Adult Myoclonic, 4. Among its related pathways are Ligand-gated ion channel transport and Serotonergic synapse. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3E.
UniProtKB/Swiss-Prot Summary for HTR3D Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).