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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex... See more...
Aliases for HTR3B Gene
Aliases for HTR3B Gene
External Ids for HTR3B Gene
- HGNC: 5298
- Entrez Gene: 9177
- Ensembl: ENSG00000149305
- OMIM: 604654
- UniProtKB: O95264
Previous GeneCards Identifiers for HTR3B Gene
- GC11P116128
- GC11P115287
- GC11P113809
- GC11P113313
- GC11P113280
- GC11P109703
- GC11P113775
Summaries for HTR3B Gene
-
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
GeneCards Summary for HTR3B Gene
HTR3B (5-Hydroxytryptamine Receptor 3B) is a Protein Coding gene. Diseases associated with HTR3B include Myasthenic Syndrome, Congenital, 15 and Heroin Dependence. Among its related pathways are Ligand-gated ion channel transport and Serotonergic synapse. Gene Ontology (GO) annotations related to this gene include ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot Summary for HTR3B Gene
-
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
-
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
Additional gene information for HTR3B Gene
- HGNC(5298)
- Entrez Gene(9177)
- Ensembl(ENSG00000149305)
- OMIM(604654)
- UniProtKB(O95264)
- Open Targets Platform(ENSG00000149305)
- Monarch Initiative
- Search for HTR3B at DataMed
- Search for HTR3B at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR3B Gene
Genomics for HTR3B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HTR3B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J113898 | Promoter | 0.6 | EPDnew | 600.7 | -0.1 | -75 | 0.1 | SOX13 KDM1A SOX5 BHLHE40 | HTR3B HTR3A RNU6-1107P lnc-USP28-3 USP28 | |
| GH11J113908 | Promoter | 0.3 | EPDnew | 600.4 | +10.1 | 10054 | 0.1 | HTR3B piR-38351-088 HTR3A | ||
| GH11J113896 | Enhancer | 0.9 | Ensembl ENCODE | 0.7 | -2.7 | -2722 | 2 | RNF2 CTCF REST RAD21 TRIM22 ZBTB44 ZBTB20 TCF7L2 OSR2 SMC3 | NNMT RNU6-1107P HTR3A ATF4P4 LRRC37A13P DRD2 HTR3B lnc-USP28-3 USP28 | |
| GH11J113905 | Enhancer | 1 | Ensembl ENCODE | 0.4 | +7.5 | 7548 | 1.7 | GATAD2A CTCF ZNF629 ZNF174 FOXA1 PRDM1 RXRB PATZ1 SP1 ZNF501 | USP28 ENSG00000270179 HTR3A RNU6-1107P HTR3B piR-38351-088 | |
| GH11J113884 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | -14.3 | -14346 | 1.2 | GATAD2A ATF7 TEAD4 PRDM10 IKZF1 JUND PATZ1 CEBPA ZNF561 SOX13 | lnc-USP28-3 USP28 HTR3B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HTR3B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR3B
- Top Transcription factor binding sites by QIAGEN in the HTR3B gene promoter:
-
- aMEF-2
- FOXF2
- GR
- GR-alpha
- IRF-2
- Lhx3a
- MEF-2A
- Pax-3
- POU3F1
- S8
Genomic Locations for HTR3B Gene
Genomic Locations for HTR3B Gene
- chr11:113,898,923-113,949,119
- (GRCh38/hg38)
- Size:
- 50,197 bases
- Orientation:
- Plus strand
- chr11:113,775,399-113,817,287
- (GRCh37/hg19)
- Size:
- 41,889 bases
- Orientation:
- Plus strand
Genomic View for HTR3B Gene
Genes around HTR3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by HGNC
- 11q23.2 by Entrez Gene
- 11q23.2 by Ensembl
HTR3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HTR3B Gene
Proteins for HTR3B Gene
-
Protein details for HTR3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95264-5HT3B_HUMAN
- Recommended name:
- 5-hydroxytryptamine receptor 3B
- Protein Accession:
- O95264
- B0YJ23
- Q0VJC3
Protein attributes for HTR3B Gene
- Size:
- 441 amino acids
- Molecular mass:
- 50292 Da
- Quaternary structure:
-
- Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
- Miscellaneous:
-
- The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers.
Protein Expression for HTR3B Gene
Post-translational modifications for HTR3B Gene
- N-glycosylation required for membrane localization.
-
Glycosylation at Asn52, Asn96, Asn138, Asn168, Asn203, and Asn287
- NX_O95264 (NX_O95264-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HTR3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences HTR3B / 5-HT3B Receptor Antibody (LS-B971) and HTR3B / 5-HT3B Receptor Antibody (LS-B7535)
- G Biosciences Immunotag™ HTR3B Antibody
- HUABIO Anti-5HT3B receptor Antibody
-
Custom Antibody ServicesOriGene Antibodies for HTR3B
- Novus Biologicals Antibodies for HTR3B
-
Abcam antibodies for HTR3B
- Invitrogen Antibodies for HTR3B (AFLGC-HTR3B)
-
Boster Bio Antibodies for HTR3B
-
Santa Cruz Biotechnology (SCBT) Antibodies for HTR3B
- Sino Biological Antibodies for HTR3B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HTR3B
- Origene Custom Protein Services for HTR3B
No data available for DME Specific Peptides for HTR3B Gene
Domains & Families for HTR3B Gene
Gene Families for HTR3B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HTR3B Gene
- InterPro:
- Blocks:
-
- Neurotransmitter-gated ion-channel
- 5-hydroxytryptamine 3 receptor signature
- 5-hydroxytryptamine 3 receptor B subunit signature
- ProtoNet:
Suggested Antigen Peptide Sequences for HTR3B Gene
- GenScript: Design optimal peptide antigens:
-
- Serotonin receptor 3B (5HT3B_HUMAN)
- 5-hydroxytryptamine (Serotonin) receptor 3B (B3VRK5_HUMAN)
- 5-hydroxytryptamine (Serotonin) receptor 3B (B3VRL0_HUMAN)
- 5-hydroxytryptamine (Serotonin) receptor 3B (B3VRL5_HUMAN)
- 5-hydroxytryptamine (Serotonin) receptor 3B (B3VRM0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95264UniProtKB/Swiss-Prot:
5HT3B_HUMAN :- Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
- Family:
-
- Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
Function for HTR3B Gene
Molecular function for HTR3B Gene
- UniProtKB/Swiss-Prot Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- GENATLAS Biochemistry:
- 5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
Phenotypes From GWAS Catalog for HTR3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
| GO:0015276 | ligand-gated ion channel activity | IEA | -- |
| GO:0022850 | serotonin-gated cation-selective channel activity | IGI | 9950429 |
Phenotypes for HTR3B Gene
- MGI mutant phenotypes for HTR3B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HTR3B:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Reduced mammosphere formation
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Cells with protrusions
Animal Models for HTR3B Gene
- MGI Knock Outs for HTR3B:
-
- Htr3b Htr3b<tm1.1(KOMP)Vlcg>
Animal Model Products
-
Taconic Biosciences Mouse Models for HTR3B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HTR3B - Select products 50% OFF >
- * HTR3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HTR3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HTR3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR3B
miRNA for HTR3B Gene
- miRTarBase miRNAs that target HTR3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HTR3B
- Browse OriGene Inhibitory RNA Products For HTR3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3B
Clone Products
- Applied Biological Materials (abm): Clones for HTR3B - Select products 50% OFF >
- * HTR3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HTR3B
- Addgene plasmids for HTR3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HTR3B
Cell Line Products
-
Horizon Cell Lines for HTR3B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR3B Gene
Localization for HTR3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTR3B Gene
- Cell membrane. Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0009986 | cell surface | IDA | 16571125 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3B Gene
Pathways & Interactions for HTR3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics | ||
| 2 | Serotonergic synapse | ||
| 3 | Taste transduction | ||
| 4 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
| 5 | Ion channel transport | ||
Pathways by source for HTR3B Gene
3 Reactome pathways for HTR3B Gene
2 PharmGKB pathways for HTR3B Gene
2 KEGG pathways for HTR3B Gene
1 Qiagen pathway for HTR3B Gene
- Intracellular Calcium Signaling
Interacting Proteins for HTR3B Gene
GPS-Prot Interaction Network for HTR3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0007165 | signal transduction | IBA | 21873635 |
| GO:0007210 | serotonin receptor signaling pathway | IEA | -- |
| GO:0007268 | chemical synaptic transmission | TAS | -- |
| GO:0034220 | ion transmembrane transport | IEA,IBA | 21873635 |
No data available for SIGNOR curated interactions for HTR3B Gene
Drugs & Compounds for HTR3B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Paroxetine | Approved, Investigational | Pharma | Inhibitor, Inhibition, Target | 259 | ||
| Ethanol | Approved | Pharma | Target | 3266 | ||
| Granisetron | Approved, Investigational | Pharma | antagonist | Serotonin 5-HT3 receptor antagonist | 95 | |
| Chlorprothixene | Approved, Experimental, Investigational, Withdrawn | Pharma | Target, inhibitor | 4 | ||
| Dihydroergocornine | Approved | Pharma | Target, antagonist, agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Methyl-5-hydroxytryptamine hydrochloride |
|
845861-49-6 |
|
|
(4) Tocris Compounds for HTR3B Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-Methyl-5-hydroxytryptamine hydrochloride | 5-HT3 agonist/potent 5-HT6 ligand | 845861-49-6 |
| m-Chlorophenylbiguanide hydrochloride | Potent and specific 5-HT3 agonist | 2113-05-5 |
| N-Methylquipazine dimaleate | 5-HT3 agonist | 171205-17-7 |
| Zacopride hydrochloride | Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist | 101303-98-4 |
(16) ApexBio Compounds for HTR3B Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Phenylbiguanide hydrochloride | 55-57-2 | |
| 3-AQC | 201216-42-4 | |
| Alosetron Hydrochloride | 5-HT3 receptor antagonist,potent and highly selective | 122852-69-1 |
| Azasetron HCl | 5-HT3 receptor antagonist | 123040-16-4 |
| EMD 386088 hydrochloride | 1171123-46-8 | |
| Granisetron | Serotonin 5-HT3 receptor antagonist | 109889-09-0 |
| Granisetron HCl | 5-HT3 receptor antagonist | 107007-99-8 |
| m-Chlorophenylbiguanide hydrochloride | 2113-05-5 | |
| N-Methylquipazine dimaleate | 171205-17-7 | |
| Ondansetron HCl | 5-HT3 receptor antagonist | 99614-01-4 |
| Quipazine dimaleate | 150323-78-7 | |
| RS 56812 hydrochloride | 143339-12-2 | |
| SDZ 205-557 hydrochloride | 1197334-02-3 | |
| SR 57227 hydrochloride | 77145-61-0 | |
| Tianeptine | 5-HT facilitator | 66981-73-5 |
| Zacopride hydrochloride | 101303-98-4 |
Transcripts for HTR3B Gene
mRNA/cDNA for HTR3B Gene
- 2 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260191 4524 nts (view in UCSC)
- ENST00000537778 1692 nts (view in UCSC)
- ENST00000543092 612 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HTR3B - Select products 50% OFF >
- * HTR3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HTR3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HTR3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HTR3B
- Browse OriGene Inhibitory RNA Products For HTR3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3B
Clone Products
- Applied Biological Materials (abm): Clones for HTR3B - Select products 50% OFF >
- * HTR3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HTR3B
- Addgene plasmids for HTR3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HTR3B
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: |
Relevant External Links for HTR3B Gene
- GeneLoc Exon Structure for
- HTR3B
Expression for HTR3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Head Mesenchyme (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HTR3B Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x16.5), Brain - Cortex (x14.2), and Brain - Anterior cingulate cortex (BA24) (x9.4).
This gene is overexpressed in Pancreatic juice (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR3B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR3B
SOURCE GeneReport for Unigene cluster for HTR3B Gene:
Hs.241377mRNA Expression by UniProt/SwissProt for HTR3B Gene:
O95264-5HT3B_HUMAN
Tissue specificity:
Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
Evidence on tissue expression from TISSUES for HTR3B Gene
- Nervous system(4.5)
- Intestine(4.4)
Primer Products
-
OriGene qPCR primer pairs for HTR3B
-
OriGene qPCR primer pairs and template standards for HTR3B
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3B Gene
Orthologs for HTR3B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Htr3b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Htr3b 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | HTR3B 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HTR3B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | htr3b 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC571632 30 |
|
||
| htr3b 31 |
|
OneToOne |
- Species where no ortholog for HTR3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HTR3B Gene
- ENSEMBL:
- Gene Tree for HTR3B (if available)
- TreeFam:
- Gene Tree for HTR3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HTR3B: view image
Paralogs for HTR3B Gene
Paralogs for HTR3B Gene
- HTR3A 5
- HTR3E 5
- HTR3C 5
- CHRNA4 5
- CHRNA7 5
- CHRNA2 5
- CHRNB2 5
- CHRNB3 5
- CHRNA5 5
- CHRND 5
- CHRNB4 5
- CHRNA10 5
- CHRNB1 5
- CHRNA9 5
- CHRNG 5
- CHRNA6 5
- CHRNA3 5
- CHRNA1 5
- CHRNE 5
- HTR3D 5
- ZACN 5
- CHRFAM7A 5
- GABRR3 5
- GABRR1 5
- GABRB2 5
- GABRE 5
- GABRG3 5
- GLRA2 5
- GABRD 5
- GABRR2 5
- GLRA3 5
- GABRG1 5
- GLRA1 5
- GABRA2 5
- GABRA4 5
- GABRB1 5
- GABRP 5
- GABRA6 5
- GABRA3 5
- GABRA1 5
- GABRG2 5
- GABRB3 5
- GABRA5 5
- GABRQ 5
- GLRB 5
- GLRA4 5
(8) SIMAP similar genes for HTR3B Gene using alignment to 11 proteins:
- 5HT3B_HUMAN
- B3VRK5_HUMAN
- B3VRL0_HUMAN
- B3VRL5_HUMAN
- B3VRM0_HUMAN
- B3VRM5_HUMAN
- B3VRN0_HUMAN
- B3VRN5_HUMAN
- B3VRP0_HUMAN
- B3VRP5_HUMAN
- H0YFX8_HUMAN
Variants for HTR3B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR3B Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716973 | Benign: not provided | 113,943,097(+) | T/G | MISSENSE_VARIANT | |
| 777860 | Likely Benign: not provided | 113,944,632(+) | T/G | MISSENSE_VARIANT | |
| 785385 | Benign: not provided | 113,944,725(+) | G/A | MISSENSE_VARIANT | |
| 790848 | Benign: not provided | 113,932,286(+) | T/C | INTRON_VARIANT | |
| rs1176744 | - | p.Tyr129Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv724n106 | CNV | deletion | 24896259 |
| esv2675456 | CNV | deletion | 23128226 |
| esv2745091 | CNV | deletion | 23290073 |
| esv2745092 | CNV | deletion | 23290073 |
| esv3548363 | CNV | deletion | 23714750 |
| nsv1070069 | CNV | deletion | 25765185 |
| nsv1125534 | CNV | tandem duplication | 24896259 |
| nsv832273 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.90;
87.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HTR3B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3B Gene
Disorders for HTR3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myasthenic syndrome, congenital, 15 |
|
|
| heroin dependence |
|
|
| pigmented paravenous chorioretinal atrophy |
|
|
| gilles de la tourette syndrome |
|
|
| drug dependence |
|
|
Search HTR3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HTR3B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3B Gene
Publications for HTR3B Gene
- Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PMID: 15293096) Frank B … Rappold G (Clinical rheumatology 2004) 3 4 23 41
- The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PMID: 10521471) Dubin AE … Erlander MG (The Journal of biological chemistry 1999) 2 3 4 23
- The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PMID: 9950429) Davies PA … Kirkness EF (Nature 1999) 2 3 4 23
- Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PMID: 19741568) Hammer C … Niesler B (Pharmacogenetics and genomics 2009) 3 23 41
- An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. (PMID: 18807291) Ji X … Ozaki N (Nagoya journal of medical science 2008) 3 23 41
ExternalLinks
Products for HTR3B Gene
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Sources for HTR3B Gene
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