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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
HTR3B (5-Hydroxytryptamine Receptor 3B) is a Protein Coding gene. Diseases associated with HTR3B include Myasthenic Syndrome, Congenital, 15 and Fibromyalgia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Taste transduction. Gene Ontology (GO) annotations related to this gene include ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3A.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J113898 | Promoter | 0.6 | EPDnew | 250.7 | -0.1 | -75 | 0.1 | SOX5 BHLHE40 KDM1A SOX13 | HSALNG0087282 HTR3B HTR3A RNU6-1107P USP28 | |
GH11J113908 | Promoter | 0.3 | EPDnew | 250.4 | +10.1 | 10054 | 0.1 | HTR3B piR-38351-088 HTR3A | ||
GH11J113894 | Enhancer | 0.9 | Ensembl ENCODE | 0.7 | -3.0 | -3022 | 2.6 | FEZF1 IRF2 CTCF REST TRIM22 SMC3 RAD21 PRDM6 NRF1 ZNF362 | HSALNG0087282 NNMT RNU6-1107P HTR3A ATF4P4 LRRC37A13P DRD2 HTR3B lnc-USP28-3 USP28 | |
GH11J113905 | Enhancer | 1 | Ensembl ENCODE | 0.4 | +7.6 | 7599 | 1.8 | ZSCAN16 FEZF1 CEBPA CTCF ZEB1 KDM6A THAP11 ZNF513 FOXA2 ZNF639 | USP28 ENSG00000270179 HTR3A RNU6-1107P HTR3B piR-38351-088 | |
GH11J113884 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | -14.3 | -14346 | 1.2 | CEBPA IKZF1 CEBPB SMAD4 ZEB2 TEAD3 IRF9 RBPJ ZNF48 EP400 | lnc-USP28-3 USP28 HTR3B HSALNG0087282 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005216 | ion channel activity | IEA | -- |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
GO:0015276 | ligand-gated ion channel activity | IEA | -- |
GO:0022850 | serotonin-gated cation-selective channel activity | IGI | 9950429 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IDA | 16571125 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics | ||
2 | Serotonergic synapse | ||
3 | Taste transduction | ||
4 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
5 | Ion channel transport |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007210 | serotonin receptor signaling pathway | IEA | -- |
GO:0007268 | chemical synaptic transmission | TAS | -- |
GO:0034220 | ion transmembrane transport | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Paroxetine | Approved, Investigational | Pharma | Target | 264 | ||
Ethanol | Approved | Pharma | Target | 3481 | ||
Granisetron | Approved, Investigational | Pharma | antagonist | Serotonin 5-HT3 receptor antagonist | 100 | |
Chlorprothixene | Approved, Experimental, Investigational, Withdrawn | Pharma | Target, inhibitor | 4 | ||
Dihydroergocornine | Approved | Pharma | Target, antagonist, agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride |
|
845861-49-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride | 5-HT3 agonist/potent 5-HT6 ligand | 845861-49-6 |
m-Chlorophenylbiguanide hydrochloride | Potent and specific 5-HT3 agonist | 2113-05-5 |
N-Methylquipazine dimaleate | 5-HT3 agonist | 171205-17-7 |
Zacopride hydrochloride | Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist | 101303-98-4 |
Compound | Action | Cas Number |
---|---|---|
1-Phenylbiguanide hydrochloride | 55-57-2 | |
3-AQC | 201216-42-4 | |
Alosetron Hydrochloride | 5-HT3 receptor antagonist,potent and highly selective | 122852-69-1 |
Azasetron HCl | 5-HT3 receptor antagonist | 123040-16-4 |
EMD 386088 hydrochloride | 1171123-46-8 | |
Granisetron | Serotonin 5-HT3 receptor antagonist | 109889-09-0 |
Granisetron HCl | 5-HT3 receptor antagonist | 107007-99-8 |
m-Chlorophenylbiguanide hydrochloride | 2113-05-5 | |
N-Methylquipazine dimaleate | 171205-17-7 | |
Ondansetron HCl | 5-HT3 receptor antagonist | 99614-01-4 |
Quipazine dimaleate | 150323-78-7 | |
RS 56812 hydrochloride | 143339-12-2 | |
SDZ 205-557 hydrochloride | 1197334-02-3 | |
SR 57227 hydrochloride | 77145-61-0 | |
Tianeptine | 5-HT facilitator | 66981-73-5 |
Zacopride hydrochloride | 101303-98-4 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Htr3b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Htr3b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | HTR3B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HTR3B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | htr3b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC571632 30 |
|
||
htr3b 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11214773 | Benign: not provided | 113,932,286(+) |
T/C NM_006028.4(HTR3B):c.369-3T>C |
INTRON | |
rs140529422 | Benign: not provided | 113,944,725(+) |
G/A NM_006028.4(HTR3B):c.1060G>A (p.Glu354Lys) |
MISSENSE | |
rs145278314 | Benign: not provided | 113,943,097(+) |
T/G NM_006028.4(HTR3B):c.812T>G (p.Ile271Ser) |
MISSENSE | |
rs78418698 | Likely Benign: not provided | 113,944,632(+) |
T/G NM_006028.4(HTR3B):c.967T>G (p.Leu323Val) |
MISSENSE | |
rs1176744 | - |
p.Tyr129Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv724n106 | CNV | deletion | 24896259 |
esv2675456 | CNV | deletion | 23128226 |
esv2745091 | CNV | deletion | 23290073 |
esv2745092 | CNV | deletion | 23290073 |
esv3548363 | CNV | deletion | 23714750 |
nsv1070069 | CNV | deletion | 25765185 |
nsv1125534 | CNV | tandem duplication | 24896259 |
nsv832273 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myasthenic syndrome, congenital, 15 |
|
|
fibromyalgia |
|
|
gilles de la tourette syndrome |
|
|
pigmented paravenous chorioretinal atrophy |
|
|
drug dependence |
|
|