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HTR3B Gene(Protein Coding)

5-Hydroxytryptamine Receptor 3B

GCID:
GC11P113905
GIFtS:
52
Genes Participants
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Aliases for HTR3B Gene

Aliases for HTR3B Gene

  • 5-Hydroxytryptamine Receptor 3B 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic 2 3
  • 5-HT3-B 3 4
  • 5-HT3B 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3B 2
  • 5-Hydroxytryptamine 3 Receptor B Subunit 3
  • Serotonin-Gated Ion Channel Subunit 3
  • Serotonin Receptor 3B 4

External Ids for HTR3B Gene

Previous GeneCards Identifiers for HTR3B Gene

  • GC11P116128
  • GC11P115287
  • GC11P113809
  • GC11P113313
  • GC11P113280
  • GC11P109703
  • GC11P113775

Summaries for HTR3B Gene

Entrez Gene Summary for HTR3B Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

GeneCards Summary for HTR3B Gene

HTR3B (5-Hydroxytryptamine Receptor 3B) is a Protein Coding gene. Diseases associated with HTR3B include Gilles De La Tourette Syndrome. Among its related pathways are Ligand-gated ion channel transport and CREB Pathway. Gene Ontology (GO) annotations related to this gene include ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3B Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3B Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3B Gene

Additional gene information for HTR3B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3B Gene

Genomics for HTR3B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for HTR3B Gene

Promoters and enhancers for HTR3B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I113895 Enhancer 0.7 ENCODE 0.8 -2.6 -2593 0.8 CTCF ZNF654 ZNF362 RNF2 TRIM22 REST RAD21 OSR2 ZNF335 ARID2 NNMT RNU6-1107P HTR3A ATF4P4 DRD2 HTR3B USP28
GH11I113896 Enhancer 0.6 ENCODE 0.8 -3.3 -3329 0.2 CTCF FEZF1 OSR2 PRDM6 GATA3 CTBP1 PRDM4 TRIM28 ZBTB20 TCF7L2 NNMT RNU6-1107P HTR3A HTR3B USP28
GH11I113905 Enhancer 0.9 ENCODE 0.4 +7.5 7548 1.7 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF213 ZNF143 MIER2 TSHZ1 ZSCAN16 USP28 ENSG00000270179 HTR3A RNU6-1107P HTR3B
GH11I113884 Enhancer 0.8 ENCODE 0.4 -14.3 -14331 1.1 TFAP4 ZNF384 CEBPG ZNF644 ZNF48 TEAD3 IRF9 CTBP1 PATZ1 PRDM10 USP28 HTR3B
GH11I113881 Enhancer 0.5 ENCODE 0.4 -16.9 -16889 0.2 FOSL1 MEIS2 PKNOX1 PBX2 IKZF1 DPF2 NFE2 USP28 HTR3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HTR3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HTR3B gene promoter:

Genomic Locations for HTR3B Gene

Genomic Locations for HTR3B Gene
chr11:113,898,923-113,946,565
(GRCh38/hg38)
Size:
47,643 bases
Orientation:
Plus strand
chr11:113,775,399-113,817,287
(GRCh37/hg19)

Genomic View for HTR3B Gene

Genes around HTR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HTR3B Gene

Proteins for HTR3B Gene

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  • Protein details for HTR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95264-5HT3B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3B
    Protein Accession:
    O95264
    Secondary Accessions:
    • B0YJ23
    • Q0VJC3

    Protein attributes for HTR3B Gene

    Size:
    441 amino acids
    Molecular mass:
    50292 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
    Miscellaneous:
    • The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers.

    Alternative splice isoforms for HTR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3B Gene

Protein Expression for HTR3B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HTR3B Gene

Other Protein References for HTR3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3B Gene

Domains & Families for HTR3B Gene

Gene Families for HTR3B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HTR3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HTR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95264

UniProtKB/Swiss-Prot:

5HT3B_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
genes like me logo Genes that share domains with HTR3B: view

Function for HTR3B Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for HTR3B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Phenotypes From GWAS Catalog for HTR3B Gene

Gene Ontology (GO) - Molecular Function for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015276 ligand-gated ion channel activity IEA --
GO:0022850 serotonin-gated cation-selective channel activity IGI 9950429
genes like me logo Genes that share ontologies with HTR3B: view
genes like me logo Genes that share phenotypes with HTR3B: view

Animal Models for HTR3B Gene

MGI Knock Outs for HTR3B:

Animal Model Products

miRNA for HTR3B Gene

miRTarBase miRNAs that target HTR3B

Clone Products

  • Addgene plasmids for HTR3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR3B Gene

Localization for HTR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3B Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3B gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 16571125
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3B Gene

Pathways & Interactions for HTR3B Gene

genes like me logo Genes that share pathways with HTR3B: view

Pathways by source for HTR3B Gene

2 KEGG pathways for HTR3B Gene
1 Qiagen pathway for HTR3B Gene

Gene Ontology (GO) - Biological Process for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0007268 chemical synaptic transmission TAS --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with HTR3B: view

No data available for SIGNOR curated interactions for HTR3B Gene

Drugs & Compounds for HTR3B Gene

Products:

  1. Drug

(36) Drugs for HTR3B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2326
Granisetron Approved, Investigational Pharma antagonist Serotonin 5-HT3 receptor antagonist 79
Dopamine Approved Pharma Full agonist, Agonist, Target 4008
Ergoloid mesylate Approved Pharma Target, antagonist 0
Setiptiline Approved Pharma Target, antagonist Serotonin receptor antagonist 0

(1) Additional Compounds for HTR3B Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for HTR3B Gene

Compound Action Cas Number
2-Methyl-5-hydroxytryptamine hydrochloride 5-HT3 agonist/potent 5-HT6 ligand 845861-49-6
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
N-Methylquipazine dimaleate 5-HT3 agonist 171205-17-7
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(18) ApexBio Compounds for HTR3B Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 155106-73-3
3-AQC 201216-42-4
Alosetron Hydrochloride 5-HT3 receptor antagonist,potent and highly selective 122852-69-1
Azasetron HCl 5-HT3 receptor antagonist 123040-16-4
EMD 386088 hydrochloride 1171123-46-8
Granisetron Serotonin 5-HT3 receptor antagonist 109889-09-0
Granisetron HCl 5-HT3 receptor antagonist 107007-99-8
m-Chlorophenylbiguanide hydrochloride 2113-05-5
N-Methylquipazine dimaleate 171205-17-7
Ondansetron HCl 5-HT3 receptor antagonist 99614-01-4
Palonosetron 5-HT3 antagonist 135729-61-2
Quipazine dimaleate 150323-78-7
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Tianeptine 5-HT facilitator 66981-73-5
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3B: view

Drug Products

Transcripts for HTR3B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HTR3B Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3B Gene

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic:
Representative Sequences:

Clone Products

  • Addgene plasmids for HTR3B

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: -
SP3:

Relevant External Links for HTR3B Gene

GeneLoc Exon Structure for
HTR3B
ECgene alternative splicing isoforms for
HTR3B

Expression for HTR3B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR3B Gene

mRNA expression in normal human tissues for HTR3B Gene
mRNA expression by BioGPS for HTR3B GenemRNA expression by GTEx for HTR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR3B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x16.5), Brain - Cortex (x14.2), and Brain - Anterior cingulate cortex (BA24) (x9.4).

Protein differential expression in normal tissues from HIPED for HTR3B Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR3B Gene



Protein tissue co-expression partners for HTR3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTR3B Gene:

HTR3B

SOURCE GeneReport for Unigene cluster for HTR3B Gene:

Hs.241377

mRNA Expression by UniProt/SwissProt for HTR3B Gene:

O95264-5HT3B_HUMAN
Tissue specificity: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.

Evidence on tissue expression from TISSUES for HTR3B Gene

  • Nervous system(4.4)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with HTR3B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3B Gene

Orthologs for HTR3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HTR3B 33 34
  • 99.17 (n)
cow
(Bos Taurus)
 Mammalia HTR3B 33 34
  • 84.44 (n)
dog
(Canis familiaris)
 Mammalia HTR3B 33 34
  • 84.18 (n)
mouse
(Mus musculus)
 Mammalia Htr3b 33 16 34
  • 80.11 (n)
rat
(Rattus norvegicus)
 Mammalia Htr3b 33
  • 79.95 (n)
oppossum
(Monodelphis domestica)
 Mammalia HTR3B 34
  • 68 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia HTR3B 34
  • 52 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia htr3b 33
  • 57.25 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC571632 33
  • 57.85 (n)
htr3b 34
  • 47 (a)
 OneToOne
Species where no ortholog for HTR3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3B Gene

ENSEMBL:
Gene Tree for HTR3B (if available)
TreeFam:
Gene Tree for HTR3B (if available)

Paralogs for HTR3B Gene

Paralogs for HTR3B Gene

(8) SIMAP similar genes for HTR3B Gene using alignment to 11 proteins:

genes like me logo Genes that share paralogs with HTR3B: view

Variants for HTR3B Gene

Sequence variations from dbSNP and Humsavar for HTR3B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000086244 -- 113,947,345(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000149846 -- 113,912,624(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000188228 -- 113,918,412(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000272816 -- 113,947,479(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000292402 -- 113,915,675(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3B Gene

Variant ID Type Subtype PubMed ID
nsv832273 CNV loss 17160897
nsv1125534 CNV tandem duplication 24896259
nsv1070069 CNV deletion 25765185
esv3548363 CNV deletion 23714750
esv2745092 CNV deletion 23290073
esv2745091 CNV deletion 23290073
esv2675456 CNV deletion 23128226
dgv724n106 CNV deletion 24896259

Variation tolerance for HTR3B Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.90; 87.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR3B Gene

Human Gene Mutation Database (HGMD)
HTR3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3B Gene

Disorders for HTR3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR3B Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • gts
- elite association - COSMIC cancer census association via MalaCards
Search HTR3B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTR3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3B Gene

Publications for HTR3B Gene

  1. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PMID: 15293096) Frank B … Rappold G (Clinical rheumatology 2004) 3 4 22 44 58
  2. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PMID: 10521471) Dubin AE … Erlander MG (The Journal of biological chemistry 1999) 2 3 4 22 58
  3. The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PMID: 9950429) Davies PA … Kirkness EF (Nature 1999) 2 3 4 22 58
  4. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PMID: 19741568) Hammer C … Niesler B (Pharmacogenetics and genomics 2009) 3 22 44 58
  5. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. (PMID: 18807291) Ji X … Ozaki N (Nagoya journal of medical science 2008) 3 22 44 58

Products for HTR3B Gene

  • Addgene plasmids for HTR3B

Sources for HTR3B Gene

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