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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
HTR3B (5-Hydroxytryptamine Receptor 3B) is a Protein Coding gene. Diseases associated with HTR3B include Myasthenic Syndrome, Congenital, 15 and Heroin Dependence. Among its related pathways are Ligand-gated ion channel transport and Serotonergic synapse. Gene Ontology (GO) annotations related to this gene include ion channel activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR3A.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J113898 | Promoter | 0.6 | EPDnew | 600.7 | -0.1 | -75 | 0.1 | SOX13 KDM1A SOX5 BHLHE40 | HTR3B HTR3A RNU6-1107P lnc-USP28-3 USP28 | |
GH11J113908 | Promoter | 0.3 | EPDnew | 600.4 | +10.1 | 10054 | 0.1 | HTR3B piR-38351-088 HTR3A | ||
GH11J113896 | Enhancer | 0.9 | Ensembl ENCODE | 0.7 | -2.7 | -2722 | 2 | RNF2 CTCF REST RAD21 TRIM22 ZBTB44 ZBTB20 TCF7L2 OSR2 SMC3 | NNMT RNU6-1107P HTR3A ATF4P4 LRRC37A13P DRD2 HTR3B lnc-USP28-3 USP28 | |
GH11J113905 | Enhancer | 1 | Ensembl ENCODE | 0.4 | +7.5 | 7548 | 1.7 | GATAD2A CTCF ZNF629 ZNF174 FOXA1 PRDM1 RXRB PATZ1 SP1 ZNF501 | USP28 ENSG00000270179 HTR3A RNU6-1107P HTR3B piR-38351-088 | |
GH11J113884 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | -14.3 | -14346 | 1.2 | GATAD2A ATF7 TEAD4 PRDM10 IKZF1 JUND PATZ1 CEBPA ZNF561 SOX13 | lnc-USP28-3 USP28 HTR3B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005216 | ion channel activity | IEA | -- |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
GO:0015276 | ligand-gated ion channel activity | IEA | -- |
GO:0022850 | serotonin-gated cation-selective channel activity | IGI | 9950429 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IDA | 16571125 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics | ||
2 | Serotonergic synapse | ||
3 | Taste transduction | ||
4 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
5 | Ion channel transport |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007210 | serotonin receptor signaling pathway | IEA | -- |
GO:0007268 | chemical synaptic transmission | TAS | -- |
GO:0034220 | ion transmembrane transport | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Paroxetine | Approved, Investigational | Pharma | Inhibitor, Inhibition, Target | 259 | ||
Ethanol | Approved | Pharma | Target | 3266 | ||
Granisetron | Approved, Investigational | Pharma | antagonist | Serotonin 5-HT3 receptor antagonist | 95 | |
Chlorprothixene | Approved, Experimental, Investigational, Withdrawn | Pharma | Target, inhibitor | 4 | ||
Dihydroergocornine | Approved | Pharma | Target, antagonist, agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride |
|
845861-49-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride | 5-HT3 agonist/potent 5-HT6 ligand | 845861-49-6 |
m-Chlorophenylbiguanide hydrochloride | Potent and specific 5-HT3 agonist | 2113-05-5 |
N-Methylquipazine dimaleate | 5-HT3 agonist | 171205-17-7 |
Zacopride hydrochloride | Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist | 101303-98-4 |
Compound | Action | Cas Number |
---|---|---|
1-Phenylbiguanide hydrochloride | 55-57-2 | |
3-AQC | 201216-42-4 | |
Alosetron Hydrochloride | 5-HT3 receptor antagonist,potent and highly selective | 122852-69-1 |
Azasetron HCl | 5-HT3 receptor antagonist | 123040-16-4 |
EMD 386088 hydrochloride | 1171123-46-8 | |
Granisetron | Serotonin 5-HT3 receptor antagonist | 109889-09-0 |
Granisetron HCl | 5-HT3 receptor antagonist | 107007-99-8 |
m-Chlorophenylbiguanide hydrochloride | 2113-05-5 | |
N-Methylquipazine dimaleate | 171205-17-7 | |
Ondansetron HCl | 5-HT3 receptor antagonist | 99614-01-4 |
Quipazine dimaleate | 150323-78-7 | |
RS 56812 hydrochloride | 143339-12-2 | |
SDZ 205-557 hydrochloride | 1197334-02-3 | |
SR 57227 hydrochloride | 77145-61-0 | |
Tianeptine | 5-HT facilitator | 66981-73-5 |
Zacopride hydrochloride | 101303-98-4 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HTR3B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Htr3b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Htr3b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | HTR3B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HTR3B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | htr3b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC571632 30 |
|
||
htr3b 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716973 | Benign: not provided | 113,943,097(+) | T/G | MISSENSE_VARIANT | |
777860 | Likely Benign: not provided | 113,944,632(+) | T/G | MISSENSE_VARIANT | |
785385 | Benign: not provided | 113,944,725(+) | G/A | MISSENSE_VARIANT | |
790848 | Benign: not provided | 113,932,286(+) | T/C | INTRON_VARIANT | |
rs1176744 | - | p.Tyr129Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv724n106 | CNV | deletion | 24896259 |
esv2675456 | CNV | deletion | 23128226 |
esv2745091 | CNV | deletion | 23290073 |
esv2745092 | CNV | deletion | 23290073 |
esv3548363 | CNV | deletion | 23714750 |
nsv1070069 | CNV | deletion | 25765185 |
nsv1125534 | CNV | tandem duplication | 24896259 |
nsv832273 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myasthenic syndrome, congenital, 15 |
|
|
heroin dependence |
|
|
pigmented paravenous chorioretinal atrophy |
|
|
gilles de la tourette syndrome |
|
|
drug dependence |
|
|