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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
HTR3A (5-Hydroxytryptamine Receptor 3A) is a Protein Coding gene. Diseases associated with HTR3A include Irritable Bowel Syndrome and Motion Sickness. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Ligand-gated ion channel transport. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3B.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005216 | ion channel activity | IEA | -- |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
GO:0005515 | protein binding | IPI | 17392525 |
GO:0015276 | ligand-gated ion channel activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics | ||
2 | Serotonergic synapse | ||
3 | Taste transduction | ||
4 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics | ||
5 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007210 | serotonin receptor signaling pathway | IEA | -- |
GO:0007268 | chemical synaptic transmission | TAS | -- |
GO:0032414 | positive regulation of ion transmembrane transporter activity | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Alosetron | Approved, Withdrawn | Pharma | Target, antagonist | 5 | ||
Granisetron | Approved, Investigational | Pharma | Target, antagonist | Serotonin 5-HT3 receptor antagonist | 95 | |
Dolasetron | Approved, Investigational | Pharma | Target, antagonist | 10 | ||
Ondansetron | Approved | Pharma | Target, antagonist, agonist | 409 | ||
Palonosetron | Approved, Investigational | Pharma | Target, antagonist | 110 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride |
|
845861-49-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
2-Methyl-5-hydroxytryptamine hydrochloride | 5-HT3 agonist/potent 5-HT6 ligand | 845861-49-6 |
m-Chlorophenylbiguanide hydrochloride | Potent and specific 5-HT3 agonist | 2113-05-5 |
N-Methylquipazine dimaleate | 5-HT3 agonist | 171205-17-7 |
Zacopride hydrochloride | Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist | 101303-98-4 |
Compound | Action | Cas Number |
---|---|---|
1-Phenylbiguanide hydrochloride | 55-57-2 | |
3-AQC | 201216-42-4 | |
Alosetron | 122852-42-0 | |
Alosetron Hydrochloride | 5-HT3 receptor antagonist,potent and highly selective | 122852-69-1 |
Azasetron HCl | 5-HT3 receptor antagonist | 123040-16-4 |
EMD 386088 hydrochloride | 1171123-46-8 | |
Granisetron | Serotonin 5-HT3 receptor antagonist | 109889-09-0 |
Granisetron HCl | 5-HT3 receptor antagonist | 107007-99-8 |
m-Chlorophenylbiguanide hydrochloride | 2113-05-5 | |
Mosapride | 112885-41-3 | |
N-Methylquipazine dimaleate | 171205-17-7 | |
Ondansetron HCl | 5-HT3 receptor antagonist | 99614-01-4 |
Ondansetron hydrochloride dihydrate | 103639-04-9 | |
Paroxetine maleate | 64006-44-6 | |
Pizotifen | 15574-96-6 | |
PU 02 | 313984-77-9 | |
Quipazine dimaleate | 150323-78-7 | |
Ramosetron Hydrochloride | 132907-72-3 | |
RS 56812 hydrochloride | 143339-12-2 | |
SDZ 205-557 hydrochloride | 1197334-02-3 | |
SR 57227 hydrochloride | 77145-61-0 | |
Tianeptine | 5-HT facilitator | 66981-73-5 |
Tropisetron Hydrochloride | 105826-92-4 | |
Zacopride hydrochloride | 101303-98-4 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HTR3A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HTR3A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HTR3A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Htr3a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Htr3a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | HTR3A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HTR3A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HTR3A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HTR3A 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | htr3a 31 31 |
|
OneToMany | |
LOC571641 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | acr-17 32 |
|
|
|
acr-22 32 |
|
|
|||
C04C3.2 32 |
|
|
|||
Y57G11C.2 32 |
|
|
|||
acr-18 32 |
|
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714264 | Likely Benign: not provided | 113,981,322(+) | G/A | INTRON_VARIANT | |
716587 | Benign: not provided | 113,989,552(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
729176 | Benign: not provided | 113,981,321(+) | C/T | INTRON_VARIANT | |
732221 | Benign: not provided | 113,975,319(+) | G/T | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
754001 | Likely Benign: not provided | 113,989,523(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3627783 | CNV | loss | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
irritable bowel syndrome |
|
|
motion sickness |
|
|
serotonin syndrome |
|
|
fibromyalgia |
|
|
social phobia |
|