HTR3A Gene (Protein Coding)

5-Hydroxytryptamine Receptor 3A

GC11P113974
GIFtS:
47
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination... See more...

Aliases for HTR3A Gene

Aliases for HTR3A Gene

  • 5-Hydroxytryptamine Receptor 3A 2 3 4 5
  • 5-HT3A 2 3 4
  • 5-HT3R 2 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic 2 3
  • Serotonin-Gated Ion Channel Receptor 3 4
  • 5-Hydroxytryptamine Receptor 3 3 4
  • Serotonin Receptor 3A 3 4
  • 5-HT-3 3 4
  • 5HT3R 3 4
  • HTR3 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3A 2
  • 5HT3 Serotonin Receptor 3
  • 5-HT3-A 4
  • HTR3A 5

External Ids for HTR3A Gene

Previous HGNC Symbols for HTR3A Gene

  • HTR3

Previous GeneCards Identifiers for HTR3A Gene

  • GC11P116198
  • GC11P115357
  • GC11P113879
  • GC11P113383
  • GC11P113351
  • GC11P109774

Summaries for HTR3A Gene

Entrez Gene Summary for HTR3A Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3A Gene

HTR3A (5-Hydroxytryptamine Receptor 3A) is a Protein Coding gene. Diseases associated with HTR3A include Serotonin Syndrome and Motion Sickness. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3B.

UniProtKB/Swiss-Prot Summary for HTR3A Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3A Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3A Gene

Additional gene information for HTR3A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR3A Gene

Genomics for HTR3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HTR3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR3A

Top Transcription factor binding sites by QIAGEN in the HTR3A gene promoter:
  • GR
  • GR-alpha
  • NRSF form 1
  • NRSF form 2

Genomic Locations for HTR3A Gene

Latest Assembly
chr11:113,974,881-113,990,313
(GRCh38/hg38)
Size:
15,433 bases
Orientation:
Plus strand

Previous Assembly
chr11:113,845,830-113,861,035
(GRCh37/hg19 by Entrez Gene)
Size:
15,206 bases
Orientation:
Plus strand

chr11:113,845,603-113,861,035
(GRCh37/hg19 by Ensembl)
Size:
15,433 bases
Orientation:
Plus strand

Genomic View for HTR3A Gene

Genes around HTR3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HTR3A Gene

Proteins for HTR3A Gene

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  • Protein details for HTR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46098-5HT3A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3A
    Protein Accession:
    P46098
    Secondary Accessions:
    • B4DSY6
    • G5E986
    • O60854
    • Q7KZM7
    • Q99918
    • Q9BSZ9

    Protein attributes for HTR3A Gene

    Size:
    478 amino acids
    Molecular mass:
    55280 Da
    Quaternary structure:
    • Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
    Miscellaneous:
    • The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

    Alternative splice isoforms for HTR3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3A Gene

Protein Expression for HTR3A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HTR3A Gene

  • Glycosylation at Asn28, Asn104, Asn170, and Asn186
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for HTR3A

No data available for DME Specific Peptides for HTR3A Gene

Domains & Families for HTR3A Gene

Gene Families for HTR3A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for HTR3A Gene

InterPro:
Blocks:
  • Myb DNA-binding domain
  • Neurotransmitter-gated ion-channel
  • 5-hydroxytryptamine 3 receptor signature
  • 5-hydroxytryptamine 3 receptor A subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for HTR3A Gene

GenScript: Design optimal peptide antigens:
  • Serotonin-gated ion channel receptor (5HT3A_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 3A (B3VRG0_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 3A (B3VRG5_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 3A (B3VRH0_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 3A (B3VRH5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46098

UniProtKB/Swiss-Prot:

5HT3A_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
genes like me logo Genes that share domains with HTR3A: view

Function for HTR3A Gene

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Molecular function for HTR3A Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 3a,coexpressed with HTR3B in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses

Phenotypes From GWAS Catalog for HTR3A Gene

Gene Ontology (GO) - Molecular Function for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005515 protein binding IPI 17392525
GO:0015276 ligand-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with HTR3A: view
genes like me logo Genes that share phenotypes with HTR3A: view

Animal Models for HTR3A Gene

MGI Knock Outs for HTR3A:

Animal Models for research

  • Taconic Biosciences Mouse Models for HTR3A

miRNA for HTR3A Gene

miRTarBase miRNAs that target HTR3A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3A

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR3A Gene

Localization for HTR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3A Gene

Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3A gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3A Gene

Pathways & Interactions for HTR3A Gene

genes like me logo Genes that share pathways with HTR3A: view

Pathways by source for HTR3A Gene

2 KEGG pathways for HTR3A Gene
1 Qiagen pathway for HTR3A Gene
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007268 chemical synaptic transmission TAS --
GO:0032414 positive regulation of ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with HTR3A: view

No data available for SIGNOR curated interactions for HTR3A Gene

Drugs & Compounds for HTR3A Gene

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(171) Drugs for HTR3A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alosetron Approved, Withdrawn Pharma Target, antagonist 5
Granisetron Approved, Investigational Pharma Target, antagonist Serotonin 5-HT3 receptor antagonist 100
Dolasetron Approved, Investigational Pharma Target, antagonist 10
Ondansetron Approved Pharma Target, antagonist, agonist 430
Palonosetron Approved, Investigational Pharma Target, antagonist 119

(37) Additional Compounds for HTR3A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methyl-5-hydroxytryptamine hydrochloride
845861-49-6

(4) Tocris Compounds for HTR3A Gene

Compound Action Cas Number
2-Methyl-5-hydroxytryptamine hydrochloride 5-HT3 agonist/potent 5-HT6 ligand 845861-49-6
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
N-Methylquipazine dimaleate 5-HT3 agonist 171205-17-7
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(24) ApexBio Compounds for HTR3A Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
3-AQC 201216-42-4
Alosetron 122852-42-0
Alosetron Hydrochloride 5-HT3 receptor antagonist,potent and highly selective 122852-69-1
Azasetron HCl 5-HT3 receptor antagonist 123040-16-4
EMD 386088 hydrochloride 1171123-46-8
Granisetron Serotonin 5-HT3 receptor antagonist 109889-09-0
Granisetron HCl 5-HT3 receptor antagonist 107007-99-8
m-Chlorophenylbiguanide hydrochloride 2113-05-5
Mosapride 112885-41-3
N-Methylquipazine dimaleate 171205-17-7
Ondansetron HCl 5-HT3 receptor antagonist 99614-01-4
Ondansetron hydrochloride dihydrate 103639-04-9
Paroxetine maleate 64006-44-6
Pizotifen 15574-96-6
PU 02 313984-77-9
Quipazine dimaleate 150323-78-7
Ramosetron Hydrochloride 132907-72-3
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Tianeptine 5-HT facilitator 66981-73-5
Tropisetron Hydrochloride 105826-92-4
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3A: view

Drug products for research

Transcripts for HTR3A Gene

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mRNA/cDNA for HTR3A Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR3A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for HTR3A Gene

GeneLoc Exon Structure for
HTR3A

Expression for HTR3A Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR3A Gene

mRNA expression in normal human tissues for HTR3A Gene
mRNA expression by BioGPS for HTR3A GenemRNA expression by GTEx for HTR3A Gene

mRNA differential expression in normal tissues according to GTEx for HTR3A Gene

This gene is overexpressed in Minor Salivary Gland (x14.4), Pancreas (x4.8), and Brain - Caudate (basal ganglia) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR3A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR3A

SOURCE GeneReport for Unigene cluster for HTR3A Gene:

Hs.413899

mRNA Expression by UniProt/SwissProt for HTR3A Gene:

P46098-5HT3A_HUMAN
Tissue specificity: Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.

Evidence on tissue expression from TISSUES for HTR3A Gene

  • Nervous system(4.5)
  • Intestine(4.4)
  • Blood(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with HTR3A: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3A Gene

Orthologs for HTR3A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HTR3A 30 31
  • 98.97 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia HTR3A 30 31
  • 87.94 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia HTR3A 30 31
  • 87.17 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Htr3a 30 17 31
  • 83.92 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Htr3a 30
  • 83.84 (n)
Oppossum
(Monodelphis domestica)
 Mammalia HTR3A 31
  • 78 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia HTR3A 31
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves HTR3A 30 31
  • 73.85 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia HTR3A 31
  • 67 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii htr3a 31 31
  • 73 (a)
 OneToMany
LOC571641 30
  • 67.79 (n)
Worm
(Caenorhabditis elegans)
 Secernentea acr-17 32
  • 29 (a)
acr-22 32
  • 28 (a)
C04C3.2 32
  • 27 (a)
Y57G11C.2 32
  • 27 (a)
acr-18 32
  • 22 (a)
Species where no ortholog for HTR3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HTR3A Gene

ENSEMBL:
Gene Tree for HTR3A (if available)
TreeFam:
Gene Tree for HTR3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR3A: view image

Paralogs for HTR3A Gene

Paralogs for HTR3A Gene

(17) SIMAP similar genes for HTR3A Gene using alignment to 11 proteins:

  • 5HT3A_HUMAN
  • B3VRG0_HUMAN
  • B3VRG5_HUMAN
  • B3VRH0_HUMAN
  • B3VRH5_HUMAN
  • B3VRI0_HUMAN
  • B3VRI5_HUMAN
  • B3VRJ0_HUMAN
  • B3VRJ5_HUMAN
  • B3VRK0_HUMAN
  • Q9UEP2_HUMAN
genes like me logo Genes that share paralogs with HTR3A: view

Variants for HTR3A Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR3A Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs139246177 Likely Benign: not provided 113,986,125(+) C/T
NM_000869.6(HTR3A):c.655C>T (p.Arg219Trp) 		MISSENSE
rs141387942 Benign: not provided 113,986,625(+) C/T
NM_000869.6(HTR3A):c.813C>T (p.Gly271=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs183698487 Benign: not provided. - 113,989,552(+) G/Ap.Arg409Gln
NM_000869.6(HTR3A):c.1226G>A (p.Arg409Gln) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs190646973 Benign: not provided 113,975,319(+) G/T
NM_000869.6(HTR3A):c.-7G>T 		NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs35944954 Benign: not provided 113,989,667(+) C/T
NM_000869.6(HTR3A):c.1341C>T (p.Ser447=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HTR3A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HTR3A Gene

Variant ID Type Subtype PubMed ID
esv3627783 CNV loss 21293372

Variation tolerance for HTR3A Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR3A Gene

Human Gene Mutation Database (HGMD)
HTR3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3A Gene

Disorders for HTR3A Gene

MalaCards: The human disease database

(39) MalaCards diseases for HTR3A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
serotonin syndrome
  • serotonergic syndrome
motion sickness
  • travel sickness
irritable bowel syndrome
  • ibd
fibromyalgia
  • diffuse myofascial pain syndrome
social phobia
  • phobia social
- elite association - COSMIC cancer census association via MalaCards
Search HTR3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HTR3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3A Gene

Publications for HTR3A Gene

  1. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PMID: 15293096) Frank B … Rappold G (Clinical rheumatology 2004) 3 4 23 41
  2. A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. (PMID: 12867984) Kelley SP … Peters JA (Nature 2003) 2 3 4 23
  3. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PMID: 19741568) Hammer C … Niesler B (Pharmacogenetics and genomics 2009) 3 23 41
  4. Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients. (PMID: 18622264) Gu B … Xing QH (Pharmacogenetics and genomics 2008) 3 23 41
  5. Candidate genotypes associated with functional dyspepsia. (PMID: 18331431) van Lelyveld N … Samsom M (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2008) 3 23 41

ExternalLinks

View latest publications for HTR3A gene in Mastermind

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