Aliases for HTR3A Gene
External Ids for HTR3A Gene
Previous HGNC Symbols for HTR3A Gene
Previous GeneCards Identifiers for HTR3A Gene
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for HTR3A Gene
HTR3A (5-Hydroxytryptamine Receptor 3A) is a Protein Coding gene. Diseases associated with HTR3A include Irritable Bowel Syndrome and Motion Sickness. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Ligand-gated ion channel transport. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3B.
UniProtKB/Swiss-Prot Summary for HTR3A Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).