This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby g... See more...

Aliases for HTR2C Gene

Aliases for HTR2C Gene

  • 5-Hydroxytryptamine Receptor 2C 2 3 4 5
  • 5-HT2C 2 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled 2 3
  • 5-Hydroxytryptamine Receptor 1C 3 4
  • 5-HTR2C 3 4
  • 5-HT1C 3 4
  • 5HTR2C 2 3
  • HTR1C 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2C 2
  • Serotonin 5-HT-1C Receptor 3
  • Serotonin 5-HT-2C Receptor 3
  • Serotonin Receptor 2C 4
  • 5-HT-2C 4
  • 5-HT-1C 4
  • HTR2C 5

External Ids for HTR2C Gene

Previous HGNC Symbols for HTR2C Gene

  • HTR1C

Previous GeneCards Identifiers for HTR2C Gene

  • GC0XP108837
  • GC0XP110943
  • GC0XP111854
  • GC0XP112582
  • GC0XP113641
  • GC0XP113818
  • GC0XP103403

Summaries for HTR2C Gene

Entrez Gene Summary for HTR2C Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for HTR2C Gene

HTR2C (5-Hydroxytryptamine Receptor 2C) is a Protein Coding gene. Diseases associated with HTR2C include Anxiety and Premature Ejaculation. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot Summary for HTR2C Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Tocris Summary for HTR2C Gene

  • Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety.

Gene Wiki entry for HTR2C Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR2C Gene

Genomics for HTR2C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HTR2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ114583 Promoter/Enhancer 0.7 EPDnew ENCODE 600.7 -0.1 -66 0.2 POLR2A EZH2 CTCF HTR2C piR-61532-369
GH0XJ114584 Enhancer 0.3 ENCODE 600.7 +0.8 755 0.1 EZH2 POLR2A HTR2C RPL36AP53 IL13RA2
GH0XJ114603 Promoter 0.3 EPDnew 600.4 +19.6 19621 0.1 piR-30444-353 piR-37432-138 piR-37567-244 piR-37656-308 piR-56399-079 HTR2C IL13RA2
GH0XJ114592 Enhancer 0.3 Ensembl 6.9 +7.4 7423 2.6 ELF4 ZBTB40 RPL36AP53 lnc-RBMXL3-4 HTR2C piR-41245-317 IL13RA2
GH0XJ114557 Enhancer 0.2 Ensembl 12.2 -26.5 -26477 0.8 piR-61532-369 HTR2C IL13RA2 lnc-IL13RA2-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR2C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR2C

Top Transcription factor binding sites by QIAGEN in the HTR2C gene promoter:
  • aMEF-2
  • AP-2gamma
  • AREB6
  • CUTL1
  • LCR-F1
  • MAZR
  • MEF-2A
  • POU3F1

Genomic Locations for HTR2C Gene

Genomic Locations for HTR2C Gene
chrX:114,584,078-114,910,061
(GRCh38/hg38)
Size:
325,984 bases
Orientation:
Plus strand
chrX:113,818,551-114,144,624
(GRCh37/hg19)
Size:
326,074 bases
Orientation:
Plus strand

Genomic View for HTR2C Gene

Genes around HTR2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2C Gene

Proteins for HTR2C Gene

  • Protein details for HTR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28335-5HT2C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2C
    Protein Accession:
    P28335
    Secondary Accessions:
    • B1AMW4
    • Q5VUF8
    • Q9NP28

    Protein attributes for HTR2C Gene

    Size:
    458 amino acids
    Molecular mass:
    51821 Da
    Quaternary structure:
    • Interacts with MPDZ. Interacts with ARRB2.

    Three dimensional structures from OCA and Proteopedia for HTR2C Gene

    Alternative splice isoforms for HTR2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2C Gene

Post-translational modifications for HTR2C Gene

Other Protein References for HTR2C Gene

Antibody Products

  • Boster Bio Antibodies for HTR2C
  • Santa Cruz Biotechnology (SCBT) Antibodies for HTR2C

No data available for DME Specific Peptides for HTR2C Gene

Domains & Families for HTR2C Gene

Gene Families for HTR2C Gene

Protein Domains for HTR2C Gene

InterPro:
Blocks:
  • 5-hydroxytryptamine receptor signature
  • 5-hydroxytryptamine 2C receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for HTR2C Gene

GenScript: Design optimal peptide antigens:
  • Serotonin receptor 2C (5HT2C_HUMAN)
  • cDNA FLJ60572, highly similar to 5-hydroxytryptamine 2C receptor (B1AMW4_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2C (B3VRE0_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2C (B3VRE5_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2C (B3VRF0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28335

UniProtKB/Swiss-Prot:

5HT2C_HUMAN :
  • The PDZ domain-binding motif is involved in the interaction with MPDZ.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The PDZ domain-binding motif is involved in the interaction with MPDZ.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2C: view

Function for HTR2C Gene

Molecular function for HTR2C Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle

Gene Ontology (GO) - Molecular Function for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001587 Gq/11-coupled serotonin receptor activity IDA 18703043
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004993 G protein-coupled serotonin receptor activity IDA 7582481
GO:0005515 protein binding IPI 15518545
GO:0008144 drug binding IDA 12970106
genes like me logo Genes that share ontologies with HTR2C: view
genes like me logo Genes that share phenotypes with HTR2C: view

Animal Models for HTR2C Gene

MGI Knock Outs for HTR2C:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR2C

CRISPR Products

miRNA for HTR2C Gene

miRTarBase miRNAs that target HTR2C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2C

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR2C Gene

Localization for HTR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2C Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR2C gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IMP 18703043
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR2C Gene

Pathways & Interactions for HTR2C Gene

genes like me logo Genes that share pathways with HTR2C: view

Pathways by source for HTR2C Gene

1 GeneGo (Thomson Reuters) pathway for HTR2C Gene
  • Transcription_Transcription factor Tubby signaling pathways
2 Qiagen pathways for HTR2C Gene
  • Intracellular Calcium Signaling
  • Signaling in Gap Junctions

SIGNOR curated interactions for HTR2C Gene

Gene Ontology (GO) - Biological Process for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response ISS --
GO:0006874 cellular calcium ion homeostasis IDA 19057895
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
genes like me logo Genes that share ontologies with HTR2C: view

Drugs & Compounds for HTR2C Gene

(209) Drugs for HTR2C Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Agomelatine Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Target, antagonist, agonist MT1/MT2 / 5-HT2C agonist 0
Olanzapine Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Inverse agonist, Target, antagonist, agonist 442
Ziprasidone Approved Pharma Antagonist, Agonist, Partial agonist, Full agonist, Inverse agonist, Target, antagonist, agonist 5-HT (serotonin)/dopamine receptor antagonist 151
Clozapine Approved Pharma Antagonist, Allosteric regulator, Positive, Agonist, Full agonist, Inverse agonist, Target, antagonist Antipsychotic medication 136
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist, Target, antagonist SR-2A inhibitor 532

(22) Additional Compounds for HTR2C Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
<i>m</i>-CPP
Antagonist, Agonist, Partial agonist
5-HT
Agonist, Full agonist, Inhibitor, Inhibition
DOB
Agonist, Full agonist
MDL-100,907
Antagonist
MDL-11,939
Antagonist

(5) Tocris Compounds for HTR2C Gene

Compound Action Cas Number
PNU 22394 hydrochloride 5-HT2C agonist and 5-HT2A/2B partial agonist 15923-42-9
SB 200646 hydrochloride 5-HT2C/2B antagonist 143797-62-0
SB 206553 hydrochloride Potent, selective 5-HT2C/5-HT2B antagonist. Orally active 1197334-04-5
SB 221284 Potent, selective 5-HT2C/2B antagonist 196965-14-7
SB 228357 5-HT2C/2B antagonist/inverse agonist 181629-93-6

(36) ApexBio Compounds for HTR2C Gene

Compound Action Cas Number
1-Methylpsilocin 1465-16-3
Agomelatine MT1/MT2 / 5-HT2C agonist 138112-76-2
Cinanserin hydrochloride 54-84-2
CP-809101 5-HT2C receptor agonist 479683-64-2
CP-809101 hydrochloride 5-HT2C receptor agonist, potent and selective 1215721-40-6
Cyclobenzaprine HCl 5-HT2 receptor antagonist 6202-23-9
DV 7028 hydrochloride 133364-62-2
EMD 281014 hydrochloride 443144-27-2
Lamotrigine 5-HT inhibitor 84057-84-1
LY 215840 137328-52-0
MDL 72222 40796-97-2
Mesulergine hydrochloride 72786-12-0
Metergoline 17692-51-2
Methiothepin maleate 19728-88-2
Methylergometrine maleate 57432-61-8
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Mirtazapine 85650-52-8
MK 212 hydrochloride 61655-58-1
N-Desmethylclozapine 6104-71-8
Org 12962 hydrochloride 210821-63-9
Org 37684 213007-95-5
PNU 22394 hydrochloride 15923-42-9
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective 866206-55-5
Ritanserin 87051-43-2
Ro 60-0175 fumarate 169675-09-6
RS 127445 5-HT2B receptor antagonist,high affinity 199864-87-4
S 32212 hydrochloride 847871-78-7
SB 206553 hydrochloride 1197334-04-5
SB 221284 196965-14-7
SB 228357 181629-93-6
SDZ SER 082 fumarate 1417343-80-6
Sumatriptan Succinate 5-HT1 receptor agonist 103628-48-4
WAY 161503 hydrochloride 276695-22-8
WAY 629 hydrochloride 57756-44-2
Ziprasidone 5-HT (serotonin)/dopamine receptor antagonist 146939-27-7
α-Methyl-5-hydroxytryptamine maleate 97469-12-0
genes like me logo Genes that share compounds with HTR2C: view

Drug Products

Transcripts for HTR2C Gene

mRNA/cDNA for HTR2C Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2C

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for HTR2C Gene

GeneLoc Exon Structure for
HTR2C

Expression for HTR2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR2C Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x16.9), Brain - Putamen (basal ganglia) (x10.0), Brain - Caudate (basal ganglia) (x8.7), and Brain - Hypothalamus (x7.5).

Protein differential expression in normal tissues from HIPED for HTR2C Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR2C Gene



Protein tissue co-expression partners for HTR2C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR2C

SOURCE GeneReport for Unigene cluster for HTR2C Gene:

Hs.149037

mRNA Expression by UniProt/SwissProt for HTR2C Gene:

P28335-5HT2C_HUMAN
Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for HTR2C Gene

  • Nervous system(4.7)
  • Skin(2.5)
  • Blood(2.4)
  • Adrenal gland(2.2)
  • Pancreas(2.1)
  • Kidney(2.1)
  • Stomach(2.1)
  • Liver(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with HTR2C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR2C Gene

Orthologs for HTR2C Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HTR2C 30 31
  • 99.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HTR2C 30
  • 90.62 (n)
Dog
(Canis familiaris)
Mammalia HTR2C 30 31
  • 90.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Htr2c 30
  • 86.65 (n)
Mouse
(Mus musculus)
Mammalia Htr2c 30 17 31
  • 86.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HTR2C 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HTR2C 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HTR2C 31
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii htr2cl2 31
  • 53 (a)
OneToMany
htr2cl1 31
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT2A 30
  • 49.74 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta TyrRII 31
  • 19 (a)
ManyToMany
5-HT1B 31
  • 17 (a)
ManyToMany
TyrR 31
  • 17 (a)
ManyToMany
CG42796 31
  • 15 (a)
ManyToMany
5-HT2 31 32
  • 15 (a)
ManyToMany
5-HT1A 31
  • 13 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea M03F4.3 32
  • 41 (a)
sca-1 32
  • 31 (a)
ser-1 31 32
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for HTR2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HTR2C Gene

ENSEMBL:
Gene Tree for HTR2C (if available)
TreeFam:
Gene Tree for HTR2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR2C: view image

Paralogs for HTR2C Gene

Paralogs for HTR2C Gene

(18) SIMAP similar genes for HTR2C Gene using alignment to 6 proteins:

  • 5HT2C_HUMAN
  • B3VRE0_HUMAN
  • B3VRE5_HUMAN
  • B3VRF0_HUMAN
  • B3VRF5_HUMAN
  • Q7Z579_HUMAN
genes like me logo Genes that share paralogs with HTR2C: view

Variants for HTR2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2C Gene

5HT2C_HUMAN-P28335
Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR2C Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
676336 Benign: not provided 114,584,109(+) C/. NO_SEQUENCE_ALTERATION
738592 Likely Benign: not provided 114,731,382(+) G/C MISSENSE_VARIANT
750988 Likely Benign: not provided 114,726,956(+) C/T MISSENSE_VARIANT
784433 Benign: not provided 114,906,905(+) AAAG/A INFRAME_DELETION,THREE_PRIME_UTR_VARIANT
rs1414334 Drug Response: not specified; antipsychotics response - Toxicity/ADR; clozapine response - Toxicity/ADR; olanzapine response - Toxicity/ADR; risperidone response - Toxicity/ADR 114,903,581(+) C/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for HTR2C Gene

Structural Variations from Database of Genomic Variants (DGV) for HTR2C Gene

Variant ID Type Subtype PubMed ID
dgv4277n106 CNV duplication 24896259
dgv523n21 CNV loss 19592680
dgv524n21 CNV gain 19592680
esv1117381 CNV deletion 17803354
esv1501559 CNV insertion 17803354
esv2660156 CNV deletion 23128226
esv2740401 CNV deletion 23290073
esv3305724 CNV mobile element insertion 20981092
esv3342375 CNV insertion 20981092
esv33994 CNV gain+loss 17666407
esv3574320 CNV loss 25503493
esv3574321 CNV loss 25503493
nsv1110834 CNV insertion 24896259
nsv1115280 CNV deletion 24896259
nsv1128548 CNV deletion 24896259
nsv1150985 CNV duplication 26484159
nsv507990 OTHER sequence alteration 20534489
nsv527347 CNV gain 19592680
nsv7044 CNV deletion 18451855

Variation tolerance for HTR2C Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR2C Gene

Human Gene Mutation Database (HGMD)
HTR2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR2C

SNP Genotyping and Copy Number Assay Products

Disorders for HTR2C Gene

MalaCards: The human disease database

(42) MalaCards diseases for HTR2C Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
premature ejaculation
depression
  • major depressive disorder
bipolar i disorder
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search HTR2C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR2C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HTR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2C Gene

Publications for HTR2C Gene

  1. The association between serotonin 2C receptor polymorphisms and weight gain and eating behavior in patients using mirtazapine: a prospective follow-up study. (PMID: 20520301) Risselada AJ … Egberts TC (Journal of clinical psychopharmacology 2010) 3 23 41
  2. Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample. (PMID: 20504252) Opgen-Rhein C … Dettling M (Pharmacogenomics 2010) 3 23 41
  3. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 23 41
  4. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. (PMID: 20010450) Dehning S … Zill P (Psychiatric genetics 2010) 3 23 41
  5. Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain. (PMID: 20015120) Bundo M … Kato T (Psychiatry and clinical neurosciences 2010) 3 23 41

Products for HTR2C Gene

  • Signalway ELISA kits for HTR2C
  • Signalway Proteins for HTR2C

Sources for HTR2C Gene