Aliases for HTR2B Gene
Aliases for HTR2B Gene
External Ids for HTR2B Gene
- HGNC: 5294
- Entrez Gene: 3357
- Ensembl: ENSG00000135914
- OMIM: 601122
- UniProtKB: P41595
Previous GeneCards Identifiers for HTR2B Gene
- GC02M230030
- GC02M230704
- GC02M231936
- GC02M232175
- GC02M231798
- GC02M231681
- GC02M223815
Summaries for HTR2B Gene
-
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
GeneCards Summary for HTR2B Gene
HTR2B (5-Hydroxytryptamine Receptor 2B) is a Protein Coding gene. Diseases associated with HTR2B include Ocular Hypotension and Heart Valve Disease. Among its related pathways are Gap junction and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is HTR2A.
UniProtKB/Swiss-Prot for HTR2B Gene
-
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
-
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. 5-HT2B overexpression leads to ventricular hypertrophy.
Additional gene information for HTR2B Gene
- Monarch Initiative
- Search for HTR2B at DataMed
- Search for HTR2B at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2B Gene
Genomics for HTR2B Gene
GeneHancer (GH) Regulatory Elements for HTR2B Gene
Promoters and enhancers for HTR2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around HTR2B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HTR2B gene promoter:
-
- c-Ets-1
- GATA-1
- Evi-1
- HSF1short
- HSF1 (long)
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
Regulatory Element Products
Genomic Locations for HTR2B Gene
Genomic Locations for HTR2B Gene
- chr2:231,108,230-231,125,778
- (GRCh38/hg38)
- Size:
- 17,549 bases
- Orientation:
- Minus strand
- chr2:231,972,944-231,989,832
- (GRCh37/hg19)
- Size:
- 16,889 bases
- Orientation:
- Minus strand
Genomic View for HTR2B Gene
Genes around HTR2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.1 by Entrez Gene
- 2q37.1 by HGNC
- 2q37.1 by Ensembl
HTR2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HTR2B Gene
Proteins for HTR2B Gene
-
Protein details for HTR2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41595-5HT2B_HUMAN
- Recommended name:
- 5-hydroxytryptamine receptor 2B
- Protein Accession:
- P41595
- B2R9D5
- Q53TI1
- Q62221
- Q6P523
Protein attributes for HTR2B Gene
- Size:
- 481 amino acids
- Molecular mass:
- 54298 Da
- Quaternary structure:
-
- Interacts (via C-terminus) with MPDZ.
- Miscellaneous:
-
- Binds lysergic acid diethylamine (LSD) in the orthosteric pocket, but is not the principal LSD receptor in the brain. Bound LSD dissociates extremely slowly, with a residence time of about 46 minutes at 37 degrees Celsius.
Post-translational modifications for HTR2B Gene
Other Protein References for HTR2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HTR2B
-
Abcam antibodies for HTR2B
- Invitrogen Antibodies for HTR2B
- antibodies-online: Search results for 126 available Serotonin Receptor 2B Antibodies ranked by validation data
- Compare Top Serotonin Receptor 2B Antibodies
-
Recommended
- 22 WB Antibodies (anti-mouse)
- 19 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 60 WB Antibodies (anti-human)
- 31 IF (p) Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 19 IF (p) Antibodies (anti-rat)
- 15 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex HTR2B Antibody for HTR2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for HTR2B
- Sino Biological Antibodies for HTR2B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HTR2B
- Origene Custom Protein Services for HTR2B
- Search GeneTex for Proteins for HTR2B
-
Abcam proteins for HTR2B
Assay Products
No data available for DME Specific Peptides for HTR2B Gene
Domains & Families for HTR2B Gene
Gene Families for HTR2B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
- Transporters
Protein Domains for HTR2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HTR2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P41595UniProtKB/Swiss-Prot:
5HT2B_HUMAN :- Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
- Belongs to the G-protein coupled receptor 1 family.
- Domain:
-
- Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for HTR2B Gene
Molecular function for HTR2B Gene
- UniProtKB/Swiss-Prot Function:
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
- GENATLAS Biochemistry:
- 5-hydroxytryptamine (serotonin) receptor,subtype 2B,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle
Phenotypes From GWAS Catalog for HTR2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001965 | G-protein alpha-subunit binding | IMP | 15625277 |
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA,IBA | -- |
| GO:0004993 | G-protein coupled serotonin receptor activity | IDA | 7582481 |
| GO:0005096 | GTPase activator activity | IEA,ISS | -- |
Phenotypes for HTR2B Gene
- MGI mutant phenotypes for HTR2B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for HTR2B:
-
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
Animal Models for HTR2B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HTR2B
-
CRISPR Products
-
OriGene CRISPR knockouts for HTR2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HTR2B
- Applied Biological Materials CRISPR for HTR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR2B
- GenScript: Design CRISPR guide RNA sequences for HTR2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HTR2B
- Browse OriGene Inhibitory RNA Products For HTR2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2B
Clone Products
- Sino Biological Human cDNA Clone for HTR2B
- VectorBuilder custom plasmid, inducible vectors for HTR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HTR2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HTR2B
- genomics-online: cdna clones - Search results for 97 available Serotonin Receptor 2B gene related products
- Overview of 97 available Serotonin Receptor 2B gene related products
- orf clones - Search results for 97 available Serotonin Receptor 2B gene related products
- Overview of 97 available Serotonin Receptor 2B gene related products
- Applied Biological Materials Clones for HTR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HTR2B (5-HT2B)
Cell Line Products
-
Horizon Cell Lines for HTR2B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR2B Gene
Localization for HTR2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTR2B Gene
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15925089 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for HTR2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Monoamine GPCRs |
.75
|
|
| 3 | Signaling by GPCR | ||
| 4 | RET signaling | ||
| 5 | Calcium signaling pathway | ||
Pathways by source for HTR2B Gene
3 BioSystems pathways for HTR2B Gene
5 KEGG pathways for HTR2B Gene
2 Qiagen pathways for HTR2B Gene
Interacting Proteins for HTR2B Gene
Selected Interacting proteins:
P41595-5HT2B_HUMAN
ENSP00000258400
for HTR2B Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for HTR2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001755 | neural crest cell migration | ISS | -- |
| GO:0001819 | positive regulation of cytokine production | IDA | 19023134 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA,IMP | 19308295 |
| GO:0002031 | G-protein coupled receptor internalization | IEA | -- |
| GO:0003007 | heart morphogenesis | IEA,ISS | -- |
No data available for SIGNOR curated interactions for HTR2B Gene
Drugs & Compounds for HTR2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Apomorphine | Approved, Investigational | Pharma | Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target | 40 | ||
| Bromocriptine | Approved, Investigational | Pharma | Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target | 33 | ||
| Cabergoline | Approved | Pharma | Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target | 50 | ||
| Lisuride | Approved, Investigational | Pharma | Antagonist, Partial agonist, Agonist, Full agonist, agonist, Target, antagonist | 5 | ||
| Methysergide | Approved | Pharma | Antagonist, Partial agonist, Agonist, antagonist, Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (plusmn)-norfenfluramine |
|
Full agonist, Agonist |
|
|||
| <i>m</i>-CPP |
|
Partial agonist, Agonist, Antagonist |
|
|||
| 5-HT |
|
Full agonist, Agonist, Inhibition, Inhibitor |
|
|||
| alpha-methyl-5-HT |
|
Full agonist, Agonist |
|
|||
| DOB |
|
Full agonist, Agonist |
|
(5) Tocris Compounds for HTR2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| alpha-Methyl-5-hydroxytryptamine maleate | 5-HT2B agonist | 97469-12-0 |
| BW 723C86 hydrochloride | 5-HT2B agonist | 160521-72-2 |
| m-CPP hydrochloride | 5-HT2B/2C receptor agonist | 13078-15-4 |
| SB 204741 | Potent, selective 5-HT2B antagonist | 152239-46-8 |
| SDZ SER 082 fumarate | Selective 5-HT2B/2C antagonist | 1417343-80-6 |
Drug Products
Transcripts for HTR2B Gene
mRNA/cDNA for HTR2B Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000258400 2246 bps (uc002vro.4)
Unigene Clusters for HTR2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for HTR2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HTR2B
- Applied Biological Materials CRISPR for HTR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR2B
- GenScript: Design CRISPR guide RNA sequences for HTR2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HTR2B
- Browse OriGene Inhibitory RNA Products For HTR2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2B
Clone Products
- Sino Biological Human cDNA Clone for HTR2B
- VectorBuilder custom plasmid, inducible vectors for HTR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HTR2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HTR2B
- genomics-online: cdna clones - Search results for 97 available Serotonin Receptor 2B gene related products
- Overview of 97 available Serotonin Receptor 2B gene related products
- orf clones - Search results for 97 available Serotonin Receptor 2B gene related products
- Overview of 97 available Serotonin Receptor 2B gene related products
- Applied Biological Materials Clones for HTR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HTR2B (5-HT2B)
Expression for HTR2B Gene
mRNA differential expression in normal tissues according to GTEx for HTR2B Gene
This gene is overexpressed in Adrenal Gland (x6.9), Uterus (x6.3), Esophagus - Muscularis (x5.9), and Colon - Sigmoid (x4.0).
NURSA nuclear receptor signaling pathways regulating expression of HTR2B Gene:
HTR2BSOURCE GeneReport for Unigene cluster for HTR2B Gene:
Hs.421649mRNA Expression by UniProt/SwissProt for HTR2B Gene:
P41595-5HT2B_HUMAN
Tissue specificity:
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
Evidence on tissue expression from TISSUES for HTR2B Gene
- Nervous system(4.5)
- Intestine(4.4)
- Skin(4.1)
- Stomach(2.2)
- Heart(2.1)
- Muscle(2.1)
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR2B Gene
Orthologs for HTR2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HTR2B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HTR2B 33 |
|
||
| 5HTR2B 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | HTR2B 33 |
|
||
| 5HT2B 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Htr2b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Htr2b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HTR2B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HTR2B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-6558 34 |
|
OneToOne | |
| HTR2B 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HTR2B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | htr2b 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | htr2b 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG42796 34 |
|
ManyToMany | |
| 5-HT2 34 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ser-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HTR2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HTR2B Gene
- ENSEMBL:
- Gene Tree for HTR2B (if available)
- TreeFam:
- Gene Tree for HTR2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HTR2B: view image
Paralogs for HTR2B Gene
Paralogs for HTR2B Gene
(13) SIMAP similar genes for HTR2B Gene using alignment to 5 proteins:
- 5HT2B_HUMAN
- B3VRC5_HUMAN
- B3VRD0_HUMAN
- B3VRD5_HUMAN
- Q7Z580_HUMAN
Variants for HTR2B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2B Gene
- 5HT2B_HUMAN-P41595
- A variation at a single nucleotide base, which results in an erroneous stop codon and affects Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and stress exposure are other factors playing important roles.
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012769 | -- | 231,126,126(-) | G/A | upstream_transcript_variant | |
| rs1000023009 | -- | 231,123,042(-) | G/T | intron_variant | |
| rs1000347784 | -- | 231,113,592(-) | G/A | intron_variant | |
| rs1000383137 | -- | 231,120,814(-) | T/G | intron_variant | |
| rs1000436922 | -- | 231,121,079(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4181n100 | CNV | loss | 25217958 |
| esv3307622 | CNV | mobile element insertion | 20981092 |
| esv3339619 | CNV | insertion | 20981092 |
| nsv524208 | CNV | gain | 19592680 |
| nsv525474 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.83;
67.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HTR2B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for HTR2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ocular hypotension |
|
|
| heart valve disease |
|
|
| chronic pulmonary heart disease |
|
|
| pulmonary hypertension |
|
|
| migraine with or without aura 1 |
|
Search HTR2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HTR2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2B Gene
Publications for HTR2B Gene
- Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D … Rauly-Lestienne I (European journal of pharmacology 2008) 3 4 22 25 58
- Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. (PMID: 12970106) Schaerlinger B … Maroteaux L (British journal of pharmacology 2003) 3 4 22 25 58
- 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. (PMID: 8882600) Ullmer C … Lübbert H (British journal of pharmacology 1996) 3 4 22 58
- The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. (PMID: 7926008) Choi DS … Maroteaux L (FEBS letters 1994) 3 4 22 58
- Cloning and functional characterization of the human 5-HT2B serotonin receptor. (PMID: 8143856) Schmuck K … Lübbert H (FEBS letters 1994) 2 3 4 58
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