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This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
HTR2B (5-Hydroxytryptamine Receptor 2B) is a Protein Coding gene. Diseases associated with HTR2B include Heart Valve Disease and Ocular Hypotension. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and drug binding. An important paralog of this gene is HTR2A.
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. 5-HT2B overexpression leads to ventricular hypertrophy.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001965 | G-protein alpha-subunit binding | IMP | 15625277 |
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004993 | G protein-coupled serotonin receptor activity | IDA | 7582481 |
GO:0005096 | GTPase activator activity | IEA,ISS | -- |
GO:0005515 | protein binding | IPI | 28258217 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 15925089 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Monoamine GPCRs |
.75
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|
3 | Signaling by GPCR | ||
4 | RET signaling | ||
5 | Calcium signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001755 | neural crest cell migration | IEA,ISS | -- |
GO:0001819 | positive regulation of cytokine production | IDA | 19023134 |
GO:0001938 | positive regulation of endothelial cell proliferation | IEA,IMP | 19308295 |
GO:0002031 | G protein-coupled receptor internalization | IEA | -- |
GO:0003007 | heart morphogenesis | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Apomorphine | Approved, Investigational | Pharma | Agonist, Partial agonist, Antagonist, Full agonist, Activator, Activation, Target, agonist | 48 | ||
Bromocriptine | Approved, Investigational | Pharma | Antagonist, Agonist, Partial agonist, Full agonist, Target, agonist | 44 | ||
Cabergoline | Approved | Pharma | Antagonist, Agonist, Full agonist, Partial agonist, Target, agonist | 60 | ||
Lisuride | Approved, Investigational | Pharma | Antagonist, Agonist, Partial agonist, Full agonist, Target, antagonist, agonist | 5 | ||
Methysergide | Approved | Pharma | Antagonist, Agonist, Partial agonist, Target, antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(±)-norfenfluramine |
|
Agonist, Full agonist |
|
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<i>m</i>-CPP |
|
Antagonist, Agonist, Partial agonist |
|
|||
5-HT |
|
Agonist, Full agonist, Inhibitor, Inhibition |
|
|||
DOB |
|
Agonist, Full agonist |
|
|||
MDL-100,907 |
|
Antagonist |
|
Compound | Action | Cas Number |
---|---|---|
alpha-Methyl-5-hydroxytryptamine maleate | 5-HT2B agonist | 97469-12-0 |
BW 723C86 hydrochloride | 5-HT2B agonist | 160521-72-2 |
m-CPP hydrochloride | 5-HT2B/2C receptor agonist | 13078-15-4 |
SB 204741 | Potent, selective 5-HT2B antagonist | 152239-46-8 |
SDZ SER 082 fumarate | Selective 5-HT2B/2C antagonist | 1417343-80-6 |
Compound | Action | Cas Number |
---|---|---|
BW 723C86 hydrochloride | 5-HT2B agonist | 160521-72-2 |
Cinanserin hydrochloride | 54-84-2 | |
Cyclobenzaprine HCl | 5-HT2 receptor antagonist | 6202-23-9 |
DV 7028 hydrochloride | 133364-62-2 | |
LY 215840 | 137328-52-0 | |
LY 266097 hydrochloride | 172895-39-5 | |
LY 272015 hydrochloride | 172895-15-7 | |
LY 393558 | 271780-64-4 | |
Metergoline | 17692-51-2 | |
Methiothepin maleate | 19728-88-2 | |
Methylergometrine maleate | 57432-61-8 | |
Org 12962 hydrochloride | 210821-63-9 | |
Org 37684 | 213007-95-5 | |
PNU 22394 hydrochloride | 15923-42-9 | |
PRX-08066 | 5-HT2BR antagonist | 866206-54-4 |
PRX-08066 Maleic acid | 5-HT2B receptor antagonist,potent and selective | 866206-55-5 |
Ritanserin | 87051-43-2 | |
RS 127445 | 5-HT2B receptor antagonist,high affinity | 199864-87-4 |
SB 204741 | 152239-46-8 | |
SB 206553 hydrochloride | 1197334-04-5 | |
SB 221284 | 196965-14-7 | |
SB 228357 | 181629-93-6 | |
SDZ SER 082 fumarate | 1417343-80-6 | |
α-Methyl-5-hydroxytryptamine maleate | 97469-12-0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HTR2B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HTR2B 30 |
|
||
5HTR2B 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | HTR2B 30 |
|
||
5HT2B 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Htr2b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Htr2b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | HTR2B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HTR2B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-6558 31 |
|
OneToOne | |
HTR2B 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | HTR2B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | htr2b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | htr2b 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG42796 31 |
|
ManyToMany | |
5-HT2 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ser-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709655 | Benign: not provided | 231,109,341(-) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
725269 | Benign: not provided | 231,109,129(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
779323 | Benign: not provided | 231,108,649(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
779324 | Benign: not provided | 231,123,613(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
791235 | Benign: not provided | 231,108,702(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4181n100 | CNV | loss | 25217958 |
esv3307622 | CNV | mobile element insertion | 20981092 |
esv3339619 | CNV | insertion | 20981092 |
nsv524208 | CNV | gain | 19592680 |
nsv525474 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
heart valve disease |
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ocular hypotension |
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pulmonary hypertension |
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chronic pulmonary heart disease |
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hypoactive sexual desire disorder |
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