This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this g... See more...

Aliases for HTR2A Gene

Aliases for HTR2A Gene

  • 5-Hydroxytryptamine Receptor 2A 2 3 4 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled 2 3
  • 5-HT2A 2 3
  • HTR2 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2A 2
  • Serotonin 5-HT-2A Receptor 3
  • Serotonin Receptor 2A 4
  • 5-HT2 Receptor 3
  • 5-HT-2A 4
  • 5-HT-2 4
  • HTR2A 5

External Ids for HTR2A Gene

Previous HGNC Symbols for HTR2A Gene

  • HTR2

Previous GeneCards Identifiers for HTR2A Gene

  • GC13M045407
  • GC13M041394
  • GC13M046344
  • GC13M045205
  • GC13M046305
  • GC13M047407
  • GC13M028201

Summaries for HTR2A Gene

Entrez Gene Summary for HTR2A Gene

  • This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for HTR2A Gene

HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Major Depressive Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and drug binding. An important paralog of this gene is HTR2C.

UniProtKB/Swiss-Prot Summary for HTR2A Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
  • (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.

Tocris Summary for HTR2A Gene

  • Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, hippocampus, and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in the control of appetite.

Gene Wiki entry for HTR2A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTR2A Gene

Genomics for HTR2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HTR2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J046896 Promoter/Enhancer 1.1 EPDnew Ensembl CraniofacialAtlas 607.6 +1.6 1582 1.8 ZIC2 EZH2 CREB1 HTR2A lnc-ESD-2 HTR2A-AS1 ESD
GH13J046795 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.2 +101.0 101027 2.9 GATAD2A PRDM10 ZNF629 REST TFE3 NFKBIZ ZNF692 POLR2A NFRKB ZNF7 ESD HTR2A lnc-ESD-1 LOC107984563 LRCH1
GH13J046757 Enhancer 0.9 Ensembl ENCODE 15.6 +139.4 139381 4.2 ZNF512 FOXA1 PRDM1 ZIC2 SP1 CEBPA CEBPB FOXA2 ATF3 CREB1 FJ601684-101 HSALNG0096896 LOC107984563 HTR2A ESD LRCH1 lnc-ESD-1
GH13J046866 Enhancer 0.7 Ensembl ENCODE 16.9 +32.4 32441 2.9 CEBPG CEBPB ZBTB17 FOXA1 MYC MAX MNT SPI1 HTR2A HTR2A-AS1 lnc-ESD-2 ESD
GH13J046982 Enhancer 1 Ensembl ENCODE 10.5 -85.6 -85619 2.2 SP1 BACH1 STAT3 ZNF143 RELA RAD21 TCF12 IKZF2 RCOR1 TRIM22 HTR2A RF00100-035 MN309174-138 HTR2A-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTR2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTR2A

Top Transcription factor binding sites by QIAGEN in the HTR2A gene promoter:
  • Brachyury
  • c-Myb
  • MIF-1
  • Nkx2-5
  • Nkx6-1
  • Pbx1a
  • POU2F1
  • POU2F1a
  • S8
  • STAT3

Genomic Locations for HTR2A Gene

Genomic Locations for HTR2A Gene
chr13:46,831,546-46,898,082
(GRCh38/hg38)
Size:
66,537 bases
Orientation:
Minus strand
chr13:47,405,685-47,471,169
(GRCh37/hg19)
Size:
65,485 bases
Orientation:
Minus strand

Genomic View for HTR2A Gene

Genes around HTR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2A Gene

Proteins for HTR2A Gene

  • Protein details for HTR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28223-5HT2A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2A
    Protein Accession:
    P28223
    Secondary Accessions:
    • B2RAC5
    • B4DZ79
    • F5GWE8
    • Q5T8C0

    Protein attributes for HTR2A Gene

    Size:
    471 amino acids
    Molecular mass:
    52603 Da
    Quaternary structure:
    • Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405). Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).
    Miscellaneous:
    • Binds lysergic acid diethylamine (LSD) in the orthosteric pocket (Probable). Bound LSD dissociates extremely slowly, with a residence time of about 221 minutes at 37 degrees Celsius.

    Three dimensional structures from OCA and Proteopedia for HTR2A Gene

    Alternative splice isoforms for HTR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2A Gene

Post-translational modifications for HTR2A Gene

  • Glycosylation at Asn8, Asn38, Asn44, Asn51, and Asn54
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR2A Gene

No data available for DME Specific Peptides for HTR2A Gene

Domains & Families for HTR2A Gene

Gene Families for HTR2A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for HTR2A Gene

InterPro:
Blocks:
  • 5-hydroxytryptamine receptor signature
  • 5-hydroxytryptamine 2A receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for HTR2A Gene

GenScript: Design optimal peptide antigens:
  • Serotonin receptor 2A (5HT2A_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2A (B3VRB0_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2A (B3VRB5_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2A (B3VRC0_HUMAN)
  • 5-hydroxytryptamine (Serotonin) receptor 2A (Q9P2Q9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28223

UniProtKB/Swiss-Prot:

5HT2A_HUMAN :
  • The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2A: view

Function for HTR2A Gene

Molecular function for HTR2A Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated with schizophrenia

Phenotypes From GWAS Catalog for HTR2A Gene

Gene Ontology (GO) - Molecular Function for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004993 G protein-coupled serotonin receptor activity TAS,IDA 7582481
GO:0005515 protein binding IPI 28258217
genes like me logo Genes that share ontologies with HTR2A: view
genes like me logo Genes that share phenotypes with HTR2A: view

Human Phenotype Ontology for HTR2A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HTR2A Gene

MGI Knock Outs for HTR2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR2A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2A

Clone Products

  • Addgene plasmids for HTR2A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HTR2A Gene

Localization for HTR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2A Gene

Cell membrane. Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Cell junction, synapse, presynapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR2A gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
genes like me logo Genes that share ontologies with HTR2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR2A Gene

Pathways & Interactions for HTR2A Gene

genes like me logo Genes that share pathways with HTR2A: view

SIGNOR curated interactions for HTR2A Gene

Activates:

Gene Ontology (GO) - Biological Process for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0006874 cellular calcium ion homeostasis IDA 16517693
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
genes like me logo Genes that share ontologies with HTR2A: view

Drugs & Compounds for HTR2A Gene

(339) Drugs for HTR2A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Inverse agonist, Target, antagonist, agonist 442
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist, Target, antagonist SR-2A inhibitor 532
Loxapine Approved Pharma Antagonist, Inverse agonist, Target, antagonist 35
Ziprasidone Approved Pharma Antagonist, Agonist, Partial agonist, Full agonist, Inverse agonist, Target, antagonist, agonist 5-HT (serotonin)/dopamine receptor antagonist 151
Zotepine Approved, Investigational, Withdrawn Pharma Antagonist, Inverse agonist, Target, antagonist 3

(37) Additional Compounds for HTR2A Gene - From: HMDB, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>11</sup>C]MDL100907
Antagonist
<i>m</i>-CPP
Antagonist, Agonist, Partial agonist
5-HT
Agonist, Full agonist, Inhibitor, Inhibition
DOB
Agonist, Full agonist
MDL-100,907
Antagonist

(5) Tocris Compounds for HTR2A Gene

Compound Action Cas Number
4F 4PP oxalate Selective 5-HT2A antagonist 144734-36-1
DOI hydrochloride Mixed 5-HT2A/2C agonist 42203-78-1
MDL 11,939 5-HT2A antagonist 107703-78-6
NBOH-2C-CN hydrochloride High affinity, selective 5-HT2A agonist 1539266-32-4
TCB-2 Potent, high affinity 5-HT2A agonist 912342-28-0

(107) ApexBio Compounds for HTR2A Gene

Compound Action Cas Number
4F 4PP oxalate 144734-36-1
Altanserin hydrochloride 1135280-78-2
Amitriptyline HCl Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor 549-18-8
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Asenapine hydrochloride Atypical antipsychotic 1412458-61-7
AT 1015 Long-acting 5-HT2A antagonist 190508-50-0
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
Cinanserin hydrochloride 54-84-2
Cisapride 81098-60-4
Citalopram hydrobromide 59729-32-7
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
Cyclobenzaprine HCl 5-HT2 receptor antagonist 6202-23-9
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Duloxetine HCl 136434-34-9
DV 7028 hydrochloride 133364-62-2
EMD 281014 hydrochloride 443144-27-2
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fananserin 127625-29-0
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine 54739-18-3
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 46611 185259-85-2
Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist 133454-47-4
Iloperidone hydrochloride 1299470-39-5
Ketanserin 74050-98-9
Lamotrigine 5-HT inhibitor 84057-84-1
Loxapine 1977-10-2
Loxapine Succinate 27833-64-3
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
LY 215840 137328-52-0
LY 393558 271780-64-4
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
MDL 100907 139290-65-6
MDL 11,939 107703-78-6
Mesulergine hydrochloride 72786-12-0
Metergoline 17692-51-2
Methiothepin maleate 19728-88-2
Methylergometrine maleate 57432-61-8
Methysergide maleate 129-49-7
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Milnacipran HCl 101152-94-7
MK 212 hydrochloride 61655-58-1
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
NBOH-2C-CN hydrochloride 1539266-32-4
Nefazodone hydrochloride 82752-99-6
NPEC-caged-serotonin 1257326-22-9
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Ondansetron hydrochloride dihydrate 103639-04-9
Org 12962 hydrochloride 210821-63-9
Org 37684 213007-95-5
Palonosetron HCl 135729-62-3
Penfluridol 26864-56-2
Pimavanserin 706779-91-1
Pizotifen 15574-96-6
Pizotifen Malate 5189-11-7
PNU 22394 hydrochloride 15923-42-9
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective 866206-55-5
R-96544 hydrochloride 167144-80-1
Risperidone SR-2A inhibitor 106266-06-2
Ritanserin 87051-43-2
Rizatriptan Benzoate 145202-66-0
RS 127445 5-HT2B receptor antagonist,high affinity 199864-87-4
RS 39604 hydrochloride 167710-87-4
RS 67333 hydrochloride 168986-60-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258719 hydrochloride 1217674-10-6
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Spiperone hydrochloride 2022-29-9
Sumatriptan 5-HT1 receptor agonist 103628-46-2
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
TCB-2 912342-28-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Tropisetron Hydrochloride 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WY 45233 succinate 448904-47-0
Ziprasidone 5-HT (serotonin)/dopamine receptor antagonist 146939-27-7
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
Zotepine 26615-21-4
α-Methyl-5-hydroxytryptamine maleate 97469-12-0
genes like me logo Genes that share compounds with HTR2A: view

Drug Products

Transcripts for HTR2A Gene

mRNA/cDNA for HTR2A Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTR2A

Clone Products

  • Addgene plasmids for HTR2A

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2A Gene

No ASD Table

Relevant External Links for HTR2A Gene

GeneLoc Exon Structure for
HTR2A

Expression for HTR2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR2A Gene

mRNA differential expression in normal tissues according to GTEx for HTR2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.3), Brain - Anterior cingulate cortex (BA24) (x8.5), and Brain - Cortex (x7.6).

Protein differential expression in normal tissues from HIPED for HTR2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR2A Gene



Protein tissue co-expression partners for HTR2A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR2A

SOURCE GeneReport for Unigene cluster for HTR2A Gene:

Hs.72630

mRNA Expression by UniProt/SwissProt for HTR2A Gene:

P28223-5HT2A_HUMAN
Tissue specificity: Detected in brain cortex (at protein level). Detected in blood platelets.

Evidence on tissue expression from TISSUES for HTR2A Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Lung(4.3)
  • Skin(2.7)
  • Muscle(2.6)
  • Adrenal gland(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with HTR2A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR2A Gene

Orthologs for HTR2A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HTR2A 30 31
  • 99.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HTR2A 30 31
  • 90.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HTR2A 30
  • 89.22 (n)
Mouse
(Mus musculus)
Mammalia Htr2a 30 17 31
  • 87.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Htr2a 30
  • 87.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia HTR2A 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HTR2A 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HTR2A 30 31
  • 75.23 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HTR2A 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia htr2a 30
  • 70.6 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-276l13.4 30
  • 67.12 (n)
htr2a 31
  • 66 (a)
OneToMany
HTR2A (2 of 2) 31
  • 60 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta 5-HT2 31 32
  • 16 (a)
ManyToMany
CG42796 31
  • 16 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ser-1 30 31
  • 48.73 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for HTR2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HTR2A Gene

ENSEMBL:
Gene Tree for HTR2A (if available)
TreeFam:
Gene Tree for HTR2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR2A: view image

Paralogs for HTR2A Gene

Paralogs for HTR2A Gene

(23) SIMAP similar genes for HTR2A Gene using alignment to 6 proteins:

  • 5HT2A_HUMAN
  • B3VRB0_HUMAN
  • B3VRB5_HUMAN
  • B3VRC0_HUMAN
  • L7QJB5_HUMAN
  • Q9P2Q9_HUMAN
genes like me logo Genes that share paralogs with HTR2A: view

Variants for HTR2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTR2A Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
712185 Likely Benign: not provided 46,835,596(-) C/T SYNONYMOUS_VARIANT
723564 Benign: not provided 46,835,566(-) G/A SYNONYMOUS_VARIANT
727046 Likely Benign: not provided 46,835,155(-) A/G SYNONYMOUS_VARIANT
731446 Benign: not provided 46,895,856(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
736153 Likely Benign: not provided 46,895,721(-) T/G SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for HTR2A Gene

Structural Variations from Database of Genomic Variants (DGV) for HTR2A Gene

Variant ID Type Subtype PubMed ID
esv2763019 CNV loss 21179565
esv3631996 CNV loss 21293372
nsv1027 CNV insertion 18451855
nsv510334 OTHER sequence alteration 20534489
nsv561583 CNV loss 21841781

Variation tolerance for HTR2A Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR2A Gene

Human Gene Mutation Database (HGMD)
HTR2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2A Gene

Disorders for HTR2A Gene

MalaCards: The human disease database

(103) MalaCards diseases for HTR2A Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HTR2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HTR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2A Gene

Publications for HTR2A Gene

  1. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D … Rauly-Lestienne I (European journal of pharmacology 2008) 3 4 23 26
  2. Lack of association between five serotonin metabolism-related genes and medication overuse headache. (PMID: 19936617) Cevoli S … Cortelli P (The journal of headache and pain 2010) 3 23 41
  3. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 23 41
  4. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. (PMID: 20010450) Dehning S … Zill P (Psychiatric genetics 2010) 3 23 41
  5. Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment. (PMID: 19924111) Horstmann S … Binder EB (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 23 41

Products for HTR2A Gene

  • Signalway ELISA kits for HTR2A
  • Signalway Proteins for HTR2A

Sources for HTR2A Gene