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Aliases for HTR1E Gene

Aliases for HTR1E Gene

  • 5-Hydroxytryptamine Receptor 1E 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled 2 3
  • Serotonin Receptor 1E 3 4
  • 5-HT-1E 3 4
  • 5-HT1E 3 4
  • S31 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1E 2

External Ids for HTR1E Gene

Previous GeneCards Identifiers for HTR1E Gene

  • GC06P087593
  • GC06P087643
  • GC06P087704
  • GC06P087647
  • GC06P084863

Summaries for HTR1E Gene

GeneCards Summary for HTR1E Gene

HTR1E (5-Hydroxytryptamine Receptor 1E) is a Protein Coding gene. Diseases associated with HTR1E include Spherocytosis, Type 3 and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1E Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1E Gene

  • Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15); the receptor is closely related to the serotonin 5-HT1F receptor.

Gene Wiki entry for HTR1E Gene

Additional gene information for HTR1E Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1E Gene

Genomics for HTR1E Gene

GeneHancer (GH) Regulatory Elements for HTR1E Gene

Promoters and enhancers for HTR1E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I086936 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.1 91 1.2 CTCF MXI1 ZNF777 FOXA2 ZBTB6 RB1 MAX SIN3A ZNF2 RAD21 HTR1E GC06P086925 GC06M086958
GH06I087017 Enhancer 0.2 FANTOM5 14.8 +80.6 80601 0.4 HTR1E GJB7 GC06P087015 ENSG00000217776
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HTR1E on UCSC Golden Path with GeneCards custom track

Genomic Locations for HTR1E Gene

Genomic Locations for HTR1E Gene
chr6:86,937,306-87,016,683
(GRCh38/hg38)
Size:
79,378 bases
Orientation:
Plus strand
chr6:87,647,024-87,726,397
(GRCh37/hg19)

Genomic View for HTR1E Gene

Genes around HTR1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1E Gene

Proteins for HTR1E Gene

  • Protein details for HTR1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28566-5HT1E_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1E
    Protein Accession:
    P28566
    Secondary Accessions:
    • E1P503
    • Q9P1Y1

    Protein attributes for HTR1E Gene

    Size:
    365 amino acids
    Molecular mass:
    41682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1E Gene

Post-translational modifications for HTR1E Gene

  • Glycosylation at posLast=22 and posLast=55

Other Protein References for HTR1E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1E Gene

Domains & Families for HTR1E Gene

Gene Families for HTR1E Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for HTR1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28566

UniProtKB/Swiss-Prot:

5HT1E_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1E: view

Function for HTR1E Gene

Molecular function for HTR1E Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Phenotypes From GWAS Catalog for HTR1E Gene

Gene Ontology (GO) - Molecular Function for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 1733778
GO:0004993 G-protein coupled serotonin receptor activity IMP,IDA 21422162
GO:0005515 protein binding IPI 25416956
GO:0030594 neurotransmitter receptor activity IBA --
GO:0051378 serotonin binding IDA 1608964
genes like me logo Genes that share ontologies with HTR1E: view
genes like me logo Genes that share phenotypes with HTR1E: view

Clone Products

  • Addgene plasmids for HTR1E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR1E Gene

Localization for HTR1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1E Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR1E gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IMP 21422162
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR1E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR1E Gene

Pathways & Interactions for HTR1E Gene

genes like me logo Genes that share pathways with HTR1E: view

Gene Ontology (GO) - Biological Process for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1733778
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007268 chemical synaptic transmission TAS,IEA --
genes like me logo Genes that share ontologies with HTR1E: view

No data available for SIGNOR curated interactions for HTR1E Gene

Drugs & Compounds for HTR1E Gene

(55) Drugs for HTR1E Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ziprasidone Approved Pharma Antagonist, Target, antagonist, agonist 5-HT (serotonin)/dopamine receptor antagonist 146
Methysergide Approved Pharma Antagonist, Target, binder, antagonist 0
Clozapine Approved Pharma Antagonist, Target, antagonist Antipsychotic medication 121
Eletriptan Approved, Investigational Pharma Full agonist, Agonist, Target, agonist 19
Olanzapine Approved, Investigational Pharma Antagonist, Target, antagonist, agonist 408

(7) Additional Compounds for HTR1E Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
<i>m</i>-CPP
Antagonist
5-HT
Full agonist, Agonist
alpha-methyl-5-HT
Full agonist, Agonist
N-Desmethyleletriptan
BRL 54443
57477-39-1

(1) Tocris Compounds for HTR1E Gene

Compound Action Cas Number
BRL 54443 Potent 5-ht1E/F agonist 57477-39-1

(1) ApexBio Compounds for HTR1E Gene

Compound Action Cas Number
BRL-54443 5-HT1E/1F receptor agonist,potent and selective 57477-39-1
genes like me logo Genes that share compounds with HTR1E: view

Drug Products

Transcripts for HTR1E Gene

mRNA/cDNA for HTR1E Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1E Gene

5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled:
Representative Sequences:

Clone Products

  • Addgene plasmids for HTR1E

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1E Gene

No ASD Table

Relevant External Links for HTR1E Gene

GeneLoc Exon Structure for
HTR1E
ECgene alternative splicing isoforms for
HTR1E

Expression for HTR1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR1E Gene

mRNA differential expression in normal tissues according to GTEx for HTR1E Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.6), Brain - Cortex (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of HTR1E Gene:

HTR1E

SOURCE GeneReport for Unigene cluster for HTR1E Gene:

Hs.1611

mRNA Expression by UniProt/SwissProt for HTR1E Gene:

P28566-5HT1E_HUMAN
Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for HTR1E Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with HTR1E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR1E Gene

Orthologs for HTR1E Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR1E 33 34
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia HTR1E 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1E 33 34
  • 90.5 (n)
cow
(Bos Taurus)
Mammalia HTR1E 33 34
  • 89.13 (n)
mouse
(Mus musculus)
Mammalia Htr5b 34
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HTR1E 33 34
  • 75.73 (n)
lizard
(Anolis carolinensis)
Reptilia HTR1E 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1e 33
  • 71.88 (n)
Str.3647 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22172 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330681 33
  • 65.93 (n)
HTR1E 34
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 35
  • 43 (a)
5-HT1B 35
  • 42 (a)
5-HT7 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 35
  • 37 (a)
Species where no ortholog for HTR1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1E Gene

ENSEMBL:
Gene Tree for HTR1E (if available)
TreeFam:
Gene Tree for HTR1E (if available)

Paralogs for HTR1E Gene

Paralogs for HTR1E Gene

(16) SIMAP similar genes for HTR1E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1E: view

Variants for HTR1E Gene

Sequence variations from dbSNP and Humsavar for HTR1E Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000005459 -- 87,004,277(+) C/A intron_variant
rs1000006379 -- 86,996,137(+) T/C intron_variant
rs1000057428 -- 87,003,698(+) T/C intron_variant
rs1000118371 -- 86,997,349(+) A/G intron_variant
rs1000149127 -- 86,977,415(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HTR1E Gene

Variant ID Type Subtype PubMed ID
esv2444959 CNV deletion 19546169
esv2763585 CNV gain 21179565
esv3303343 CNV mobile element insertion 20981092
esv3383001 CNV insertion 20981092
esv3425923 CNV insertion 20981092
esv3609856 CNV loss 21293372
nsv604106 CNV gain 21841781
nsv965742 CNV duplication 23825009

Variation tolerance for HTR1E Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1E Gene

Disorders for HTR1E Gene

MalaCards: The human disease database

(2) MalaCards diseases for HTR1E Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HTR1E in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTR1E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTR1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1E Gene

Publications for HTR1E Gene

  1. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. (PMID: 1733778) Levy FO … Birnbaumer L (FEBS letters 1992) 3 4 22 58
  2. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. (PMID: 1608964) McAllister G … Whiting P (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 58
  3. Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. (PMID: 1513320) Zgombick JM … Weinshank RL (Molecular pharmacology 1992) 3 4 22 58
  4. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. (PMID: 21422162) Klein MT … Teitler M (The Journal of pharmacology and experimental therapeutics 2011) 3 4 58
  5. Association study of the serotoninergic system in migraine in the Spanish population. (PMID: 19455600) Corominas R … Cormand B (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58

Products for HTR1E Gene

Sources for HTR1E Gene

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