Aliases for HTR1B Gene
External Ids for HTR1B Gene
Previous GeneCards Identifiers for HTR1B Gene
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]
GeneCards Summary for HTR1B Gene
HTR1B (5-Hydroxytryptamine Receptor 1B) is a Protein Coding gene. Diseases associated with HTR1B include Prinzmetal's Variant Angina and Obsessive-Compulsive Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1D.
UniProtKB/Swiss-Prot for HTR1B Gene
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.