HTR1A Gene - 5-Hydroxytryptamine Receptor 1A

Protein Coding (Updated: Nov 13, 2025)
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of thi... See more...

Aliases for HTR1A Gene

Aliases for HTR1A Gene

  • GeneCards Symbol: HTR1A 2
  • 5-Hydroxytryptamine Receptor 1A 2 3 4 5
  • 5-HT1A 2 3 4 5
  • ADRB2RL1 3 4 5
  • ADRBRL1 3 4 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled 2 3
  • 5-HT-1A 3 4
  • G-21 3 4
  • Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1A 2
  • Serotonin Receptor 1A 4
  • 5-HT1a Receptor 3
  • 5HT1a 3
  • PFMCD 3

External Ids for HTR1A Gene

Previous HGNC Symbols for HTR1A Gene

  • ADRB2RL1
  • ADRBRL1

Previous GeneCards Identifiers for HTR1A Gene

  • GC05M063417
  • GC05M064794
  • GC05M063226
  • GC05M063272
  • GC05M063292
  • GC05M060210

Summaries for HTR1A Gene

NCBI Gene Summary for HTR1A Gene

  • This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

GeneCards Summary for HTR1A Gene

HTR1A (5-Hydroxytryptamine Receptor 1A) is a Protein Coding gene. Diseases associated with HTR1A include Periodic Fever, Menstrual Cycle-Dependent and Generalized Anxiety Disorder. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled serotonin receptor activity. An important paralog of this gene is HTR1D.

UniProtKB/Swiss-Prot Summary for HTR1A Gene

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, 3138543, 33762731, 37935376, 37935377, 8138923, 8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, 3138543, 33762731, 38552625, 8138923, 8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, 3138543, 33762731, 8138923, 8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, 35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, 20363322, 20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, 20363322, 20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, 20363322, 20945968). Plays a role in the response to anxiogenic stimuli (PubMed:18476671, 20363322, 20945968). ( 5HT1A_HUMAN,P08908 )

Tocris Summary for HTR1A Gene

  • The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced. 5-HT1A receptor binding sites are located primarily in limbic brain areas, notably the hypothalamus and cortical areas. The human gene encoding this receptor has been localized to chromosome 5.

Gene Wiki entry for HTR1A Gene

PharmGKB Summary for HTR1A Gene

Additional gene information for HTR1A Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for HTR1A Gene

Genomics for HTR1A Gene

Subsections:

  1. Promoters/Enhancers
  2. Location

GeneHancer (GH) Regulatory Elements (see citations)

Download GeneHancer 2017 data
Promoters and enhancers for HTR1A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J063965 Enhancer 0.7 Ensembl 300.70 205.72 -0.7 0 0.4 KLF6 MIER1 CTCF BCLAF1 ZNF654 KLF11 REST ETS1 RAD21 SIN3A HTR1A HSALNG0042237 RNF180 ENSG00000248285
GH05J063961 Enhancer 0.6 RefSeq Ensembl 300.70 182.54 +0.8 0 1.0 REST EZH2 HTR1A piR-35312-027 ENSG00000248285
GH05J063958 Enhancer 1 RefSeq Ensembl ENCODE 0.73 0.7 +2.9 0 1.8 POLR2A TCF12 SIN3A YY1 CTCF TAF1 CHD1 EGR1 TBP RAD21 RNF180 HTR1A piR-35312-027 ENSG00000248285
GH05J063923 Enhancer 0.3 Ensembl 0.28 0.09 +38.4 0 0.2 JUND FOXA1 HTR1A piR-35312-027
GH05J064020 Enhancer 0.3 RefSeq 0.23 0.06 -57.6 1 0.2 RNF180 HSALNG0042237 HTR1A piR-33605-360 ENSG00000248285

GeneHancers around HTR1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from The Signaling Pathways Project (SPP) (The Signaling Pathways Project) for HTR1A

Top Transcription factor binding sites by QIAGEN in the HTR1A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • GATA-2

Genomic Locations for HTR1A Gene

Latest Assembly
chr5:63,957,874-63,962,507
(GRCh38/hg38)
Size:
4,634 bases
Orientation:
Minus strand

Previous Assembly
chr5:63,253,701-63,258,272
(GRCh37/hg19 by NCBI Gene)
Size:
4,572 bases
Orientation:
Minus strand

chr5:63,256,183-63,258,334
(GRCh37/hg19 by Ensembl)
Size:
2,152 bases
Orientation:
Minus strand

Genomic View for HTR1A Gene

Genes around HTR1A on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Cytogenetic band:
HTR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or NCBI Gene and/or Ensembl if different)
Genomic Location for HTR1A Gene
Genomic Neighborhood
•
Exon Structure
•
Gene Densities

RefSeq DNA sequence for HTR1A Gene

Proteins for HTR1A Gene

Subsections:

  1. 3D Structures
  2. Protein References
  3. Post-Translational Modifications

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  • Protein details for HTR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08908-5HT1A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1A
    Protein Accession:
    P08908
    Secondary Accessions:
    • Q6LAE7

    Protein attributes for HTR1A Gene

    Size:
    422 amino acids
    Molecular mass:
    46107 Da
    Protein existence level:
    PE1
    Quaternary structure:

    • Heterodimer; heterodimerizes with GPER1 (PubMed:23300088).
      Interacts with YIF1B (By similarity).
      Interacts with GPR39 and GALR1 (PubMed:26365466).

    Three dimensional structures from PDB (representative) and AlphaFold (predicted) for HTR1A Gene

    Model Confidence:
    Very high (pLDDT > 90)
    Confident (90 > pLDDT > 70)
    Low (70 > pLDDT > 50)
    Very low (pLDDT < 50)
    Identifier Method Resolution PDBe RCSB-PDB OCA Proteopedia
    GeneCards.Business.Types.Common.LinkDto EM 3 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto EM 3 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto EM 3.1 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto EM 2.79 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto EM 2.85 (3D) (3D) (3D)

Protein Expression for HTR1A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HTR1A Gene

  • Glycosylation at Asn10, Asn11, and Asn24 ( NX_P08908 [NX_P08908-1] )
  • Modification sites at PhosphoSitePlus ( P08908 )
  • Glycosylation from GlyGen (P08908) 6 sites, 1 O-linked glycan (2 sites)

Other Protein References for HTR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1A Gene

Domains & Families for HTR1A Gene

Gene Families for HTR1A Gene

HGNC:
IUPHAR:
The Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for HTR1A Gene

InterPro:
Blocks:
  • 5-hydroxytryptamine 1A receptor signature
  • 5-hydroxytryptamine receptor signature

Suggested Antigen Peptide Sequences for HTR1A Gene

GenScript: Design optimal peptide antigens:
  • Serotonin receptor 1A (5HT1A_HUMAN)
  • 5HT1a protein (A0N5V3_HUMAN)
  • 5-hydroxytryptamine receptor 1A (Q5ZGX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08908

UniProtKB/Swiss-Prot:

5HT1A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Genes that share domains with HTR1A: view

Function for HTR1A Gene

Subsections:

  1. GWAS Phenotypes
  2. GO Terms
  3. MGI/GenomeRNAi Phenotypes
  4. HPO Terms

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Molecular function for HTR1A Gene according to UniProtKB/Swiss-Prot

Function:
  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, 3138543, 33762731, 37935376, 37935377, 8138923, 8393041).
    Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, 3138543, 33762731, 38552625, 8138923, 8393041).
    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, 3138543, 33762731, 8138923, 8393041).
    HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, 35610220).
    Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, 20363322, 20945968).
    Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, 20363322, 20945968).
    Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, 20363322, 20945968).
    Plays a role in the response to anxiogenic stimuli (PubMed:18476671, 20363322, 20945968). 5HT1A_HUMAN,P08908
EnzymeRegulation:
  • G-protein coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity (PubMed:33762731).
    Binding to aripiprazol drug is regulated by cholesterol, which shapes the ligand-binding pocket, determining the specificity for aripiprazol (PubMed:33762731).
    Activated by IHCH-7179 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and as an antagonist inhibitor for HTR2A (PubMed:38552625).
    Activated by SEP-363856 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and TAAR1 (PubMed:37935376, 37935377). 5HT1A_HUMAN,P08908

Molecular function for HTR1A Gene according to GENATLAS

Biochemistry:
  • 5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate cyclase HTR1A

Gene Ontology (GO) - Molecular Function for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001586 3 5 enables Gi/o-coupled serotonin receptor activity IDA, IEA
GO:0004930 3 5 enables G protein-coupled receptor activity IEA
GO:0004993 3 5 enables G protein-coupled serotonin receptor activity IDA, IMP, IBA, TAS, IEA 9736659
GO:0005515 3 5 enables protein binding IPI 22035699
GO:0030594 3 5 enables neurotransmitter receptor activity IBA
Genes that share ontologies with HTR1A: view
Genes that share phenotypes with HTR1A: view

Human Phenotype Ontology for HTR1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms
HP:0003118 Increased circulating cortisol level HP:0000850, HP:0001578, HP:0004316 Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features. Cushing syndrome;Hypercortisolism;Increased circulating cortisol level;Increased cortisol production
HP:0002076 Migraine HP:0007194 Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms. Intermittent migraine headaches;Migraine;Migraine headache;Migraine headaches
HP:0200067 Recurrent spontaneous abortion Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference. Spontaneous abortion, recurrent
HP:0000006 Autosomal dominant inheritance HP:0001415, HP:0001447, HP:0001448, HP:0001451, HP:0001452, HP:0001455, HP:0001456, HP:0001463 A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. Autosomal dominant;Autosomal dominant form;Autosomal dominant type;monoallelic_autosomal
HP:0001945 Fever Body temperature elevated above the normal range. Fever;Hyperthermia;Pyrexia

Animal Models for HTR1A Gene

MGI Knock Outs for HTR1A:

miRNA for HTR1A Gene

miRTarBase miRNAs that target HTR1A

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No data available for Enzyme Numbers (IUBMB) , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for HTR1A Gene

Localization for HTR1A Gene

Subsections:

  1. Cellular Components

Subcellular locations from UniProtKB/Swiss-Prot for HTR1A Gene

Protein: 5HT1A_HUMAN

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR1A gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 3
cytosol 2
endoplasmic reticulum 2
peroxisome 2
mitochondrion 2
cytoskeleton 2
golgi apparatus 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 3 5 located_in plasma membrane IDA, IBA, TAS, IEA 3138543
GO:0016020 3 5 located_in membrane IEA
GO:0030425 3 5 located_in dendrite IBA, IEA
GO:0042995 3 5 located_in cell projection IEA
GO:0045202 3 5 located_in synapse IEA
Genes that share ontologies with HTR1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR1A Gene

Pathways & Interactions for HTR1A Gene

Subsections:

  1. SuperPathways
  2. String Interactions
  3. Interacting Proteins
  4. Curated Interactions
  5. GO Terms
Genes that share pathways with HTR1A: view

Additional Pathway Information for HTR1A Gene

SIGNOR curated interactions for HTR1A Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 3 5 involved_in behavioral fear response ISS, IEA
GO:0007165 3 5 involved_in signal transduction IEA
GO:0007186 3 5 involved_in G protein-coupled receptor signaling pathway IMP, TAS, IEA 1330092
GO:0007187 3 5 involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
GO:0007189 3 5 acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Genes that share ontologies with HTR1A: view

Drugs & Compounds for HTR1A Gene

Subsections:

  1. Drugs
  2. Inferred drugs
  3. Compounds
  4. Inferred compounds
  5. Commercial compounds

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  1. Drug products

(268) Drugs for HTR1A Gene - From DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ziprasidone 21 23 24 74 80 91 Approved, Investigational 23 Pharma agonist, Target, Partial agonist 5-HT (serotonin)/dopamine receptor antagonist, Antipsychotic Agents, Small Molecule
Quetiapine 21 22 23 24 74 91 Approved, Investigational 23 Pharma partial agonist, antagonist, Target, Full agonist, Agonist Antipsychotic Agents, Small Molecule
Aripiprazole 21 23 23 24 74 91 Approved, Investigational 23 23 Pharma Agonist, partial agonist, Target Antipsychotic, Small Molecule, Antipsychotic Agents, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
Flibanserin 21 23 74 80 91 Approved, Investigational 23 Pharma agonist, Target full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A., Small Molecule
Clozapine 21 22 23 74 91 Approved, Investigational 23 Pharma antagonist, Target, Full agonist, Agonist Antipsychotic medication, Antipsychotic Agents, Small Molecule

(29) Inferred Drugs for HTR1A Gene

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetylcholine 21 Approved, Investigational 23 Pharma
Betaxolol 21 Approved 23 Pharma Promote the direct formation of amides from carboxylic acids and amines., βadrenergic receptor blocker, Antihypertensive Agents, Small Molecule
Levodopa 21 Approved, Investigational 23 Pharma Antiparkinson Agents, Small Molecule
Metergoline 21 Approved 23 Pharma
Norepinephrine 21 Approved, Investigational 23 Pharma Small Molecule, Antihypotensive Agents, Vasoconstrictor Agents

(10) Additional Compounds for HTR1A Gene - From: IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(<i>R</i>)-flurocarazolol
Antagonist
(<i>S</i>)-flurocarazolol
Antagonist
[<sup>11</sup>C]WAY100635
  • [<sup>11</sup>C]WAY-100635
  • [<sup>11</sup>C]WAY100635 (PET ligand)
 Antagonist
[<sup>3</sup>H]<i>p</i>-MPPF
  • 4-(2' Methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine
  • 4-MPPF
 Antagonist
[<sup>3</sup>H]LY334370
  • LY 334370
  • LY-334,370
  • LY334370
  • LY-334370
 Full agonist, Agonist

(32) Additional Inferred Compounds for HTR1A Gene

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(125I)Gti
(TFMPP)
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane
1-(2-Methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide
1-(2-Pyrimidinyl)piperazine

(5) Tocris Compounds for HTR1A Gene

Compound Action Cas Number
8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist; also has moderate affinity for 5-HT7 76135-31-4
8-Hydroxy-PIPAT oxalate High affinity 5-HT1A agonist 1451210-48-2
BP 554 maleate Selective 5-HT1A agonist 1221401-95-1
MDL 73005EF hydrochloride Potent and selective 5-HT1A partial agonist 102908-60-1
RU 24969 hemisuccinate 5-HT1B/1A agonist 66611-27-6

(47) ApexBio Compounds for HTR1A Gene

Compound Action Cas Number
(R)-(+)-8-Hydroxy-DPAT hydrobromide 78095-19-9
(S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective 149007-54-5
5-Carboxamidotryptamine maleate 74885-72-6
5-Methoxytryptamine A complete agonist of 5-HT1, 5-HT2, 5-HT4, 5-HT6 and 5-HT7 receptors. 608-07-1
8-Hydroxy-DPAT hydrobromide 76135-31-4
8-Hydroxy-PIPAT oxalate 1451210-48-2
Afobazole anxiolytic drug 173352-21-1
Asenapine hydrochloride Atypical antipsychotic 1412458-61-7
BMY 14802 hydrochloride Sigma receptor antagonist 105565-55-7
BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist 21102-95-4
BP 554 maleate Selective 5-HT1A agonist 1221401-95-1
Buspirone HCl 33386-08-2
Citalopram hydrobromide 59729-32-7
Cyanopindolol hemifumarate 69906-86-1
DiscoveryProbe™ Anti-cancer Compound Library 1164 anti-cancer compounds
DiscoveryProbe™ Anti-cancer Compound Library Plus 1777 anti-cancer compounds
DiscoveryProbe™ Bioactive Compound Library 3317 bioactive compounds
DiscoveryProbe™ Bioactive Compound Library Plus 4417 bioactive compounds
DiscoveryProbe™ FDA-approved Drug Library 1971 FDA-approved drugs
DiscoveryProbe™ GPCR Compound Library A unique collection of 677 GPCR-related small molecules for GPCR screening.
DiscoveryProbe™ Neuronal Signaling Compound Library Plus A unique collection of 948 neuronal signaling-related small molecules for neuroscience reasearch.
DiscoveryProbe™ Neuronal Signaling Library A unique collection of 556 neuronal signaling-related small molecules for neuroscience reasearch.
Flibanserin full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A. 167933-07-5
Flopropione 2295-58-1
Fluvoxamine 54739-18-3
Iloperidone hydrochloride 1299470-39-5
Ipsapirone 95847-70-4
L-703,664 succinate 144776-01-2
Lamotrigine 5-HT inhibitor 84057-84-1
Lofepramine 23047-25-8
LP 20 hydrochloride 1386928-34-2
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
MDL 72832 hydrochloride 113777-40-5
MDL 73005EF hydrochloride 102908-60-1
Methiothepin maleate 19728-88-2
Methylergometrine maleate 57432-61-8
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
MM 77 dihydrochloride 159187-70-9
NAN-190 hydrobromide 115338-32-4
Paroxetine maleate 64006-44-6
S 14506 hydrochloride 286369-38-8
Sumatriptan Succinate 5-HT1 receptor agonist 103628-48-4
Vilazodone Combined SSRI and 5-HT1A receptor partial agonist 163521-12-8
Vilazodone Hydrochloride Combined SSRI and 5-HT1A receptor partial agonist 163521-08-2
WAY-100635 5-HT1A receptor antagonist,potent and selective 162760-96-5
WAY-100635 Maleate 5-HT1A receptor agonist 1092679-51-0
Ziprasidone 5-HT (serotonin)/dopamine receptor antagonist 146939-27-7
Genes that share compounds with HTR1A: view

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Transcripts for HTR1A Gene

Subsections:

  1. Alternative Splicing

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mRNA/cDNA for HTR1A Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

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Alternative Splicing Database (ASD) splice patterns (SP) for HTR1A Gene

No ASD Table

Exon structure for HTR1A gene

Exon Structure

Expression for HTR1A Gene

Subsections:

  1. Expression in stem cells
  2. Protein expression
  3. Co-Expression partners
  4. Phenotype-based gene-organ relationships

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR1A Gene

mRNA expression in normal human tissues for HTR1A Gene
mRNA expression by GTEx for HTR1A GenemRNA expression by BioGPS for HTR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Brain (Nervous System)
    • Hypothalamus
    • Hippocampus
    • Thalamus
    • Cerebellum
    • Amygdala

mRNA differential expression in normal tissues according to GTEx for HTR1A Gene

This gene is overexpressed in Brain - Hippocampus (x13.8), Brain - Frontal Cortex (BA9) (x9.7), Brain - Cortex (x8.9), Brain - Anterior cingulate cortex (BA24) (x7.2), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for HTR1A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1A Gene



Protein tissue co-expression partners for HTR1A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTR1A

mRNA Expression by UniProt/SwissProt for HTR1A Gene:

P08908-5HT1A_HUMAN
Tissue specificity: Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.

Evidence on tissue expression from TISSUES for HTR1A Gene

  • Nervous system(4.9)
  • Muscle(2.8)
  • Adrenal gland(2.8)
  • Heart(2.8)
  • Intestine(2.7)
  • Blood(2.7)
  • Kidney(2.6)
  • Liver(2.3)
  • Stomach(2.1)

Bgee gene expression patterns for HTR1A gene:

  • Expressed in entorhinal cortex, middle temporal gyrus, cortical plate and 46 other cell types or tissues.

Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR1A Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
Regions:
Head and neck:
  • brain
  • head
General:
  • blood
  • white blood cell
Genes that share expression patterns with HTR1A: view

Buy Primer products for research

Orthologs for HTR1A Gene

Subsections:

  1. CladeOScope co-evolved genes

This gene was present in the common ancestor of animals.

Orthologs for HTR1A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)		 Mammalia HTR1A 27 28
  • 99.68 (n)
OneToOne
Cow
(Bos Taurus)		 Mammalia 5HTR1A 28
  • 92 (a)
OneToOne
HTR1A 27
  • 88.31 (n)
Dog
(Canis familiaris)		 Mammalia HTR1A 27 28
  • 89.1 (n)
OneToOne
Mouse
(Mus musculus)		 Mammalia Htr1a 27 16 28
  • 85.59 (n)
OneToOne
Rat
(Rattus norvegicus)		 Mammalia Htr1a 27
  • 85.47 (n)
Species where no ortholog for HTR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HTR1A Gene

ENSEMBL:
Gene Tree for HTR1A (if available)
TreeFam:
Gene Tree for HTR1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTR1A: view image
Alliance of Genome Resources:
Additional Orthologs for HTR1A

CladeOScope co-evolved genes for HTR1A gene

Clade Top 10 Co-Evolved Genes Normalized Phylogenetic Profile HeatMap (PPH)
Top Genes From All Clades
Archelosauria
Arthropoda
Chordata
Ecdysozoa
Eukaryota
Mammalia
Nematoda
Platyhelminthes

Paralogs for HTR1A Gene

Paralogs for HTR1A Gene

(17) SIMAP paralogs for HTR1A Gene using alignment to 4 proteins:

  • A0N5V3_HUMAN
  • Q5ZGX3_HUMAN
  • 5HT1A_HUMAN
  • D6RA34_HUMAN
Genes that share paralogs with HTR1A: view

Variants for HTR1A Gene

Subsections:

  1. Variation Tolerance
  2. External Links

Sequence variations, with clinical significance, from ClinVar and UniProt Humsavar, with links to dbSNP and Ensembl, for HTR1A Gene

Accession rsID Clinical significance and condition Chr 05 pos Variation Name Ref/Alt AA Chg Type
31658 5 rs367956927

Pathogenic: Periodic Fever, Menstrual Cycle-Dependent

Uncertain significance: not specified

Likely benign: not provided

63,962,199(-) NM_000524.4(HTR1A):c.-480del CT/C 5 prime UTR variant
1048921 5 rs201953609

Uncertain significance: not provided; not specified

63,961,445(-) NM_000524.4(HTR1A):c.275T>C (p.Met92Thr) A/G M92T missense variant
2205795 5 rs201654331

Uncertain significance: not specified

63,961,688(-) NM_000524.4(HTR1A):c.32A>C (p.Asn11Thr) T/G N11T missense variant
2228373 5 rs148698436

Uncertain significance: not specified

63,960,972(-) NM_000524.4(HTR1A):c.748C>T (p.Pro250Ser) G/A P250S missense variant
2237962 5 rs2530979669

Uncertain significance: not specified

63,961,046(-) NM_000524.4(HTR1A):c.674G>A (p.Arg225His) C/T R225H missense variant

Identifiers for variants without clinical significance from dbSNP and UniProt Humsavar for HTR1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HTR1A Gene

Variant ID Type Subtype PubMed ID
nsv4337631 OTHER sequence alteration 32461652
nsv4131633 CNV duplication 32461652
nsv4521974 CNV duplication 32461652
nsv598351 CNV gain 21841781
nsv4860 CNV insertion 18451855
SVs/CNVs around HTR1A on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for HTR1A Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTR1A Gene

Human Gene Mutation Database (HGMD)
HTR1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1A Gene

Disorders for HTR1A Gene

Subsections:

  1. Uniprot disorders
  2. External links

5 diseases for HTR1A Gene - From: OMIM®, ClinVar, GTR, Orphanet, GeneCards, DISEASES, and Novoseek

(click the icon to the left of a disorder to see descriptions and symptoms)

Disorder Aliases PubMed IDs
Periodic Fever, Menstrual Cycle-Dependent 1 6 97 99 107
  • Menstrual Cycle-Dependent Periodic Fever
  • Menstrual Cycle-Dependent Febrile Episode
  • Luteal-Phase-Dependent Febrile Episode
  • Luteal-Phase-Dependent Periodic Fever
  • PFMC
 21990073
Periodic Fever Syndrome 99
Epilepsy 1 21 63 99
  • Epilepsy Syndrome
  • Epileptic Syndrome
  • Epilepsies
  • Epilepsy Due To Structural Or Metabolic Conditions Or Diseases
  • Symptomatic Epilepsies
  • Epilepsy Due To Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Prenatal Or Perinatal Vascular Insults
  • Epilepsy Due To Neonatal Hypoxic Ischemic Encephalopathy
  • Epilepsy Due To Other Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Unspecified Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Cerebrovascular Disorders
  • Epilepsy Due To Degenerative Brain Disorders
  • Epilepsy Due To Dementias
  • Epilepsy Due To Central Nervous System Infections Or Infestations
  • Epilepsy Due To Injuries To The Head
  • Post Traumatic Epilepsy
  • Traumatic Epilepsy
  • Traumatic Epileptic
  • Epilepsy Due To Tumours Of The Nervous System
  • Epilepsy With Mesial Temporal Sclerosis
  • Epilepsy Due To Hippocampal Sclerosis
  • Epilepsy With Ammon'S Horn Sclerosis
  • Epilepsy Due To Immune Disorders
  • Epilepsy Due To Abnormalities Of Brain Development
  • Epilepsy Due To Cortical Dysplasia
  • Epilepsy Due To Neuronal Migration Disorders
  • Epilepsy Due To Genetic Syndromes With Widespread Or Progressive Effects
  • Epilepsy Due To Multiple Sclerosis Or Other Demyelinating Disorders
  • Epilepsy Due To Other Structural Or Metabolic Condition Or Disease
  • Epilepsy Due To Unspecified Structural Or Metabolic Condition Or Disease
 17442003 10081934 19236949 15112462 10400249
Immune Deficiency Disease 63 99
  • Immunodeficiency
  • Primary Immunodeficiency Disease
  • Primary Immunodeficiency
  • Immunologic Deficiency Syndromes
  • Hypoimmunity
  • Immune Deficiency Disorder
  • Immunodeficiency Syndrome
  • Immune Disorder
  • Primary Immune Deficiency Disorder
  • Immune System Diseases
  • Human Immunodeficiency Virus Disease
  • Human Immunodeficiency Virus Disease Without Mention Of Tuberculosis Or Malaria
  • HIV
  • ARC
  • Human Immunodeficiency Virus Infection
  • Hiv Positive Nos
  • Hiv Disease
  • Acquired Immune Deficiency Syndrome-Related Complex
  • Aids-Like Syndrome
  • Aids-Related Complex Nos
  • Immunodeficiency Due To Human Immunodeficiency Virus Infection
  • Unspecified Human Immunodeficiency Virus Disease
  • Hiv Disease Nos
  • Human Immunodeficiency Virus Positive Nos
  • Hiv Nos
  • Human Immunodeficiency Virus Disease Without Mention Of Tuberculosis Or Malaria, Clinical Stage Unspecified
  • Primary Immunodeficiencies
  • Primary Immunodeficiencies Due To Disorders Of Innate Immunity
  • Immunodeficiency With An Early Component Of Complement Deficiency
  • Deficiency Of Complement Initial Pathway
  • Immunodeficiency With A Late Component Of Complement Deficiency
  • Deficiency Of Complement Terminal Pathway
  • Immunodeficiency With Factor B Deficiency
  • Immunodeficiency With Factor D Anomaly
  • CFDD
  • Immunodeficiency With Natural-Killer Cell Deficiency
  • Immunodeficiency With Nk-Cell Deficiency
  • Other Specified Primary Immunodeficiencies Due To Disorders Of Innate Immunity
  • Primary Immunodeficiencies Due To Disorders Of Innate Immunity, Unspecified
  • Primary Immunodeficiencies Due To Disorders Of Adaptive Immunity
  • Immunodeficiencies With Predominantly Antibody Defects
  • Immunodeficiencies With Severe Reduction In At Least Two Serum Immunoglobulin Isotypes With Normal Or Low Numbers Of B Cells
  • Nonfamilial Hypogammaglobulinaemia
  • Common Variable Immune Deficiency
  • Nonfamilial Agammaglobulinaemia
  • Common Variable Agammaglobulinaemia
  • Agammaglobulinaemia Nos
  • Agammaglobulinaemia Antibody Deficiency Syndrome
  • Hypogammaglobulinaemia Antibody Deficiency Syndrome
  • Acquired Agammaglobulinaemia Nos
  • Hypogammaglobulinaemia Nos
  • Immunodeficiencies With Isotype Or Light Chain Deficiencies With Normal Number Of B Cells
  • Immunodeficiencies With Severe Reduction In Serum Igg Or Iga With Normal Or Elevated Igm And Normal Numbers Of B-Cells
  • Hyper Igm
  • Other Specified Immunodeficiencies With Predominantly Antibody Defects
  • Immunodeficiencies With Predominantly Antibody Defects, Unspecified
  • Immunodeficiency Due To Defects Of The Thymus
  • Primary Immunodeficiencies Due To Disorders Of Adaptive Immunity, Unspecified
  • Other Specified Primary Immunodeficiencies
  • Primary Immunodeficiencies, Unspecified
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome 99
  • AAMR
  • Alacrima, Achalasia, And Mental Retardation Syndrome
  • Alacrima, Achalasia, And Intellectual Disability Syndrome
  • Intellectual Disability
- elite association - COSMIC cancer census association via MalaCards
Search HTR1A in MalaCards View complete list of genes associated with diseases

111 text mining disease associations for HTR1A Gene - From: GeneCards, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
Generalized Anxiety Disorder 1 21 63
  • Anxiety Generalized
 10150261 10356651 18344738 16856115 14985704 9064274 18840371 16722631
Anxiety 1 21 63
  • Anxiety Disorder
  • Anxiety Disorders
  • Anxiety State
  • Anxieties
  • Anxiety Neurosis
 16979141 18047755 1763190 18163385 19423077 11498723 1498813
Agoraphobia 1 21 63
  • Fear Of Open Spaces
  • Phobia Of Going Out
 10870873 14984628
Mood Disorder 1 21 63
  • Mood Disorders
  • Episodic Mood Disorder
  • Other Specified Mood Disorders
  • Mood Disorders, Unspecified
 16467535 16863269 16756688 15262317 18047755 7753966 15458611 7612160 1971701 9164586 18499474 9084895 10893489 12917378
Premature Ejaculation 1 63
- COSMIC cancer census association via MalaCards
Search HTR1A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

5HT1A_HUMAN
  • Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269 PubMed:21990073}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for HTR1A

Human Genome Epidemiology Literature Finder
(Human Genome Epidemiology Literature Finder)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
The FABRIC Cancer Portal
(FABRIC)
Genes that share disorders with HTR1A: view

No data available for GENATLAS for HTR1A Gene

Publications for HTR1A Gene

Publications for HTR1A from MalaCards, NCBI Gene, PubMed, Novoseek, ClinVar, GAD, HMDB, UniProtKB/Swiss-Prot, HGNC, SIGNOR

(click the icon to the left of a publication to see abstract and related MeSH terms)

Title Association Year # Cit
Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene.
(Human mutation) Jiang YC … Sunny Sun H (21990073) 		Protein 4 Disorder 69 GeneVariant 107 2012 3
Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia.
(American journal of medical genetics) Kawanishi Y … Shiraishi H (9754630) 		Gene 3 38 Protein 4 1998 14
Lack of association between five serotonin metabolism-related genes and medication overuse headache.
(The journal of headache and pain) Cevoli S … Cortelli P (19936617) 		Gene 3 38 21* 2010 4
A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome.
(Psychiatric genetics) Dehning S … Zill P (20010450) 		Gene 3 38 21* 2010 16
No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment.
(European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology) Bukh JD … Kessing LV (20022223) 		Gene 3 38 21* 2010 9
Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.
(Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology) Juhasz G … Anderson IM (20043001) 		Gene 3 38 21* 2010 18
Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).
(Molecular psychiatry) Strug LJ … Weissman MM (18663369) 		Gene 3 38 21* 2010 30
Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter.
(European addiction research) Lee YS … Joe KH (19060480) 		Gene 3 38 21* 2009 12
Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
(Pharmacogenetics and genomics) Peters EJ … Hamilton SP (19077664) 		Gene 3 38 21* 2009 32
Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.
(American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics) Haenisch B … Bönisch H (19105200) 		Gene 3 38 21* 2009 20

Products for HTR1A Gene

  • Sino Biological Clones for HTR1A

Sources for HTR1A Gene