Aliases for HTN3 Gene
External Ids for HTN3 Gene
Previous GeneCards Identifiers for HTN3 Gene
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
GeneCards Summary for HTN3 Gene
HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include Oral Candidiasis and Candida Glabrata. Among its related pathways are Defensins and Salivary secretion. An important paralog of this gene is HTN1.
UniProtKB/Swiss-Prot for HTN3 Gene
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.