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Aliases for HTD2 Gene

Aliases for HTD2 Gene

  • Hydroxyacyl-Thioester Dehydratase Type 2 2 3 5
  • 3-Hydroxyacyl-[Acyl-Carrier-Protein] Dehydratase 3 4
  • Hydroxyacyl-Thioester Dehydratase Type 2, Mitochondrial 3
  • EC 4.2.1.- 4
  • HsHTD2 4

External Ids for HTD2 Gene

Summaries for HTD2 Gene

Entrez Gene Summary for HTD2 Gene

  • This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thought to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins. [provided by RefSeq, May 2017]

GeneCards Summary for HTD2 Gene

HTD2 (Hydroxyacyl-Thioester Dehydratase Type 2) is a Protein Coding gene. Among its related pathways are palmitate biosynthesis.

UniProtKB/Swiss-Prot for HTD2 Gene

  • Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.

Additional gene information for HTD2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTD2 Gene

Genomics for HTD2 Gene

GeneHancer (GH) Regulatory Elements for HTD2 Gene

Promoters and enhancers for HTD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J058305 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.0 1047 3.3 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 RPP14 HTD2 DENND6A ABHD6 PDHB ENSG00000273493 PXK PIR62243
GH03J058332 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 +28.2 28197 4.6 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF416 PXK DENND6A FLNB-AS1 FLNB KCTD6 RPP14 PDE12 LOC105377110 HTD2 FAM107A
GH03J058177 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -128.2 -128214 0.9 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF213 ZNF143 RUNX3 PPARG ENSG00000283148 ENSG00000283511 RPP14 DNASE1L3 HTD2 FLNB ABHD6 PXK LOC105377650
GH03J058469 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +165.4 165363 3.4 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 SLC30A9 RPP14 PXK PDHB LOC105377110 KCTD6 ACOX2 HTD2 FAM107A ENSG00000243384 ENSG00000272182
GH03J058172 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -131.1 -131105 4.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 SP5 MXD4 FLNB DNASE1L3 RPP14 HTD2 FLNB-AS1 ABHD6 KCTD6 LOC105377650 ENSG00000283148
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HTD2 Gene

Genomic Locations for HTD2 Gene
12,313 bases
Plus strand
507 bases
Plus strand

Genomic View for HTD2 Gene

Genes around HTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTD2 Gene

Proteins for HTD2 Gene

  • Protein details for HTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hydroxyacyl-thioester dehydratase type 2, mitochondrial
    Protein Accession:

    Protein attributes for HTD2 Gene

    168 amino acids
    Molecular mass:
    18559 Da
    Quaternary structure:
    No Data Available
    • This protein is produced by a bicistronic gene which also produces the RPP14 protein from an overlapping reading frame.

    Three dimensional structures from OCA and Proteopedia for HTD2 Gene

neXtProt entry for HTD2 Gene

Post-translational modifications for HTD2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HTD2 Gene

Domains & Families for HTD2 Gene

Protein Domains for HTD2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HTD2 family.
  • Belongs to the HTD2 family.
genes like me logo Genes that share domains with HTD2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for HTD2 Gene

Function for HTD2 Gene

Molecular function for HTD2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-hydroxyacyl-CoA = trans-2-enoyl-CoA + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-hydroxyacyl-[acyl-carrier-protein] = trans-2-enoyl-[acyl-carrier-protein] + H(2)O.

Enzyme Numbers (IUBMB) for HTD2 Gene

Phenotypes From GWAS Catalog for HTD2 Gene

Gene Ontology (GO) - Molecular Function for HTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0018812 3-hydroxyacyl-CoA dehydratase activity TAS --
genes like me logo Genes that share ontologies with HTD2: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTD2 Gene

Localization for HTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTD2 gene
Compartment Confidence
mitochondrion 4
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with HTD2: view

Pathways & Interactions for HTD2 Gene

genes like me logo Genes that share pathways with HTD2: view

Pathways by source for HTD2 Gene

2 BioSystems pathways for HTD2 Gene

Interacting Proteins for HTD2 Gene

Gene Ontology (GO) - Biological Process for HTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0046949 fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with HTD2: view

No data available for SIGNOR curated interactions for HTD2 Gene

Drugs & Compounds for HTD2 Gene

No Compound Related Data Available

Transcripts for HTD2 Gene

mRNA/cDNA for HTD2 Gene

(4) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HTD2 Gene

No ASD Table

Relevant External Links for HTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTD2 Gene

mRNA Expression by UniProt/SwissProt for HTD2 Gene:

Tissue specificity: Highly expressed in heart and liver. Expressed at lower levels in skeletal muscle, spleen, kidney and placenta.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTD2 Gene

Orthologs for HTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPP14 34
  • 99 (a)
(Mus musculus)
Mammalia Rpp14 34
  • 79 (a)
(Gallus gallus)
Aves -- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
Species where no ortholog for HTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTD2 Gene

Gene Tree for HTD2 (if available)
Gene Tree for HTD2 (if available)

Paralogs for HTD2 Gene

No data available for Paralogs for HTD2 Gene

Variants for HTD2 Gene

Additional Variant Information for HTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for HTD2 Gene

Disorders for HTD2 Gene

Additional Disease Information for HTD2

No disorders were found for HTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HTD2 Gene

Publications for HTD2 Gene

  1. An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. (PMID: 17898086) Autio KJ … Hiltunen JK (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008) 2 3 4 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  3. Death of a dogma: eukaryotic mRNAs can code for more than one protein. (PMID: 26578573) Mouilleron H … Roucou X (Nucleic acids research 2016) 3 58
  4. A draft map of the human proteome. (PMID: 24870542) Kim MS … Pandey A (Nature 2014) 3 58
  5. Direct detection of alternative open reading frames translation products in human significantly expands the proteome. (PMID: 23950983) Vanderperre B … Roucou X (PloS one 2013) 3 58

Products for HTD2 Gene

Sources for HTD2 Gene

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