Aliases for HTATIP2 Gene

Aliases for HTATIP2 Gene

  • HIV-1 Tat Interactive Protein 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 44U, Member 1 2 3
  • HIV-1 Tat Interactive Protein 2, 30kDa 2 3
  • 30 KDa HIV-1 TAT-Interacting Protein 3 4
  • HIV-1 TAT-Interactive Protein 2 3 4
  • Tat-Interacting Protein (30kD) 2 3
  • Oxidoreductase HTATIP2 3 4
  • TIP30 3 4
  • CC3 3 4
  • HIV-1 Tat Interactive Protein 2, 30 KDa 2
  • EC 1.1.1.- 4
  • EC 1.1.1 52
  • SDR44U1 3

External Ids for HTATIP2 Gene

Previous GeneCards Identifiers for HTATIP2 Gene

  • GC11P021546
  • GC11P021329
  • GC11P020424
  • GC11P020349
  • GC11P020341
  • GC11P020068
  • GC11P020385

Summaries for HTATIP2 Gene

GeneCards Summary for HTATIP2 Gene

HTATIP2 (HIV-1 Tat Interactive Protein 2) is a Protein Coding gene. Diseases associated with HTATIP2 include Cervical Cancer and Lacrimal Gland Carcinoma. Among its related pathways are Apoptosis and Autophagy and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding.

UniProtKB/Swiss-Prot Summary for HTATIP2 Gene

  • Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Gene Wiki entry for HTATIP2 Gene

Additional gene information for HTATIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HTATIP2 Gene

Genomics for HTATIP2 Gene

GeneHancer (GH) Regulatory Elements for HTATIP2 Gene

Promoters and enhancers for HTATIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J020362 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 574.1 +2.6 2554 7.1 NRF1 TCF12 USF1 GTF2E2 PHF8 JUND TEAD4 FOS ZFX ZNF10 HTATIP2 SLC6A5 NONHSAG007838.2
GH11J020386 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 29.5 +24.7 24711 4 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 MYC POLR2G PRMT3 lnc-DBX1-7 HTATIP2 piR-45035-033
GH11J020360 Enhancer 0.7 ENCODE 61.2 -2.8 -2829 1.2 USF1 TOE1 RAD51 USF2 IRF1 IRF2 ELF1 FOXM1 PRDM1 MITF piR-46847-045 HTATIP2 piR-40110-096
GH11J020458 Enhancer 1.1 Ensembl ENCODE 28.8 +95.6 95616 5.8 ZBTB40 PHB2 ZBTB11 AFF1 TARDBP HES1 ZNF740 NR3C1 MYC CTBP1 HTATIP2 PRMT3 piR-45035-033
GH11J020473 Enhancer 1 Ensembl ENCODE 16 +112.5 112515 5.2 ZBTB11 FOXA1 CUX1 ZNF740 JUN TAF9B RELA FOXA2 ZNF316 ARNT HTATIP2 piR-45035-033 HSALNG0083094 PRMT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HTATIP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HTATIP2

Top Transcription factor binding sites by QIAGEN in the HTATIP2 gene promoter:
  • GCNF
  • HNF-1A
  • LCR-F1

Genomic Locations for HTATIP2 Gene

Genomic Locations for HTATIP2 Gene
chr11:20,363,685-20,383,783
(GRCh38/hg38)
Size:
20,099 bases
Orientation:
Plus strand
chr11:20,385,231-20,405,329
(GRCh37/hg19)
Size:
20,099 bases
Orientation:
Plus strand

Genomic View for HTATIP2 Gene

Genes around HTATIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTATIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTATIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTATIP2 Gene

Proteins for HTATIP2 Gene

  • Protein details for HTATIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUP3-HTAI2_HUMAN
    Recommended name:
    Oxidoreductase HTATIP2
    Protein Accession:
    Q9BUP3
    Secondary Accessions:
    • A8K7S7
    • D3DQY8
    • O15383
    • O60520
    • O95345
    • Q53GC1
    • Q53GG2
    • Q6IBI3

    Protein attributes for HTATIP2 Gene

    Size:
    242 amino acids
    Molecular mass:
    27049 Da
    Quaternary structure:
    • Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus.
    • (Microbial infection) Interacts with HIV-1 Tat (via activation domain).
    Miscellaneous:
    • [Isoform 2]: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect.

    Three dimensional structures from OCA and Proteopedia for HTATIP2 Gene

    Alternative splice isoforms for HTATIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTATIP2 Gene

Selected DME Specific Peptides for HTATIP2 Gene

Q9BUP3:
  • YASAFQGHDVGFCCLGTTR
  • QMELLENKAI
  • MQNKSVFILGASGETG
  • VPVVTVVRAMLN
  • LFSKVTLIGRRKLTF
  • EEAYKNVNQEVVDFEKLD
  • FLYLQVKGEVEAKVEELKFDR

Post-translational modifications for HTATIP2 Gene

  • Ubiquitination at Lys36 and Lys137
  • Modification sites at PhosphoSitePlus

Domains & Families for HTATIP2 Gene

Gene Families for HTATIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HTATIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HTATIP2 Gene

GenScript: Design optimal peptide antigens:
  • HIV-1 TAT-interactive protein 2 (HTAI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUP3

UniProtKB/Swiss-Prot:

HTAI2_HUMAN :
  • Unique C-terminus confers high proteasome-dependent instability to isoform 2.
Domain:
  • Unique C-terminus confers high proteasome-dependent instability to isoform 2.
genes like me logo Genes that share domains with HTATIP2: view

Function for HTATIP2 Gene

Molecular function for HTATIP2 Gene

UniProtKB/Swiss-Prot Function:
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Enzyme Numbers (IUBMB) for HTATIP2 Gene

Phenotypes From GWAS Catalog for HTATIP2 Gene

Gene Ontology (GO) - Molecular Function for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9482853
GO:0005515 protein binding IPI 15282309
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HTATIP2: view
genes like me logo Genes that share phenotypes with HTATIP2: view

Animal Models for HTATIP2 Gene

MGI Knock Outs for HTATIP2:

Animal Model Products

CRISPR Products

miRNA for HTATIP2 Gene

miRTarBase miRNAs that target HTATIP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTATIP2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTATIP2 Gene

Localization for HTATIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTATIP2 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTATIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9482853
GO:0005635 nuclear envelope IDA,IEA 15282309
GO:0005737 cytoplasm IBA,IDA 15282309
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HTATIP2: view

Pathways & Interactions for HTATIP2 Gene

PathCards logo

SuperPathways for HTATIP2 Gene

genes like me logo Genes that share pathways with HTATIP2: view

Pathways by source for HTATIP2 Gene

2 Cell Signaling Technology pathways for HTATIP2 Gene
1 GeneTex pathway for HTATIP2 Gene

Gene Ontology (GO) - Biological Process for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9482853
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with HTATIP2: view

No data available for SIGNOR curated interactions for HTATIP2 Gene

Drugs & Compounds for HTATIP2 Gene

(1) Drugs for HTATIP2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Polyethylene glycol 400 Approved Pharma Target 0

(1) Additional Compounds for HTATIP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with HTATIP2: view

Transcripts for HTATIP2 Gene

mRNA/cDNA for HTATIP2 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HTATIP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTATIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for HTATIP2 Gene

GeneLoc Exon Structure for
HTATIP2

Expression for HTATIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTATIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTATIP2 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for HTATIP2 Gene

This gene is overexpressed in Nasal epithelium (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HTATIP2 Gene



Protein tissue co-expression partners for HTATIP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HTATIP2

SOURCE GeneReport for Unigene cluster for HTATIP2 Gene:

Hs.90753

mRNA Expression by UniProt/SwissProt for HTATIP2 Gene:

Q9BUP3-HTAI2_HUMAN
Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.

Evidence on tissue expression from TISSUES for HTATIP2 Gene

  • Pancreas(4.2)
  • Skin(4.2)
  • Lung(3.2)
  • Liver(2.3)
  • Intestine(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with HTATIP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTATIP2 Gene

Orthologs for HTATIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HTATIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTATIP2 31 30
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HTATIP2 31 30
  • 91.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HTATIP2 31 30
  • 88.98 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Htatip2 17 31 30
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Htatip2 30
  • 85.11 (n)
oppossum
(Monodelphis domestica)
Mammalia HTATIP2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTATIP2 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTATIP2 31
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTATIP2 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htatip2 30
  • 66.96 (n)
Str.6467 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24303 30
zebrafish
(Danio rerio)
Actinopterygii htatip2 31 30
  • 64.48 (n)
OneToOne
-- 30
worm
(Caenorhabditis elegans)
Secernentea C33F10.14 31 30
  • 52.46 (n)
OneToOne
C33F10.4 32
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP52 31
  • 28 (a)
OneToOne
Species where no ortholog for HTATIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTATIP2 Gene

ENSEMBL:
Gene Tree for HTATIP2 (if available)
TreeFam:
Gene Tree for HTATIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HTATIP2: view image

Paralogs for HTATIP2 Gene

No data available for Paralogs for HTATIP2 Gene

Variants for HTATIP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HTATIP2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs761113892 A hepatocellular carcinoma sample p.Ala116Thr
VAR_023713 A hepatocellular carcinoma sample p.Arg106Ser
VAR_023714 A hepatocellular carcinoma sample p.Asp108Tyr
VAR_023716 A hepatocellular carcinoma sample p.Gly134Val
VAR_023717 A hepatocellular carcinoma sample p.Leu144Ile

Additional dbSNP identifiers (rs#s) for HTATIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HTATIP2 Gene

Variant ID Type Subtype PubMed ID
nsv467720 CNV gain 19166990
nsv469939 CNV gain 18288195
nsv553678 CNV gain 21841781
nsv7702 CNV insertion 18451855
nsv832083 CNV gain 17160897

Variation tolerance for HTATIP2 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTATIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTATIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTATIP2 Gene

Disorders for HTATIP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for HTATIP2 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cervical cancer
  • cervical cancer, somatic
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
gnathodiaphyseal dysplasia
  • gdd
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
non-invasive bladder papillary urothelial neoplasm
  • bladder papillary neoplasm of low malignant potential
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HTATIP2

genes like me logo Genes that share disorders with HTATIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTATIP2 Gene

Publications for HTATIP2 Gene

  1. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. (PMID: 9174052) Shtivelman E (Oncogene 1997) 2 3 4 23 54
  2. TIP30 deficiency increases susceptibility to tumorigenesis. (PMID: 14695192) Ito M … Xiao H (Cancer research 2003) 3 4 23 54
  3. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. (PMID: 11313954) NicAmhlaoibh R … Shtivelman E (Oncogene 2001) 3 4 23 54
  4. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. (PMID: 10611237) Whitman S … Shtivelman E (Molecular and cellular biology 2000) 3 4 23 54
  5. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. (PMID: 9482853) Xiao H … Roeder RG (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 54

Products for HTATIP2 Gene

Sources for HTATIP2 Gene