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Aliases for HSPE1-MOB4 Gene

Aliases for HSPE1-MOB4 Gene

  • HSPE1-MOB4 Readthrough 2 3 5
  • HSPE1-MOB4 Protein 3

External Ids for HSPE1-MOB4 Gene

Previous GeneCards Identifiers for HSPE1-MOB4 Gene

  • GC02U902474
  • GC02P198364

Summaries for HSPE1-MOB4 Gene

Entrez Gene Summary for HSPE1-MOB4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011]

GeneCards Summary for HSPE1-MOB4 Gene

HSPE1-MOB4 (HSPE1-MOB4 Readthrough) is a Protein Coding gene. An important paralog of this gene is MOB4.

Additional gene information for HSPE1-MOB4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1-MOB4 Gene

Genomics for HSPE1-MOB4 Gene

GeneHancer (GH) Regulatory Elements for HSPE1-MOB4 Gene

Promoters and enhancers for HSPE1-MOB4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I197495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 -0.5 -488 7.5 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 GC02P197502 HSPE1 HSPE1-MOB4 HSPD1 SF3B1 NPM1P46 GTF3C3 RNU6-1029P ANKRD44 ENSG00000202434
GH02I197513 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.4 +15.8 15824 3.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 MOB4 HSPD1 PLCL1 HSPE1-MOB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPE1-MOB4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HSPE1-MOB4 Gene

Genomic Locations for HSPE1-MOB4 Gene
53,703 bases
Plus strand

Genomic View for HSPE1-MOB4 Gene

Genes around HSPE1-MOB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPE1-MOB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPE1-MOB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1-MOB4 Gene

Proteins for HSPE1-MOB4 Gene

  • Protein details for HSPE1-MOB4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    HSPE1-MOB4 readthrough
    Protein Accession:

    Protein attributes for HSPE1-MOB4 Gene

    261 amino acids
    Molecular mass:
    29737 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPE1-MOB4 Gene

Post-translational modifications for HSPE1-MOB4 Gene

No Post-translational modifications

Other Protein References for HSPE1-MOB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPE1-MOB4 Gene

Domains & Families for HSPE1-MOB4 Gene

Gene Families for HSPE1-MOB4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPE1-MOB4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Function for HSPE1-MOB4 Gene

Phenotypes From GWAS Catalog for HSPE1-MOB4 Gene

Phenotypes for HSPE1-MOB4 Gene

genes like me logo Genes that share phenotypes with HSPE1-MOB4: view

Animal Model Products

miRNA for HSPE1-MOB4 Gene

miRTarBase miRNAs that target HSPE1-MOB4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPE1-MOB4 Gene

Localization for HSPE1-MOB4 Gene

Gene Ontology (GO) - Cellular Components for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSPE1-MOB4 Gene

Pathways & Interactions for HSPE1-MOB4 Gene

SuperPathways for HSPE1-MOB4 Gene

No Data Available

Interacting Proteins for HSPE1-MOB4 Gene

Gene Ontology (GO) - Biological Process for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Pathways by source and SIGNOR curated interactions for HSPE1-MOB4 Gene

Drugs & Compounds for HSPE1-MOB4 Gene

No Compound Related Data Available

Transcripts for HSPE1-MOB4 Gene

mRNA/cDNA for HSPE1-MOB4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1-MOB4 Gene

No ASD Table

Relevant External Links for HSPE1-MOB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPE1-MOB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPE1-MOB4 Gene

Protein differential expression in normal tissues from HIPED for HSPE1-MOB4 Gene

This gene is overexpressed in Fetal Brain (6.9) and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for HSPE1-MOB4 Gene

Protein tissue co-expression partners for HSPE1-MOB4 Gene

genes like me logo Genes that share expression patterns with HSPE1-MOB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPE1-MOB4 Gene

Orthologs for HSPE1-MOB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPE1-MOB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MOBKL3 34
  • 93 (a)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
(Gallus gallus)
Aves MOB4 34
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 92 (a)
(Danio rerio)
Actinopterygii mob4 34
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob4 34
  • 76 (a)
(Caenorhabditis elegans)
Secernentea C30A5.3 34
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5204 34
  • 70 (a)
Species where no ortholog for HSPE1-MOB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPE1-MOB4 Gene

Gene Tree for HSPE1-MOB4 (if available)
Gene Tree for HSPE1-MOB4 (if available)

Paralogs for HSPE1-MOB4 Gene

Paralogs for HSPE1-MOB4 Gene

(3) SIMAP similar genes for HSPE1-MOB4 Gene using alignment to 1 proteins: Pseudogenes for HSPE1-MOB4 Gene

genes like me logo Genes that share paralogs with HSPE1-MOB4: view

Variants for HSPE1-MOB4 Gene

Sequence variations from dbSNP and Humsavar for HSPE1-MOB4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1050347 conflicting-interpretations-of-pathogenicity, benign, not specified, Spastic Paraplegia, Dominant 197,498,780(+) A/G upstream_transcript_variant
rs1052453050 uncertain-significance, Spastic Paraplegia, Dominant 197,499,907(+) G/C upstream_transcript_variant
rs11551346 benign, likely-benign, not specified, Spastic Paraplegia, Dominant, Spastic paraplegia 197,498,705(+) G/A/C upstream_transcript_variant
rs11551349 uncertain-significance, benign, likely-benign, not provided, not specified, Spastic paraplegia, Spastic Paraplegia, Dominant 197,498,822(+) G/A/C upstream_transcript_variant
rs13165 benign, not specified, Spastic Paraplegia, Dominant 197,499,794(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPE1-MOB4 Gene

Variant ID Type Subtype PubMed ID
nsv979162 CNV duplication 23825009
nsv979161 CNV duplication 23825009
nsv963758 CNV duplication 23825009
nsv961921 CNV duplication 23825009
nsv584156 CNV gain 21841781
nsv1014881 CNV gain 25217958
esv3443077 CNV insertion 20981092

Variation tolerance for HSPE1-MOB4 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPE1-MOB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Disorders for HSPE1-MOB4 Gene

Additional Disease Information for HSPE1-MOB4

No disorders were found for HSPE1-MOB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPE1-MOB4 Gene

Publications for HSPE1-MOB4 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for HSPE1-MOB4 Gene

Sources for HSPE1-MOB4 Gene

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