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Aliases for HSPBP1 Gene

Aliases for HSPBP1 Gene

  • HSPA (Hsp70) Binding Protein 1 2 3 5
  • HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1 2 3
  • Heat Shock Protein-Binding Protein 1 3 4
  • Hsp70 Interacting Protein 2 3
  • Hsp70-Interacting Protein 1 4
  • Hsp70-Interacting Protein 2 4
  • Hsp70-Binding Protein 1 3
  • Hsp70-Binding Protein 2 4
  • HspBP1 4
  • HspBP2 4
  • HSPBP 4
  • FES1 3

External Ids for HSPBP1 Gene

Previous GeneCards Identifiers for HSPBP1 Gene

  • GC19M056638
  • GC19M056198
  • GC19M060449
  • GC19M060465
  • GC19M055773
  • GC19M052097

Summaries for HSPBP1 Gene

GeneCards Summary for HSPBP1 Gene

HSPBP1 (HSPA (Hsp70) Binding Protein 1) is a Protein Coding gene. Diseases associated with HSPBP1 include Long Qt Syndrome 2. Among its related pathways are Protein processing in endoplasmic reticulum and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for HSPBP1 Gene

  • Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Wiki entry for HSPBP1 Gene

Additional gene information for HSPBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBP1 Gene

Genomics for HSPBP1 Gene

GeneHancer (GH) Regulatory Elements for HSPBP1 Gene

Promoters and enhancers for HSPBP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055278 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.1 0.0 -22 2.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF213 HSPBP1 BRSK1 LENG8-AS1 LENG8 ENSG00000235681 U2AF2 ENSG00000267523 SSC5D ZNF581 CDC42EP5
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 26.3 +26.5 26524 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -59.4 -59445 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
GH19I055283 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.6 -4.3 -4329 2.5 HDAC1 HDGF ZNF76 GLI4 ZNF48 ZEB1 ZNF335 GLIS2 ZNF366 CREM BRSK1 FIZ1 NAT14 ENSG00000235681 LENG8-AS1 ZNF580 ENSG00000267838 LENG8 SSC5D HSPBP1
GH19I055215 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 11.5 +63.7 63678 2.9 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ENSG00000267649 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ENSG00000267096 ZNF581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPBP1 gene promoter:

Genomic Locations for HSPBP1 Gene

Genomic Locations for HSPBP1 Gene
18,162 bases
Minus strand

Genomic View for HSPBP1 Gene

Genes around HSPBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBP1 Gene

Proteins for HSPBP1 Gene

  • Protein details for HSPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hsp70-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KQP0
    • B4DG11
    • O95351
    • Q6ZNU5

    Protein attributes for HSPBP1 Gene

    362 amino acids
    Molecular mass:
    39474 Da
    Quaternary structure:
    • Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.

    Three dimensional structures from OCA and Proteopedia for HSPBP1 Gene

    Alternative splice isoforms for HSPBP1 Gene


neXtProt entry for HSPBP1 Gene

Post-translational modifications for HSPBP1 Gene

  • Ubiquitination at posLast=9797, posLast=210210, and posLast=248248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HSPBP1 Gene

Domains & Families for HSPBP1 Gene

Gene Families for HSPBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPBP1 Gene

Suggested Antigen Peptide Sequences for HSPBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPBP1: view

No data available for UniProtKB/Swiss-Prot for HSPBP1 Gene

Function for HSPBP1 Gene

Molecular function for HSPBP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Phenotypes From GWAS Catalog for HSPBP1 Gene

Gene Ontology (GO) - Molecular Function for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity TAS 9830037
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HSPBP1: view
genes like me logo Genes that share phenotypes with HSPBP1: view

Animal Models for HSPBP1 Gene

MGI Knock Outs for HSPBP1:

Animal Model Products

miRNA for HSPBP1 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPBP1 Gene

Localization for HSPBP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPBP1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSPBP1 Gene

Pathways & Interactions for HSPBP1 Gene

genes like me logo Genes that share pathways with HSPBP1: view

Pathways by source for HSPBP1 Gene

Gene Ontology (GO) - Biological Process for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9830037
GO:0031398 positive regulation of protein ubiquitination IDA 16831871
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 16831871
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with HSPBP1: view

No data available for SIGNOR curated interactions for HSPBP1 Gene

Drugs & Compounds for HSPBP1 Gene

No Compound Related Data Available

Transcripts for HSPBP1 Gene

Unigene Clusters for HSPBP1 Gene

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
SP2: - -
SP3: - -
SP5: -
SP6: -

Relevant External Links for HSPBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPBP1 Gene

Protein differential expression in normal tissues from HIPED for HSPBP1 Gene

This gene is overexpressed in Bone (27.2) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPBP1 Gene

Protein tissue co-expression partners for HSPBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPBP1 Gene:


SOURCE GeneReport for Unigene cluster for HSPBP1 Gene:


mRNA Expression by UniProt/SwissProt for HSPBP1 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HSPBP1 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Heart(4.3)
  • Spleen(4.2)
  • Pancreas(2.6)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with HSPBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPBP1 Gene

Orthologs for HSPBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPBP1 34
  • 99 (a)
(Bos Taurus)
Mammalia HSPBP1 33 34
  • 89.17 (n)
(Canis familiaris)
Mammalia HSPBP1 33 34
  • 88.52 (n)
(Rattus norvegicus)
Mammalia Hspbp1 33
  • 87.02 (n)
(Mus musculus)
Mammalia Hspbp1 33 16 34
  • 86.46 (n)
(Monodelphis domestica)
Mammalia HSPBP1 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia HSPBP1 34
  • 74 (a)
(Gallus gallus)
Aves HSPBP1 34
  • 46 (a)
(Anolis carolinensis)
Reptilia HSPBP1 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspbp1 33
  • 63.47 (n)
Str.2669 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16057 33
(Danio rerio)
Actinopterygii hspbp1 33 34
  • 58.78 (n)
idibd1110 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.342 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008392 33
  • 48.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10973 33
  • 38.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Fes1A 33
  • 39.15 (n)
(Oryza sativa)
Liliopsida Os03g0822700 33
  • 41.94 (n)
Species where no ortholog for HSPBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBP1 Gene

Gene Tree for HSPBP1 (if available)
Gene Tree for HSPBP1 (if available)

Paralogs for HSPBP1 Gene

No data available for Paralogs for HSPBP1 Gene

Variants for HSPBP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000144911 -- 55,280,969(-) G/T upstream_transcript_variant
rs1000229684 -- 55,269,832(-) C/T intron_variant
rs1000419104 -- 55,270,285(-) T/A intron_variant
rs1000434554 -- 55,263,713(-) C/G intron_variant
rs1000619537 -- 55,268,804(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPBP1 Gene

Variant ID Type Subtype PubMed ID
esv3338654 CNV duplication 20981092

Variation tolerance for HSPBP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPBP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBP1 Gene

Disorders for HSPBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPBP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
long qt syndrome 2
  • long qt syndrome 9
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPBP1

genes like me logo Genes that share disorders with HSPBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPBP1 Gene

Publications for HSPBP1 Gene

  1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PMID: 10786638) Raynes DA … Guerriero V (Biochimica et biophysica acta 2000) 2 3 4 22 58
  2. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PMID: 9830037) Raynes DA … Guerriero V (The Journal of biological chemistry 1998) 2 3 4 22 58
  3. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. (PMID: 17855353) Tanimura S … Kohno M (The Journal of biological chemistry 2007) 3 22 58
  4. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PMID: 16677834) Gottwald E … Guerriero V (Cell biology international 2006) 3 22 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for HSPBP1 Gene

Sources for HSPBP1 Gene

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