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Aliases for HSPBAP1 Gene

Aliases for HSPBAP1 Gene

  • HSPB1 Associated Protein 1 2 3 5
  • 27 KDa Heat Shock Protein-Associated Protein 1 3 4
  • HSPB (Heat Shock 27kDa) Associated Protein 1 2 3
  • PASS1 3 4
  • Protein Associating With Small Stress Protein PASS1 3
  • Protein Associated With Small Stress Protein 1 4
  • HSPB1-Associated Protein 1 3

External Ids for HSPBAP1 Gene

Previous GeneCards Identifiers for HSPBAP1 Gene

  • GC03M119179
  • GC03M122407
  • GC03M123740
  • GC03M123779
  • GC03M123941
  • GC03M119832

Summaries for HSPBAP1 Gene

Entrez Gene Summary for HSPBAP1 Gene

  • This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]

GeneCards Summary for HSPBAP1 Gene

HSPBAP1 (HSPB1 Associated Protein 1) is a Protein Coding gene. Diseases associated with HSPBAP1 include Renal Cell Carcinoma, Nonpapillary. An important paralog of this gene is HIF1AN.

UniProtKB/Swiss-Prot for HSPBAP1 Gene

  • May play a role in cellular stress response.

Additional gene information for HSPBAP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBAP1 Gene

Genomics for HSPBAP1 Gene

GeneHancer (GH) Regulatory Elements for HSPBAP1 Gene

Promoters and enhancers for HSPBAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I122792 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559 +0.8 790 3.9 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF213 ZNF207 HSPBAP1 DIRC2 ENSG00000273454 IQCB1 PARP14 SEC22A LOC102723582 LINC02035
GH03I122766 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 42.8 +26.9 26895 3.8 POLR2A DIRC2 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1
GH03I122678 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +113.9 113918 5.9 HDGF SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ATF7 RUNX3 PARP14 DTX3L PARP9 HSPBAP1 DIRC2 LINC02035 CSTA KPNA1
GH03I122758 Enhancer 0.8 Ensembl ENCODE dbSUPER 22.9 +35.8 35762 1.7 POLR2A PRDM4 HSPBAP1 DIRC2 LINC02035 PARP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPBAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPBAP1 gene promoter:

Genomic Locations for HSPBAP1 Gene

Genomic Locations for HSPBAP1 Gene
55,220 bases
Minus strand

Genomic View for HSPBAP1 Gene

Genes around HSPBAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPBAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPBAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBAP1 Gene

Proteins for HSPBAP1 Gene

  • Protein details for HSPBAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HSPB1-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6P476
    • Q8N8J4
    • Q8NHH6
    • Q8WWF0

    Protein attributes for HSPBAP1 Gene

    488 amino acids
    Molecular mass:
    55167 Da
    Quaternary structure:
    • Interacts with CRYAB and HSPB1.
    • Sequence=AAH17763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPBAP1 Gene


neXtProt entry for HSPBAP1 Gene

Post-translational modifications for HSPBAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPBAP1 Gene

No data available for DME Specific Peptides for HSPBAP1 Gene

Domains & Families for HSPBAP1 Gene

Gene Families for HSPBAP1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HSPBAP1 Gene

Suggested Antigen Peptide Sequences for HSPBAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPBAP1: view

No data available for UniProtKB/Swiss-Prot for HSPBAP1 Gene

Function for HSPBAP1 Gene

Molecular function for HSPBAP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular stress response.

Phenotypes From GWAS Catalog for HSPBAP1 Gene

Gene Ontology (GO) - Molecular Function for HSPBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSPBAP1: view
genes like me logo Genes that share phenotypes with HSPBAP1: view

Animal Model Products

CRISPR Products

miRNA for HSPBAP1 Gene

miRTarBase miRNAs that target HSPBAP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPBAP1 Gene

Localization for HSPBAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPBAP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPBAP1 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSPBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPBAP1: view

Pathways & Interactions for HSPBAP1 Gene

SuperPathways for HSPBAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPBAP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSPBAP1 Gene

Drugs & Compounds for HSPBAP1 Gene

No Compound Related Data Available

Transcripts for HSPBAP1 Gene

Unigene Clusters for HSPBAP1 Gene

HSPB (heat shock 27kDa) associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBAP1 Gene

No ASD Table

Relevant External Links for HSPBAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPBAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPBAP1 Gene

mRNA differential expression in normal tissues according to GTEx for HSPBAP1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for HSPBAP1 Gene

This gene is overexpressed in Testis (33.1), Placenta (14.3), and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPBAP1 Gene

Protein tissue co-expression partners for HSPBAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPBAP1 Gene:


SOURCE GeneReport for Unigene cluster for HSPBAP1 Gene:


mRNA Expression by UniProt/SwissProt for HSPBAP1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HSPBAP1 Gene

  • Lung(4.2)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPBAP1 Gene

Germ Layers:
  • mesoderm
  • urinary
  • kidney
genes like me logo Genes that share expression patterns with HSPBAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HSPBAP1 Gene

Orthologs for HSPBAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPBAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPBAP1 33 34
  • 99.45 (n)
(Bos Taurus)
Mammalia HSPBAP1 33 34
  • 87.14 (n)
(Canis familiaris)
Mammalia HSPBAP1 33 34
  • 86.79 (n)
(Rattus norvegicus)
Mammalia Hspbap1 33
  • 78.78 (n)
(Mus musculus)
Mammalia Hspbap1 33 16 34
  • 78.29 (n)
(Monodelphis domestica)
Mammalia HSPBAP1 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HSPBAP1 34
  • 48 (a)
(Gallus gallus)
Aves HSPBAP1 33 34
  • 68.05 (n)
(Anolis carolinensis)
Reptilia HSPBAP1 34
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20828 33
(Danio rerio)
Actinopterygii hspbap1 33 34
  • 57.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43320 34
  • 23 (a)
Species where no ortholog for HSPBAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBAP1 Gene

Gene Tree for HSPBAP1 (if available)
Gene Tree for HSPBAP1 (if available)

Paralogs for HSPBAP1 Gene

Paralogs for HSPBAP1 Gene Pseudogenes for HSPBAP1 Gene

genes like me logo Genes that share paralogs with HSPBAP1: view

Variants for HSPBAP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBAP1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000027824 -- 122,743,820(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000115234 -- 122,768,440(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000121196 -- 122,763,876(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000272972 -- 122,787,266(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000299953 -- 122,753,992(-) G/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPBAP1 Gene

Variant ID Type Subtype PubMed ID
esv1422853 CNV deletion 17803354
nsv3975 CNV deletion 18451855
nsv822228 CNV loss 20364138
nsv829705 CNV loss 17160897

Variation tolerance for HSPBAP1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPBAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBAP1 Gene

Disorders for HSPBAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPBAP1 Gene - From: Orphanet

Disorder Aliases PubMed IDs
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving HSPBAP1 has been found in a family with renal carcinoma (PubMed:12939738). Translocation t(2;3)(q35;q21) with the putative pseudogene DIRC3 (PubMed:12939738). Produces a hybrid mRNA encoding a truncated HSPBAP1 lacking the first 36 amino acids (PubMed:12939738). {ECO:0000269 PubMed:12939738}.

Additional Disease Information for HSPBAP1

genes like me logo Genes that share disorders with HSPBAP1: view

No data available for Genatlas for HSPBAP1 Gene

Publications for HSPBAP1 Gene

  1. Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain. (PMID: 11978969) Jiang M … Mao Y (Cytogenetics and cell genetics 2001) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions. (PMID: 25359680) Saeed K … Rantala JK (International journal of cancer 2015) 3 58

Products for HSPBAP1 Gene

Sources for HSPBAP1 Gene

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