Aliases for HSPB6 Gene
External Ids for HSPB6 Gene
Previous GeneCards Identifiers for HSPB6 Gene
This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
GeneCards Summary for HSPB6 Gene
HSPB6 (Heat Shock Protein Family B (Small) Member 6) is a Protein Coding gene. Diseases associated with HSPB6 include Cerebral Amyloid Angiopathy, Cst3-Related and Myopathy, Myofibrillar, 6. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is CRYAB.
UniProtKB/Swiss-Prot Summary for HSPB6 Gene
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.