This locus represents naturally occurring read-through transcription between the neighboring heat shock 27kDa protein 2 (HSPB2) and chromosome 11 open reading frame 52 (C11orf52) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) based on the use of the supported HSPB2 translational start codon, and it is therefore unlikely to produce a pro... See more...

Aliases for HSPB2-C11orf52 Gene

Data sources for HSPB2-C11orf52 Gene:

RNA type for HSPB2-C11orf52 Gene

lncRNA

Aliases for HSPB2-C11orf52 Gene

External Ids for HSPB2-C11orf52 Gene

Previous GeneCards Identifiers for HSPB2-C11orf52 Gene

  • GC11U901862
  • GC11P111785

Summaries for HSPB2-C11orf52 Gene

Entrez Gene Summary for HSPB2-C11orf52 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring heat shock 27kDa protein 2 (HSPB2) and chromosome 11 open reading frame 52 (C11orf52) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) based on the use of the supported HSPB2 translational start codon, and it is therefore unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

GeneCards Summary for HSPB2-C11orf52 Gene

HSPB2-C11orf52 (HSPB2-C11orf52 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is HSPB2.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPB2-C11orf52 Gene

Genomics for HSPB2-C11orf52 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPB2-C11orf52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPB2-C11orf52 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for HSPB2-C11orf52 Gene

Latest Assembly
chr11:111,912,736-111,926,871
(GRCh38/hg38)
Size:
14,136 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,783,460-111,797,595
(GRCh37/hg19 by Entrez Gene)
Size:
14,136 bases
Orientation:
Plus strand

chr11:111,783,460-111,797,595
(GRCh37/hg19 by Ensembl)
Size:
14,136 bases
Orientation:
Plus strand

Genomic View for HSPB2-C11orf52 Gene

Genes around HSPB2-C11orf52 on UCSC Golden Path with GeneCards custom track
HSPB2-C11orf52 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
HSPB2-C11orf52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB2-C11orf52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB2-C11orf52 Gene

Proteins for HSPB2-C11orf52 Gene

  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A8KAH6-A8KAH6_HUMAN
    Recommended name:
    Heat shock 27kDa protein 2, isoform CRA_a
    Protein Accession:
    A8KAH6

    Protein attributes for HSPB2-C11orf52 Gene

    Size:
    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    No Data Available
  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PN16-E9PN16_HUMAN
    Recommended name:
    HSPB2-C11orf52 readthrough (NMD candidate)
    Protein Accession:
    E9PN16

    Protein attributes for HSPB2-C11orf52 Gene

    Size:
    52 amino acids
    Molecular mass:
    5934 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPB2-C11orf52 Gene

Protein Expression for HSPB2-C11orf52 Gene

Post-translational modifications for HSPB2-C11orf52 Gene

No Post-translational modifications

Other Protein References for HSPB2-C11orf52 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HSPB2-C11orf52 Gene

Domains & Families for HSPB2-C11orf52 Gene

Gene Families for HSPB2-C11orf52 Gene

Unknown:
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB2-C11orf52: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HSPB2-C11orf52 Gene

Function for HSPB2-C11orf52 Gene

Phenotypes From GWAS Catalog for HSPB2-C11orf52 Gene

Gene Ontology (GO) - Molecular Function for HSPB2-C11orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
genes like me logo Genes that share ontologies with HSPB2-C11orf52: view

CRISPR products for research

miRNA for HSPB2-C11orf52 Gene

miRTarBase miRNAs that target HSPB2-C11orf52

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPB2-C11orf52 Gene

Localization for HSPB2-C11orf52 Gene

Gene Ontology (GO) - Cellular Components for HSPB2-C11orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPB2-C11orf52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSPB2-C11orf52 Gene

Pathways & Interactions for HSPB2-C11orf52 Gene

PathCards logo

SuperPathways for HSPB2-C11orf52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPB2-C11orf52 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for HSPB2-C11orf52 Gene

Drugs & Compounds for HSPB2-C11orf52 Gene

No Compound Related Data Available

Transcripts for HSPB2-C11orf52 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for HSPB2-C11orf52 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075D214_9606 lncRNA 1527 1

RefSeq: NR_037651,

URS00009C320E_9606 lncRNA 1035 2

LncBook: HSALNT0181108,

NONCODE: NONHSAT159650.1,

HSPB2-C11orf52 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for HSPB2-C11orf52 Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2-C11orf52 Gene

No ASD Table

Relevant External Links for HSPB2-C11orf52 Gene

GeneLoc Exon Structure for
HSPB2-C11orf52

Expression for HSPB2-C11orf52 Gene

Protein differential expression in normal tissues from HIPED for HSPB2-C11orf52 Gene

This gene is overexpressed in Fetal heart (26.4), Tonsil (20.0), and Heart (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for HSPB2-C11orf52 Gene



Protein tissue co-expression partners for HSPB2-C11orf52 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB2-C11orf52 Gene

Orthologs for HSPB2-C11orf52 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2-C11orf52 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 99 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia HSPB2 30
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Hspb2 30
  • 97 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 96 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 90 (a)
OneToMany
Chicken
(Gallus gallus)
Aves HSPB2 30
  • 57 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 59 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii hspb2 30
  • 50 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta l(2)efl 30
  • 28 (a)
ManyToMany
Hsp23 30
  • 25 (a)
ManyToMany
CG7409 30
  • 25 (a)
ManyToMany
Hsp27 30
  • 23 (a)
ManyToMany
Hsp26 30
  • 21 (a)
ManyToMany
Hsp22 30
  • 21 (a)
ManyToMany
Hsp67Bc 30
  • 21 (a)
ManyToMany
CG4461 30
  • 20 (a)
ManyToMany
CG14207 30
  • 19 (a)
ManyToMany
CG13133 30
  • 18 (a)
ManyToMany
Hsp67Ba 30
  • 11 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea hsp-12.2 30
  • 30 (a)
ManyToMany
F08H9.4 30
  • 29 (a)
ManyToMany
hsp-12.1 30
  • 28 (a)
ManyToMany
hsp-12.6 30
  • 26 (a)
ManyToMany
hsp-16.2 30
  • 25 (a)
ManyToMany
hsp-16.11 30
  • 25 (a)
ManyToMany
hsp-16.1 30
  • 25 (a)
ManyToMany
hsp-16.48 30
  • 24 (a)
ManyToMany
hsp-16.49 30
  • 24 (a)
ManyToMany
hsp-17 30
  • 23 (a)
ManyToMany
hsp-16.41 30
  • 23 (a)
ManyToMany
hsp-12.3 30
  • 22 (a)
ManyToMany
Y55F3BR.6 30
  • 22 (a)
ManyToMany
F08H9.3 30
  • 20 (a)
ManyToMany
sip-1 30
  • 19 (a)
ManyToMany
hsp-25 30
  • 17 (a)
ManyToMany
hsp-43 30
  • 9 (a)
ManyToMany
Species where no ortholog for HSPB2-C11orf52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HSPB2-C11orf52 Gene

ENSEMBL:
Gene Tree for HSPB2-C11orf52 (if available)
TreeFam:
Gene Tree for HSPB2-C11orf52 (if available)
Alliance of Genome Resources:
Additional Orthologs for HSPB2-C11orf52

Paralogs for HSPB2-C11orf52 Gene

Paralogs for HSPB2-C11orf52 Gene

genes like me logo Genes that share paralogs with HSPB2-C11orf52: view

Variants for HSPB2-C11orf52 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPB2-C11orf52 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1592513163 Uncertain Significance: not provided 111,913,756(+) CCCATGAT/C
NM_001541.4(HSPB2):c.411_417del (p.His138fs)
FRAMESHIFT_VARIANT,INTRON
rs4252589 Benign: not provided 111,913,677(+) G/A
NM_001541.4(HSPB2):c.331G>A (p.Gly111Ser)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSPB2-C11orf52 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSPB2-C11orf52 Gene

Variant ID Type Subtype PubMed ID
nsv1070987 CNV deletion 25765185

Additional Variant Information for HSPB2-C11orf52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPB2-C11orf52
Leiden Open Variation Database (LOVD)
HSPB2-C11orf52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSPB2-C11orf52 Gene

Disorders for HSPB2-C11orf52 Gene

Additional Disease Information for HSPB2-C11orf52

No disorders were found for HSPB2-C11orf52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPB2-C11orf52 Gene

Publications for HSPB2-C11orf52 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 13
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 13

Products for HSPB2-C11orf52 Gene

Sources for HSPB2-C11orf52 Gene