Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPB2-C11orf52 Gene

Subcategory (RNA class) for HSPB2-C11orf52 Gene


Quality Score for this RNA gene is


Aliases for HSPB2-C11orf52 Gene

  • HSPB2-C11orf52 Readthrough (NMD Candidate) 2 3 5

External Ids for HSPB2-C11orf52 Gene

Previous GeneCards Identifiers for HSPB2-C11orf52 Gene

  • GC11U901862
  • GC11P111785

Summaries for HSPB2-C11orf52 Gene

Entrez Gene Summary for HSPB2-C11orf52 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring heat shock 27kDa protein 2 (HSPB2) and chromosome 11 open reading frame 52 (C11orf52) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) based on the use of the supported HSPB2 translational start codon, and it is therefore unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

GeneCards Summary for HSPB2-C11orf52 Gene

HSPB2-C11orf52 (HSPB2-C11orf52 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is HSPB2.

Additional gene information for HSPB2-C11orf52 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB2-C11orf52 Gene

Genomics for HSPB2-C11orf52 Gene

GeneHancer (GH) Regulatory Elements for HSPB2-C11orf52 Gene

Promoters and enhancers for HSPB2-C11orf52 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I111908 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -933 6.3 HDAC1 HDGF NFXL1 TCF12 GATA2 SCRT2 CREM ZNF263 ZBTB2 NCOA1 HSPB2 HSPB2-C11orf52 CRYAB PPP2R1B C11orf52 DLAT RPL37AP8
GH11I111934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 +27.3 27329 11.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DIXDC1 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 TIMM8B ENSG00000255292 FDXACB1 C11orf1
GH11I111974 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +64.3 64258 5 PKNOX1 KLF17 MZF1 SIN3A FEZF1 RAD21 ZNF335 GLIS2 ELK1 SCRT2 DIXDC1 C11orf52 PPP2R1B CRYAB HSPB2 HSPB2-C11orf52 SDHD SIK2 ENSG00000255286 ENSG00000255334
GH11I111870 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -41.4 -41414 2.2 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ALG9 PPP2R1B DIXDC1 HSPB2 HSPB2-C11orf52 C11orf52 CRYAB NKAPD1 PIH1D2 ENSG00000258529
GH11I111981 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 +70.2 70165 2.9 HDAC1 FOXA2 ARNT ARID4B SIN3A RAD21 YY1 ZNF766 ARID2 ATF7 RNA5SP351 DIXDC1 CRYAB C11orf52 HSPB2 HSPB2-C11orf52 PPP2R1B ENSG00000255334 ENSG00000255286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPB2-C11orf52 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HSPB2-C11orf52 Gene

Genomic Locations for HSPB2-C11orf52 Gene
14,136 bases
Plus strand

Genomic View for HSPB2-C11orf52 Gene

Genes around HSPB2-C11orf52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB2-C11orf52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB2-C11orf52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB2-C11orf52 Gene

Proteins for HSPB2-C11orf52 Gene

  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Heat shock 27kDa protein 2, isoform CRA_a
    Protein Accession:

    Protein attributes for HSPB2-C11orf52 Gene

    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    No Data Available
  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    HSPB2-C11orf52 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for HSPB2-C11orf52 Gene

    52 amino acids
    Molecular mass:
    5934 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPB2-C11orf52 Gene

Protein Expression for HSPB2-C11orf52 Gene

Post-translational modifications for HSPB2-C11orf52 Gene

No Post-translational modifications

Other Protein References for HSPB2-C11orf52 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HSPB2-C11orf52 Gene

Domains & Families for HSPB2-C11orf52 Gene

Protein Domains for HSPB2-C11orf52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPB2-C11orf52: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HSPB2-C11orf52 Gene

Function for HSPB2-C11orf52 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPB2-C11orf52 Gene

Localization for HSPB2-C11orf52 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HSPB2-C11orf52 Gene

Pathways & Interactions for HSPB2-C11orf52 Gene

SuperPathways for HSPB2-C11orf52 Gene

No Data Available

Interacting Proteins for HSPB2-C11orf52 Gene

Gene Ontology (GO) - Biological Process for HSPB2-C11orf52 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSPB2-C11orf52 Gene

Drugs & Compounds for HSPB2-C11orf52 Gene

No Compound Related Data Available

Transcripts for HSPB2-C11orf52 Gene

mRNA/cDNA for HSPB2-C11orf52 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2-C11orf52 Gene

No ASD Table

Relevant External Links for HSPB2-C11orf52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB2-C11orf52 Gene

Protein differential expression in normal tissues from HIPED for HSPB2-C11orf52 Gene

This gene is overexpressed in Fetal heart (26.4), Tonsil (20.0), and Heart (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for HSPB2-C11orf52 Gene

Protein tissue co-expression partners for HSPB2-C11orf52 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB2-C11orf52 Gene

Orthologs for HSPB2-C11orf52 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2-C11orf52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
(Bos Taurus)
Mammalia HSPB2 34
  • 98 (a)
(Mus musculus)
Mammalia Hspb2 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
(Gallus gallus)
Aves HSPB2 34
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
(Danio rerio)
Actinopterygii hspb2 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)efl 34
  • 28 (a)
CG7409 34
  • 25 (a)
Hsp23 34
  • 25 (a)
Hsp27 34
  • 23 (a)
Hsp22 34
  • 21 (a)
Hsp26 34
  • 21 (a)
Hsp67Bc 34
  • 21 (a)
CG4461 34
  • 20 (a)
CG14207 34
  • 19 (a)
CG13133 34
  • 18 (a)
Hsp67Ba 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea hsp-12.2 34
  • 30 (a)
F08H9.4 34
  • 29 (a)
hsp-12.1 34
  • 28 (a)
hsp-12.6 34
  • 26 (a)
hsp-16.1 34
  • 25 (a)
hsp-16.11 34
  • 25 (a)
hsp-16.2 34
  • 25 (a)
hsp-16.48 34
  • 24 (a)
hsp-16.49 34
  • 24 (a)
hsp-16.41 34
  • 23 (a)
hsp-17 34
  • 23 (a)
hsp-12.3 34
  • 22 (a)
Y55F3BR.6 34
  • 22 (a)
F08H9.3 34
  • 20 (a)
sip-1 34
  • 19 (a)
hsp-25 34
  • 17 (a)
hsp-43 34
  • 9 (a)
Species where no ortholog for HSPB2-C11orf52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPB2-C11orf52 Gene

Gene Tree for HSPB2-C11orf52 (if available)
Gene Tree for HSPB2-C11orf52 (if available)

Paralogs for HSPB2-C11orf52 Gene

Paralogs for HSPB2-C11orf52 Gene

genes like me logo Genes that share paralogs with HSPB2-C11orf52: view

Variants for HSPB2-C11orf52 Gene

Sequence variations from dbSNP and Humsavar for HSPB2-C11orf52 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs149787233 uncertain-significance, likely-benign, not specified, Posterior polar cataract, Alpha-B crystallinopathy, Myofibrillar Myopathy, Dominant 111,911,609(+) G/A upstream_transcript_variant
rs2228387 benign, not specified, Dilated cardiomyopathy 1II, Cardiovascular phenotype, Alpha-B crystallinopathy, Posterior polar cataract, Myofibrillar Myopathy, Dominant 111,911,560(+) C/G/T upstream_transcript_variant
rs2234704 conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Alpha-B crystallinopathy, Myofibrillar Myopathy, Dominant, Posterior polar cataract, Dilated cardiomyopathy 1II 111,911,573(+) G/A upstream_transcript_variant
rs281865141 pathogenic, Alpha-B crystallinopathy 111,911,665(+) GGGGG/GGGG upstream_transcript_variant
rs374981255 likely-benign, Dilated cardiomyopathy 1II 111,911,605(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB2-C11orf52 Gene

Variant ID Type Subtype PubMed ID
nsv1070987 CNV deletion 25765185

Additional Variant Information for HSPB2-C11orf52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSPB2-C11orf52 Gene

Disorders for HSPB2-C11orf52 Gene

Additional Disease Information for HSPB2-C11orf52

No disorders were found for HSPB2-C11orf52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPB2-C11orf52 Gene

Publications for HSPB2-C11orf52 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for HSPB2-C11orf52 Gene

Sources for HSPB2-C11orf52 Gene

Loading form....