The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and ... See more...

Aliases for HSPB2 Gene

Aliases for HSPB2 Gene

  • Heat Shock Protein Family B (Small) Member 2 2 3 5
  • MKBP 2 3 4
  • Heat Shock 27kDa Protein 2 2 3
  • Heat Shock Protein Beta-2 3 4
  • DMPK-Binding Protein 3 4
  • Hs.78846 2 3
  • Heat Shock 27kD Protein 2 2
  • Heat-Shock Protein Beta-2 3
  • LOH11CR1K 3
  • HSP27 3
  • HSPB2 5
  • HspB2 4

External Ids for HSPB2 Gene

Previous GeneCards Identifiers for HSPB2 Gene

  • GC11P114136
  • GC11P113295
  • GC11P111817
  • GC11P111320
  • GC11P111321
  • GC11P111288
  • GC11P111782
  • GC11P107707

Summaries for HSPB2 Gene

Entrez Gene Summary for HSPB2 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSPB2 Gene

HSPB2 (Heat Shock Protein Family B (Small) Member 2) is a Protein Coding gene. Diseases associated with HSPB2 include Myotonic Dystrophy and Malignant Fibrous Histiocytoma. Among its related pathways are Proteoglycans in cancer and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is HSPB2-C11orf52.

UniProtKB/Swiss-Prot Summary for HSPB2 Gene

Gene Wiki entry for HSPB2 Gene

Additional gene information for HSPB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPB2 Gene

Genomics for HSPB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPB2

Top Transcription factor binding sites by QIAGEN in the HSPB2 gene promoter:
  • c-Myc
  • FOXI1
  • HFH-3
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • Sp1

Genomic Locations for HSPB2 Gene

Genomic Locations for HSPB2 Gene
chr11:111,912,734-111,914,093
(GRCh38/hg38)
Size:
1,360 bases
Orientation:
Plus strand
chr11:111,782,966-111,789,574
(GRCh37/hg19)
Size:
6,609 bases
Orientation:
Plus strand

Genomic View for HSPB2 Gene

Genes around HSPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB2 Gene

Proteins for HSPB2 Gene

  • Protein details for HSPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16082-HSPB2_HUMAN
    Recommended name:
    Heat shock protein beta-2
    Protein Accession:
    Q16082
    Secondary Accessions:
    • Q6I9U7

    Protein attributes for HSPB2 Gene

    Size:
    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    • Interacts with DMPK; may enhance its kinase activity.

    Three dimensional structures from OCA and Proteopedia for HSPB2 Gene

neXtProt entry for HSPB2 Gene

Post-translational modifications for HSPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPB2 Gene

Domains & Families for HSPB2 Gene

Gene Families for HSPB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPB2 Gene

InterPro:
Blocks:
  • Heat shock protein Hsp20
ProtoNet:

Suggested Antigen Peptide Sequences for HSPB2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77220, highly similar to Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA (A8KAH6_HUMAN)
  • DMPK-binding protein (HSPB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16082

UniProtKB/Swiss-Prot:

HSPB2_HUMAN :
  • Belongs to the small heat shock protein (HSP20) family.
Family:
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB2: view

Function for HSPB2 Gene

Molecular function for HSPB2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the kinase DMPK.
GENATLAS Biochemistry:
heat shock protein 2,located near the 5' flanking region of the CRYAB gene in a head to orientation manner,expressed in muscle and heart,localized to the cross sections of individual myofibrils at the Z membrane as well as at the neuromuscular junction,complexing with HSPB3 during myogenic differentiation,binding and activating MDPK,may be involved in the pathogenesis of DM,not induced by heat shock,potentially involved in chaperone activity and maintenance of cytoskeletal network in muscle,alpha crystallin/small hsp family

Phenotypes From GWAS Catalog for HSPB2 Gene

Gene Ontology (GO) - Molecular Function for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14594798
GO:0008047 enzyme activator activity TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view
genes like me logo Genes that share phenotypes with HSPB2: view

Animal Models for HSPB2 Gene

MGI Knock Outs for HSPB2:
  • Hspb2 Hspb2<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for HSPB2 Gene

miRTarBase miRNAs that target HSPB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPB2 Gene

Localization for HSPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB2 Gene

Cytoplasm. Nucleus. Note=Localizes to nuclear foci.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPB2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19464326
GO:0005737 cytoplasm IEA,IDA 19464326
GO:0005829 cytosol TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSPB2 Gene

Pathways & Interactions for HSPB2 Gene

genes like me logo Genes that share pathways with HSPB2: view

Pathways by source for HSPB2 Gene

2 BioSystems pathways for HSPB2 Gene
1 KEGG pathway for HSPB2 Gene

Gene Ontology (GO) - Biological Process for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 9344664
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with HSPB2: view

No data available for SIGNOR curated interactions for HSPB2 Gene

Drugs & Compounds for HSPB2 Gene

(22) Drugs for HSPB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for HSPB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPB2: view

Transcripts for HSPB2 Gene

mRNA/cDNA for HSPB2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB2

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2 Gene

No ASD Table

Relevant External Links for HSPB2 Gene

GeneLoc Exon Structure for
HSPB2

Expression for HSPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPB2 Gene

This gene is overexpressed in Fetal heart (25.0), Tonsil (18.9), and Heart (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPB2 Gene



Protein tissue co-expression partners for HSPB2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPB2

SOURCE GeneReport for Unigene cluster for HSPB2 Gene:

Hs.709660

mRNA Expression by UniProt/SwissProt for HSPB2 Gene:

Q16082-HSPB2_HUMAN
Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens.

Evidence on tissue expression from TISSUES for HSPB2 Gene

  • Muscle(4.7)
  • Heart(3.5)
  • Nervous system(2.9)
  • Kidney(2.6)
  • Blood(2.6)
  • Lung(2.6)
  • Liver(2.6)
  • Skin(2.5)
  • Intestine(2.4)
  • Eye(2.2)
  • Pancreas(2.2)
  • Lymph node(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with HSPB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB2 Gene

Orthologs for HSPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 96 (a)
OneToMany
HSPB2 30
  • 90.84 (n)
Rat
(Rattus norvegicus)
Mammalia Hspb2 30
  • 92.53 (n)
Mouse
(Mus musculus)
Mammalia Hspb2 30 17 31
  • 91.52 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia HSPB2 30 31
  • 91.11 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
OneToMany
Chicken
(Gallus gallus)
Aves HSPB2 30 31
  • 65.41 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hspb2 30
  • 56.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii hspb2 30 31
  • 56.94 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta l(2)efl 31
  • 28 (a)
ManyToMany
CG7409 31
  • 25 (a)
ManyToMany
Hsp23 31
  • 25 (a)
ManyToMany
Hsp27 31
  • 23 (a)
ManyToMany
Hsp26 31
  • 21 (a)
ManyToMany
Hsp22 31
  • 21 (a)
ManyToMany
Hsp67Bc 31
  • 21 (a)
ManyToMany
CG4461 31
  • 20 (a)
ManyToMany
CG14207 31
  • 19 (a)
ManyToMany
CG13133 31
  • 18 (a)
ManyToMany
Hsp67Ba 31
  • 11 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea hsp-12.2 31
  • 30 (a)
ManyToMany
F08H9.4 31
  • 29 (a)
ManyToMany
hsp-12.1 31
  • 28 (a)
ManyToMany
hsp-12.6 31
  • 26 (a)
ManyToMany
hsp-16.2 31
  • 25 (a)
ManyToMany
hsp-16.11 31
  • 25 (a)
ManyToMany
hsp-16.1 31
  • 25 (a)
ManyToMany
hsp-16.48 31
  • 24 (a)
ManyToMany
hsp-16.49 31
  • 24 (a)
ManyToMany
hsp-16.41 31
  • 23 (a)
ManyToMany
hsp-17 31
  • 23 (a)
ManyToMany
hsp-12.3 31
  • 22 (a)
ManyToMany
Y55F3BR.6 31
  • 22 (a)
ManyToMany
F08H9.3 31
  • 20 (a)
ManyToMany
sip-1 31
  • 19 (a)
ManyToMany
hsp-25 31
  • 17 (a)
ManyToMany
hsp-43 31
  • 9 (a)
ManyToMany
Species where no ortholog for HSPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSPB2 Gene

ENSEMBL:
Gene Tree for HSPB2 (if available)
TreeFam:
Gene Tree for HSPB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPB2: view image

Paralogs for HSPB2 Gene

(4) SIMAP similar genes for HSPB2 Gene using alignment to 2 proteins:

  • HSPB2_HUMAN
  • A8KAH6_HUMAN
genes like me logo Genes that share paralogs with HSPB2: view

Variants for HSPB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPB2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
638454 Uncertain Significance: not provided 111,913,756(+) CCCATGAT/C FRAMESHIFT_VARIANT,INTRON_VARIANT
785891 Benign: not provided 111,913,677(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs4252589 - p.Gly111Ser

Additional dbSNP identifiers (rs#s) for HSPB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPB2 Gene

Variant ID Type Subtype PubMed ID
nsv1070987 CNV deletion 25765185

Variation tolerance for HSPB2 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB2 Gene

Disorders for HSPB2 Gene

MalaCards: The human disease database

(18) MalaCards diseases for HSPB2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HSPB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HSPB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB2 Gene

Publications for HSPB2 Gene

  1. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PMID: 9490724) Suzuki A … Ohno S (The Journal of cell biology 1998) 2 3 4 23
  2. Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner. (PMID: 9344664) Iwaki A … Fukumaki Y (Genomics 1997) 2 3 4
  3. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. (PMID: 20101233) Andrieu C … Rocchi P (Oncogene 2010) 3 23
  4. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PMID: 20378664) Sombekke MH … Uitdehaag BM (Multiple sclerosis (Houndmills, Basingstoke, England) 2010) 3 41
  5. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos MJ … Kampinga HH (Biochimica et biophysica acta 2009) 3 4

Products for HSPB2 Gene

Sources for HSPB2 Gene