Aliases for HSPB11 Gene

Aliases for HSPB11 Gene

  • Heat Shock Protein Family B (Small) Member 11 2 3 5
  • IFT25 2 3 4
  • PP25 2 3 4
  • Heat Shock Protein Family B (Small), Member 11 2 3
  • Intraflagellar Transport Protein 25 Homolog 3 4
  • Heat Shock Protein Beta-11 3 4
  • Placental Protein 25 3 4
  • C1orf41 3 4
  • HSPCO34 2 3
  • FAP232 2 3
  • Intraflagellar Transport 25 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport 25 Homolog 3
  • Chromosome 1 Open Reading Frame 41 2
  • HSPB11 5
  • Hspb11 4

External Ids for HSPB11 Gene

Previous HGNC Symbols for HSPB11 Gene

  • C1orf41

Previous GeneCards Identifiers for HSPB11 Gene

  • GC01M054159
  • GC01M054387
  • GC01M052502

Summaries for HSPB11 Gene

GeneCards Summary for HSPB11 Gene

HSPB11 (Heat Shock Protein Family B (Small) Member 11) is a Protein Coding gene. Diseases associated with HSPB11 include Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly and Bardet-Biedl Syndrome 19. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

UniProtKB/Swiss-Prot Summary for HSPB11 Gene

  • Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPB11 Gene

Genomics for HSPB11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPB11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPB11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPB11

Top Transcription factor binding sites by QIAGEN in the HSPB11 gene promoter:
  • AhR
  • GATA-1
  • HNF-1
  • HNF-1A
  • MIF-1
  • MZF-1
  • STAT3
  • TBP
  • TFIID
  • ZID

Genomic Locations for HSPB11 Gene

Latest Assembly
chr1:53,916,573-53,946,305
(GRCh38/hg38)
Size:
29,733 bases
Orientation:
Minus strand

Previous Assembly
chr1:54,382,246-54,411,978
(GRCh37/hg19 by Entrez Gene)
Size:
29,733 bases
Orientation:
Minus strand

chr1:54,382,247-54,411,602
(GRCh37/hg19 by Ensembl)
Size:
29,356 bases
Orientation:
Minus strand

Genomic View for HSPB11 Gene

Genes around HSPB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB11 Gene

Proteins for HSPB11 Gene

  • Protein details for HSPB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y547-IFT25_HUMAN
    Recommended name:
    Intraflagellar transport protein 25 homolog
    Protein Accession:
    Q9Y547
    Secondary Accessions:
    • A6NG57
    • D3DQ45
    • Q9Y684

    Protein attributes for HSPB11 Gene

    Size:
    144 amino acids
    Molecular mass:
    16297 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27. Interacts with IFT88 (By similarity).
    SequenceCaution:
    • Sequence=AAD43011.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSPB11 Gene

neXtProt entry for HSPB11 Gene

Post-translational modifications for HSPB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSPB11 Gene

Domains & Families for HSPB11 Gene

Gene Families for HSPB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPB11 Gene

Suggested Antigen Peptide Sequences for HSPB11 Gene

GenScript: Design optimal peptide antigens:
  • Placental protein 25 (HSB11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y547

UniProtKB/Swiss-Prot:

IFT25_HUMAN :
  • Belongs to the IFT25 family.
Family:
  • Belongs to the IFT25 family.
genes like me logo Genes that share domains with HSPB11: view

Function for HSPB11 Gene

Molecular function for HSPB11 Gene

UniProtKB/Swiss-Prot Function:
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).

Phenotypes From GWAS Catalog for HSPB11 Gene

Gene Ontology (GO) - Molecular Function for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HSPB11: view
genes like me logo Genes that share phenotypes with HSPB11: view

Animal Models for HSPB11 Gene

MGI Knock Outs for HSPB11:
  • Hspb11 Hspb11<tm1a(EUCOMM)Wtsi>
  • Hspb11 Hspb11<tm1b(EUCOMM)Wtsi>

miRNA for HSPB11 Gene

miRTarBase miRNAs that target HSPB11

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPB11 Gene

Localization for HSPB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB11 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPB11 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA 21873635
GO:0005929 cilium IEA,TAS --
GO:0030992 intraciliary transport particle B IEA,ISS --
GO:0042995 cell projection IEA --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with HSPB11: view

Pathways & Interactions for HSPB11 Gene

genes like me logo Genes that share pathways with HSPB11: view

Pathways by source for HSPB11 Gene

Gene Ontology (GO) - Biological Process for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0007283 spermatogenesis ISS --
GO:0015031 protein transport IEA --
GO:0030154 cell differentiation IEA --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with HSPB11: view

No data available for SIGNOR curated interactions for HSPB11 Gene

Drugs & Compounds for HSPB11 Gene

No Compound Related Data Available

Transcripts for HSPB11 Gene

mRNA/cDNA for HSPB11 Gene

9 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPB11

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - -
SP7:

Relevant External Links for HSPB11 Gene

GeneLoc Exon Structure for
HSPB11

Expression for HSPB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPB11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPB11 Gene



Protein tissue co-expression partners for HSPB11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPB11

SOURCE GeneReport for Unigene cluster for HSPB11 Gene:

Hs.525462

mRNA Expression by UniProt/SwissProt for HSPB11 Gene:

Q9Y547-IFT25_HUMAN
Tissue specificity: Detected in placenta.

Evidence on tissue expression from TISSUES for HSPB11 Gene

  • Lung(4.3)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Nervous system(2.7)
  • Thyroid gland(2.1)
  • Skin(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with HSPB11: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB11 Gene

Orthologs for HSPB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSPB11 29 30
  • 99.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSPB11 29 30
  • 91.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HSPB11 29
  • 90.44 (n)
C3H1ORF41 30
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Hspb11 29 16 30
  • 86.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hspb11 29
  • 86.62 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia HSPB11 30
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HSPB11 30
  • 33 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HSPB11 29
  • 66.67 (n)
Lizard
(Anolis carolinensis)
Reptilia HSPB11 30
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hspb11 29
  • 61.48 (n)
Str.541 29
Zebrafish
(Danio rerio)
Actinopterygii zgc:158640 29
  • 58.08 (n)
HSPB11 30
  • 51 (a)
OneToOne
Species where no ortholog for HSPB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HSPB11 Gene

ENSEMBL:
Gene Tree for HSPB11 (if available)
TreeFam:
Gene Tree for HSPB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPB11: view image
Alliance of Genome Resources:
Additional Orthologs for HSPB11

Paralogs for HSPB11 Gene

Pseudogenes.org Pseudogenes for HSPB11 Gene

genes like me logo Genes that share paralogs with HSPB11: view

No data available for Paralogs for HSPB11 Gene

Variants for HSPB11 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSPB11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSPB11 Gene

Variant ID Type Subtype PubMed ID
nsv1011262 CNV gain 25217958

Variation tolerance for HSPB11 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPB11 Gene

Human Gene Mutation Database (HGMD)
HSPB11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPB11
Leiden Open Variation Database (LOVD)
HSPB11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPB11 Gene

Disorders for HSPB11 Gene

MalaCards: The human disease database

(10) MalaCards diseases for HSPB11 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPB11

genes like me logo Genes that share disorders with HSPB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB11 Gene

Publications for HSPB11 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. Characterization of mouse IFT complex B. (PMID: 19253336) Follit JA … Pazour GJ (Cell motility and the cytoskeleton 2009) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26). (PMID: 2018407) Bohn H … Winckler W (Archives of gynecology and obstetrics 1991) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for HSPB11 Gene

Sources for HSPB11 Gene