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This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Primary Hyperoxaluria and Oral Lichen Planus. Among its related pathways are Vesicle-mediated transport and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J123055 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 750.6 | +2.1 | 2118 | 10.9 | ZNF24 SP1 ZBTB40 ZBTB6 FOXA1 RBPJ SMARCE1 POLR2A FOS MIXL1 | ENSG00000288061 HSPA8 LOC101929289 SNORD14C lnc-CLMP-3 lnc-JHY-5 piR-59038 piR-61486 ZNF202 CLMP |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | IPI | 12150907 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9305631 |
GO:0005524 | ATP binding | IEA,IDA | 23921388 |
GO:0016887 | ATPase activity | TAS,IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000974 | Prp19 complex | IDA | 20176811 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005634 | nucleus | IDA,IBA | 20176811 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
2 | Clathrin derived vesicle budding | ||
3 | Innate Immune System |
.61
|
|
4 | MAPK signaling pathway | ||
5 | HSF1-dependent transactivation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0006457 | protein folding | NAS | 8530083 |
GO:0006986 | response to unfolded protein | NAS,IBA | 11093761 |
GO:0007269 | neurotransmitter secretion | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 227 | ||
Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 312 | |
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Experimental | Pharma | Target | 0 | ||
Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 108 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
chimpanzee (Pan troglodytes) |
Mammalia | HSPA8 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | HSPA8 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | HSPA8 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Hspa8 32 |
|
||
mouse (Mus musculus) |
Mammalia | Hspa8 17 33 32 |
|
||
chicken (Gallus gallus) |
Aves | HSPA8 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | HSPA8 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | hspa8 32 |
|
||
Str.5671 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | HSPA8 (1 of 2) 33 |
|
OneToMany | |
hspa8 33 32 |
|
OneToMany | |||
-- 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | Hsc70-4 33 34 |
|
ManyToMany | |
Hsp70Bc 34 |
|
|
|||
Hsp70Aa 34 |
|
|
|||
Hsp70Bb 34 |
|
|
|||
Hsp70Ba 34 |
|
|
|||
Hsp70Ab 34 |
|
|
|||
Hsc70-2 34 |
|
|
|||
Hsc70-1 33 34 32 |
|
ManyToMany | |||
Hsp68 34 |
|
|
|||
Hsc70-3 34 |
|
|
|||
CG7182 34 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004944 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | hsp-2 34 |
|
|
|
hsp-1 33 34 32 |
|
OneToMany | |||
F44E5.5 34 |
|
|
|||
F44E5.4 34 |
|
|
|||
hsp-70 34 |
|
|
|||
hsp-4 34 |
|
|
|||
hsp-3 34 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 33 |
|
OneToMany | |
SSB2 35 |
|
|
|||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G09440 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11098 33 |
|
ManyToMany | |
CSA.971 33 |
|
ManyToMany | |||
Cin.2748 32 |
|
||||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2748 32 |
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000333769 | -- | 123,059,644(-) | C/T | coding_sequence_variant, missense_variant | |
rs1000893027 | -- | 123,062,137(-) | A/C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000900919 | -- | 123,064,291(-) | T/C | upstream_transcript_variant | |
rs1001112689 | -- | 123,058,554(-) | G/C | intron_variant | |
rs1001113413 | -- | 123,061,368(-) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1039284 | CNV | gain | 25217958 |
nsv983069 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
primary hyperoxaluria |
|
|
oral lichen planus |
|
|
sleeping sickness |
|
|
dowling-degos disease |
|
|
leber congenital amaurosis |
|
|