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This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Auditory System Disease and Oral Lichen Planus. Among its related pathways are Protein methylation and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001664 | G protein-coupled receptor binding | IPI | 12150907 |
GO:0001786 | phosphatidylserine binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9305631 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000974 | Prp19 complex | IDA | 20176811 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005634 | nucleus | IBA,IDA | 20176811 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
2 | Clathrin derived vesicle budding | ||
3 | Innate Immune System |
.61
|
|
4 | MAPK signaling pathway | ||
5 | HSF1-dependent transactivation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0006457 | protein folding | NAS | 8530083 |
GO:0006986 | response to unfolded protein | IBA,NAS | 11093761 |
GO:0007269 | neurotransmitter secretion | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 249 | ||
Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 324 | |
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Experimental | Pharma | Target | 0 | ||
Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chimpanzee (Pan troglodytes) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hspa8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hspa8 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSPA8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HSPA8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hspa8 30 |
|
||
Str.5671 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | HSPA8 (1 of 2) 31 |
|
OneToMany | |
hspa8 30 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Hsc70-4 31 32 |
|
ManyToMany | |
Hsp70Aa 32 |
|
|
|||
Hsp70Ba 32 |
|
|
|||
Hsp70Bb 32 |
|
|
|||
Hsp70Bc 32 |
|
|
|||
Hsp70Ab 32 |
|
|
|||
Hsc70-2 32 |
|
|
|||
Hsc70-1 30 31 32 |
|
ManyToMany | |||
Hsp68 32 |
|
|
|||
Hsc70-3 32 |
|
|
|||
CG7182 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004944 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | hsp-2 32 |
|
|
|
hsp-1 30 31 32 |
|
OneToMany | |||
F44E5.4 32 |
|
|
|||
F44E5.5 32 |
|
|
|||
hsp-70 32 |
|
|
|||
hsp-3 32 |
|
|
|||
hsp-4 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 31 |
|
OneToMany | |
SSB1 33 |
|
|
|||
SSB2 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G09440 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11098 31 |
|
ManyToMany | |
CSA.971 31 |
|
ManyToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2748 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
730598 | Benign: not provided | 123,060,671(-) | G/C | SYNONYMOUS_VARIANT | |
784206 | Benign: not provided | 123,060,629(-) | T/C | SYNONYMOUS_VARIANT | |
786217 | Benign: not provided | 123,059,519(-) | T/C | SYNONYMOUS_VARIANT | |
791179 | Benign: not provided | 123,059,588(-) | G/A | SYNONYMOUS_VARIANT | |
rs11551598 | - | p.Phe459Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1039284 | CNV | gain | 25217958 |
nsv983069 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
auditory system disease |
|
|
oral lichen planus |
|
|
mucolipidosis |
|
|
primary hyperoxaluria |
|
|
sleeping sickness |
|
|