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This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembl... See more...
Aliases for HSPA8 Gene
Aliases for HSPA8 Gene
- Heat Shock Protein Family A (Hsp70) Member 8 2 3 5
- HSC70 2 3 4
- HSP73 2 3 4
- Lipopolysaccharide-Associated Protein 1 3 4
- Heat Shock Cognate 71 KDa Protein 3 4
- Heat Shock 70kDa Protein 8 2 3
- LPS-Associated Protein 1 3 4
- HSPA10 3 4
- HSC71 2 3
- LAP-1 3 4
- Epididymis Secretory Sperm Binding Protein Li 72p 3
- N-Myristoyltransferase Inhibitor Protein 71 3
External Ids for HSPA8 Gene
- HGNC: 5241
- Entrez Gene: 3312
- Ensembl: ENSG00000109971
- OMIM: 600816
- UniProtKB: P11142
Previous HGNC Symbols for HSPA8 Gene
- HSPA10
Previous GeneCards Identifiers for HSPA8 Gene
- GC11M124929
- GC11M124441
- GC11M122962
- GC11M122465
- GC11M122436
- GC11M122437
- GC11M122439
- GC11M122444
- GC11M122450
- GC11M122452
- GC11M122454
- GC11M122456
- GC11M122458
- GC11M122460
- GC11M122463
- GC11M122468
- GC11M122934
- GC11M122938
- GC11M118870
- GC11M122942
- GC11M122947
- GC11M122948
- GC11M122952
- GC11M122959
- GC11M122969
- GC11M122982
Summaries for HSPA8 Gene
-
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for HSPA8 Gene
HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Auditory System Disease and Oral Lichen Planus. Among its related pathways are Protein methylation and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.
UniProtKB/Swiss-Prot Summary for HSPA8 Gene
-
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).
Additional gene information for HSPA8 Gene
- HGNC(5241)
- Entrez Gene(3312)
- Ensembl(ENSG00000109971)
- OMIM(600816)
- UniProtKB(P11142)
- Open Targets Platform(ENSG00000109971)
- Monarch Initiative
- Search for HSPA8 at DataMed
- Search for HSPA8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA8 Gene
Genomics for HSPA8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HSPA8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSPA8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA8
- Top Transcription factor binding sites by QIAGEN in the HSPA8 gene promoter:
-
- p300
- Sp1
- STAT1
- STAT3
Genomic Locations for HSPA8 Gene
Genomic Locations for HSPA8 Gene
- chr11:123,057,489-123,063,230
- (GRCh38/hg38)
- Size:
- 5,742 bases
- Orientation:
- Minus strand
- chr11:122,928,197-122,933,938
- (GRCh37/hg19)
- Size:
- 5,742 bases
- Orientation:
- Minus strand
Genomic View for HSPA8 Gene
Genes around HSPA8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.1 by HGNC
- 11q24.1 by Entrez Gene
- 11q24.1 by Ensembl
HSPA8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSPA8 Gene
Proteins for HSPA8 Gene
-
Protein details for HSPA8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11142-HSP7C_HUMAN
- Recommended name:
- Heat shock cognate 71 kDa protein
- Protein Accession:
- P11142
- Q9H3R6
Protein attributes for HSPA8 Gene
- Size:
- 646 amino acids
- Molecular mass:
- 70898 Da
- Quaternary structure:
-
- Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7. Interacts with DNAJB12 (via J domain) (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661). Interacts with DNAJB14 (via J domain) (PubMed:23018488, PubMed:24732912, PubMed:27916661). Interacts (via C-terminus) with the E3 ligase CHIP forming a 210 kDa complex of one CHIP and two HSPA8 molecules. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts with TRIM5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with METTL21A. Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1. Interacts with PRKN. Interacts with FOXP3. Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with MLLT11 (PubMed:24880125). Interacts with RNF207 (PubMed:25281747). Interacts with DNAJC21 (PubMed:27346687). Interacts with DNAJB2 (PubMed:15936278). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with SGTA (via TPR repeats) (By similarity). Interacts with HSF1 (via transactivation domain) (PubMed:9499401). Interacts with HOPX, HSP40 and HSP90 (PubMed:27708256). Interacts with STUB1 (PubMed:27708256). Interacts with BAG2 (PubMed:24318877). Interacts with BAG3 (PubMed:27474739, PubMed:24318877). Interacts with DNAJC12 (PubMed:24122553). Interacts with ZMYND10 (PubMed:29601588). Interacts with HSPC138 (PubMed:25760597). Interacts with BCL2L1, GIMAP5 and MCL1; the interaction with BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (By similarity). Interacts with NLPR12 (PubMed:17947705). Interacts with TTC4 (PubMed:18320024).
- (Microbial infection) Interacts with SV40 VP1.
Three dimensional structures from OCA and Proteopedia for HSPA8 Gene
Protein Expression for HSPA8 Gene
Post-translational modifications for HSPA8 Gene
- Acetylated.
- ISGylated.
- Trimethylation at Lys-561 reduces fibrillar SNCA binding.
-
Glycosylation at Asn35
- NX_P11142 (NX_P11142-1)
-
Ubiquitination at Lys3, Lys25, Lys56, Lys71, Lys88, Lys112, Lys126, Lys128, Lys137, Lys159, Lys187, Lys188, Lys246, Lys319, Lys325, Lys328, Lys361, Lys423, Lys458, Lys512, Lys539, Lys573, Lys583, Lys597, and Lys601
- NX_P11142 (NX_P11142-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- HSP7C_HUMAN (1299)
Other Protein References for HSPA8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences HSPA8 / HSC70 Antibody and HSPA8 / HSC70 Monoclonal Antibody
- NSJ Bioreagents HSPA8 Antibody
- BioLegend HSC70 (HSPA8) Antibody
- Novus Biologicals Antibodies for HSPA8
-
Abcam antibodies for HSPA8
- Invitrogen Antibodies for HSPA8 (AFLGC-Hspa8)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSPA8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HSPA8
- Origene Custom Protein Services for HSPA8
- Sino Biological Recombinant Proteins for HSPA8
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HSPA8
-
Signalway Proteins for HSPA8
-
Abcam proteins for HSPA8
Assay Products
- antibodies-online: Show 32 available HSPA8 Elisa Kits ranked by validation data
- Compare Top HSPA8 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for HSPA8
No data available for DME Specific Peptides for HSPA8 Gene
Domains & Families for HSPA8 Gene
Gene Families for HSPA8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HSPA8 Gene
- InterPro:
- Blocks:
-
- Heat shock protein Hsp70
- ProtoNet:
Suggested Antigen Peptide Sequences for HSPA8 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ77848 (A8K7Q2_HUMAN)
- Heat shock 70 kDa protein 8 (HSP7C_HUMAN)
- HSPA8 protein (Q96H53_HUMAN)
- HSPA8 protein (Q96IS6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P11142UniProtKB/Swiss-Prot:
HSP7C_HUMAN :- The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
- Belongs to the heat shock protein 70 family.
- Domain:
-
- The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
- Family:
-
- Belongs to the heat shock protein 70 family.
Function for HSPA8 Gene
Molecular function for HSPA8 Gene
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).
- UniProtKB/Swiss-Prot Induction:
- Constitutively synthesized.
- GENATLAS Biochemistry:
- heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program
Phenotypes From GWAS Catalog for HSPA8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001664 | G protein-coupled receptor binding | IPI | 12150907 |
| GO:0001786 | phosphatidylserine binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9305631 |
Phenotypes for HSPA8 Gene
- GenomeRNAi human phenotypes for HSPA8:
-
- no effect
- shRNA abundance <= 50%
- Decreased viability of wild-type and TP53 knockout cells
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased ionizing radiation sensitivity
- Decreased viability in colon lineage
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSPA8 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for HSPA8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSPA8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSPA8
miRNA for HSPA8 Gene
- miRTarBase miRNAs that target HSPA8
-
- hsa-miR-877-5p (MIRT037227)
- hsa-miR-151a-5p (MIRT038193)
- hsa-miR-130b-5p (MIRT038316)
- hsa-miR-615-3p (MIRT039668)
- hsa-miR-324-3p (MIRT042836)
- hsa-miR-320a (MIRT044798)
- hsa-miR-149-5p (MIRT045436)
- hsa-miR-15b-5p (MIRT046453)
- hsa-miR-10a-5p (MIRT047545)
- hsa-miR-92a-3p (MIRT049282)
- hsa-miR-26a-5p (MIRT050082)
- hsa-miR-25-3p (MIRT050343)
- hsa-miR-16-5p (MIRT051117)
- hsa-let-7b-5p (MIRT052021)
- bta-miR-15b (MIRT053821)
- bta-miR-16a (MIRT053845)
- bta-miR-17-5p (MIRT053859)
- bta-miR-221 (MIRT054000)
- hsa-miR-3692-3p (MIRT241335)
- rno-miR-17-5p (MIRT438010)
- hsa-miR-587 (MIRT475449)
- hsa-miR-448 (MIRT475450)
- hsa-miR-106a-3p (MIRT475451)
- hsa-miR-6868-3p (MIRT475452)
- hsa-miR-6826-3p (MIRT475453)
- hsa-miR-4436b-5p (MIRT475454)
- hsa-miR-6509-3p (MIRT475455)
- hsa-miR-340-5p (MIRT475456)
- hsa-miR-3667-3p (MIRT475457)
- hsa-miR-6734-3p (MIRT475458)
- hsa-miR-1914-5p (MIRT475459)
- hsa-miR-331-3p (MIRT475460)
- hsa-miR-6810-3p (MIRT475461)
- hsa-miR-6801-3p (MIRT475462)
- hsa-miR-338-5p (MIRT475463)
- hsa-miR-519c-3p (MIRT475464)
- hsa-miR-519b-3p (MIRT475465)
- hsa-miR-519a-3p (MIRT475466)
- hsa-miR-4796-3p (MIRT475467)
- hsa-miR-548ah-5p (MIRT475468)
- hsa-miR-3609 (MIRT475469)
- hsa-miR-142-5p (MIRT475470)
- hsa-miR-5590-3p (MIRT475471)
- hsa-miR-519d-3p (MIRT475472)
- hsa-miR-106a-5p (MIRT475473)
- hsa-miR-526b-3p (MIRT475474)
- hsa-miR-93-5p (MIRT475475)
- hsa-miR-20b-5p (MIRT475476)
- hsa-miR-20a-5p (MIRT475477)
- hsa-miR-17-5p (MIRT475478)
- hsa-miR-106b-5p (MIRT475479)
- hsa-miR-3666 (MIRT475480)
- hsa-miR-4295 (MIRT475481)
- hsa-miR-454-3p (MIRT475482)
- hsa-miR-301b-3p (MIRT475483)
- hsa-miR-301a-3p (MIRT475484)
- hsa-miR-130a-3p (MIRT475485)
- hsa-miR-130b-3p (MIRT475486)
- hsa-miR-33a-5p (MIRT735100)
- hsa-miR-105-5p (MIRT735818)
- hsa-miR-1297 (MIRT737232)
- hsa-miR-15a-5p (MIRT737939)
- hsa-miR-195-5p (MIRT738628)
- hsa-miR-205-5p (MIRT738849)
- hsa-miR-26b-5p (MIRT739437)
- hsa-miR-3064-3p (MIRT739688)
- hsa-miR-32-3p (MIRT741227)
- hsa-miR-33a-3p (MIRT741369)
- hsa-miR-365a-3p (MIRT741961)
- hsa-miR-365b-3p (MIRT741971)
- hsa-miR-3671 (MIRT742096)
- hsa-miR-424-5p (MIRT743301)
- hsa-miR-4272 (MIRT743656)
- hsa-miR-4307 (MIRT743931)
- hsa-miR-4461 (MIRT744864)
- hsa-miR-4465 (MIRT744885)
- hsa-miR-4524a-5p (MIRT745868)
- hsa-miR-4524b-5p (MIRT745901)
- hsa-miR-497-5p (MIRT749282)
- hsa-miR-503-5p (MIRT749542)
- hsa-miR-5089-3p (MIRT749647)
- hsa-miR-5697 (MIRT751261)
- hsa-miR-580-3p (MIRT751503)
- hsa-miR-6074 (MIRT751684)
- hsa-miR-607 (MIRT751747)
- hsa-miR-625-3p (MIRT752576)
- hsa-miR-646 (MIRT752754)
- hsa-miR-6509-5p (MIRT752986)
- hsa-miR-6838-5p (MIRT757283)
- hsa-miR-7853-5p (MIRT759910)
- hsa-miR-802 (MIRT760006)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSPA8
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Clone Products
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-
- MG209728
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- RC202209
- RC202209L1
- RC202209L2
- RC202209L3
- RC202209L4
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- RG212092
- RR211007
- RR211007L3
- RR211007L4
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- MR209729L4V
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- RC202209L2V
- RC202209L3V
- RC202209L4V
- RC212092L3V
- RC212092L4V
- RR211007L3V
- RR211007L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSPA8
- Addgene plasmids for HSPA8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA8
Cell Line Products
-
Horizon Cell Lines for HSPA8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA8 Gene
Localization for HSPA8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSPA8 Gene
- Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| endosome | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| endoplasmic reticulum | 3 |
| peroxisome | 2 |
| golgi apparatus | 2 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000974 | Prp19 complex | IDA | 20176811 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | IBA,IDA | 20176811 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for HSPA8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
| 2 | Clathrin derived vesicle budding | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | MAPK signaling pathway | ||
| 5 | HSF1-dependent transactivation | ||
Pathways by source for HSPA8 Gene
5 BioSystems pathways for HSPA8 Gene
35 Reactome pathways for HSPA8 Gene
10 KEGG pathways for HSPA8 Gene
7 GeneGo (Thomson Reuters) pathways for HSPA8 Gene
- CFTR folding and maturation (norm and CF)
- Development_Glucocorticoid receptor signaling
- Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
- Proteolysis_Putative ubiquitin pathway
1 Qiagen pathway for HSPA8 Gene
- Cellular Transformation by HTLV1
1 GeneTex pathway for HSPA8 Gene
Interacting Proteins for HSPA8 Gene
Selected Interacting proteins:
P11142-HSP7C_HUMAN
ENSP00000432083
for HSPA8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HSPA8
SIGNOR curated interactions for HSPA8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006457 | protein folding | NAS | 8530083 |
| GO:0006986 | response to unfolded protein | IBA,NAS | 11093761 |
| GO:0007269 | neurotransmitter secretion | TAS | -- |
Drugs & Compounds for HSPA8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 | ||
| Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 324 | |
| (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Experimental | Pharma | Target | 0 | ||
| Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for HSPA8 Gene
mRNA/cDNA for HSPA8 Gene
- 2 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000227378 2186 nts (view in UCSC)
- ENST00000453788 2004 nts (view in UCSC)
- ENST00000524552 963 nts (view in UCSC)
- ENST00000524590 536 nts (view in UCSC)
- ENST00000525463 583 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSPA8 - Select products 50% OFF >
- * HSPA8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for HSPA8
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-
Santa Cruz Biotechnology (SCBT) CRISPR for HSPA8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSPA8
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Clone Products
- Applied Biological Materials (abm): Clones for HSPA8 - Select products 50% OFF >
- * HSPA8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
- MG209728
- MG209729
- MR209728
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- RC202209
- RC202209L1
- RC202209L2
- RC202209L3
- RC202209L4
- RC212092
- RC212092L3
- RC212092L4
- RG202209
- RG212092
- RR211007
- RR211007L3
- RR211007L4
- MR209728L3V
- MR209728L4V
- MR209729L3V
- MR209729L4V
- RC202209L1V
- RC202209L2V
- RC202209L3V
- RC202209L4V
- RC212092L3V
- RC212092L4V
- RR211007L3V
- RR211007L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSPA8
- Addgene plasmids for HSPA8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA8
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for HSPA8 Gene
- GeneLoc Exon Structure for
- HSPA8
Expression for HSPA8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Tooth (Integumentary System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Smooth Muscle (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Lymph node (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA8 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA8
SOURCE GeneReport for Unigene cluster for HSPA8 Gene:
Hs.180414mRNA Expression by UniProt/SwissProt for HSPA8 Gene:
P11142-HSP7C_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for HSPA8 Gene
- Nervous system(5)
- Skin(5)
- Blood(5)
- Kidney(5)
- Intestine(5)
- Liver(5)
- Lung(4.9)
- Muscle(4.9)
- Spleen(4.9)
- Eye(4.8)
- Heart(4.8)
- Pancreas(4.7)
- Stomach(4.7)
- Bone(4.4)
- Lymph node(3.5)
- Adrenal gland(3.4)
- Bone marrow(3.2)
- Thyroid gland(3.2)
- Gall bladder(2.5)
Primer Products
-
OriGene qPCR primer pairs for HSPA8
-
OriGene qPCR primer pairs and template standards for HSPA8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA8 Gene
Orthologs for HSPA8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HSPA8 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hspa8 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hspa8 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HSPA8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HSPA8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hspa8 30 |
|
||
| Str.5671 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | HSPA8 (1 of 2) 31 |
|
OneToMany | |
| hspa8 30 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Hsc70-4 31 32 |
|
ManyToMany | |
| Hsp70Aa 32 |
|
|
|||
| Hsp70Ba 32 |
|
|
|||
| Hsp70Bb 32 |
|
|
|||
| Hsp70Bc 32 |
|
|
|||
| Hsp70Ab 32 |
|
|
|||
| Hsc70-2 32 |
|
|
|||
| Hsc70-1 30 31 32 |
|
ManyToMany | |||
| Hsp68 32 |
|
|
|||
| Hsc70-3 32 |
|
|
|||
| CG7182 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004944 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | hsp-2 32 |
|
|
|
| hsp-1 30 31 32 |
|
OneToMany | |||
| F44E5.4 32 |
|
|
|||
| F44E5.5 32 |
|
|
|||
| hsp-70 32 |
|
|
|||
| hsp-3 32 |
|
|
|||
| hsp-4 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 31 |
|
OneToMany | |
| SSB1 33 |
|
|
|||
| SSB2 33 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G09440 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11098 31 |
|
ManyToMany | |
| CSA.971 31 |
|
ManyToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2748 30 |
|
- Species where no ortholog for HSPA8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HSPA8 Gene
- ENSEMBL:
- Gene Tree for HSPA8 (if available)
- TreeFam:
- Gene Tree for HSPA8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSPA8: view image
Paralogs for HSPA8 Gene
Paralogs for HSPA8 Gene
(19) SIMAP similar genes for HSPA8 Gene using alignment to 16 proteins:
- HSP7C_HUMAN
- A8K7Q2_HUMAN
- E9PI65_HUMAN
- E9PK54_HUMAN
- E9PKE3_HUMAN
- E9PLF4_HUMAN
- E9PM13_HUMAN
- E9PN25_HUMAN
- E9PN89_HUMAN
- E9PNE6_HUMAN
- E9PPY6_HUMAN
- E9PQK7_HUMAN
- E9PQQ4_HUMAN
- E9PS65_HUMAN
- Q96H53_HUMAN
- Q96IS6_HUMAN
Pseudogenes.org Pseudogenes for HSPA8 Gene
- PGOHUM00000291512
- PGOHUM00000291801
- PGOHUM00000291802
- PGOHUM00000291803
- PGOHUM00000292022
- PGOHUM00000296857
- PGOHUM00000298311
- PGOHUM00000298360
- PGOHUM00000298361
- PGOHUM00000298966
- PGOHUM00000299595
- PGOHUM00000299596
- PGOHUM00000299608
- PGOHUM00000300465
- PGOHUM00000300466
- PGOHUM00000301113
- PGOHUM00000301440
- PGOHUM00000301598
- PGOHUM00000301599
- PGOHUM00000301978
- PGOHUM00000302530
- PGOHUM00000302837
- PGOHUM00000302838
- PGOHUM00000303494
- PGOHUM00000303495
- PGOHUM00000303529
- PGOHUM00000304145
- PGOHUM00000304806
- PGOHUM00000304828
- PGOHUM00000290074
Variants for HSPA8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA8 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 730598 | Benign: not provided | 123,060,671(-) | G/C | SYNONYMOUS_VARIANT | |
| 784206 | Benign: not provided | 123,060,629(-) | T/C | SYNONYMOUS_VARIANT | |
| 786217 | Benign: not provided | 123,059,519(-) | T/C | SYNONYMOUS_VARIANT | |
| 791179 | Benign: not provided | 123,059,588(-) | G/A | SYNONYMOUS_VARIANT | |
| rs11551598 | - | p.Phe459Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1039284 | CNV | gain | 25217958 |
| nsv983069 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
4.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
5.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSPA8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA8 Gene
Disorders for HSPA8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| auditory system disease |
|
|
| oral lichen planus |
|
|
| mucolipidosis |
|
|
| primary hyperoxaluria |
|
|
| sleeping sickness |
|
|
Search HSPA8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HSPA8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA8 Gene
Publications for HSPA8 Gene
- Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. (PMID: 20053985) Hwang CY … Song B (The Journal of biological chemistry 2010) 3 4 23
- Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70. (PMID: 11093761) Tsukahara F … Muraki T (Molecular pharmacology 2000) 3 4 23
- BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PMID: 9305631) Takayama S … Reed JC (The EMBO journal 1997) 3 4 23
- Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PMID: 8530083) Tavaria M … Kola I (Genomics 1995) 2 3 23
- Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PMID: 3037489) Dworniczak B … Mirault ME (Nucleic acids research 1987) 2 3 4
ExternalLinks
Products for HSPA8 Gene
- Custom Antibody ServicesOriGene Antibodies for HSPA8
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For HSPA8
- OriGene qPCR primer pairs for HSPA8
- OriGene qPCR primer pairs and template standards for HSPA8
- OriGene CRISPR knockouts for HSPA8
- MG209728
- MG209729
- MR209728
- MR209728L3
- MR209728L4
- MR209729
- MR209729L3
- MR209729L4
- RC202209
- RC202209L1
- RC202209L2
- RC202209L3
- RC202209L4
- RC212092
- RC212092L3
- RC212092L4
- RG202209
- RG212092
- RR211007
- RR211007L3
- RR211007L4
- MR209728L3V
- MR209728L4V
- MR209729L3V
- MR209729L4V
- RC202209L1V
- RC202209L2V
- RC202209L3V
- RC202209L4V
- RC212092L3V
- RC212092L4V
- RR211007L3V
- RR211007L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HSPA8
- Sino Biological Human cDNA Clone for HSPA8
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- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for HSPA8
- Novus Biologicals proteins and lysates for HSPA8
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for HSPA8
- Abcam proteins for HSPA8
- Find your target
- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for HSPA8 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Stable cell line generation for HSPA8
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- antibodies-online: Show 241 available HSPA8 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for HSPA8
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- Santa Cruz Biotechnology (SCBT) CRISPR for HSPA8
- Horizon Cell Lines for HSPA8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSPA8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HSPA8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA8
Sources for HSPA8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
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- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (90) CYP
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- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (104) diseasecard
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- (163) LncBase
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- (165) LNCipedia
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB