HSPA8 Gene (Protein Coding)

Heat Shock Protein Family A (Hsp70) Member 8

GC11M123057
GIFtS:
48
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembl... See more...

Aliases for HSPA8 Gene

Aliases for HSPA8 Gene

  • Heat Shock Protein Family A (Hsp70) Member 8 2 3 5
  • Lipopolysaccharide-Associated Protein 1 3 4
  • Heat Shock Cognate 71 KDa Protein 3 4
  • Heat Shock 70kDa Protein 8 2 3
  • LPS-Associated Protein 1 3 4
  • HSPA10 3 4
  • HSC70 3 4
  • HSP73 3 4
  • LAP-1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 72p 3
  • N-Myristoyltransferase Inhibitor Protein 71 3
  • Constitutive Heat Shock Protein 70 3
  • Epididymis Luminal Protein 33 3
  • Heat Shock Cognate Protein 54 3
  • Heat Shock 70 KDa Protein 8 4
  • Heat Shock 70kd Protein 10 3
  • Heat Shock 70kD Protein 8 2
  • HEL-S-72p 3
  • HEL-33 3
  • HSC54 3
  • HSC71 3
  • HSP71 3
  • NIP71 3
  • LAP1 3

External Ids for HSPA8 Gene

Previous HGNC Symbols for HSPA8 Gene

  • HSPA10

Previous GeneCards Identifiers for HSPA8 Gene

  • GC11M124929
  • GC11M124441
  • GC11M122962
  • GC11M122465
  • GC11M122436
  • GC11M122437
  • GC11M122439
  • GC11M122444
  • GC11M122450
  • GC11M122452
  • GC11M122454
  • GC11M122456
  • GC11M122458
  • GC11M122460
  • GC11M122463
  • GC11M122468
  • GC11M122934
  • GC11M122938
  • GC11M118870
  • GC11M122942
  • GC11M122947
  • GC11M122948
  • GC11M122952
  • GC11M122959
  • GC11M122969
  • GC11M122982

Summaries for HSPA8 Gene

Entrez Gene Summary for HSPA8 Gene

  • This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HSPA8 Gene

HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Primary Hyperoxaluria and Oral Lichen Planus. Among its related pathways are Vesicle-mediated transport and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot Summary for HSPA8 Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).

Gene Wiki entry for HSPA8 Gene

Additional gene information for HSPA8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA8 Gene

Genomics for HSPA8 Gene

GeneHancer (GH) Regulatory Elements for HSPA8 Gene

Promoters and enhancers for HSPA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J123055 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +2.1 2118 10.9 ZNF24 SP1 ZBTB40 ZBTB6 FOXA1 RBPJ SMARCE1 POLR2A FOS MIXL1 ENSG00000288061 HSPA8 LOC101929289 SNORD14C lnc-CLMP-3 lnc-JHY-5 piR-59038 piR-61486 ZNF202 CLMP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA8 gene promoter:
  • p300
  • Sp1
  • STAT1
  • STAT3

Genomic Locations for HSPA8 Gene

Genomic Locations for HSPA8 Gene
chr11:123,057,489-123,063,230
(GRCh38/hg38)
Size:
5,742 bases
Orientation:
Minus strand
chr11:122,928,197-122,933,938
(GRCh37/hg19)
Size:
5,742 bases
Orientation:
Minus strand

Genomic View for HSPA8 Gene

Genes around HSPA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSPA8 Gene

Proteins for HSPA8 Gene

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  • Protein details for HSPA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11142-HSP7C_HUMAN
    Recommended name:
    Heat shock cognate 71 kDa protein
    Protein Accession:
    P11142
    Secondary Accessions:
    • Q9H3R6

    Protein attributes for HSPA8 Gene

    Size:
    646 amino acids
    Molecular mass:
    70898 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7. Interacts with DNAJB12 (via J domain) (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661). Interacts with DNAJB14 (via J domain) (PubMed:23018488, PubMed:24732912, PubMed:27916661). Interacts (via C-terminus) with the E3 ligase CHIP forming a 210 kDa complex of one CHIP and two HSPA8 molecules. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts with TRIM5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with METTL21A. Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1. Interacts with PRKN. Interacts with FOXP3. Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with MLLT11 (PubMed:24880125). Interacts with RNF207 (PubMed:25281747). Interacts with DNAJC21 (PubMed:27346687). Interacts with DNAJB2 (PubMed:15936278). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with SGTA (via TPR repeats) (By similarity). Interacts with HSF1 (via transactivation domain) (PubMed:9499401). Interacts with HOPX, HSP40 and HSP90 (PubMed:27708256). Interacts with STUB1 (PubMed:27708256). Interacts with BAG2 (PubMed:24318877). Interacts with BAG3 (PubMed:27474739, PubMed:24318877). Interacts with DNAJC12 (PubMed:24122553). Interacts with ZMYND10 (PubMed:29601588). Interacts with HSPC138 (PubMed:25760597). Interacts with BCL2L1, GIMAP5 and MCL1; the interaction with BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (By similarity). Interacts with NLPR12 (PubMed:17947705).
    • (Microbial infection) Interacts with SV40 VP1.

    Three dimensional structures from OCA and Proteopedia for HSPA8 Gene

    Alternative splice isoforms for HSPA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA8 Gene

Protein Expression for HSPA8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSPA8 Gene

  • Acetylated.
  • ISGylated.
  • Trimethylation at Lys-561 reduces fibrillar SNCA binding.
  • Glycosylation at Asn35
  • Ubiquitination at Lys3, Lys25, Lys56, Lys71, Lys88, Lys112, Lys126, Lys128, Lys137, Lys159, Lys187, Lys188, Lys246, Lys319, Lys325, Lys328, Lys361, Lys423, Lys458, Lys512, Lys539, Lys573, Lys583, Lys597, and Lys601
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HSP7C_HUMAN (1299)

Other Protein References for HSPA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HSPA8

No data available for DME Specific Peptides for HSPA8 Gene

Domains & Families for HSPA8 Gene

Gene Families for HSPA8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA8 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77848 (A8K7Q2_HUMAN)
  • Heat shock 70 kDa protein 8 (HSP7C_HUMAN)
  • HSPA8 protein (Q96H53_HUMAN)
  • HSPA8 protein (Q96IS6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11142

UniProtKB/Swiss-Prot:

HSP7C_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA8: view

Function for HSPA8 Gene

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Molecular function for HSPA8 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).
UniProtKB/Swiss-Prot Induction:
Constitutively synthesized.
GENATLAS Biochemistry:
heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program

Phenotypes From GWAS Catalog for HSPA8 Gene

Gene Ontology (GO) - Molecular Function for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IPI 12150907
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9305631
GO:0005524 ATP binding IEA,IDA 23921388
GO:0016887 ATPase activity TAS,IDA --
genes like me logo Genes that share ontologies with HSPA8: view
genes like me logo Genes that share phenotypes with HSPA8: view

Animal Model Products

CRISPR Products

miRNA for HSPA8 Gene

miRTarBase miRNAs that target HSPA8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA8

Clone Products

  • Addgene plasmids for HSPA8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA8 Gene

Localization for HSPA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA8 Gene

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA8 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
lysosome 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IDA 20176811
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IDA,IBA 20176811
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HSPA8: view

Pathways & Interactions for HSPA8 Gene

genes like me logo Genes that share pathways with HSPA8: view

SIGNOR curated interactions for HSPA8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0006457 protein folding NAS 8530083
GO:0006986 response to unfolded protein NAS,IBA 11093761
GO:0007269 neurotransmitter secretion TAS --
genes like me logo Genes that share ontologies with HSPA8: view

Drugs & Compounds for HSPA8 Gene

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(69) Drugs for HSPA8 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 227
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 312
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Experimental Pharma Target 0
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 108

(52) Additional Compounds for HSPA8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA8: view

Transcripts for HSPA8 Gene

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mRNA/cDNA for HSPA8 Gene

(2) REFSEQ mRNAs :
(26) Additional mRNA sequences :
(2778) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA8

Clone Products

  • Addgene plasmids for HSPA8

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - - -
SP3: - - - - - - -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for HSPA8 Gene

GeneLoc Exon Structure for
HSPA8
ECgene alternative splicing isoforms for
HSPA8

Expression for HSPA8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA8 Gene

mRNA expression in normal human tissues for HSPA8 Gene
mRNA expression by GTEx for HSPA8 GenemRNA expression by BioGPS for HSPA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA8 Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA8 Gene



Protein tissue co-expression partners for HSPA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA8 Gene:

HSPA8

SOURCE GeneReport for Unigene cluster for HSPA8 Gene:

Hs.180414

mRNA Expression by UniProt/SwissProt for HSPA8 Gene:

P11142-HSP7C_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HSPA8 Gene

  • Intestine(5)
  • Kidney(5)
  • Liver(5)
  • Skin(5)
  • Nervous system(5)
  • Blood(4.9)
  • Lung(4.9)
  • Muscle(4.9)
  • Spleen(4.9)
  • Eye(4.8)
  • Heart(4.7)
  • Pancreas(4.7)
  • Stomach(4.7)
  • Bone(4.1)
  • Adrenal gland(3)
  • Lymph node(3)
  • Gall bladder(2.5)
  • Thyroid gland(2.4)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with HSPA8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA8 Gene

Orthologs for HSPA8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA8 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 100 (a)
 OneToMany
-- 33
  • 99 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia HSPA8 33 32
  • 99.33 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia HSPA8 33 32
  • 92.12 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia HSPA8 33 32
  • 91.07 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hspa8 32
  • 89.78 (n)
mouse
(Mus musculus)
 Mammalia Hspa8 17 33 32
  • 89.53 (n)
chicken
(Gallus gallus)
 Aves HSPA8 33 32
  • 84.42 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HSPA8 33
  • 99 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hspa8 32
  • 82.3 (n)
Str.5671 32
zebrafish
(Danio rerio)
 Actinopterygii HSPA8 (1 of 2) 33
  • 93 (a)
 OneToMany
hspa8 33 32
  • 82.54 (n)
 OneToMany
-- 32
fruit fly
(Drosophila melanogaster)
 Insecta Hsc70-4 33 34
  • 85 (a)
 ManyToMany
Hsp70Bc 34
  • 76 (a)
Hsp70Aa 34
  • 76 (a)
Hsp70Bb 34
  • 76 (a)
Hsp70Ba 34
  • 76 (a)
Hsp70Ab 34
  • 75 (a)
Hsc70-2 34
  • 73 (a)
Hsc70-1 33 34 32
  • 71.41 (n)
 ManyToMany
Hsp68 34
  • 71 (a)
Hsc70-3 34
  • 64 (a)
CG7182 34
  • 25 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004944 32
  • 72.33 (n)
worm
(Caenorhabditis elegans)
 Secernentea hsp-2 34
  • 75 (a)
hsp-1 33 34 32
  • 74.01 (n)
 OneToMany
F44E5.5 34
  • 69 (a)
F44E5.4 34
  • 69 (a)
hsp-70 34
  • 68 (a)
hsp-4 34
  • 63 (a)
hsp-3 34
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SSA2 33
  • 76 (a)
 OneToMany
SSB2 35
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G09440 32
  • 70.66 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11098 33
  • 86 (a)
 ManyToMany
CSA.971 33
  • 79 (a)
 ManyToMany
Cin.2748 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2748 32
Species where no ortholog for HSPA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA8 Gene

ENSEMBL:
Gene Tree for HSPA8 (if available)
TreeFam:
Gene Tree for HSPA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA8: view image

Paralogs for HSPA8 Gene

Paralogs for HSPA8 Gene

(19) SIMAP similar genes for HSPA8 Gene using alignment to 16 proteins:

  • HSP7C_HUMAN
  • A8K7Q2_HUMAN
  • E9PI65_HUMAN
  • E9PK54_HUMAN
  • E9PKE3_HUMAN
  • E9PLF4_HUMAN
  • E9PM13_HUMAN
  • E9PN25_HUMAN
  • E9PN89_HUMAN
  • E9PNE6_HUMAN
  • E9PPY6_HUMAN
  • E9PQK7_HUMAN
  • E9PQQ4_HUMAN
  • E9PS65_HUMAN
  • Q96H53_HUMAN
  • Q96IS6_HUMAN

Pseudogenes.org Pseudogenes for HSPA8 Gene

genes like me logo Genes that share paralogs with HSPA8: view

Variants for HSPA8 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for HSPA8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000333769 -- 123,059,644(-) C/T coding_sequence_variant, missense_variant
rs1000893027 -- 123,062,137(-) A/C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000900919 -- 123,064,291(-) T/C upstream_transcript_variant
rs1001112689 -- 123,058,554(-) G/C intron_variant
rs1001113413 -- 123,061,368(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA8 Gene

Variant ID Type Subtype PubMed ID
nsv1039284 CNV gain 25217958
nsv983069 CNV duplication 23825009

Variation tolerance for HSPA8 Gene

Residual Variation Intolerance Score: 4.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA8 Gene

Human Gene Mutation Database (HGMD)
HSPA8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA8 Gene

Disorders for HSPA8 Gene

MalaCards: The human disease database

(7) MalaCards diseases for HSPA8 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
primary hyperoxaluria
  • glycolic aciduria
oral lichen planus
  • oral lichenoid lesions
sleeping sickness
  • african sleeping sickness
dowling-degos disease
  • ddd
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search HSPA8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPA8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA8 Gene

Publications for HSPA8 Gene

  1. Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70. (PMID: 11093761) Tsukahara F … Muraki T (Molecular pharmacology 2000) 3 4 23 56
  2. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PMID: 8530083) Tavaria M … Kola I (Genomics 1995) 2 3 23 56
  3. Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PMID: 3037489) Dworniczak B … Mirault ME (Nucleic acids research 1987) 2 3 4 56
  4. ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. (PMID: 29601588) Cho KJ … Gee HY (PLoS genetics 2018) 3 4 56
  5. Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins. (PMID: 27916661) Li K … Cai SQ (Molecular cell 2017) 3 4 56

ExternalLinks

View latest publications for HSPA8 gene in Mastermind

Products for HSPA8 Gene

  • Addgene plasmids for HSPA8

Sources for HSPA8 Gene