Aliases for HSPA7 Gene

Aliases for HSPA7 Gene

  • Heat Shock Protein Family A (Hsp70) Member 7 (Pseudogene) 2 3 5
  • HSP70B 2 3 4
  • Heat Shock 70kDa Protein 7 (HSP70B) 2 3
  • Heat Shock 70kD Protein 7 (HSP70B) 2 3
  • Heat Shock Protein Family A (Hsp70) Member 7 2
  • Putative Heat Shock 70 KDa Protein 7 4
  • Heat Shock 70 KDa Protein B 4
  • HSPA7 5

External Ids for HSPA7 Gene

Previous GeneCards Identifiers for HSPA7 Gene

  • GC01U990091
  • GC01P158763
  • GC01P158307
  • GC01P159842
  • GC01P159762
  • GC01P161494
  • GC01P161575

Summaries for HSPA7 Gene

GeneCards Summary for HSPA7 Gene

HSPA7 (Heat Shock Protein Family A (Hsp70) Member 7 (Pseudogene)) is a Pseudogene. Among its related pathways are Cellular response to heat stress and Development_Glucocorticoid receptor signaling.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA7 Gene

Genomics for HSPA7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161605 Promoter/Enhancer 0.6 Ensembl dbSUPER 250.7 +0.2 242 2.2 ZBTB33 HSPA7 TRD-GTC9-1 FCGR3B FCGR2B HSALNG0007924 TRL-CAA6-1 lnc-FCGR2B-2 FCGR2C
GH01J161313 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 -291.6 -291558 2.6 SP1 NCOR1 ZNF580 ZNF592 POLR2A BRCA1 ZIC2 ZBTB10 YY1 REST SDHC lnc-MPZ-2 piR-52261-025 DUSP12 USP21 PPOX HSPA7 CFAP126 HSALNG0007924
GH01J161705 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 7 +101.1 101086 3.2 BCLAF1 IKZF1 POLR2A CEBPA BCL11A SMAD5 HES1 BHLHE40 ZNF639 ARNT FCRLA HSALNG0007969 FCRLB FCGR2B HSPA7
GH01J161539 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 6 -64.5 -64464 5.2 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 ZNF600 ZNF580 ZNF592 ATF2 CEBPA K01921-010 TRN-GTT1-1 MK279986 piR-33470-008 DUSP12 FCGR2C USP21 ARHGAP30 FCGR2A FCRLB
GH01J161304 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 5.9 -299.8 -299791 3.3 MYC NCOR1 IKZF1 ZNF592 POLR2A YY1 CTCF SMAD5 MBD2 TBP HSALNG0007929 lnc-CFAP126-2 FCER1G NDUFS2 NR1I3 TOMM40L APOA2 PCP4L1 SDHC HSPA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA7 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the HSPA7 gene promoter:
  • AML1a
  • E47
  • Hand1
  • NRSF form 1
  • NRSF form 2
  • p53
  • STAT3

Genomic Locations for HSPA7 Gene

Latest Assembly
chr1:161,606,059-161,608,551
(GRCh38/hg38)
Size:
2,493 bases
Orientation:
Plus strand

Previous Assembly
chr1:161,575,849-161,578,341
(GRCh37/hg19 by Entrez Gene)
Size:
2,493 bases
Orientation:
Plus strand

chr1:161,576,081-161,578,007
(GRCh37/hg19 by Ensembl)
Size:
1,927 bases
Orientation:
Plus strand

Genomic View for HSPA7 Gene

Genes around HSPA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA7 Gene

Proteins for HSPA7 Gene

  • Protein details for HSPA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48741-HSP77_HUMAN
    Recommended name:
    Putative heat shock 70 kDa protein 7
    Protein Accession:
    P48741
    Secondary Accessions:
    • P19790

    Protein attributes for HSPA7 Gene

    Size:
    367 amino acids
    Molecular mass:
    40244 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPA7 Gene

Post-translational modifications for HSPA7 Gene

  • Glycosylation at Asn37
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HSP77_HUMAN (1695)

No data available for DME Specific Peptides for HSPA7 Gene

Domains & Families for HSPA7 Gene

Gene Families for HSPA7 Gene

Protein Domains for HSPA7 Gene

Suggested Antigen Peptide Sequences for HSPA7 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 70 kDa protein B (HSP77_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48741

UniProtKB/Swiss-Prot:

HSP77_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA7: view

Function for HSPA7 Gene

Molecular function for HSPA7 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A7,structurally related to aconitase

Phenotypes From GWAS Catalog for HSPA7 Gene

Gene Ontology (GO) - Molecular Function for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
GO:0031072 heat shock protein binding IBA 21873635
GO:0031625 ubiquitin protein ligase binding IBA 21873635
genes like me logo Genes that share ontologies with HSPA7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPA7 Gene

Localization for HSPA7 Gene

Gene Ontology (GO) - Cellular Components for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0008180 colocalizes_with COP9 signalosome IDA, IBA 18850735
genes like me logo Genes that share ontologies with HSPA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSPA7 Gene

Pathways & Interactions for HSPA7 Gene

PathCards logo

SuperPathways for HSPA7 Gene

SuperPathway Contained pathways
1 Cellular response to heat stress
2 Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
.37
.37
3 Cellular Senescence (REACTOME)
4 Development_Glucocorticoid receptor signaling
-
5 Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
.97
genes like me logo Genes that share pathways with HSPA7: view

Pathways by source for HSPA7 Gene

6 GeneGo (Thomson Reuters) pathways for HSPA7 Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway

Interacting Proteins for HSPA7 Gene

Gene Ontology (GO) - Biological Process for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0034620 cellular response to unfolded protein IBA 21873635
GO:0042026 protein refolding IBA 21873635
GO:0051085 chaperone cofactor-dependent protein refolding IBA 21873635
genes like me logo Genes that share ontologies with HSPA7: view

No data available for SIGNOR curated interactions for HSPA7 Gene

Drugs & Compounds for HSPA7 Gene

No Compound Related Data Available

Transcripts for HSPA7 Gene

mRNA/cDNA for HSPA7 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA7 Gene

No ASD Table

Relevant External Links for HSPA7 Gene

GeneLoc Exon Structure for
HSPA7

Expression for HSPA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA7 Gene

mRNA differential expression in normal tissues according to GTEx for HSPA7 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for HSPA7 Gene

This gene is overexpressed in Lavage (51.3) and Urine (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSPA7 Gene



Protein tissue co-expression partners for HSPA7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA7

SOURCE GeneReport for Unigene cluster for HSPA7 Gene:

Hs.662180
genes like me logo Genes that share expression patterns with HSPA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA7 Gene

Orthologs for HSPA7 Gene

Evolution for HSPA7 Gene

ENSEMBL:
Gene Tree for HSPA7 (if available)
TreeFam:
Gene Tree for HSPA7 (if available)
Alliance of Genome Resources:
Additional Orthologs for HSPA7

No data available for Orthologs for HSPA7 Gene

Paralogs for HSPA7 Gene

(18) SIMAP similar genes for HSPA7 Gene using alignment to 1 proteins:

  • HSP77_HUMAN
genes like me logo Genes that share paralogs with HSPA7: view

No data available for Paralogs for HSPA7 Gene

Variants for HSPA7 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPA7 Gene

Variant ID Type Subtype PubMed ID
dgv22n16 CNV deletion 17901297
dgv23n16 CNV insertion 17901297
dgv24n16 CNV insertion 17901297
dgv38e201 CNV deletion 23290073
dgv447n100 CNV gain 25217958
dgv448n100 CNV loss 25217958
dgv449n100 CNV gain+loss 25217958
dgv450n100 CNV gain 25217958
dgv451n100 CNV loss 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv605n54 CNV loss 21841781
dgv606n54 CNV loss 21841781
dgv607n54 CNV loss 21841781
dgv75e199 CNV deletion 23128226
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2507888 CNV deletion 19546169
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv2997123 CNV deletion 24192839
esv3325 CNV loss 18987735
esv33393 CNV gain+loss 17666407
esv3541689 CNV deletion 23714750
esv3584532 CNV gain 24956385
esv3587731 CNV loss 21293372
esv3587732 CNV loss 21293372
esv3587733 CNV gain 21293372
esv3890693 CNV loss 25118596
esv5752 CNV loss 19470904
esv990743 CNV loss 20482838
esv997087 CNV loss 20482838
nsv1112219 CNV deletion 24896259
nsv1115373 CNV duplication 24896259
nsv1161862 CNV duplication 26073780
nsv428257 CNV loss 18775914
nsv442209 CNV gain 18776908
nsv464173 CNV gain 19166990
nsv509546 CNV insertion 20534489
nsv514915 CNV gain 21397061
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548066 CNV gain 21841781
nsv548072 CNV loss 21841781
nsv818489 CNV gain 17921354
nsv818500 CNV gain 17921354
nsv819523 CNV loss 19587683
nsv820341 CNV duplication 20802225
nsv821621 CNV loss 15273396
nsv825176 CNV gain 20364138
nsv825242 CNV loss 20364138
nsv825254 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946468 CNV duplication 23825009

Additional Variant Information for HSPA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA7
Leiden Open Variation Database (LOVD)
HSPA7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for HSPA7 Gene

Disorders for HSPA7 Gene

Additional Disease Information for HSPA7

No disorders were found for HSPA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA7 Gene

Publications for HSPA7 Gene

  1. The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional. (PMID: 11072087) Parsian AJ … Hunt CR (Biochimica et biophysica acta 2000) 2 3 22
  2. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PMID: 1346391) Leung TK … Lim L (Genomics 1992) 2 3
  3. Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. (PMID: 3927293) Voellmy R … Rungger D (Proceedings of the National Academy of Sciences of the United States of America 1985) 3 4
  4. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3

Products for HSPA7 Gene

Sources for HSPA7 Gene