Aliases for HSPA6 Gene
External Ids for HSPA6 Gene
Previous GeneCards Identifiers for HSPA6 Gene
GeneCards Summary for HSPA6 Gene
HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a Protein Coding gene. Diseases associated with HSPA6 include Hepatocellular Carcinoma. Among its related pathways are Cellular response to heat stress and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and heat shock protein binding. An important paralog of this gene is HSPA1A.
UniProtKB/Swiss-Prot Summary for HSPA6 Gene
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).