Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPA5 Gene

Aliases for HSPA5 Gene

  • Heat Shock Protein Family A (Hsp70) Member 5 2 3 5
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) 2 3
  • Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78 3 4
  • Immunoglobulin Heavy Chain-Binding Protein 3 4
  • Glucose-Regulated Protein, 78kDa 2 3
  • GRP78 3 4
  • BIP 3 4
  • Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD) 2
  • Epididymis Secretory Sperm Binding Protein Li 89n 3
  • 78 KDa Glucose-Regulated Protein 3
  • Heat Shock 70 KDa Protein 5 4
  • HEL-S-89n 3
  • GRP-78 4
  • MIF2 3

External Ids for HSPA5 Gene

Previous HGNC Symbols for HSPA5 Gene

  • GRP78

Previous GeneCards Identifiers for HSPA5 Gene

  • GC09M119111
  • GC09M119643
  • GC09M121450
  • GC09M123373
  • GC09M125076
  • GC09M127036
  • GC09M127997
  • GC09M097610

Summaries for HSPA5 Gene

Entrez Gene Summary for HSPA5 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

CIViC summary for HSPA5 Gene

GeneCards Summary for HSPA5 Gene

HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) is a Protein Coding gene. Diseases associated with HSPA5 include Borna Disease and Wolfram Syndrome 1. Among its related pathways are Unfolded Protein Response (UPR) and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot for HSPA5 Gene

  • Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).

Gene Wiki entry for HSPA5 Gene

Additional gene information for HSPA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA5 Gene

Genomics for HSPA5 Gene

GeneHancer (GH) Regulatory Elements for HSPA5 Gene

Promoters and enhancers for HSPA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I125238 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 0.0 -49 6.6 PKNOX1 CLOCK SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 GAPVD1 ENSG00000239705 GC09M125241 HSPA5 GOLGA1 PRPS1P2 RABEPK RPL35 OLFML2A
GH09I125659 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -418.6 -418600 1.5 PKNOX1 EBF1 BATF IRF4 RELA NFATC1 ATF7 ETV6 FOS IKZF2 RNU6-1020P GAPVD1 HSPA5 MAPKAP1 HNRNPA1P15
GH09I125236 Enhancer 0.5 dbSUPER 0.8 +4.6 4567 1.3 CTCF SMAD5 ZBED1 ZNF384 PRDM4 GC09M125241 HSPA5 RABEPK
GH09I125233 Enhancer 0.9 ENCODE dbSUPER 0.4 +7.3 7256 2.1 IRF2 SMAD1 JUN CHD7 FOSL1 CCNT2 POLR2A NFATC1 PRDM10 FOS RABEPK SCAI MIR181A2HG PRPS1P2 GC09M125241 HSPA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA5 gene promoter:

Genomic Locations for HSPA5 Gene

Genomic Locations for HSPA5 Gene
6,540 bases
Minus strand

Genomic View for HSPA5 Gene

Genes around HSPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA5 Gene

Proteins for HSPA5 Gene

  • Protein details for HSPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    78 kDa glucose-regulated protein
    Protein Accession:
    Secondary Accessions:
    • B0QZ61
    • Q2EF78
    • Q9NPF1
    • Q9UK02

    Protein attributes for HSPA5 Gene

    654 amino acids
    Molecular mass:
    72333 Da
    Quaternary structure:
    • Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity). Interacts with TMEM132A and TRIM21 (PubMed:12699405). May form a complex with ERLEC1, OS9, SEL1L and SYVN1 (PubMed:18264092,PubMed:18502753). Interacts with DNAJC10 (PubMed:12411443, PubMed:23769672). Interacts with MX1 (By similarity). Interacts with METTL23 (PubMed:23349634). Interacts with CEMIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration (PubMed:23990668). Interacts with PCSK4 form; the interaction takes place in the endoplasmic reticulum (PubMed:21080038). Interacts with CIPC (PubMed:26657846). Interacts with CCDC88B (via C-terminus); the interaction opposes ERN1-mediated JNK activation, protecting against apoptosis (PubMed:21289099). Interacts with INPP5K; necessary for INPP5K localization at the endoplasmic reticulum (PubMed:26940976).

    Three dimensional structures from OCA and Proteopedia for HSPA5 Gene

neXtProt entry for HSPA5 Gene

Post-translational modifications for HSPA5 Gene

  • Ubiquitination at isoforms=96, posLast=113113, posLast=118118, posLast=268268, isoforms=326, posLast=370370, posLast=376376, posLast=523523, posLast=547547, posLast=573573, and isoforms=601
  • Glycosylation at posLast=6969, posLast=203203, and posLast=643643
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA5 Gene

Domains & Families for HSPA5 Gene

Gene Families for HSPA5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for HSPA5 Gene

Suggested Antigen Peptide Sequences for HSPA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA5: view

Function for HSPA5 Gene

Molecular function for HSPA5 Gene

GENATLAS Biochemistry:
glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2
UniProtKB/Swiss-Prot Function:
Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding TAS 16130169
GO:0005515 protein binding IPI 11907036
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IDA,ISS --
GO:0019899 enzyme binding IPI 23921388
genes like me logo Genes that share ontologies with HSPA5: view
genes like me logo Genes that share phenotypes with HSPA5: view

Animal Models for HSPA5 Gene

MGI Knock Outs for HSPA5:

Clone Products

  • Addgene plasmids for HSPA5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA5 Gene

Localization for HSPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA5 Gene

Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:12643545}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA5 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
mitochondrion 4
cytosol 4
plasma membrane 3
cytoskeleton 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 11943137
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA,TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with HSPA5: view

Pathways & Interactions for HSPA5 Gene

genes like me logo Genes that share pathways with HSPA5: view

Gene Ontology (GO) - Biological Process for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006983 ER overload response IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response IEA --
GO:0009314 response to radiation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0021589 cerebellum structural organization IEA --
genes like me logo Genes that share ontologies with HSPA5: view

No data available for SIGNOR curated interactions for HSPA5 Gene

Drugs & Compounds for HSPA5 Gene

(55) Drugs for HSPA5 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Antihemophilic factor, human recombinant Approved, Investigational Pharma Target, chaperone 0
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, binding 1232
Platinum compounds Pharma 0

(46) Additional Compounds for HSPA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA5: view

Transcripts for HSPA5 Gene

mRNA/cDNA for HSPA5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1367) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA5 Gene

Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa):
Representative Sequences:

Clone Products

  • Addgene plasmids for HSPA5

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA5 Gene

No ASD Table

Relevant External Links for HSPA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA5 Gene

Protein differential expression in normal tissues from HIPED for HSPA5 Gene

This gene is overexpressed in Bone marrow stromal cell (6.9) and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA5 Gene

Protein tissue co-expression partners for HSPA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA5 Gene:


SOURCE GeneReport for Unigene cluster for HSPA5 Gene:


Evidence on tissue expression from TISSUES for HSPA5 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Muscle(4.6)
  • Intestine(4.3)
  • Pancreas(4.2)
  • Lung(4.1)
  • Thyroid gland(3.8)
  • Heart(3.7)
  • Eye(3.4)
  • Kidney(3.4)
  • Blood(3.1)
  • Bone(3.1)
  • Skin(3)
  • Stomach(3)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Spleen(2.8)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with HSPA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA5 Gene

Orthologs for HSPA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPA5 33 34
  • 99.69 (n)
(Monodelphis domestica)
Mammalia HSPA5 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia HSPA5 34
  • 96 (a)
(Canis familiaris)
Mammalia HSPA5 33 34
  • 94.09 (n)
(Bos Taurus)
Mammalia HSPA5 33
  • 94.05 (n)
(Mus musculus)
Mammalia Hspa5 33 16 34
  • 92.35 (n)
(Rattus norvegicus)
Mammalia Hspa5 33
  • 91.03 (n)
(Gallus gallus)
Aves HSPA5 33 34
  • 84.59 (n)
(Anolis carolinensis)
Reptilia HSPA5 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492570 33
  • 80.91 (n)
Str.3462 33
African clawed frog
(Xenopus laevis)
Amphibia hspa5-prov 33
(Danio rerio)
Actinopterygii hspa5 33 34
  • 77.55 (n)
Dr.26116 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11216 33
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-3 33 34
  • 73.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004192 33
  • 71.81 (n)
(Caenorhabditis elegans)
Secernentea hsp-4 34
  • 75 (a)
hsp-3 33 34
  • 71.02 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09559g 33
  • 64.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR2 33 36
  • 64.59 (n)
SSA2 34
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR038W 33
  • 62.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons BIP1 33
  • 64.91 (n)
(Glycine max)
eudicotyledons Gma.17631 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4801 33
(Oryza sativa)
Liliopsida Os02g0115900 33
  • 66.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bip1 33
  • 66.83 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03982 33
  • 65.76 (n)
Species where no ortholog for HSPA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA5 Gene

Gene Tree for HSPA5 (if available)
Gene Tree for HSPA5 (if available)

Paralogs for HSPA5 Gene

Paralogs for HSPA5 Gene

(14) SIMAP similar genes for HSPA5 Gene using alignment to 1 proteins: Pseudogenes for HSPA5 Gene

genes like me logo Genes that share paralogs with HSPA5: view

Variants for HSPA5 Gene

Sequence variations from dbSNP and Humsavar for HSPA5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000089203 -- 125,242,018(-) T/C upstream_transcript_variant
rs1000192312 -- 125,241,627(-) C/G upstream_transcript_variant
rs1001027372 -- 125,235,962(-) TGGATT/T 3_prime_UTR_variant
rs1001147608 -- 125,243,149(-) G/A upstream_transcript_variant
rs1001276387 -- 125,234,659(-) TATATATGTATACATAAACACATATATATGTATACATA/TATATATGTATACATA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA5 Gene

Variant ID Type Subtype PubMed ID
nsv982345 CNV duplication 23825009

Variation tolerance for HSPA5 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA5 Gene

Disorders for HSPA5 Gene

MalaCards: The human disease database

(13) MalaCards diseases for HSPA5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
borna disease
  • enzootic encephalomyelitis
wolfram syndrome 1
  • wfs1
wolfram syndrome
  • wfs
halothane hepatitis
  • hepatitis halothane
short-rib thoracic dysplasia 2 with or without polydactyly
  • srtd2
- elite association - COSMIC cancer census association via MalaCards
Search HSPA5 in MalaCards View complete list of genes associated with diseases


  • Note=Autoantigen in rheumatoid arthritis. {ECO:0000269 PubMed:11160188}.

Additional Disease Information for HSPA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA5: view

No data available for Genatlas for HSPA5 Gene

Publications for HSPA5 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  2. ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor. (PMID: 23769672) Oka OB … Bulleid NJ (Molecular cell 2013) 3 4 58
  3. Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration. (PMID: 23990668) Evensen NA … Cao J (Journal of the National Cancer Institute 2013) 3 4 58
  4. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson ME … Falnes PØ (The Journal of biological chemistry 2013) 3 4 58
  5. The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone. (PMID: 21080038) Gyamera-Acheampong C … Mbikay M (Molecular and cellular biochemistry 2011) 3 4 58

Products for HSPA5 Gene

  • Addgene plasmids for HSPA5

Sources for HSPA5 Gene

Loading form....