The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provid... See more...

Aliases for HSPA4L Gene

Aliases for HSPA4L Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 Like 2 3 5
  • Heat Shock 70-Related Protein APG-1 3 4
  • Heat Shock 70kDa Protein 4-Like 2 3
  • Heat Shock 70 KDa Protein 4L 3 4
  • Osmotic Stress Protein 94 3 4
  • APG-1 2 3
  • HSPH3 2 3
  • Osp94 2 3
  • Testis Tissue Sperm-Binding Protein Li 64n 3
  • Heat Shock 70 KDa Protein 4-Like Protein 3
  • Heat Shock Protein (Hsp110 Family) 3
  • HSPA4L 5
  • OSP94 4
  • APG1 4

External Ids for HSPA4L Gene

Previous GeneCards Identifiers for HSPA4L Gene

  • GC04P129062
  • GC04P128922
  • GC04P128703
  • GC04P124431

Summaries for HSPA4L Gene

Entrez Gene Summary for HSPA4L Gene

  • The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for HSPA4L Gene

HSPA4L (Heat Shock Protein Family A (Hsp70) Member 4 Like) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). An important paralog of this gene is HSPA4.

UniProtKB/Swiss-Prot Summary for HSPA4L Gene

  • Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.

Gene Wiki entry for HSPA4L Gene

Additional gene information for HSPA4L Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA4L Gene

Genomics for HSPA4L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPA4L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J127781 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 609.7 +1.4 1449 4.3 ARHGAP35 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 NFKBIZ ZNF692 HSPA4L SLC25A31 INTU ABHD18 ENSG00000282855 PLK4
GH04J127879 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 8 +99.2 99205 3.2 BRCA1 SP1 CREB1 ATF7 ZNF629 LEF1 IKZF1 KDM1A ZNF692 POLR2A PLK4 lnc-MFSD8-12 INTU HSPA4L ABHD18
GH04J128059 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.8 +279.9 279905 3.8 BRCA1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 NFKBIZ ZNF692 POLR2A BACH1 LARP1B lnc-MFSD8-7 INTU MFSD8 HSPA4L ABHD18 lnc-LARP1B-4 ENSG00000241651 PGRMC2
GH04J127760 Enhancer 0.5 Ensembl 11.9 -21.7 -21695 0.2 CREB1 SP1 FOXA2 JUND FOXA1 FOSL2 FOS HSPA4L piR-51137-092 LOC105377414 SLC25A31
GH04J128159 Enhancer 0.9 Ensembl ENCODE 5.4 +380.0 380039 6.1 GATAD2A RXRB CTCF TCF7 JUND CEBPB FOXA1 SMARCC2 FOS FOXA2 HSPA4L INTU PGRMC2 FOSL1P1 RF00994-772 LARP1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA4L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA4L

Top Transcription factor binding sites by QIAGEN in the HSPA4L gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • Evi-1
  • FOXI1
  • GATA-1
  • HFH-3

Genomic Locations for HSPA4L Gene

Genomic Locations for HSPA4L Gene
chr4:127,781,796-127,840,733
(GRCh38/hg38)
Size:
58,938 bases
Orientation:
Plus strand
chr4:128,702,976-128,761,888
(GRCh37/hg19)
Size:
58,913 bases
Orientation:
Plus strand

Genomic View for HSPA4L Gene

Genes around HSPA4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4L Gene

Proteins for HSPA4L Gene

  • Protein details for HSPA4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95757-HS74L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 4L
    Protein Accession:
    O95757
    Secondary Accessions:
    • A2ICT2
    • Q4W5M5
    • Q8IWA2

    Protein attributes for HSPA4L Gene

    Size:
    839 amino acids
    Molecular mass:
    94512 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSPA4L Gene

Post-translational modifications for HSPA4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA4L Gene

Antibody Products

  • Abcam antibodies for HSPA4L
  • Boster Bio Antibodies for HSPA4L

No data available for DME Specific Peptides for HSPA4L Gene

Domains & Families for HSPA4L Gene

Gene Families for HSPA4L Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA4L Gene

Suggested Antigen Peptide Sequences for HSPA4L Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 70kDa protein 4-like, isoform CRA_b (A2ICT2_HUMAN)
  • Osmotic stress protein 94 (HS74L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95757

UniProtKB/Swiss-Prot:

HS74L_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4L: view

Function for HSPA4L Gene

Molecular function for HSPA4L Gene

UniProtKB/Swiss-Prot Function:
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
UniProtKB/Swiss-Prot Induction:
By heat shock and osmotic imbalance.

Phenotypes From GWAS Catalog for HSPA4L Gene

Gene Ontology (GO) - Molecular Function for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with HSPA4L: view
genes like me logo Genes that share phenotypes with HSPA4L: view

Animal Models for HSPA4L Gene

MGI Knock Outs for HSPA4L:

Animal Model Products

CRISPR Products

miRNA for HSPA4L Gene

miRTarBase miRNAs that target HSPA4L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4L Gene

Localization for HSPA4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4L Gene

Cytoplasm. Nucleus. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA4L gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IBA,IDA 21231916
genes like me logo Genes that share ontologies with HSPA4L: view

Pathways & Interactions for HSPA4L Gene

genes like me logo Genes that share pathways with HSPA4L: view

Pathways by source for HSPA4L Gene

Gene Ontology (GO) - Biological Process for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding ISS --
GO:0006986 response to unfolded protein TAS,ISS --
genes like me logo Genes that share ontologies with HSPA4L: view

No data available for SIGNOR curated interactions for HSPA4L Gene

Drugs & Compounds for HSPA4L Gene

(1) Drugs for HSPA4L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HSPA4L: view

Transcripts for HSPA4L Gene

mRNA/cDNA for HSPA4L Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4L

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: -
SP3:

Relevant External Links for HSPA4L Gene

GeneLoc Exon Structure for
HSPA4L

Expression for HSPA4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA4L Gene

This gene is overexpressed in Testis (x9.2).

Protein differential expression in normal tissues from HIPED for HSPA4L Gene

This gene is overexpressed in Brain (9.5), Cervix (9.2), Frontal cortex (8.8), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSPA4L Gene



Protein tissue co-expression partners for HSPA4L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA4L

SOURCE GeneReport for Unigene cluster for HSPA4L Gene:

Hs.135554

Evidence on tissue expression from TISSUES for HSPA4L Gene

  • Heart(4.3)
  • Nervous system(3.4)
  • Eye(2.7)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with HSPA4L: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA4L Gene

Orthologs for HSPA4L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSPA4L 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSPA4L 30 31
  • 94.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HSPA4L 30 31
  • 93.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HSPA4L 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hspa4l 30
  • 88.89 (n)
Mouse
(Mus musculus)
Mammalia Hspa4l 30 17 31
  • 88.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Chicken
(Gallus gallus)
Aves HSPA4L 30 31
  • 78.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HSPA4L 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii HSPA4L 31
  • 67 (a)
OneToOne
si:dkey-21a6.6 30
  • 66.67 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Hsc70Cb 31
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hsp-110 31
  • 45 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE2 31
  • 37 (a)
ManyToMany
SSE1 31
  • 37 (a)
ManyToMany
Corn
(Zea mays)
Liliopsida Zm.4273 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9760 31
  • 46 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1750 30
Species where no ortholog for HSPA4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HSPA4L Gene

ENSEMBL:
Gene Tree for HSPA4L (if available)
TreeFam:
Gene Tree for HSPA4L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA4L: view image

Paralogs for HSPA4L Gene

(16) SIMAP similar genes for HSPA4L Gene using alignment to 4 proteins:

  • HS74L_HUMAN
  • D6RJ96_HUMAN
  • E7ES43_HUMAN
  • E9PDE8_HUMAN
genes like me logo Genes that share paralogs with HSPA4L: view

Variants for HSPA4L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA4L Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
711912 Benign: not provided 127,795,779(+) C/T SYNONYMOUS_VARIANT
771363 Benign: not provided 127,827,310(+) C/T SYNONYMOUS_VARIANT
rs12507229 - p.Asn216Thr
rs1380154 - p.Leu211Ser
rs35518193 - p.Ile601Thr

Additional dbSNP identifiers (rs#s) for HSPA4L Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPA4L Gene

Variant ID Type Subtype PubMed ID
dgv199n111 CNV duplication 26073780
esv2669954 CNV deletion 23128226
esv2728291 CNV deletion 23290073
esv3602152 CNV loss 21293372
nsv1161147 CNV duplication 26073780
nsv437935 CNV loss 16468122
nsv830057 CNV loss 17160897
nsv980256 CNV duplication 23825009

Variation tolerance for HSPA4L Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA4L Gene

Human Gene Mutation Database (HGMD)
HSPA4L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA4L Gene

Disorders for HSPA4L Gene

Additional Disease Information for HSPA4L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for HSPA4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA4L Gene

Publications for HSPA4L Gene

  1. Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. (PMID: 10524232) Nonoguchi K … Fujita J (Gene 1999) 2 3 4 23
  2. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. (PMID: 19169850) Mala JG … Takeuchi S (Molecular biotechnology 2009) 3 4 23
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for HSPA4L Gene

Sources for HSPA4L Gene