Aliases for HSPA4 Gene

Aliases for HSPA4 Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 2 3 5
  • Heat Shock 70-Related Protein APG-2 3 4
  • Heat Shock 70 KDa Protein 4 3 4
  • Heat Shock 70kD Protein 4 2 3
  • Hsp70 RY 2 3
  • HS24/P52 2 3
  • HSPH2 2 3
  • Epididymis Secretory Sperm Binding Protein Li 5a 3
  • Heat Shock Protein, 110 KDa 3
  • Heat Shock 70kDa Protein 4 2
  • HEL-S-5a 3
  • Hsp70RY 3
  • HSP70RY 4
  • APG-2 3
  • Hsp70 3
  • HSPA4 5
  • APG2 4
  • RY 3

External Ids for HSPA4 Gene

Previous GeneCards Identifiers for HSPA4 Gene

  • GC05P131909
  • GC05P132834
  • GC05P132418
  • GC05P132463
  • GC05P132415
  • GC05P127579

Summaries for HSPA4 Gene

GeneCards Summary for HSPA4 Gene

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Vulvovaginitis and Babesiosis. Among its related pathways are Cellular response to heat stress and Validated targets of C-MYC transcriptional activation. An important paralog of this gene is HSPA4L.

Gene Wiki entry for HSPA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA4 Gene

Genomics for HSPA4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA4

Top Transcription factor binding sites by QIAGEN in the HSPA4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for HSPA4 Gene

Latest Assembly
54,437 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
54,437 bases
Plus strand

(GRCh37/hg19 by Ensembl)
54,488 bases
Plus strand

Genomic View for HSPA4 Gene

Genes around HSPA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4 Gene

Proteins for HSPA4 Gene

  • Protein details for HSPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 4
    Protein Accession:
    Secondary Accessions:
    • O95756
    • Q2TAL4
    • Q9BUK9

    Protein attributes for HSPA4 Gene

    840 amino acids
    Molecular mass:
    94331 Da
    Quaternary structure:
    • Interacts with TJP1/ZO-1.
    • Sequence=AAA02807.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPA4 Gene


neXtProt entry for HSPA4 Gene

Post-translational modifications for HSPA4 Gene

  • Ubiquitination at Lys44, Lys53, Lys61, Lys124, Lys194, Lys221, Lys235, Lys305, Lys422, Lys430, Lys573, Lys638, Lys674, Lys679, Lys686, Lys697, Lys704, Lys711, Lys719, Lys736, Lys748, Lys754, and Lys773
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA4 Gene

No data available for DME Specific Peptides for HSPA4 Gene

Domains & Families for HSPA4 Gene

Gene Families for HSPA4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HSPA4 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 70-related protein APG-2 (HSP74_HUMAN)
  • HS24/P52 (O14992_HUMAN)
  • HS24/P52 protein (Q7KYN0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4: view

Function for HSPA4 Gene

Molecular function for HSPA4 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A4,structurally related to aconitase

Phenotypes From GWAS Catalog for HSPA4 Gene

Gene Ontology (GO) - Molecular Function for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 20029029
GO:0005524 ATP binding IEA,NAS 8335910
genes like me logo Genes that share ontologies with HSPA4: view
genes like me logo Genes that share phenotypes with HSPA4: view

Animal Models for HSPA4 Gene

MGI Knock Outs for HSPA4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4 Gene

Localization for HSPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 3
cytoskeleton 3
endoplasmic reticulum 3
endosome 3
lysosome 3
peroxisome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IBA,IDA 21231916
GO:0070062 extracellular exosome IDA 21276792
genes like me logo Genes that share ontologies with HSPA4: view

Pathways & Interactions for HSPA4 Gene

PathCards logo

SuperPathways for HSPA4 Gene

genes like me logo Genes that share pathways with HSPA4: view

Pathways by source for HSPA4 Gene

6 GeneGo (Thomson Reuters) pathways for HSPA4 Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway
4 Qiagen pathways for HSPA4 Gene
  • Androgen Signaling
  • Cellular Transformation by HTLV1
  • eNOS Signaling
  • Parkinson's Disease Pathway
1 GeneTex pathway for HSPA4 Gene

Gene Ontology (GO) - Biological Process for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 8335910
GO:0045040 protein import into mitochondrial outer membrane IDA 15644312
GO:0051131 chaperone-mediated protein complex assembly IDA 15644312
genes like me logo Genes that share ontologies with HSPA4: view

No data available for SIGNOR curated interactions for HSPA4 Gene

Drugs & Compounds for HSPA4 Gene

(85) Drugs for HSPA4 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(66) Additional Compounds for HSPA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HSPA4 Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA4: view

Drug products for research

Transcripts for HSPA4 Gene

mRNA/cDNA for HSPA4 Gene

41 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4 Gene

No ASD Table

Relevant External Links for HSPA4 Gene

GeneLoc Exon Structure for

Expression for HSPA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA4 Gene

Protein differential expression in normal tissues from HIPED for HSPA4 Gene

This gene is overexpressed in Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA4 Gene

Protein tissue co-expression partners for HSPA4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA4

SOURCE GeneReport for Unigene cluster for HSPA4 Gene:


Evidence on tissue expression from TISSUES for HSPA4 Gene

  • Nervous system(4.9)
  • Skin(4.8)
  • Liver(4.7)
  • Blood(4.7)
  • Stomach(3.7)
  • Heart(3.6)
  • Muscle(3.6)
  • Kidney(3.6)
  • Spleen(3.5)
  • Eye(3.4)
  • Intestine(3.3)
  • Lung(3.2)
  • Adrenal gland(3.1)
  • Lymph node(3.1)
  • Pancreas(2.9)
  • Bone marrow(2.7)
  • Thyroid gland(2.7)
genes like me logo Genes that share expression patterns with HSPA4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA4 Gene

Orthologs for HSPA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPA4 29 30
  • 99.84 (n)
(Bos Taurus)
Mammalia HSPA4 29 30
  • 94.8 (n)
(Canis familiaris)
Mammalia HSPA4 29 30
  • 94.4 (n)
(Mus musculus)
Mammalia Hspa4 29 16 30
  • 90.6 (n)
(Rattus norvegicus)
Mammalia Hspa4 29
  • 90.36 (n)
(Ornithorhynchus anatinus)
Mammalia HSPA4 30
  • 90 (a)
(Monodelphis domestica)
Mammalia HSPA4 30
  • 79 (a)
(Gallus gallus)
Aves HSPA4 29 30
  • 79.94 (n)
(Anolis carolinensis)
Reptilia HSPA4 30
  • 84 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hspa4 29
  • 76.69 (n)
MGC76295 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.5799 29
(Danio rerio)
Actinopterygii hspa4b 30
  • 73 (a)
hspa4a 29 30
  • 68.11 (n)
wufc41d05 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10287 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010331 29
  • 53.19 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Hsc70Cb 29 30
  • 51.89 (n)
(Caenorhabditis elegans)
Secernentea C30C11.4 29 31
  • 51.41 (n)
hsp-110 30
  • 45 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24597g 29
  • 50 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 29 30
  • 49.53 (n)
SSE2 30
  • 39 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR212W 29
  • 48.15 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons HSP91 29
  • 50.85 (n)
(Oryza sativa)
Liliopsida Os01g0180800 29
  • 51.8 (n)
Os.26495 29
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pss1 29
  • 51.49 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU05269 29
  • 49.16 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9760 30
  • 44 (a)
Species where no ortholog for HSPA4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSPA4 Gene

Gene Tree for HSPA4 (if available)
Gene Tree for HSPA4 (if available)
Evolutionary constrained regions (ECRs) for HSPA4: view image
Alliance of Genome Resources:
Additional Orthologs for HSPA4

Paralogs for HSPA4 Gene

(15) SIMAP similar genes for HSPA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPA4: view

Variants for HSPA4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA4 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs115939709 Benign: not provided 133,074,057(+) A/C
NM_002154.4(HSPA4):c.594A>C (p.Val198=)
rs116457609 Benign: not provided 133,096,088(+) A/G
rs143631835 Benign: not provided 133,052,346(+) C/T
NM_002154.4(HSPA4):c.96C>T (p.Asp32=)
rs145291096 Benign: not provided 133,073,253(+) A/G
NM_002154.4(HSPA4):c.453A>G (p.Ala151=)
rs145548542 Benign: not provided 133,076,816(+) T/C
NM_002154.4(HSPA4):c.826T>C (p.Leu276=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSPA4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSPA4 Gene

Variant ID Type Subtype PubMed ID
nsv1128190 CNV deletion 24896259
nsv830490 CNV gain 17160897

Variation tolerance for HSPA4 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA4 Gene

Disorders for HSPA4 Gene

MalaCards: The human disease database

(81) MalaCards diseases for HSPA4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • vulvo-vaginitis
  • babesiasis
chronic cervicitis
transient cerebral ischemia
  • tia
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HSPA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPA4

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HSPA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA4 Gene

Publications for HSPA4 Gene

  1. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. (PMID: 8335910) Fathallah DM … Arnaout MA (Journal of immunology (Baltimore, Md. : 1950) 1993) 2 3 4
  2. Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. (PMID: 20026329) Yamamoto S … Itoh H (FEBS letters 2010) 3 22
  3. Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. (PMID: 20053985) Hwang CY … Song B (The Journal of biological chemistry 2010) 3 22
  4. [The significance of the changes in expressions of heat shock protein 70 and heme oxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]. (PMID: 20170613) Zuo LP … Ma ZF (Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2010) 3 22
  5. Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes. (PMID: 20146531) Graf C … Mayer MP (Biochemistry 2010) 3 22

Products for HSPA4 Gene

Sources for HSPA4 Gene