Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPA2 Gene

Aliases for HSPA2 Gene

  • Heat Shock Protein Family A (Hsp70) Member 2 2 3 5
  • Heat Shock 70kDa Protein 2 2 3
  • Heat Shock 70kD Protein 2 2 3
  • Heat Shock-Related 70 KDa Protein 2 3
  • Heat Shock 70 KDa Protein 2 4
  • HSP70-2 3
  • HSP70-3 3

External Ids for HSPA2 Gene

Previous GeneCards Identifiers for HSPA2 Gene

  • GC14P062330
  • GC14P058796
  • GC14P062992
  • GC14P064072
  • GC14P065002
  • GC14P045179

Summaries for HSPA2 Gene

GeneCards Summary for HSPA2 Gene

HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Inflammatory Bowel Disease 3 and Papillary Cystadenocarcinoma. Among its related pathways are Meiosis and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot for HSPA2 Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene Wiki entry for HSPA2 Gene

Additional gene information for HSPA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA2 Gene

Genomics for HSPA2 Gene

GeneHancer (GH) Regulatory Elements for HSPA2 Gene

Promoters and enhancers for HSPA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I064538 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +4.8 4842 4.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A BRCA1 ZNF48 YY1 GLIS2 LOC102723809 HSPA2 ZBTB25 ZBTB1 PPP1R36 ENSG00000214770 GCATP1 WDR89 SYNE2 PLEKHG3
GH14I064535 Promoter 0.5 EPDnew 550.8 -0.5 -514 0.1 HSPA2 ENSG00000259160 LOC102723809 GC14P064524
GH14I064536 Enhancer 0.3 ENCODE 550.8 +1.1 1123 1.1 ZNF366 HSPA2 ENSG00000259160 PPP1R36 ZBTB1 ZBTB25 LOC102723809
GH14I064499 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -31.2 -31155 9.9 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB1 ZBTB25 LOC102723809 PPP1R36 AKAP5 HSPA2 TEX21P SYNE2 ENSG00000214770
GH14I064628 Enhancer 0.8 Ensembl ENCODE 23.6 +93.2 93153 1.9 SIN3A REST SP1 JUND POLR2A ATF3 FOS FOSL2 HSPA2 PPP1R36 ZBTB1 GC14P064620 PLEKHG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA2 gene promoter:

Genomic Locations for HSPA2 Gene

Genomic Locations for HSPA2 Gene
chr14:64,535,905-64,546,173
(GRCh38/hg38)
Size:
10,269 bases
Orientation:
Plus strand
chr14:65,002,623-65,009,955
(GRCh37/hg19)

Genomic View for HSPA2 Gene

Genes around HSPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA2 Gene

Proteins for HSPA2 Gene

  • Protein details for HSPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54652-HSP72_HUMAN
    Recommended name:
    Heat shock-related 70 kDa protein 2
    Protein Accession:
    P54652
    Secondary Accessions:
    • Q15508
    • Q53XM3
    • Q9UE78

    Protein attributes for HSPA2 Gene

    Size:
    639 amino acids
    Molecular mass:
    70021 Da
    Quaternary structure:
    • Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity). Interacts with FKBP6 (PubMed:18529014).

    Three dimensional structures from OCA and Proteopedia for HSPA2 Gene

neXtProt entry for HSPA2 Gene

Post-translational modifications for HSPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA2 Gene

Domains & Families for HSPA2 Gene

Gene Families for HSPA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA2 Gene

Graphical View of Domain Structure for InterPro Entry

P54652

UniProtKB/Swiss-Prot:

HSP72_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA2: view

Function for HSPA2 Gene

Molecular function for HSPA2 Gene

GENATLAS Biochemistry:
heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohns disease
UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Phenotypes From GWAS Catalog for HSPA2 Gene

Gene Ontology (GO) - Molecular Function for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0019899 enzyme binding IPI 23921388
GO:0051082 unfolded protein binding TAS,IDA 21231916
GO:0051861 glycolipid binding IEA --
genes like me logo Genes that share ontologies with HSPA2: view
genes like me logo Genes that share phenotypes with HSPA2: view

Animal Models for HSPA2 Gene

MGI Knock Outs for HSPA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA2 Gene

Localization for HSPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA2 Gene

Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250 UniProtKB:P17156}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IEA --
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus HDA,IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with HSPA2: view

Pathways & Interactions for HSPA2 Gene

genes like me logo Genes that share pathways with HSPA2: view

SIGNOR curated interactions for HSPA2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006986 response to unfolded protein TAS 7829106
GO:0007140 male meiotic nuclear division TAS 8622925
GO:0007141 male meiosis I IEA --
GO:0007283 spermatogenesis ISS --
genes like me logo Genes that share ontologies with HSPA2: view

Drugs & Compounds for HSPA2 Gene

(1) Drugs for HSPA2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental, Investigational Nutra Target Antitumor agent 42
genes like me logo Genes that share compounds with HSPA2: view

Transcripts for HSPA2 Gene

mRNA/cDNA for HSPA2 Gene

Unigene Clusters for HSPA2 Gene

Heat shock 70kDa protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA2

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for HSPA2 Gene

GeneLoc Exon Structure for
HSPA2
ECgene alternative splicing isoforms for
HSPA2

Expression for HSPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.8).

Protein differential expression in normal tissues from HIPED for HSPA2 Gene

This gene is overexpressed in Brain (8.4) and Spinal cord (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of HSPA2 Gene:

HSPA2

SOURCE GeneReport for Unigene cluster for HSPA2 Gene:

Hs.432648

Evidence on tissue expression from TISSUES for HSPA2 Gene

  • Nervous system(5)
  • Eye(4.4)
  • Kidney(3.2)
  • Skin(2.5)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with HSPA2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA2 Gene

Orthologs for HSPA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA2 33
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA2 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA2 33 34
  • 93.88 (n)
cow
(Bos Taurus)
Mammalia HSPA2 33
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia Hspa2 16 34 33
  • 92.2 (n)
rat
(Rattus norvegicus)
Mammalia Hspa2 33
  • 91.44 (n)
chicken
(Gallus gallus)
Aves HSP70 34
  • 93 (a)
OneToOne
HSPA2 33
  • 81.08 (n)
lizard
(Anolis carolinensis)
Reptilia HSPA2 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa2 33
  • 78.97 (n)
zebrafish
(Danio rerio)
Actinopterygii hsp70l 34
  • 82 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 34 35
  • 81 (a)
ManyToMany
Hsc70-1 34 35
  • 79 (a)
ManyToMany
Hsp70Ab 35
  • 75 (a)
Hsp70Aa 35
  • 75 (a)
Hsp70Bc 35
  • 74 (a)
Hsp70Bb 35
  • 74 (a)
Hsp70Ba 35
  • 74 (a)
Hsp68 35
  • 71 (a)
Hsc70-2 35
  • 71 (a)
Hsc70-3 35
  • 62 (a)
CG7182 35
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 35 34
  • 83 (a)
hsp-2 35
  • 77 (a)
F44E5.4 35
  • 68 (a)
F44E5.5 35
  • 68 (a)
hsp-70 35
  • 67 (a)
hsp-3 35
  • 61 (a)
hsp-4 35
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 34
  • 72 (a)
OneToMany
SSB1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ERD2 33
  • 65.68 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.24515 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 34
  • 80 (a)
ManyToMany
CSA.971 34
  • 76 (a)
ManyToMany
Species where no ortholog for HSPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSPA2 Gene

ENSEMBL:
Gene Tree for HSPA2 (if available)
TreeFam:
Gene Tree for HSPA2 (if available)

Paralogs for HSPA2 Gene

Paralogs for HSPA2 Gene

(15) SIMAP similar genes for HSPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA2: view

Variants for HSPA2 Gene

Sequence variations from dbSNP and Humsavar for HSPA2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000287320 -- 64,539,846(+) T/A upstream_transcript_variant
rs1001860111 -- 64,538,832(+) G/T upstream_transcript_variant
rs1004478522 -- 64,540,093(+) G/A upstream_transcript_variant
rs1005246529 -- 64,543,227(+) T/C 3_prime_UTR_variant
rs1006085493 -- 64,539,244(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv1308 CNV insertion 18451855

Variation tolerance for HSPA2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA2 Gene

Human Gene Mutation Database (HGMD)
HSPA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA2 Gene

Disorders for HSPA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 3
  • ibd3
papillary cystadenocarcinoma
  • papillary cystadenocarcinoma, nos
varicocele
  • scrotal varices
- elite association - COSMIC cancer census association via MalaCards
Search HSPA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA2 Gene

Publications for HSPA2 Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson ME … Falnes PØ (The Journal of biological chemistry 2013) 3 4 58
  2. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. (PMID: 18813331) Konings A … Van Camp G (European journal of human genetics : EJHG 2009) 3 44 58
  3. HLA-association of serum levels of natural antibodies. (PMID: 19167759) Pozsonyi E … Füst G (Molecular immunology 2009) 3 44 58
  4. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (PMID: 19661373) Tahara T … Hirata I (Anticancer research 2009) 3 44 58
  5. Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis. (PMID: 17940904) Lee SH … Yoon YB (Digestive diseases and sciences 2008) 3 44 58

Products for HSPA2 Gene

  • Addgene plasmids for HSPA2

Sources for HSPA2 Gene

Content
Loading form....