This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also enco... See more...

Aliases for HSPA1L Gene

Aliases for HSPA1L Gene

  • Heat Shock Protein Family A (Hsp70) Member 1 Like 2 3 5
  • Heat Shock 70 KDa Protein 1-Like 3 4
  • Heat Shock 70kDa Protein 1-Like 2 3
  • Heat Shock 70 KDa Protein 1-Hom 3 4
  • Heat Shock 70kD Protein-Like 1 2 3
  • Heat Shock 70 KDa Protein 1L 3 4
  • HSP70-HOM 2 3
  • Hum70t 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Heat Shock 10kDa Protein 1-Like 3
  • HSP70-Hom 4
  • HSP70-1L 3
  • HSP70T 3
  • HSPA1L 5

External Ids for HSPA1L Gene

Previous GeneCards Identifiers for HSPA1L Gene

  • GC06M031849
  • GC06M031548
  • GC06M031881
  • GC06M031885
  • GC06M031777
  • GC06M031563

Summaries for HSPA1L Gene

Entrez Gene Summary for HSPA1L Gene

  • This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1L Gene

HSPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like) is a Protein Coding gene. Diseases associated with HSPA1L include Paranoid Schizophrenia and Inflammatory Bowel Disease 1. Among its related pathways are Cellular response to heat stress and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot Summary for HSPA1L Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Gene Wiki entry for HSPA1L Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA1L Gene

Genomics for HSPA1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSPA1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031813 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 254.2 -11.0 -10950 26.3 BCLAF1 SP1 ZNF207 MYC NCOR1 ZNF654 IKZF1 ZNF600 SSRP1 ZNF580 SNHG32 HSPA1B HSPA1A HSPA1L HSALNG0049335 RF00495 DDX39B ATF6B LY6G5B LSM2
GH06J031733 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.5 +77.8 77828 8.5 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SIX5 SSRP1 JUND MSH5 CLIC1 MSH5-SAPCD1 LY6G5B DDX39B ATF6B LSM2 NFKBIL1 SKIV2L GTF2H4
GH06J031557 Enhancer 1 ENCODE 10 +255.7 255692 4.2 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 JUND ZNF592 POLR2A NFIC LTA lnc-NFKBIL1-9 CSNK2B DDX39B LST1 NCR3 UQCRHP1 LTB AIF1 SNORD117
GH06J031841 Enhancer 0.7 Ensembl 11.3 -27.0 -26951 2.7 IKZF1 ZNF600 POLR2A IRF2 NFATC3 PRDM1 NKRF RBM22 BCL11B KLF16 RF00017-4931 lnc-NEU1-3 LSM2 LY6G5B DDX39B VARS1 MSH5 ATF6B STK19B C4A
GH06J031385 Enhancer 0.2 FANTOM5 2.5 +430.1 430062 0.1 ENSG00000272221 CCHCR1 PSORS1C2 HSPA1L MCCD1 BAG6 GPANK1 lnc-MICA-6 lnc-MICA-5 MICA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA1L

Top Transcription factor binding sites by QIAGEN in the HSPA1L gene promoter:
  • ATF
  • CP2
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • PPAR-alpha
  • STAT3

Genomic Locations for HSPA1L Gene

Latest Assembly
chr6:31,809,619-31,815,283
(GRCh38/hg38)
Size:
5,665 bases
Orientation:
Minus strand

Previous Assembly
chr6:31,777,396-31,783,060
(GRCh37/hg19 by Entrez Gene)
Size:
5,665 bases
Orientation:
Minus strand

chr6:31,777,396-31,783,437
(GRCh37/hg19 by Ensembl)
Size:
6,042 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):3,142,241-3,147,905 (-)
  • chr6(ALT_REF_LOCI_2):3,286,871-3,292,534 (-)
  • chr6(ALT_REF_LOCI_3):3,057,398-3,063,062 (-)
  • chr6(ALT_REF_LOCI_6):3,065,448-3,071,111 (-)

Genomic View for HSPA1L Gene

Genes around HSPA1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA1L Gene

Proteins for HSPA1L Gene

  • Protein details for HSPA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34931-HS71L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1-like
    Protein Accession:
    P34931
    Secondary Accessions:
    • A6NNB0
    • B0UXW8
    • O75634
    • Q2HXR3
    • Q8NE72
    • Q96QC9
    • Q9UQM1

    Protein attributes for HSPA1L Gene

    Size:
    641 amino acids
    Molecular mass:
    70375 Da
    Quaternary structure:
    • Interacts with PRKN.

    Three dimensional structures from OCA and Proteopedia for HSPA1L Gene

neXtProt entry for HSPA1L Gene

Post-translational modifications for HSPA1L Gene

  • Glycosylation at Asn37 and Asn419
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HS71L_HUMAN (1297)

Other Protein References for HSPA1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1L Gene

Domains & Families for HSPA1L Gene

Gene Families for HSPA1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA1L Gene

InterPro:
Blocks:
  • Heat shock protein Hsp70

Suggested Antigen Peptide Sequences for HSPA1L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56517, highly similar to Heat shock 70 kDa protein 1L (B4DXY3_HUMAN)
  • Heat shock 70 kDa protein 1-Hom (HS71L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P34931

UniProtKB/Swiss-Prot:

HS71L_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1L: view

Function for HSPA1L Gene

Molecular function for HSPA1L Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).
UniProtKB/Swiss-Prot Induction:
Not induced by heat shock.
GENATLAS Biochemistry:
heat shock 70kDa protein A1-like 2,acting as a molecular chaperone

Phenotypes From GWAS Catalog for HSPA1L Gene

Gene Ontology (GO) - Molecular Function for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 17184779
GO:0005524 ATP binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
GO:0031072 heat shock protein binding IBA,IPI 17182002
genes like me logo Genes that share ontologies with HSPA1L: view
genes like me logo Genes that share phenotypes with HSPA1L: view

miRNA for HSPA1L Gene

miRTarBase miRNAs that target HSPA1L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA1L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA1L Gene

Localization for HSPA1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1L gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 4
nucleus 4
mitochondrion 3
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA1L Gene

Pathways & Interactions for HSPA1L Gene

PathCards logo

SuperPathways for HSPA1L Gene

genes like me logo Genes that share pathways with HSPA1L: view

Pathways by source for HSPA1L Gene

6 GeneGo (Thomson Reuters) pathways for HSPA1L Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway
1 GeneTex pathway for HSPA1L Gene

Gene Ontology (GO) - Biological Process for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 9685725
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0034620 cellular response to unfolded protein IBA 21873635
GO:0042026 protein refolding IBA,IDA 21231916
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for SIGNOR curated interactions for HSPA1L Gene

Drugs & Compounds for HSPA1L Gene

(1) Drugs for HSPA1L Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 109
genes like me logo Genes that share compounds with HSPA1L: view

Transcripts for HSPA1L Gene

mRNA/cDNA for HSPA1L Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA1L

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1L Gene

No ASD Table

Relevant External Links for HSPA1L Gene

GeneLoc Exon Structure for
HSPA1L

Expression for HSPA1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1L Gene

This gene is overexpressed in Testis (x19.5).

Protein differential expression in normal tissues from HIPED for HSPA1L Gene

This gene is overexpressed in Neutrophil (11.6), Saliva (10.9), Blymphocyte (6.2), and Nasal epithelium (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA1L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA1L

SOURCE GeneReport for Unigene cluster for HSPA1L Gene:

Hs.690634

mRNA Expression by UniProt/SwissProt for HSPA1L Gene:

P34931-HS71L_HUMAN
Tissue specificity: Expressed in spermatids.

Evidence on tissue expression from TISSUES for HSPA1L Gene

  • Blood(2.2)
  • Nervous system(2.1)
  • Liver(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with HSPA1L: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA1L Gene

Orthologs for HSPA1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSPA1L 29 30
  • 99.48 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HSPA1L 30
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia HSPA1L 29 30
  • 90.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSPA1L 29 30
  • 89.34 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hspa1l 29 16 30
  • 85.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hspa1l 29
  • 84.56 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 82 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii hsp70.3 30
  • 84 (a)
ManyToMany
hsc70 30
  • 82 (a)
ManyToMany
si:ch211-199o1.2 29
  • 75.04 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Hsc70-4 30 31
  • 80 (a)
ManyToMany
Hsc70-1 30 31
  • 78 (a)
ManyToMany
Hsp70Bbb 30
  • 74 (a)
ManyToMany
Hsp70Ab 30 31
  • 74 (a)
ManyToMany
Hsp70Bc 30 31
  • 74 (a)
ManyToMany
Hsp70Ba 30 31
  • 74 (a)
ManyToMany
Hsp70Aa 30 31
  • 74 (a)
ManyToMany
Hsp70Bb 30 31
  • 74 (a)
ManyToMany
Hsc70-2 30 31
  • 72 (a)
ManyToMany
Hsp68 30 31
  • 72 (a)
ManyToMany
Hsc70-3 31
  • 62 (a)
CG7182 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea hsp-1 30 31
  • 81 (a)
OneToMany
hsp-2 31
  • 73 (a)
F44E5.4 31
  • 67 (a)
F44E5.5 31
  • 67 (a)
hsp-70 31
  • 66 (a)
hsp-3 31
  • 61 (a)
hsp-4 31
  • 60 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 30
  • 72 (a)
OneToMany
SSA1 29 32
  • 64.66 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR114W 29
  • 67.09 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04224g 29
  • 65.93 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons Hsp70b 29
  • 64.79 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11098 30
  • 79 (a)
ManyToMany
CSA.971 30
  • 74 (a)
ManyToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssa2 29
  • 67.56 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09602 29
  • 66.51 (n)
Species where no ortholog for HSPA1L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HSPA1L Gene

ENSEMBL:
Gene Tree for HSPA1L (if available)
TreeFam:
Gene Tree for HSPA1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA1L: view image
Alliance of Genome Resources:
Additional Orthologs for HSPA1L

Paralogs for HSPA1L Gene

(16) SIMAP similar genes for HSPA1L Gene using alignment to 1 proteins:

  • HS71L_HUMAN

Pseudogenes.org Pseudogenes for HSPA1L Gene

genes like me logo Genes that share paralogs with HSPA1L: view

Variants for HSPA1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA1L Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs139868987 Association: Inflammatory bowel disease 1 31,811,173(-) G/A
NM_005527.4(HSPA1L):c.800C>T (p.Thr267Ile)
MISSENSE
rs201198988 Likely Benign: not provided 31,811,389(-) C/T
NM_005527.4(HSPA1L):c.584G>A (p.Arg195Gln)
MISSENSE
rs2227955 Association: Inflammatory bowel disease 1 31,810,300(-) T/Gp.Glu558Ala
NM_005527.4(HSPA1L):c.1673A>C (p.Glu558Ala)
MISSENSE
rs2227956 Association: Chronic obstructive pulmonary disease 31,810,495(-) G/Tp.Thr493Met
NM_005527.4(HSPA1L):c.1478C>A (p.Thr493Lys)
MISSENSE
rs2227957 Benign: not provided 31,810,530(-) G/A
NM_005527.4(HSPA1L):c.1443C>T (p.Asp481=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSPA1L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSPA1L Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv823502 CNV loss 20364138
nsv823503 CNV loss 20364138

Variation tolerance for HSPA1L Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA1L Gene

Human Gene Mutation Database (HGMD)
HSPA1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1L
Leiden Open Variation Database (LOVD)
HSPA1L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1L Gene

Disorders for HSPA1L Gene

MalaCards: The human disease database

(4) MalaCards diseases for HSPA1L Gene - From: COP and GCD

Disorder Aliases PubMed IDs
paranoid schizophrenia
  • chronic paranoid schizophrenia
inflammatory bowel disease 1
  • ibd1
inflammatory bowel disease
  • inflammatory bowel diseases
primary hypomagnesemia
  • homg
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPA1L

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HSPA1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1L Gene

Publications for HSPA1L Gene

  1. Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. (PMID: 9685725) Ito Y … Fujimoto H (Journal of biochemistry 1998) 2 3 4 22
  2. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li JX … Niu WQ (Cell stress & chaperones 2009) 3 22 40
  3. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae CU … Serretti A (Neuropsychobiology 2009) 3 22 40
  4. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. (PMID: 19731315) Mir KA … Ramakrishna BS (The British journal of surgery 2009) 3 22 40
  5. Heat-shock protein-70 genes and response to antidepressants in major depression. (PMID: 17428599) Pae CU … Paik IH (Progress in neuro-psychopharmacology & biological psychiatry 2007) 3 22 40

Products for HSPA1L Gene

Sources for HSPA1L Gene