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This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B) is a Protein Coding gene. Diseases associated with HSPA1B include Mulibrey Nanism and Acute Mountain Sickness. Among its related pathways are HIF1Alpha Pathway and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001618 | virus receptor activity | IEA | -- |
GO:0001664 | G protein-coupled receptor binding | IDA | 12150907 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005102 | signaling receptor binding | IPI | 24790089 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 10205060 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,TAS | 16130169 |
GO:0005739 | mitochondrion | TAS | 16130169 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
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2 | HSF1-dependent transactivation | ||
3 | Cellular response to heat stress | ||
4 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) |
CFTR folding and maturation (norm and CF)
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Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
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5 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway |
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006402 | mRNA catabolic process | IDA | 10205060 |
GO:0006986 | response to unfolded protein | IBA | 21873635 |
GO:0008285 | negative regulation of cell proliferation | IMP | 9553041 |
GO:0010628 | positive regulation of gene expression | IMP | 25281747 |
GO:0010941 | NOT regulation of cell death | IMP | 21231916 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Elesclomol (STA-4783) | Pharma | Oxidative stress/apoptosis inducer,potent and novel | 0 |
Compound | Action | Cas Number |
---|---|---|
Elesclomol (STA-4783) | Oxidative stress/apoptosis inducer,potent and novel | 488832-69-5 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
HSPA1A 30 |
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Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
HSPA1 31 |
|
ManyToMany | |||
LOC102155697 30 |
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Mouse (Mus musculus) |
Mammalia | Hspa1b 31 |
|
ManyToMany | |
Hspa1a 30 17 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | HSPA1A 30 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Hspa1a 30 |
|
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Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485441 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | hsp70.2 31 |
|
ManyToMany | |
hsc70 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | Hsc70-4 31 32 |
|
ManyToMany | |
Hsc70-1 31 32 |
|
ManyToMany | |||
Hsp70Ba 32 |
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Hsp70Bb 32 |
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Hsp70Aa 32 |
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Hsp70Ab 32 |
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Hsc70-2 32 |
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Hsp70Bc 30 32 |
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Hsp68 32 |
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Hsc70-3 32 |
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CG7182 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | hsp-1 31 32 |
|
OneToMany | |
hsp-2 32 |
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F44E5.4 32 |
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F44E5.5 32 |
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hsp-70 32 |
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hsp-3 32 |
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hsp-4 32 |
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Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 31 33 |
|
OneToMany | |
SSA4 30 33 |
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A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER187W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20527g 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G02490 30 |
|
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Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11098 31 |
|
ManyToMany | |
CSA.971 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2763979 | Association: Chronic obstructive pulmonary disease | 31,826,815(+) | C/T | ||
rs6457452 | Association: Chronic obstructive pulmonary disease | 31,827,773(+) | C/T | FIVE_PRIME_UTR_VARIANT | |
rs483638 | - | p.Asn499Ser | |||
rs538280104 | - | p.Ala467Val | |||
VAR_032152 | - | p.Ile95Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10403n54 | CNV | loss | 21841781 |
dgv10404n54 | CNV | loss | 21841781 |
dgv10461n54 | CNV | loss | 21841781 |
dgv10462n54 | CNV | loss | 21841781 |
dgv10463n54 | CNV | loss | 21841781 |
esv2421830 | CNV | deletion | 20811451 |
esv2667397 | CNV | deletion | 23128226 |
esv3329350 | CNV | duplication | 20981092 |
esv3608569 | CNV | loss | 21293372 |
esv3890822 | CNV | loss | 25118596 |
nsv1073969 | CNV | deletion | 25765185 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1126749 | CNV | deletion | 24896259 |
nsv969380 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mulibrey nanism |
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acute mountain sickness |
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bladder urothelial carcinoma |
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