HSPA1B Gene (Protein Coding)

Heat Shock Protein Family A (Hsp70) Member 1B

GC06P033427
GIFtS:
41
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interacti... See more...

Aliases for HSPA1B Gene

Aliases for HSPA1B Gene

  • Heat Shock Protein Family A (Hsp70) Member 1B 2 3 5
  • Heat Shock 70 KDa Protein 1B 3 4
  • Heat Shock 70 KDa Protein 2 3 4
  • Heat Shock 70kDa Protein 1B 2 3
  • Heat Shock 70kD Protein 1B 2 3
  • HSP70-2 3 4
  • HSP70.2 3 4
  • HSP72 3 4
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • Heat Shock 70 KDa Protein 1A 3
  • Heat Shock 70 KDa Protein 1 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HSP70-1B 3
  • HSP70-1 3
  • HSP70.1 3
  • HSPA1 3
  • HSX70 3

External Ids for HSPA1B Gene

Previous GeneCards Identifiers for HSPA1B Gene

  • GC06P031867
  • GC06P031849
  • GC06P031566
  • GC06P031899
  • GC06P031903
  • GC06P031797
  • GC06P031813
  • GC06P031824
  • GC06P031853
  • GC06P031828
  • GC06P032333
  • GC06P032517
  • GC06P032624
  • GC06P031830
  • GC06P031870
  • GC06P031872
  • GC06P031934
  • GC06P031967
  • GC06P032029
  • GC06P032208
  • GC06P032237

Summaries for HSPA1B Gene

Entrez Gene Summary for HSPA1B Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1B Gene

HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B) is a Protein Coding gene. Diseases associated with HSPA1B include Mulibrey Nanism and Acute Mountain Sickness. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot Summary for HSPA1B Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
  • (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Additional gene information for HSPA1B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA1B Gene

Genomics for HSPA1B Gene

GeneHancer (GH) Regulatory Elements for HSPA1B Gene

Promoters and enhancers for HSPA1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J031813 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 508.1 -1.5 -1503 26.3 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SNHG32 HSPA1B HSPA1A HSPA1L RF00495-002 DDX39B ATF6B LY6G5B LSM2 GTF2H4
GH06J031733 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.4 -90.3 -90280 8.5 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A TCF12 MYC MSH5 CLIC1 MSH5-SAPCD1 LY6G5B DDX39B LSM2 ATF6B GTF2H4 NFKBIL1 MICA
GH06J031567 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.4 -249.3 -249316 22.2 HNRNPK ZBTB40 CTCF SIN3A NRF1 USF1 SP1 NONO GTF2E2 PHF8 TNF ATP6V1G2 LST1 AB675034 LTB lnc-TNF-1 LTA DDX39B LY6G5B MDC1
GH06J031562 Enhancer 0.8 FANTOM5 1.2 -265.5 -265495 0.4 POLR2G EP300 TRIM22 ZNF341 BCL11A MYNN ARNT NBN ZFHX2 BATF LTA lnc-NFKBIL1-9 TNF ATP6V1G2 STK19 LST1 HLA-B HSPA1B LOC100287329 MG828730-062
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA1B

Top Transcription factor binding sites by QIAGEN in the HSPA1B gene promoter:
  • ATF
  • CP2
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • PPAR-alpha
  • STAT3

Genomic Locations for HSPA1B Gene

Genomic Locations for HSPA1B Gene
chr6:31,827,735-31,830,254
(GRCh38/hg38)
Size:
2,520 bases
Orientation:
Plus strand
chr6:31,795,512-31,798,031
(GRCh37/hg19)
Size:
2,520 bases
Orientation:
Plus strand

Genomic View for HSPA1B Gene

Genes around HSPA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSPA1B Gene

Proteins for HSPA1B Gene

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  • Protein details for HSPA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV9-HS71B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1B
    Protein Accession:
    P0DMV9
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1B Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PRKN (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486). Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively (PubMed:27708256). Interacts with NEDD1 (PubMed:27137183). Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105 (PubMed:24318877). Interacts with SMAD3 (PubMed:24613385). Interacts with DNAJC8 (PubMed:27133716).

    Three dimensional structures from OCA and Proteopedia for HSPA1B Gene

neXtProt entry for HSPA1B Gene

Protein Expression for HSPA1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSPA1B Gene

  • In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
  • Glycosylation at Asn35 and Asn417
  • Glycosylation from GlyConnect
    • HS71B_HUMAN (1296)

Other Protein References for HSPA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1B Gene

Domains & Families for HSPA1B Gene

Gene Families for HSPA1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPA1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA1B Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 70 kDa protein 1/2 (HSP71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DMV9

UniProtKB/Swiss-Prot:

HS71B_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1B: view

Function for HSPA1B Gene

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Molecular function for HSPA1B Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
UniProtKB/Swiss-Prot Induction:
By heat shock.
GENATLAS Biochemistry:
heat shock 70kDa protein A1B,acting as a molecular chaperone

Phenotypes From GWAS Catalog for HSPA1B Gene

Gene Ontology (GO) - Molecular Function for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001664 G protein-coupled receptor binding IDA 12150907
GO:0003723 RNA binding HDA 22658674
GO:0005102 signaling receptor binding IPI 24790089
GO:0005515 protein binding IPI 15603737
genes like me logo Genes that share ontologies with HSPA1B: view
genes like me logo Genes that share phenotypes with HSPA1B: view

Animal Models for HSPA1B Gene

MGI Knock Outs for HSPA1B:

Animal Model Products

CRISPR Products

miRNA for HSPA1B Gene

miRTarBase miRNAs that target HSPA1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA1B Gene

Localization for HSPA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1B gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
extracellular 4
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,IBA 10205060
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS,IBA 16130169
GO:0005739 mitochondrion TAS 16130169
genes like me logo Genes that share ontologies with HSPA1B: view

Pathways & Interactions for HSPA1B Gene

PathCards logo

SuperPathways for HSPA1B Gene

genes like me logo Genes that share pathways with HSPA1B: view

Pathways by source for HSPA1B Gene

1 BioSystems pathway for HSPA1B Gene
6 GeneGo (Thomson Reuters) pathways for HSPA1B Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway
4 Qiagen pathways for HSPA1B Gene
  • Aldosterone Signaling in Epithelial Cells
  • Cellular Transformation by HTLV1
  • Glucocorticoid Receptor Signaling
  • HIF1Alpha Pathway
1 GeneTex pathway for HSPA1B Gene

SIGNOR curated interactions for HSPA1B Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 10205060
GO:0006986 response to unfolded protein IBA 21873635
GO:0008285 negative regulation of cell proliferation IMP 9553041
GO:0010628 positive regulation of gene expression IMP 25281747
GO:0010941 NOT regulation of cell death IMP 21231916
genes like me logo Genes that share ontologies with HSPA1B: view

Drugs & Compounds for HSPA1B Gene

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(1) Drugs for HSPA1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(1) ApexBio Compounds for HSPA1B Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA1B: view

Drug Products

Transcripts for HSPA1B Gene

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mRNA/cDNA for HSPA1B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

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Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1B Gene

No ASD Table

Relevant External Links for HSPA1B Gene

GeneLoc Exon Structure for
HSPA1B

Expression for HSPA1B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA1B Gene

mRNA expression in normal human tissues for HSPA1B Gene
mRNA expression by GTEx for HSPA1B GenemRNA expression by BioGPS for HSPA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for HSPA1B Gene

This gene is overexpressed in Uterus (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA1B Gene



Protein tissue co-expression partners for HSPA1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA1B

SOURCE GeneReport for Unigene cluster for HSPA1B Gene:

Hs.719966

mRNA Expression by UniProt/SwissProt for HSPA1B Gene:

P0DMV9-HS71B_HUMAN
Tissue specificity: HSPA1B is testis-specific.

Evidence on tissue expression from TISSUES for HSPA1B Gene

  • Blood(2.4)
  • Muscle(2.2)
  • Heart(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with HSPA1B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA1B Gene

Orthologs for HSPA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 100 (a)
 OneToMany
HSPA1A 30
  • 99.53 (n)
dog
(Canis familiaris)
 Mammalia -- 31
  • 99 (a)
 ManyToMany
HSPA1 31
  • 98 (a)
 ManyToMany
LOC102155697 30
  • 94.8 (n)
mouse
(Mus musculus)
 Mammalia Hspa1b 31
  • 95 (a)
 ManyToMany
Hspa1a 17 31 30
  • 91.52 (n)
cow
(Bos Taurus)
 Mammalia HSPA1A 31 30
  • 94.64 (n)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 94 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Hspa1b 30
  • 92.3 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 84 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485441 30
  • 78.36 (n)
zebrafish
(Danio rerio)
 Actinopterygii hsp70.2 31
  • 85 (a)
 ManyToMany
hsc70 30
  • 75.4 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Hsc70-4 31 32
  • 81 (a)
 ManyToMany
Hsc70-1 31 32
  • 79 (a)
 ManyToMany
Hsp70Ba 32
  • 77 (a)
Hsp70Bb 32
  • 77 (a)
Hsp70Ab 32
  • 76 (a)
Hsp70Aa 32
  • 76 (a)
Hsc70-2 32
  • 75 (a)
Hsp70Bc 32 30
  • 74.71 (n)
Hsp68 32
  • 73 (a)
Hsc70-3 32
  • 62 (a)
CG7182 32
  • 27 (a)
worm
(Caenorhabditis elegans)
 Secernentea hsp-1 31 32
  • 82 (a)
 OneToMany
hsp-2 32
  • 75 (a)
F44E5.4 32
  • 68 (a)
F44E5.5 32
  • 68 (a)
hsp-70 32
  • 66 (a)
hsp-3 32
  • 61 (a)
hsp-4 32
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SSA2 33 31
  • 74 (a)
SSA4 30
  • 63.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AER187W 30
  • 70.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E20527g 30
  • 62.82 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G02490 30
  • 68.52 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11098 31
  • 80 (a)
 ManyToMany
CSA.971 31
  • 75 (a)
 ManyToMany
Species where no ortholog for HSPA1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1B Gene

ENSEMBL:
Gene Tree for HSPA1B (if available)
TreeFam:
Gene Tree for HSPA1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA1B: view image

Paralogs for HSPA1B Gene

Paralogs for HSPA1B Gene

(16) SIMAP similar genes for HSPA1B Gene using alignment to 1 proteins:

  • HSP71_HUMAN
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Variants for HSPA1B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA1B Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2763979 Association: Chronic obstructive pulmonary disease 31,826,815(+) C/T
rs6457452 Association: Chronic obstructive pulmonary disease 31,827,773(+) C/T FIVE_PRIME_UTR_VARIANT
rs483638 - p.Asn499Ser
rs538280104 - p.Ala467Val
VAR_032152 - p.Ile95Val

Additional dbSNP identifiers (rs#s) for HSPA1B Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPA1B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2421830 CNV deletion 20811451
esv2667397 CNV deletion 23128226
esv3329350 CNV duplication 20981092
esv3608569 CNV loss 21293372
esv3890822 CNV loss 25118596
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv969380 CNV duplication 23825009

Variation tolerance for HSPA1B Gene

Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA1B Gene

Human Gene Mutation Database (HGMD)
HSPA1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1B Gene

Disorders for HSPA1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
acute mountain sickness
  • altitude anoxia
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPA1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1B Gene

Publications for HSPA1B Gene

  1. Structure and expression of the three MHC-linked HSP70 genes. (PMID: 1700760) Milner CM … Campbell RD (Immunogenetics 1990) 2 3 4 23 54
  2. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae CU … Serretti A (Neuropsychobiology 2009) 3 23 41 54
  3. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li JX … Niu WQ (Cell stress & chaperones 2009) 3 23 41 54
  4. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PMID: 18518860) Buraczynska M … Ksiazek A (Clinical science (London, England : 1979) 2009) 3 23 41 54
  5. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. (PMID: 18580445) Tukiainen E … Repo H (Pancreas 2008) 3 23 41 54

ExternalLinks

View latest publications for HSPA1B gene in Mastermind

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