HSPA1A Gene (Protein Coding)

Heat Shock Protein Family A (Hsp70) Member 1A

GC06P052001
GIFtS:
44
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interacti... See more...

Aliases for HSPA1A Gene

Aliases for HSPA1A Gene

  • Heat Shock Protein Family A (Hsp70) Member 1A 2 3 5
  • HSP70-1 2 3 4
  • Heat Shock 70 KDa Protein 1A 3 4
  • Heat Shock 70kDa Protein 1A 2 3
  • Heat Shock 70 KDa Protein 1 3 4
  • Heat Shock 70kD Protein 1A 2 3
  • HSP70.1 3 4
  • HSP72 3 4
  • HSPA1 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • DnaK-Type Molecular Chaperone HSP70-1 3
  • Epididymis Secretory Protein Li 103 3
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • Heat Shock 70 KDa Protein 1B 3
  • Heat Shock 70 KDa Protein 2 3
  • Heat Shock-Induced Protein 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HEL-S-103 3
  • HSP70-1A 3
  • HSP70-2 3
  • HSP70.2 3
  • HSP70I 3
  • HSPA1A 5
  • HSX70 4

External Ids for HSPA1A Gene

Previous HGNC Symbols for HSPA1A Gene

  • HSPA1

Previous GeneCards Identifiers for HSPA1A Gene

  • GC06P031856
  • GC06P031836
  • GC06P031553
  • GC06P031887
  • GC06P031891
  • GC06P031796
  • GC06P031792
  • GC06P031801
  • GC06P031823
  • GC06P031850
  • GC06P031820
  • GC06P031826
  • GC06P032335
  • GC06P032520
  • GC06P032625
  • GC06P033429
  • GC06P031832
  • GC06P031877
  • GC06P031923
  • GC06P031936
  • GC06P031969
  • GC06P032033
  • GC06P032210
  • GC06P032239
  • GC06P047326
  • GC06P049370

Summaries for HSPA1A Gene

Entrez Gene Summary for HSPA1A Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1A Gene

HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) is a Protein Coding gene. Diseases associated with HSPA1A include Transient Cerebral Ischemia and Carotid Artery Occlusion. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and HIF1Alpha Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA1B.

UniProtKB/Swiss-Prot Summary for HSPA1A Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558).
  • (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Gene Wiki entry for HSPA1A Gene

Additional gene information for HSPA1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA1A Gene

Genomics for HSPA1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HSPA1A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J031813 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 257.6 +10.7 10690 26.3 BCLAF1 SP1 ZNF207 MYC NCOR1 ZNF654 IKZF1 ZNF600 SSRP1 ZNF580 SNHG32 HSPA1B HSPA1A HSPA1L HSALNG0049335 RF00495 DDX39B ATF6B LY6G5B LSM2
GH06J031733 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 -78.1 -78088 8.5 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SIX5 SSRP1 JUND MSH5 CLIC1 MSH5-SAPCD1 LY6G5B DDX39B ATF6B LSM2 NFKBIL1 SKIV2L GTF2H4
GH06J031557 Enhancer 1 ENCODE 10 -256.0 -255952 4.2 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 JUND ZNF592 POLR2A NFIC LTA lnc-NFKBIL1-9 CSNK2B DDX39B LST1 NCR3 UQCRHP1 LTB AIF1 SNORD117
GH06J031841 Enhancer 0.7 Ensembl 11.3 +26.7 26691 2.7 IKZF1 ZNF600 POLR2A IRF2 NFATC3 PRDM1 NKRF RBM22 BCL11B KLF16 RF00017-4931 lnc-NEU1-3 LSM2 LY6G5B DDX39B VARS1 MSH5 ATF6B STK19B C4A
GH06J031567 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 -237.1 -237124 22.2 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 ZNF592 POLR2A ZIC2 TNF ATP6V1G2 LST1 AB675034 LTB lnc-TNF-1 LTA DDX39B LY6G5B MICB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA1A

Top Transcription factor binding sites by QIAGEN in the HSPA1A gene promoter:
  • ATF
  • CP2
  • Max1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • PPAR-alpha
  • STAT3

Genomic Locations for HSPA1A Gene

Latest Assembly
chr6:31,815,543-31,817,946
(GRCh38/hg38)
Size:
2,404 bases
Orientation:
Plus strand

Previous Assembly
chr6:31,783,320-31,785,719
(GRCh37/hg19 by Entrez Gene)
Size:
2,400 bases
Orientation:
Plus strand

chr6:31,783,291-31,785,723
(GRCh37/hg19 by Ensembl)
Size:
2,433 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):3,148,165-3,150,564 (+)
  • chr6(ALT_REF_LOCI_2):3,292,794-3,295,193 (+)
  • chr6(ALT_REF_LOCI_3):3,063,322-3,065,721 (+)
  • chr6(ALT_REF_LOCI_6):3,071,371-3,073,770 (+)

Genomic View for HSPA1A Gene

Genes around HSPA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSPA1A Gene

Proteins for HSPA1A Gene

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  • Protein details for HSPA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV8-HS71A_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1A
    Protein Accession:
    P0DMV8
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1A Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with DNAAF2 (By similarity). Interacts with PRKN (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486). Interacts with RNF207 (via the C-terminus); this interaction additively increases KCNH2 expression (PubMed:25281747). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:7935376, PubMed:9499401). Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively (PubMed:27708256). Interacts with NEDD1 (PubMed:27137183). Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105 (PubMed:24318877). Interacts with SMAD3 (PubMed:24613385). Interacts with DNAJC8 (PubMed:27133716). Interacts with NLRP12 (PubMed:17947705).

    Three dimensional structures from OCA and Proteopedia for HSPA1A Gene

    Alternative splice isoforms for HSPA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA1A Gene

Protein Expression for HSPA1A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSPA1A Gene

  • In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
  • Glycosylation at Asn35 and Asn417
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HS71A_HUMAN (1295)

Other Protein References for HSPA1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for HSPA1A

No data available for DME Specific Peptides for HSPA1A Gene

Domains & Families for HSPA1A Gene

Gene Families for HSPA1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPA1A Gene

InterPro:

Suggested Antigen Peptide Sequences for HSPA1A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA (A8K5I0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DMV8

UniProtKB/Swiss-Prot:

HS71A_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1A: view

Function for HSPA1A Gene

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  6. Cell Lines for research

Molecular function for HSPA1A Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
UniProtKB/Swiss-Prot Induction:
By heat shock.
GENATLAS Biochemistry:
heat shock 70kDa protein A1,acting as a molecular chaperone

Phenotypes From GWAS Catalog for HSPA1A Gene

Gene Ontology (GO) - Molecular Function for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0001664 G protein-coupled receptor binding IDA 12150907
GO:0003714 transcription corepressor activity IDA 9499401
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with HSPA1A: view
genes like me logo Genes that share phenotypes with HSPA1A: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA1A Gene

Localization for HSPA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1A Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1A gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
extracellular 4
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA,IDA 10205060
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,TAS 16130169
GO:0005739 mitochondrion TAS 16130169
genes like me logo Genes that share ontologies with HSPA1A: view

Pathways & Interactions for HSPA1A Gene

genes like me logo Genes that share pathways with HSPA1A: view

Pathways by source for HSPA1A Gene

1 Sino Biological pathway for HSPA1A Gene
6 GeneGo (Thomson Reuters) pathways for HSPA1A Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway
1 R&D Systems pathway for HSPA1A Gene
4 Qiagen pathways for HSPA1A Gene
  • Aldosterone Signaling in Epithelial Cells
  • Cellular Transformation by HTLV1
  • Glucocorticoid Receptor Signaling
  • HIF1Alpha Pathway
1 GeneTex pathway for HSPA1A Gene

SIGNOR curated interactions for HSPA1A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 10205060
GO:0006986 response to unfolded protein IDA --
GO:0007041 lysosomal transport ISS --
GO:0008285 negative regulation of cell proliferation IMP 9553041
GO:0010628 positive regulation of gene expression IMP 25281747
genes like me logo Genes that share ontologies with HSPA1A: view

Drugs & Compounds for HSPA1A Gene

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(52) Drugs for HSPA1A Gene - From: PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 109
ATP Investigational Nutra 0
Carnosine Investigational Pharma 0
MKT 077 Pharma Binds mot-2; selectively cytotoxic in cancer cells 0
TRC 051384 Pharma Inducer of heat shock protein Hsp70 0

(35) Additional Compounds for HSPA1A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BIX
101714-41-4

(4) Tocris Compounds for HSPA1A Gene

Compound Action Cas Number
BIX BiP (Hsp70-5) ER chaperone inducer 101714-41-4
MKT 077 Binds mot-2; selectively cytotoxic in cancer cells 147366-41-4
TRC 051384 Inducer of heat shock protein Hsp70 867164-40-7
VER 155008 Hsp70 inhibitor 1134156-31-2

(4) ApexBio Compounds for HSPA1A Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
MKT 077 147366-41-4
TRC 051384 867164-40-7
VER 155008 HSP 70 inhibitor,adenosine-derived 1134156-31-2
genes like me logo Genes that share compounds with HSPA1A: view

Drug products for research

Transcripts for HSPA1A Gene

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mRNA/cDNA for HSPA1A Gene

1 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA1A

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1A Gene

No ASD Table

Relevant External Links for HSPA1A Gene

GeneLoc Exon Structure for
HSPA1A

Expression for HSPA1A Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA1A Gene

mRNA expression in normal human tissues for HSPA1A Gene
mRNA expression by BioGPS for HSPA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA1A Gene

This gene is overexpressed in Uterus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA1A Gene



Protein tissue co-expression partners for HSPA1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA1A

SOURCE GeneReport for Unigene cluster for HSPA1A Gene:

Hs.274402

Evidence on tissue expression from TISSUES for HSPA1A Gene

  • Nervous system(5)
  • Lung(5)
  • Pancreas(4.9)
  • Spleen(4.9)
  • Liver(4.9)
  • Intestine(4.9)
  • Skin(4.9)
  • Muscle(4.8)
  • Kidney(4.8)
  • Heart(4.8)
  • Blood(4.6)
  • Stomach(4.1)
  • Eye(3.8)
  • Thyroid gland(3.6)
  • Lymph node(3)
  • Bone marrow(2.8)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with HSPA1A: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA1A Gene

Orthologs for HSPA1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 30
  • 100 (a)
 OneToMany
HSPA1A 29
  • 99.38 (n)
Dog
(Canis familiaris)
 Mammalia -- 30
  • 99 (a)
 ManyToMany
HSPA1 30
  • 98 (a)
 ManyToMany
LOC102155697 29
  • 94.8 (n)
Mouse
(Mus musculus)
 Mammalia Hspa1b 30
  • 95 (a)
 ManyToMany
Hspa1a 29 30
  • 91.58 (n)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia HSPA1A 29 30
  • 94.59 (n)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 94 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Hspa1a 29
  • 92.36 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 84 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100485441 29
  • 78.31 (n)
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-199o1.2 30
  • 86 (a)
 ManyToMany
hsc70 29
  • 75.4 (n)
hsp70 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11817 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Hsc70-4 30 31
  • 81 (a)
 ManyToMany
Hsc70-1 30 31
  • 79 (a)
 ManyToMany
Hsp70Aa 31
  • 76 (a)
Hsp70Ab 31
  • 76 (a)
Hsp70Ba 31
  • 76 (a)
Hsp70Bb 31
  • 76 (a)
Hsc70-2 31
  • 75 (a)
Hsp70Bc 29 31
  • 74.66 (n)
Hsp68 31
  • 73 (a)
Hsc70-3 31
  • 62 (a)
CG7182 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
 Secernentea hsp-1 30 31
  • 82 (a)
 OneToMany
hsp-2 31
  • 75 (a)
F44E5.4 31
  • 68 (a)
F44E5.5 31
  • 68 (a)
hsp-70 31
  • 66 (a)
hsp-3 31
  • 62 (a)
hsp-4 31
  • 60 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SSA2 30 32
  • 74 (a)
 OneToMany
SSA4 29 32
  • 63.59 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AER187W 29
  • 70.57 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E20527g 29
  • 62.87 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G02490 29
  • 68.52 (n)
Rice
(Oryza sativa)
 Liliopsida Os.46024 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11098 30
  • 80 (a)
 ManyToMany
CSA.971 30
  • 75 (a)
 ManyToMany
Species where no ortholog for HSPA1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSPA1A Gene

ENSEMBL:
Gene Tree for HSPA1A (if available)
TreeFam:
Gene Tree for HSPA1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA1A: view image
Alliance of Genome Resources:
Additional Orthologs for HSPA1A

Paralogs for HSPA1A Gene

Paralogs for HSPA1A Gene

(18) SIMAP similar genes for HSPA1A Gene using alignment to 4 proteins:

  • HSP71_HUMAN
  • A8K5I0_HUMAN
  • E7EP94_HUMAN
  • V9GZ37_HUMAN
genes like me logo Genes that share paralogs with HSPA1A: view

Variants for HSPA1A Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA1A Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1008438 Association: Chronic obstructive pulmonary disease 31,815,431(+) A/C
NC_000006.12:g.31815431A>C
rs1043618 Association: Chronic obstructive pulmonary disease 31,815,730(+) G/C
NM_005345.6(HSPA1A):c.-27G>C 		FIVE_PRIME_UTR
rs1061581 Association: Chronic obstructive pulmonary disease 31,816,809(+) G/A
NM_005345.6(HSPA1A):c.1053G>A (p.Gln351=) 		SYNONYMOUS
rs562047 Association: Chronic obstructive pulmonary disease 31,816,086(+) G/Cp.Glu110Asp
NM_005345.6(HSPA1A):c.330G>C (p.Glu110Asp) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSPA1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSPA1A Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2421830 CNV deletion 20811451
esv2667397 CNV deletion 23128226
esv3890822 CNV loss 25118596
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv482094 CNV gain 20164927
nsv823504 CNV loss 20364138

Variation tolerance for HSPA1A Gene

Gene Damage Index Score: 8.04; 84.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA1A Gene

Human Gene Mutation Database (HGMD)
HSPA1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1A
Leiden Open Variation Database (LOVD)
HSPA1A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1A Gene

Disorders for HSPA1A Gene

MalaCards: The human disease database

(19) MalaCards diseases for HSPA1A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
transient cerebral ischemia
  • tia
carotid artery occlusion
  • occlusion and stenosis of carotid artery
ischemia
  • acute coronary syndrome
tuberculoid leprosy
  • smooth leprosy
xeroderma pigmentosum, complementation group a
  • xpa
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HS71A_HUMAN
  • Note=In certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), plays a role in the cytoplasmic sequestration of misfolded N-terminal mutated PRDM1 proteins, promotes their association with SYNV1/HRD1 and degradation through the SYNV1-proteasome pathway. HSPA1A inhibition restores PRDM1 nuclear localization and transcriptional activity in lymphoma cell lines and suppresses growth in xenografts. {ECO:0000269 PubMed:28842558}.

Additional Disease Information for HSPA1A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HSPA1A: view

No data available for Genatlas for HSPA1A Gene

Publications for HSPA1A Gene

  1. Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer. (PMID: 19626584) Partida-Rodríguez O … Perez-Rodríguez M (International journal of cancer 2010) 3 22 40
  2. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PMID: 18518860) Buraczynska M … Ksiazek A (Clinical science (London, England : 1979) 2009) 3 22 40
  3. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Ménière's disease. (PMID: 19241595) Kawaguchi S … Suzuki M (Acta oto-laryngologica 2008) 3 22 40
  4. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PMID: 15963589) Pae CU … Kim JJ (Neuroscience research 2005) 3 22 40
  5. Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (PMID: 15832029) Fung HC … Lee-Chen GJ (Dementia and geriatric cognitive disorders 2005) 3 22 40

ExternalLinks

View latest publications for HSPA1A gene in Mastermind

Products for HSPA1A Gene