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This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) is a Protein Coding gene. Diseases associated with HSPA1A include Transient Cerebral Ischemia and Carotid Artery Occlusion. Among its related pathways are Apoptosis Modulation and Signaling and HIF1Alpha Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is HSPA1B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001618 | virus receptor activity | IEA | -- |
GO:0001664 | G protein-coupled receptor binding | IDA | 12150907 |
GO:0003714 | transcription corepressor activity | IDA | 9499401 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 10205060 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,TAS | 16130169 |
GO:0005739 | mitochondrion | TAS | 16130169 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HSF1-dependent transactivation | ||
2 | Innate Immune System |
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3 | MAPK signaling pathway | ||
4 | Apoptosis Modulation and Signaling | ||
5 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006402 | mRNA catabolic process | IDA | 10205060 |
GO:0006986 | response to unfolded protein | IBA,IDA | -- |
GO:0007041 | lysosomal transport | ISS | -- |
GO:0008285 | negative regulation of cell proliferation | IMP | 9553041 |
GO:0010628 | positive regulation of gene expression | IMP | 25281747 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Carbamazepine | Approved, Investigational | Pharma | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 104 | ||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
Carnosine | Investigational | Pharma | 0 | |||
MKT 077 | Pharma | Binds mot-2; selectively cytotoxic in cancer cells | 0 | |||
TRC 051384 | Pharma | Inducer of heat shock protein Hsp70 | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
BIX |
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101714-41-4 |
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Compound | Action | Cas Number |
---|---|---|
BIX | BiP (Hsp70-5) ER chaperone inducer | 101714-41-4 |
MKT 077 | Binds mot-2; selectively cytotoxic in cancer cells | 147366-41-4 |
TRC 051384 | Inducer of heat shock protein Hsp70 | 867164-40-7 |
VER 155008 | Hsp70 inhibitor | 1134156-31-2 |
Compound | Action | Cas Number |
---|---|---|
Elesclomol (STA-4783) | Oxidative stress/apoptosis inducer,potent and novel | 488832-69-5 |
MKT 077 | 147366-41-4 | |
TRC 051384 | 867164-40-7 | |
VER 155008 | HSP 70 inhibitor,adenosine-derived | 1134156-31-2 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
HSPA1A 30 |
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Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
HSPA1 31 |
|
ManyToMany | |||
LOC102155697 30 |
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Mouse (Mus musculus) |
Mammalia | Hspa1b 31 |
|
ManyToMany | |
Hspa1a 30 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | HSPA1A 30 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Hspa1a 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485441 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-199o1.2 31 |
|
ManyToMany | |
hsc70 30 |
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hsp70 30 |
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Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11817 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | Hsc70-4 31 32 |
|
ManyToMany | |
Hsc70-1 31 32 |
|
ManyToMany | |||
Hsp70Aa 32 |
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Hsp70Ab 32 |
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Hsp70Ba 32 |
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Hsp70Bb 32 |
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Hsc70-2 32 |
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Hsp70Bc 30 32 |
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Hsp68 32 |
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Hsc70-3 32 |
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CG7182 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | hsp-1 31 32 |
|
OneToMany | |
hsp-2 32 |
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F44E5.4 32 |
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F44E5.5 32 |
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hsp-70 32 |
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hsp-3 32 |
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hsp-4 32 |
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Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 31 33 |
|
OneToMany | |
SSA4 30 33 |
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A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER187W 30 |
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||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20527g 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G02490 30 |
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Rice (Oryza sativa) |
Liliopsida | Os.46024 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11098 31 |
|
ManyToMany | |
CSA.971 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1008438 | Association: Chronic obstructive pulmonary disease | 31,815,431(+) | A/C | ||
rs1043618 | Association: Chronic obstructive pulmonary disease | 31,815,730(+) | G/C | FIVE_PRIME_UTR_VARIANT | |
rs1061581 | Association: Chronic obstructive pulmonary disease | 31,816,809(+) | G/A | SYNONYMOUS_VARIANT | |
rs562047 | Association: Chronic obstructive pulmonary disease. - | 31,816,086(+) | G/Cp.Glu110Asp | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10403n54 | CNV | loss | 21841781 |
dgv10404n54 | CNV | loss | 21841781 |
dgv10461n54 | CNV | loss | 21841781 |
dgv10462n54 | CNV | loss | 21841781 |
dgv10463n54 | CNV | loss | 21841781 |
esv2421830 | CNV | deletion | 20811451 |
esv2667397 | CNV | deletion | 23128226 |
esv3890822 | CNV | loss | 25118596 |
nsv1073969 | CNV | deletion | 25765185 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1126749 | CNV | deletion | 24896259 |
nsv482094 | CNV | gain | 20164927 |
nsv823504 | CNV | loss | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
transient cerebral ischemia |
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carotid artery occlusion |
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ischemia |
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tuberculoid leprosy |
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mulibrey nanism |
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