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Aliases for HSPA14 Gene
Aliases for HSPA14 Gene
External Ids for HSPA14 Gene
- HGNC: 29526
- Entrez Gene: 51182
- Ensembl: ENSG00000187522
- OMIM: 610369
- UniProtKB: Q0VDF9
Previous GeneCards Identifiers for HSPA14 Gene
- GC10P014885
- GC10P014920
Summaries for HSPA14 Gene
GeneCards Summary for HSPA14 Gene
HSPA14 (Heat Shock Protein Family A (Hsp70) Member 14) is a Protein Coding gene. Diseases associated with HSPA14 include Pontocerebellar Hypoplasia, Type 2A and Autoimmune Atherosclerosis. Among its related pathways are Cellular response to heat stress and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). An important paralog of this gene is HSPA8.
UniProtKB/Swiss-Prot Summary for HSPA14 Gene
-
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
Additional gene information for HSPA14 Gene
- HGNC(29526)
- Entrez Gene(51182)
- Ensembl(ENSG00000187522)
- OMIM(610369)
- UniProtKB(Q0VDF9)
- Open Targets Platform(ENSG00000187522)
- Monarch Initiative
- Search for HSPA14 at DataMed
- Search for HSPA14 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA14 Gene
Genomics for HSPA14 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HSPA14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSPA14 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA14
- Top Transcription factor binding sites by QIAGEN in the HSPA14 gene promoter:
-
- aMEF-2
- ATF-2
- CRE-BP1
- HSF1 (long)
- HSF1short
- MEF-2A
- p53
- POU6F1 (c2)
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for HSPA14 Gene
Genomic Locations for HSPA14 Gene
- chr10:14,838,306-14,871,741
- (GRCh38/hg38)
- Size:
- 33,436 bases
- Orientation:
- Plus strand
- chr10:14,880,163-14,913,740
- (GRCh37/hg19)
- Size:
- 33,578 bases
- Orientation:
- Plus strand
Genomic View for HSPA14 Gene
Genes around HSPA14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p13 by HGNC
- 10p13 by Entrez Gene
- 10p13 by Ensembl
HSPA14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSPA14 Gene
Proteins for HSPA14 Gene
-
Protein details for HSPA14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q0VDF9-HSP7E_HUMAN
- Recommended name:
- Heat shock 70 kDa protein 14
- Protein Accession:
- Q0VDF9
- A8K8F8
- B0YIY9
- Q9P0X2
- Q9UI07
Protein attributes for HSPA14 Gene
- Size:
- 509 amino acids
- Molecular mass:
- 54794 Da
- Quaternary structure:
-
- Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
- Miscellaneous:
-
- Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).
Protein Expression for HSPA14 Gene
Post-translational modifications for HSPA14 Gene
Other Protein References for HSPA14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HSPA14 Antibody
- Novus Biologicals Antibodies for HSPA14
-
Abcam antibodies for HSPA14
- Invitrogen Antibodies for HSPA14 (AFLGC-HSPA14)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSPA14
- Sino Biological Antibodies for HSPA14
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HSPA14
- Origene Custom Protein Services for HSPA14
- antibodies-online: Show 5 available HSPA14 Proteins ranked by validation data
- Compare Top HSPA14 Proteins
-
Quality Products:
No data available for DME Specific Peptides for HSPA14 Gene
Domains & Families for HSPA14 Gene
Gene Families for HSPA14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HSPA14 Gene
- InterPro:
- Blocks:
-
- Heat shock protein Hsp70
- ProtoNet:
Suggested Antigen Peptide Sequences for HSPA14 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ10018 fis, clone HEMBA1000531 (A6NJU0_HUMAN)
- Heat shock 70kDa protein 14 isoform 1 variant 4 (B0YIZ2_HUMAN)
- Heat shock protein HSP60 (HSP7E_HUMAN)
- Heat shock 70kDa protein 14, isoform CRA_d (Q6P155_HUMAN)
- HSPA14 protein (Q8TAQ0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q0VDF9- Family:
-
- Belongs to the heat shock protein 70 family.
Function for HSPA14 Gene
Molecular function for HSPA14 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
Phenotypes From GWAS Catalog for HSPA14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16002468 |
| GO:0005524 | ATP binding | IBA | 21873635 |
| GO:0016887 | ATPase activity | IBA | 21873635 |
| GO:0031072 | heat shock protein binding | IBA | 21873635 |
Phenotypes for HSPA14 Gene
- GenomeRNAi human phenotypes for HSPA14:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with Ras
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased S DNA content
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSPA14 - Select products 50% OFF >
- * HSPA14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HSPA14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSPA14
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSPA14
miRNA for HSPA14 Gene
- miRTarBase miRNAs that target HSPA14
-
- hsa-miR-373-3p (MIRT002543)
- hsa-miR-222-3p (MIRT046763)
- hsa-miR-100-5p (MIRT048464)
- hsa-miR-6083 (MIRT445439)
- hsa-miR-190a-3p (MIRT445440)
- hsa-miR-410-3p (MIRT445441)
- hsa-miR-3163 (MIRT445442)
- hsa-miR-5582-3p (MIRT445443)
- hsa-miR-548x-3p (MIRT445444)
- hsa-miR-548j-3p (MIRT445445)
- hsa-miR-548aq-3p (MIRT445446)
- hsa-miR-548am-3p (MIRT445447)
- hsa-miR-548aj-3p (MIRT445448)
- hsa-miR-548ah-3p (MIRT445449)
- hsa-miR-548ae-3p (MIRT445451)
- hsa-miR-6514-3p (MIRT631430)
- hsa-miR-4633-5p (MIRT631431)
- hsa-miR-6742-5p (MIRT631432)
- hsa-miR-4472 (MIRT631433)
- hsa-miR-4447 (MIRT631434)
- hsa-miR-3151-5p (MIRT631435)
- hsa-miR-491-5p (MIRT631436)
- hsa-miR-185-3p (MIRT631437)
- hsa-miR-4283 (MIRT631438)
- hsa-miR-4489 (MIRT631439)
- hsa-miR-6811-3p (MIRT631440)
- hsa-miR-214-5p (MIRT631441)
- hsa-miR-383-3p (MIRT631442)
- hsa-miR-532-5p (MIRT631443)
- hsa-miR-7977 (MIRT645111)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSPA14
- Browse OriGene Inhibitory RNA Products For HSPA14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA14
Clone Products
- Applied Biological Materials (abm): Clones for HSPA14 - Select products 50% OFF >
- * HSPA14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HSPA14
- Addgene plasmids for HSPA14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA14
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA14 Gene
Localization for HSPA14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSPA14 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | IEA,IDA | 16002468 |
| GO:0005840 | colocalizes_with ribosome | IBA,IDA | 16002468 |
| GO:0005844 | polysome | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSPA14 Gene
Pathways & Interactions for HSPA14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) |
CFTR folding and maturation (norm and CF)
.37
|
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
.37
|
| 3 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway |
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
.97
|
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Development_Glucocorticoid receptor signaling |
Development_Glucocorticoid receptor signaling
-
|
|
Pathways by source for HSPA14 Gene
1 BioSystems pathway for HSPA14 Gene
3 Reactome pathways for HSPA14 Gene
6 GeneGo (Thomson Reuters) pathways for HSPA14 Gene
- CFTR folding and maturation (norm and CF)
- Development_Glucocorticoid receptor signaling
- Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
- Proteolysis_Putative ubiquitin pathway
Interacting Proteins for HSPA14 Gene
GPS-Prot Interaction Network for HSPA14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002181 | cytoplasmic translation | IBA | -- |
| GO:0006450 | regulation of translational fidelity | IBA | -- |
| GO:0006986 | response to unfolded protein | IBA | 21873635 |
| GO:0016192 | vesicle-mediated transport | IBA | 21873635 |
| GO:0034620 | cellular response to unfolded protein | IBA | 21873635 |
No data available for SIGNOR curated interactions for HSPA14 Gene
Drugs & Compounds for HSPA14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Elesclomol (STA-4783) | Pharma | Oxidative stress/apoptosis inducer,potent and novel | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for HSPA14 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Elesclomol (STA-4783) | Oxidative stress/apoptosis inducer,potent and novel | 488832-69-5 |
Transcripts for HSPA14 Gene
mRNA/cDNA for HSPA14 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378372 1762 nts (view in UCSC)
- ENST00000441647 578 nts (view in UCSC)
- ENST00000470430 854 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSPA14 - Select products 50% OFF >
- * HSPA14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HSPA14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSPA14
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSPA14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSPA14
- Browse OriGene Inhibitory RNA Products For HSPA14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA14
Clone Products
- Applied Biological Materials (abm): Clones for HSPA14 - Select products 50% OFF >
- * HSPA14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HSPA14
- Addgene plasmids for HSPA14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA14
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: |
Relevant External Links for HSPA14 Gene
- GeneLoc Exon Structure for
- HSPA14
Expression for HSPA14 Gene
This gene is overexpressed in Lymph node (14.4), Breast (9.4), Peripheral blood mononuclear cells (8.8), and Cervix (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA14 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA14
SOURCE GeneReport for Unigene cluster for HSPA14 Gene:
Hs.534169Evidence on tissue expression from TISSUES for HSPA14 Gene
- Liver(4.3)
- Nervous system(4.3)
- Adrenal gland(4.2)
- Lymph node(2.2)
- Spleen(2.2)
- Intestine(2.1)
- Skin(2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for HSPA14
-
OriGene qPCR primer pairs and template standards for HSPA14
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA14 Gene
Orthologs for HSPA14 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HSPA14 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HSPA14 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HSPA14 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HSPA14 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hspa14 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hspa14 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | HSPA14 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HSPA14 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hspa14 30 |
|
||
| Str.10057 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12197 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hspa14 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9232 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7182 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | F11F1.1 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSA2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for HSPA14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HSPA14 Gene
- ENSEMBL:
- Gene Tree for HSPA14 (if available)
- TreeFam:
- Gene Tree for HSPA14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSPA14: view image
Paralogs for HSPA14 Gene
Paralogs for HSPA14 Gene
(14) SIMAP similar genes for HSPA14 Gene using alignment to 6 proteins:
- HSP7E_HUMAN
- B0YIZ1_HUMAN
- B0YIZ2_HUMAN
- H7C2A1_HUMAN
- Q6P155_HUMAN
- Q8TAQ0_HUMAN
Variants for HSPA14 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA14 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 764051 | Likely Benign: not provided | 14,848,601(+) | A/G | INTRON_VARIANT | |
| 781938 | Benign: not provided | 14,867,256(+) | T/C | SYNONYMOUS_VARIANT | |
| rs374837716 | A breast cancer sample | p.Ala85Val |
Residual Variation Intolerance Score:
18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.44;
42.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSPA14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HSPA14
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA14 Gene
Disorders for HSPA14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pontocerebellar hypoplasia, type 2a |
|
|
| autoimmune atherosclerosis |
|
|
| tetralogy of fallot |
|
|
Search HSPA14 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HSPA14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA14 Gene
Publications for HSPA14 Gene
- Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity. (PMID: 21208456) Wu CY … Wu KJ (Journal of biomedical science 2011) 2 3
- Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 41
- Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez DR … Menon R (American journal of obstetrics and gynecology 2009) 3 41
- Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PMID: 19527514) Menon R … Thorsen P (Reproductive biology and endocrinology : RB&E 2009) 3 41
- Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PMID: 18818748) Velez DR … Menon R (PloS one 2008) 3 41
ExternalLinks
Products for HSPA14 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HSPA14
- Origene Custom Protein Services for HSPA14
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSPA14
- Browse OriGene Inhibitory RNA Products For HSPA14
- OriGene qPCR primer pairs for HSPA14
- OriGene qPCR primer pairs and template standards for HSPA14
- OriGene CRISPR knockouts for HSPA14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HSPA14
- Sino Biological Human cDNA Clone for HSPA14
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for HSPA14
- Browse Sino Biological Assays
- Browse Antibodies
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- Novus Biologicals Antibodies for HSPA14
- Novus Biologicals proteins and lysates for HSPA14
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- Abcam antibodies for HSPA14
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- Browse Primary Antibodies
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- Invitrogen Antibodies for HSPA14 (AFLGC-HSPA14)
- ApexBio compounds for HSPA14
- VectorBuilder Custom and pre-made DNA vectors for HSPA14 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HSPA14 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HSPA14 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HSPA14 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HSPA14
- Addgene plasmids for HSPA14
- antibodies-online: Show 9 available HSPA14 Antibodies ranked by validation data
- Compare Top HSPA14 Antibodies
- antibodies-online: Search results for available HSPA14 related products ranked by validation data
- antibodies-online: Show 5 available HSPA14 Proteins ranked by validation data
- Compare Top HSPA14 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for HSPA14
- Search Santa Cruz Biotechnology (SCBT) for HSPA14 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HSPA14
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSPA14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSPA14
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HSPA14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA14
Sources for HSPA14 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB