Aliases for HSPA14 Gene

Aliases for HSPA14 Gene

  • Heat Shock Protein Family A (Hsp70) Member 14 2 3 5
  • Heat Shock 70 KDa Protein 14 3 4
  • Heat Shock Protein HSP60 3 4
  • HSP70-Like Protein 1 3 4
  • HSP70L1 3 4
  • Heat Shock 70kDa Protein 14 Isoform 1 Variant 3 3
  • Heat Shock Protein Hsp70-Related Protein 3
  • Heat Shock 70kDa Protein 14 2
  • HSP70-4 3
  • HSP60 4

External Ids for HSPA14 Gene

Previous GeneCards Identifiers for HSPA14 Gene

  • GC10P014885
  • GC10P014920

Summaries for HSPA14 Gene

GeneCards Summary for HSPA14 Gene

HSPA14 (Heat Shock Protein Family A (Hsp70) Member 14) is a Protein Coding gene. Diseases associated with HSPA14 include Pontocerebellar Hypoplasia, Type 2A and Autoimmune Atherosclerosis. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot Summary for HSPA14 Gene

  • Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Wiki entry for HSPA14 Gene

Additional gene information for HSPA14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA14 Gene

Genomics for HSPA14 Gene

GeneHancer (GH) Regulatory Elements for HSPA14 Gene

Promoters and enhancers for HSPA14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSPA14

Top Transcription factor binding sites by QIAGEN in the HSPA14 gene promoter:
  • aMEF-2
  • ATF-2
  • CRE-BP1
  • HSF1 (long)
  • HSF1short
  • MEF-2A
  • p53
  • POU6F1 (c2)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for HSPA14 Gene

Genomic Locations for HSPA14 Gene
chr10:14,838,160-14,871,741
(GRCh38/hg38)
Size:
33,582 bases
Orientation:
Plus strand
chr10:14,880,163-14,913,740
(GRCh37/hg19)
Size:
33,578 bases
Orientation:
Plus strand

Genomic View for HSPA14 Gene

Genes around HSPA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA14 Gene

Proteins for HSPA14 Gene

  • Protein details for HSPA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDF9-HSP7E_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 14
    Protein Accession:
    Q0VDF9
    Secondary Accessions:
    • A8K8F8
    • B0YIY9
    • Q9P0X2
    • Q9UI07

    Protein attributes for HSPA14 Gene

    Size:
    509 amino acids
    Molecular mass:
    54794 Da
    Quaternary structure:
    • Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    Miscellaneous:
    • Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).

neXtProt entry for HSPA14 Gene

Post-translational modifications for HSPA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HSPA14
  • Santa Cruz Biotechnology (SCBT) Antibodies for HSPA14

No data available for DME Specific Peptides for HSPA14 Gene

Domains & Families for HSPA14 Gene

Gene Families for HSPA14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPA14 Gene

Blocks:
  • Heat shock protein Hsp70
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ10018 fis, clone HEMBA1000531 (A6NJU0_HUMAN)
  • Heat shock 70kDa protein 14 isoform 1 variant 4 (B0YIZ2_HUMAN)
  • Heat shock protein HSP60 (HSP7E_HUMAN)
  • Heat shock 70kDa protein 14, isoform CRA_d (Q6P155_HUMAN)
  • HSPA14 protein (Q8TAQ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q0VDF9

UniProtKB/Swiss-Prot:

HSP7E_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA14: view

Function for HSPA14 Gene

Molecular function for HSPA14 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Phenotypes From GWAS Catalog for HSPA14 Gene

Gene Ontology (GO) - Molecular Function for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16002468
GO:0005524 ATP binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
GO:0031072 heat shock protein binding IBA 21873635
GO:0042623 ATPase activity, coupled IBA 21873635
genes like me logo Genes that share ontologies with HSPA14: view
genes like me logo Genes that share phenotypes with HSPA14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA14 Gene

Localization for HSPA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA14 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA14 gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA,IEA 16002468
GO:0005840 colocalizes_with ribosome IBA,IDA 16002468
GO:0005844 polysome IBA 21873635
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with HSPA14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSPA14 Gene

Pathways & Interactions for HSPA14 Gene

PathCards logo

SuperPathways for HSPA14 Gene

SuperPathway Contained pathways
1 Cellular response to heat stress
2 Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
.37
.37
3 Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
.97
4 Cellular Senescence (REACTOME)
5 Development_Glucocorticoid receptor signaling
-
genes like me logo Genes that share pathways with HSPA14: view

Pathways by source for HSPA14 Gene

6 GeneGo (Thomson Reuters) pathways for HSPA14 Gene
  • CFTR folding and maturation (norm and CF)
  • Development_Glucocorticoid receptor signaling
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Proteolysis_Putative ubiquitin pathway

Gene Ontology (GO) - Biological Process for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA 21873635
GO:0006450 regulation of translational fidelity IBA 21873635
GO:0006986 response to unfolded protein IBA 21873635
GO:0034605 cellular response to heat IBA 21873635
GO:0034620 cellular response to unfolded protein IBA 21873635
genes like me logo Genes that share ontologies with HSPA14: view

No data available for SIGNOR curated interactions for HSPA14 Gene

Drugs & Compounds for HSPA14 Gene

(6) Drugs for HSPA14 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(5) Additional Compounds for HSPA14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HSPA14 Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA14: view

Transcripts for HSPA14 Gene

mRNA/cDNA for HSPA14 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA14

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSPA14 Gene

GeneLoc Exon Structure for
HSPA14

Expression for HSPA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA14 Gene

Protein differential expression in normal tissues from HIPED for HSPA14 Gene

This gene is overexpressed in Lymph node (14.4), Breast (9.4), Peripheral blood mononuclear cells (8.8), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA14 Gene



Protein tissue co-expression partners for HSPA14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSPA14

SOURCE GeneReport for Unigene cluster for HSPA14 Gene:

Hs.534169

Evidence on tissue expression from TISSUES for HSPA14 Gene

  • Adrenal gland(4.2)
  • Liver(4.2)
  • Nervous system(4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with HSPA14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA14 Gene

Orthologs for HSPA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA14 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA14 31 30
  • 92.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA14 31 30
  • 90.83 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA14 31
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa14 17 31 30
  • 85.85 (n)
rat
(Rattus norvegicus)
Mammalia Hspa14 30
  • 84.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 82 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves HSPA14 31 30
  • 77.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA14 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa14 30
  • 73.48 (n)
Str.10057 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12197 30
zebrafish
(Danio rerio)
Actinopterygii hspa14 31 30
  • 67.33 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9232 30
fruit fly
(Drosophila melanogaster)
Insecta CG7182 31
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11F1.1 31
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 31
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
ManyToMany
Species where no ortholog for HSPA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA14 Gene

ENSEMBL:
Gene Tree for HSPA14 (if available)
TreeFam:
Gene Tree for HSPA14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA14: view image

Paralogs for HSPA14 Gene

(14) SIMAP similar genes for HSPA14 Gene using alignment to 6 proteins:

  • HSP7E_HUMAN
  • B0YIZ1_HUMAN
  • B0YIZ2_HUMAN
  • H7C2A1_HUMAN
  • Q6P155_HUMAN
  • Q8TAQ0_HUMAN
genes like me logo Genes that share paralogs with HSPA14: view

Variants for HSPA14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSPA14 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
764051 Likely Benign: not provided 14,848,601(+) A/G INTRON_VARIANT
781938 Benign: not provided 14,867,256(+) T/C SYNONYMOUS_VARIANT
rs374837716 A breast cancer sample p.Ala85Val

Additional dbSNP identifiers (rs#s) for HSPA14 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPA14 Gene

Variant ID Type Subtype PubMed ID
nsv1043133 CNV loss 25217958
nsv469720 CNV gain 16826518
nsv523583 CNV gain 19592680
nsv831793 CNV loss 17160897

Variation tolerance for HSPA14 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA14 Gene

Disorders for HSPA14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA14 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPA14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA14 Gene

Publications for HSPA14 Gene

  1. Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity. (PMID: 21208456) Wu CY … Wu KJ (Journal of biomedical science 2011) 2 3 54
  2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 41 54
  3. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PMID: 19527514) Menon R … Thorsen P (Reproductive biology and endocrinology : RB&E 2009) 3 41 54
  4. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez DR … Menon R (American journal of obstetrics and gynecology 2009) 3 41 54
  5. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PMID: 18818748) Velez DR … Menon R (PloS one 2008) 3 41 54

Products for HSPA14 Gene

Sources for HSPA14 Gene