The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiq... See more...

Aliases for HSPA13 Gene

Aliases for HSPA13 Gene

  • Heat Shock Protein Family A (Hsp70) Member 13 2 3 5
  • Stress-70 Protein Chaperone Microsome-Associated 60 KDa Protein 3 4
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kDa 2 3
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kD 2 3
  • Heat Shock Protein 70kDa Family, Member 13 2 3
  • Heat Shock 70 KDa Protein 13 3 4
  • STCH 3 4
  • Testis Secretory Sperm-Binding Protein Li 199a 3
  • Microsomal Stress 70 Protein ATPase Core 3
  • Microsomal Stress-70 Protein ATPase Core 4

External Ids for HSPA13 Gene

Previous HGNC Symbols for HSPA13 Gene

  • STCH

Previous GeneCards Identifiers for HSPA13 Gene

  • GC21M014666
  • GC21M015743
  • GC21M001113

Summaries for HSPA13 Gene

Entrez Gene Summary for HSPA13 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA13 Gene

HSPA13 (Heat Shock Protein Family A (Hsp70) Member 13) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Cellular response to heat stress. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot Summary for HSPA13 Gene

Gene Wiki entry for HSPA13 Gene

Additional gene information for HSPA13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSPA13 Gene

Genomics for HSPA13 Gene

GeneHancer (GH) Regulatory Elements for HSPA13 Gene

Promoters and enhancers for HSPA13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J014381 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +1.1 1094 4.8 SP1 SIX5 ZBTB6 FOXA1 POLR2A ATF1 ZNF217 CREB1 HCFC1 MYC HSPA13 LOC105369304 lnc-RBM11-1 piR-40678-009
GH21J014760 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -379.1 -379102 3.4 SP1 ZBTB40 SMARCE1 CC2D1A ETV6 RELA L3MBTL2 TEAD4 GTF2F1 MLLT1 ENSG00000226751 HSPA13 LIPI ENSG00000232884 lnc-RBM11-10
GH21J014757 Enhancer 0.7 FANTOM5 dbSUPER 10.3 -374.3 -374316 0.3 L3MBTL2 ATF1 ZNF740 CTBP1 ZNF766 NR2C2 FOSL1 TAF7 POLR2CP1 HSPA13 lnc-RBM11-10
GH21J014361 Enhancer 0.6 Ensembl 10.9 +21.3 21283 0.8 MYC HLF MAX CEBPG TRIM24 CEBPA PKNOX1 CEBPB ZNF24 JUND HSPA13 LOC105369304 piR-40678-009 ABCC13
GH21J015301 Enhancer 0.6 ENCODE 9.9 -917.8 -917753 0.2 L3MBTL2 MAFK BACH1 NFE2L2 ZNF316 NFE2 MAFG TRIM28 CBX5 NRF1 HSPA13 HSALNG0131983 HSALNG0131994
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA13 gene promoter:
  • AREB6
  • COMP1
  • ER-alpha
  • FOXO4
  • Nkx2-2
  • Pbx1a
  • RP58
  • Sp1
  • STAT1
  • STAT1alpha

Genomic Locations for HSPA13 Gene

Genomic Locations for HSPA13 Gene
chr21:14,371,115-14,383,484
(GRCh38/hg38)
Size:
12,370 bases
Orientation:
Minus strand
chr21:15,743,436-15,755,805
(GRCh37/hg19)
Size:
12,370 bases
Orientation:
Minus strand

Genomic View for HSPA13 Gene

Genes around HSPA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA13 Gene

Proteins for HSPA13 Gene

  • Protein details for HSPA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48723-HSP13_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 13
    Protein Accession:
    P48723
    Secondary Accessions:
    • B2R616
    • Q8NE40

    Protein attributes for HSPA13 Gene

    Size:
    471 amino acids
    Molecular mass:
    51927 Da
    Quaternary structure:
    • Binds UBQLN2.

neXtProt entry for HSPA13 Gene

Post-translational modifications for HSPA13 Gene

  • Glycosylation at Asn137 and Asn184
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HSP13_HUMAN (1294)

Other Protein References for HSPA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA13 Gene

Domains & Families for HSPA13 Gene

Gene Families for HSPA13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for HSPA13 Gene

Suggested Antigen Peptide Sequences for HSPA13 Gene

GenScript: Design optimal peptide antigens:
  • Stress-70 protein chaperone microsome-associated 60 kDa protein (HSP13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48723

UniProtKB/Swiss-Prot:

HSP13_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA13: view

Function for HSPA13 Gene

Molecular function for HSPA13 Gene

UniProtKB/Swiss-Prot Function:
Has peptide-independent ATPase activity.

Phenotypes From GWAS Catalog for HSPA13 Gene

Gene Ontology (GO) - Molecular Function for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
GO:0031072 heat shock protein binding IBA 21873635
GO:0042623 ATPase activity, coupled IBA 21873635
genes like me logo Genes that share ontologies with HSPA13: view
genes like me logo Genes that share phenotypes with HSPA13: view

Animal Model Products

CRISPR Products

miRNA for HSPA13 Gene

miRTarBase miRNAs that target HSPA13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA13 Gene

Localization for HSPA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA13 Gene

Microsome. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA13 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IBA 21873635
GO:0016020 membrane IBA 21873635
genes like me logo Genes that share ontologies with HSPA13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSPA13 Gene

Pathways & Interactions for HSPA13 Gene

genes like me logo Genes that share pathways with HSPA13: view

Pathways by source for HSPA13 Gene

Gene Ontology (GO) - Biological Process for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IBA 21873635
GO:0030433 ubiquitin-dependent ERAD pathway IBA 21873635
GO:0030968 endoplasmic reticulum unfolded protein response IBA 21873635
GO:0034605 cellular response to heat IBA 21873635
GO:0034620 cellular response to unfolded protein IBA 21873635
genes like me logo Genes that share ontologies with HSPA13: view

No data available for SIGNOR curated interactions for HSPA13 Gene

Drugs & Compounds for HSPA13 Gene

(1) Drugs for HSPA13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 227
genes like me logo Genes that share compounds with HSPA13: view

Transcripts for HSPA13 Gene

mRNA/cDNA for HSPA13 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1:
SP2: - - -
SP3: - -
SP4: - - -

Relevant External Links for HSPA13 Gene

GeneLoc Exon Structure for
HSPA13
ECgene alternative splicing isoforms for
HSPA13

Expression for HSPA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA13 Gene

This gene is overexpressed in Stomach (9.7), Amniocyte (9.2), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA13 Gene



Protein tissue co-expression partners for HSPA13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA13 Gene:

HSPA13

SOURCE GeneReport for Unigene cluster for HSPA13 Gene:

Hs.352341

mRNA Expression by UniProt/SwissProt for HSPA13 Gene:

P48723-HSP13_HUMAN
Tissue specificity: Constitutively expressed in all tissues.

Evidence on tissue expression from TISSUES for HSPA13 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with HSPA13: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA13 Gene

Orthologs for HSPA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA13 33 32
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA13 33 32
  • 92.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA13 33 32
  • 90.59 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa13 32
  • 86.84 (n)
mouse
(Mus musculus)
Mammalia Hspa13 17 33 32
  • 86.55 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA13 33
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA13 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPA13 33 32
  • 72.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA13 33
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa13 32
  • 68.23 (n)
Str.9182 32
zebrafish
(Danio rerio)
Actinopterygii hspa13 33 32
  • 65.22 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2151 32
worm
(Caenorhabditis elegans)
Secernentea stc-1 33 32
  • 53.68 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSB2 33
  • 27 (a)
OneToOne
Species where no ortholog for HSPA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA13 Gene

ENSEMBL:
Gene Tree for HSPA13 (if available)
TreeFam:
Gene Tree for HSPA13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA13: view image

Paralogs for HSPA13 Gene

(9) SIMAP similar genes for HSPA13 Gene using alignment to 2 proteins:

  • HSP13_HUMAN
  • F5GWS8_HUMAN
genes like me logo Genes that share paralogs with HSPA13: view

Variants for HSPA13 Gene

Sequence variations from dbSNP and Humsavar for HSPA13 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000206146 -- 14,381,057(-) G/A intron_variant
rs1000726163 -- 14,385,114(-) A/AA upstream_transcript_variant
rs1001020582 -- 14,373,295(-) T/C 3_prime_UTR_variant
rs1001284093 -- 14,379,654(-) T/C intron_variant
rs1001474415 -- 14,372,940(-) T/C 3_prime_UTR_variant

Variation tolerance for HSPA13 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA13 Gene

Disorders for HSPA13 Gene

Additional Disease Information for HSPA13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HSPA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA13 Gene

Publications for HSPA13 Gene

  1. Stch encodes the 'ATPase core' of a microsomal stress 70 protein. (PMID: 8131751) Otterson GA … Kaye FJ (The EMBO journal 1994) 3 4 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 56
  5. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. (PMID: 10675567) Kaye FJ … Rose MD (FEBS letters 2000) 3 4 56

Products for HSPA13 Gene

Sources for HSPA13 Gene