Aliases for HSP90B1 Gene
External Ids for HSP90B1 Gene
Previous HGNC Symbols for HSP90B1 Gene
Previous GeneCards Identifiers for HSP90B1 Gene
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
GeneCards Summary for HSP90B1 Gene
HSP90B1 (Heat Shock Protein 90 Beta Family Member 1) is a Protein Coding gene. Diseases associated with HSP90B1 include Bipolar Disorder and Platyspondylic Lethal Skeletal Dysplasia, Torrance Type. Among its related pathways are Interleukin-4 and 13 signaling and IL17 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is HSP90AA1.
UniProtKB/Swiss-Prot Summary for HSP90B1 Gene
Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059).