Aliases for HSP90B1 Gene
External Ids for HSP90B1 Gene
Previous HGNC Symbols for HSP90B1 Gene
Previous GeneCards Identifiers for HSP90B1 Gene
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
GeneCards Summary for HSP90B1 Gene
HSP90B1 (Heat Shock Protein 90 Beta Family Member 1) is a Protein Coding gene. Diseases associated with HSP90B1 include Bipolar Disorder and Platyspondylic Lethal Skeletal Dysplasia, Torrance Type. Among its related pathways are AKT Siganaling Pathway and Photodynamic therapy-induced unfolded protein response. Gene Ontology (GO) annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is HSP90AB1.
UniProtKB/Swiss-Prot Summary for HSP90B1 Gene
Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity).