HSP90AB3P Gene (Pseudogene)

Heat Shock Protein 90 Alpha Family Class B Member 3, Pseudogene

GC04P087891
GIFtS:
16
See more...

Aliases for HSP90AB3P Gene

Aliases for HSP90AB3P Gene

  • Heat Shock Protein 90 Alpha Family Class B Member 3, Pseudogene 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 3, Pseudogene 2 3
  • Heat Shock 90kDa Protein 1, Beta Pseudogene 1 2 3
  • Heat Shock 90kD Protein 1, Beta Pseudogene 1 2 3
  • Heat Shock Protein 90Bc 3 4
  • HSP90BC 3 4
  • Heat Shock Protein 90kDa Alpha Family Class B Member 3, Pseudogene 3
  • Putative Heat Shock Protein HSP 90-Beta-3 4
  • Heat Shock Protein 90-Beta C 4
  • HSP90AB3P 5
  • HSPCP1 3

External Ids for HSP90AB3P Gene

Previous HGNC Symbols for HSP90AB3P Gene

  • HSPCP1

Previous GeneCards Identifiers for HSP90AB3P Gene

  • GC04P089031
  • GC04P088812

Summaries for HSP90AB3P Gene

GeneCards Summary for HSP90AB3P Gene

HSP90AB3P (Heat Shock Protein 90 Alpha Family Class B Member 3, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot Summary for HSP90AB3P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Additional gene information for HSP90AB3P Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSP90AB3P Gene

Genomics for HSP90AB3P Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HSP90AB3P Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J087891 Promoter 0.3 Ensembl 250.7 -0.6 -647 0.2 HSP90AB3P lnc-MEPE-1 piR-50968-096 SPP1 MEPE
GH04J088104 Enhancer 1.1 Ensembl ENCODE 5.1 +215.6 215611 5.9 ZSCAN16 MXD4 FEZF1 CEBPA FOXA1 HOMEZ KDM6A THAP11 CEBPB FOXA2 RNU6-818P RNU6ATAC31P PKD2 SPP1 HSP90AB3P HSALNG0035738 HSALNG0035736 ABCG2
GH04J088100 Enhancer 0.4 Ensembl dbSUPER 5.1 +209.8 209753 1.4 SPI1 RNU6-818P RNU6ATAC31P HSP90AB3P HSALNG0035736 HSALNG0035738 PKD2 ABCG2
GH04J088044 Enhancer 0.2 Ensembl 5.9 +153.5 153453 2 RNU6-818P PKD2 HSP90AB3P hsa-miR-5095-372 piR-31199-267 ABCG2
GH04J088069 Enhancer 0.2 Ensembl 5.5 +178.2 178153 1.4 PKD2 RNU6-818P HSP90AB3P piR-61945-389 hsa-miR-5095-372 ABCG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AB3P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for HSP90AB3P Gene

Latest Assembly
chr4:87,891,748-87,894,288
(GRCh38/hg38)
Size:
2,541 bases
Orientation:
Plus strand

Previous Assembly
chr4:88,812,900-88,815,440
(GRCh37/hg19 by Entrez Gene)
Size:
2,541 bases
Orientation:
Plus strand

chr4:88,812,995-88,815,167
(GRCh37/hg19 by Ensembl)
Size:
2,173 bases
Orientation:
Plus strand

Genomic View for HSP90AB3P Gene

Genes around HSP90AB3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AB3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AB3P Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSP90AB3P Gene

Proteins for HSP90AB3P Gene

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  • Protein details for HSP90AB3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58FF7-H90B3_HUMAN
    Recommended name:
    Putative heat shock protein HSP 90-beta-3
    Protein Accession:
    Q58FF7

    Protein attributes for HSP90AB3P Gene

    Size:
    597 amino acids
    Molecular mass:
    68325 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSP90AB3P Gene

Protein Expression for HSP90AB3P Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSP90AB3P Gene

  • Glycosylation at Asn46 and Asn331
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • H90B3_HUMAN (1697)

No data available for DME Specific Peptides for HSP90AB3P Gene

Domains & Families for HSP90AB3P Gene

Protein Domains for HSP90AB3P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSP90AB3P Gene

GenScript: Design optimal peptide antigens:
  • Heat shock protein 90-beta c (H90B3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q58FF7

UniProtKB/Swiss-Prot:

H90B3_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AB3P: view

No data available for Gene Families for HSP90AB3P Gene

Function for HSP90AB3P Gene

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  6. Cell Lines for research

Molecular function for HSP90AB3P Gene

UniProtKB/Swiss-Prot Function:
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Phenotypes From GWAS Catalog for HSP90AB3P Gene

Gene Ontology (GO) - Molecular Function for HSP90AB3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IBA 21873635
GO:0051082 unfolded protein binding IBA 21873635
GO:0097718 disordered domain specific binding IBA 21873635
genes like me logo Genes that share ontologies with HSP90AB3P: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSP90AB3P Gene

Localization for HSP90AB3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AB3P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HSP90AB3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0032991 protein-containing complex IBA 21873635
GO:0048471 perinuclear region of cytoplasm IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with HSP90AB3P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSP90AB3P Gene

Pathways & Interactions for HSP90AB3P Gene

PathCards logo

SuperPathways for HSP90AB3P Gene

No Data Available

Interacting Proteins for HSP90AB3P Gene

Selected Interacting proteins: Q58FF7-H90B3_HUMAN for HSP90AB3P Gene via IID

Gene Ontology (GO) - Biological Process for HSP90AB3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0008150 biological_process ND --
GO:0034605 cellular response to heat IBA 21873635
GO:0050821 protein stabilization IBA 21873635
genes like me logo Genes that share ontologies with HSP90AB3P: view

No data available for Pathways by source and SIGNOR curated interactions for HSP90AB3P Gene

Drugs & Compounds for HSP90AB3P Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for HSP90AB3P Gene

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mRNA/cDNA for HSP90AB3P Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB3P Gene

No ASD Table

Relevant External Links for HSP90AB3P Gene

GeneLoc Exon Structure for
HSP90AB3P

Expression for HSP90AB3P Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSP90AB3P Gene

mRNA expression in normal human tissues for HSP90AB3P Gene
mRNA expression by GTEx for HSP90AB3P Gene

Protein differential expression in normal tissues from HIPED for HSP90AB3P Gene

This gene is overexpressed in Plasma (17.8), Liver, secretome (13.8), Cervix (9.2), NK cells (8.7), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AB3P Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSP90AB3P

SOURCE GeneReport for Unigene cluster for HSP90AB3P Gene:

Hs.744112
genes like me logo Genes that share expression patterns with HSP90AB3P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AB3P Gene

Orthologs for HSP90AB3P Gene

Evolution for HSP90AB3P Gene

ENSEMBL:
Gene Tree for HSP90AB3P (if available)
TreeFam:
Gene Tree for HSP90AB3P (if available)

No data available for Orthologs for HSP90AB3P Gene

Paralogs for HSP90AB3P Gene

(12) SIMAP similar genes for HSP90AB3P Gene using alignment to 1 proteins:

  • H90B3_HUMAN
genes like me logo Genes that share paralogs with HSP90AB3P: view

No data available for Paralogs for HSP90AB3P Gene

Variants for HSP90AB3P Gene

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  1. SNP Genotyping and Copy Number Assays for research

Additional Variant Information for HSP90AB3P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AB3P

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for HSP90AB3P Gene

Disorders for HSP90AB3P Gene

Additional Disease Information for HSP90AB3P

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for HSP90AB3P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSP90AB3P Gene

Publications for HSP90AB3P Gene

  1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 4
  2. Assignment of an intron-containing human heat-shock protein gene (hsp90 beta, HSPCB) to chromosome 6 near TCTE1 (6p21) and two intronless pseudogenes to chromosomes 4 and 15 by polymerase chain reaction amplification from a panel of hybrid cell lines. (PMID: 8288256) Durkin AS … Nierman WC (Genomics 1993) 2 3
  3. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

ExternalLinks

View latest publications for HSP90AB3P gene in Mastermind

Products for HSP90AB3P Gene

Sources for HSP90AB3P Gene