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This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include Larynx Cancer and Powassan Encephalitis. Among its related pathways are HSF1-dependent transactivation and Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is HSP90AA1.
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0002134 | UTP binding | IEA | -- |
GO:0002135 | CTP binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003725 | double-stranded RNA binding | IDA | 21266579 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA,IDA | 18239673 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 10791971 |
GO:0005739 | mitochondrion | HDA | 20833797 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | Innate Immune System |
.61
|
|
3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
.01
|
|
4 | HSF1-dependent transactivation | ||
5 | Developmental Biology |
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001890 | placenta development | IEA | -- |
GO:0006457 | protein folding | IBA | 21873635 |
GO:0006805 | xenobiotic metabolic process | TAS | -- |
GO:0006986 | response to unfolded protein | NAS | 2768249 |
GO:0007004 | telomere maintenance via telomerase | IDA | 10197982 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bevacizumab | Approved, Investigational | Pharma | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2478 | ||
Geldanamycin | Experimental, Investigational | Pharma | Target | Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor | 10 | |
Radicicol | Experimental | Pharma | Target | ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic | 0 | |
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE | Experimental | Pharma | Target | 0 | ||
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
17-AAG |
|
75747-14-7 |
|
|
||
KRIBB11 |
|
342639-96-7 |
|
|
Compound | Action | Cas Number |
---|---|---|
17-AAG | Selective Hsp90 inhibitor | 75747-14-7 |
Geldanamycin | Selective Hsp90 inhibitor | 30562-34-6 |
KRIBB11 | HSF1 inhibitor | 342639-96-7 |
Radicicol | Hsp90 inhibitor. Antifungal antibiotic | 12772-57-5 |
Compound | Action | Cas Number |
---|---|---|
17-AAG (KOS953) | Hsp90 inhibitor | 75747-14-7 |
17-DMAG (Alvespimycin) HCl | Hsp90 inhibitor | 467214-21-7 |
AT13387 | Hsp90 inhibitor | 912999-49-6 |
AUY922 (NVP-AUY922) | Potent Hsp90 inhibitor | 747412-49-3 |
BIIB021 | Hsp90 inhibitor,selective and competitive | 848695-25-0 |
CH5138303 | 959763-06-5 | |
Ganetespib (STA-9090) | Hsp90 inhibitor,non-geldanamycin | 888216-25-9 |
Geldanamycin | Hsp90 inhibitor,potent and specific | 30562-34-6 |
HSP990 (NVP-HSP990) | 934343-74-5 | |
IPI-504 (Retaspimycin hydrochloride) | Hsp90 inhibitor,novel, potent,selective | 857402-63-2 |
KW-2478 | Potent Hsp90 inhibitor, novel, non-ansamycin, | 819812-04-9 |
MPC-3100 | Hsp90 inhibitor | 958025-66-6 |
NMS-E973 | Hsp90 inhibitor,potent and selective | 1253584-84-7 |
NVP-BEP800 | Oral Hsp90β inhibitor, novel, fully synthetic | 847559-80-2 |
PF-04929113 (SNX-5422) | Hsp90 inhibitor,potent and selective | 908115-27-5 |
PU-WS13 | Grp94-specific Hsp90 inhibitor | 1454619-14-7 |
SNX-2112 | Hsp90 inhibitor,ATP-competitve,potent and selective | 908112-43-6 |
VER-49009 | 558640-51-0 | |
VER-50589 | 747413-08-7 | |
XL-888 | Hsp90 inhibitor | 1149705-71-4 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 16b |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: | |
SP8: | |
SP9: | |
SP10: | |
SP11: | |
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | SLC29A1 31 |
|
OneToOne | |
HSP90AB1 30 |
|
||||
Chimpanzee (Pan troglodytes) |
Mammalia | HSP90AB1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HSP90AB1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HSP90AB1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hsp90ab1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hsp90ab1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HSP90AB1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSP90AB1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HSP90AB1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsp90ab1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.29353 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hsp90ab1 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1282 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Hsp83 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | HSP83_ANOGA 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | daf-21 30 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFL148C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12958g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSP82 30 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HSP90.1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os08g0500700 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.217 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11103 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04142 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hsp90 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11538965 | Benign: not provided | 44,248,746(+) |
C/T NM_007355.4(HSP90AB1):c.117C>T (p.Phe39=) |
SYNONYMOUS | |
rs150398983 | Benign: not provided | 44,253,152(+) |
C/T NM_007355.4(HSP90AB1):c.1839C>T (p.Asp613=) |
SYNONYMOUS | |
rs34684798 | Benign: not provided | 44,250,488(+) |
A/G NM_007355.4(HSP90AB1):c.846A>G (p.Leu282=) |
SYNONYMOUS | |
rs34706947 | Benign: not provided | 44,253,332(+) |
C/G NM_007355.4(HSP90AB1):c.2019C>G (p.Pro673=) |
SYNONYMOUS | |
rs35518699 | Benign: not provided | 44,252,189(+) |
G/A NM_007355.4(HSP90AB1):c.1653G>A (p.Lys551=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
larynx cancer |
|
|
powassan encephalitis |
|
|
prostate cancer |
|
|